Szafran
group
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Our main topics:
Our main topics:
The role of topoisomerase I (TopA), NAPs, and SMC condensins in chromosome organisation during Streptomyces growth and differentiation
The role of topoisomerase I (TopA), NAPs, and SMC condensins in chromosome organisation during Streptomyces growth and differentiation
Chromosome topology in bacteria is controlled by several dedicated proteins including DNA topoisomerases, nucleoid-associated proteins, and SMC condensins. We investigate the interplay between DNA-organising proteins during Streptomyces growth and differentiation, focusing on the chromosome structure rearrangements that assist Streptomyces sporulation.
Lysine post-translational modifications (PTMs) and their role in chromosome organisation
Lysine post-translational modifications (PTMs) and their role in chromosome organisation
Lysine modifications are common PTMs in bacteria strongly affecting protein activity and function. In our group, we investigate the role of acetylation and pupylation, two post-translational lysine modifications, and their role in regulating chromosome organisation and segregation in Streptomyces.
The role of CTP and CTP synthase (PyrG) in Streptomyces sporogenic differentiation
The role of CTP and CTP synthase (PyrG) in Streptomyces sporogenic differentiation
Chromosome partitioning protein ParB utilizes CTP to assemble a large nucleoprotein complex named segrosome. We study how CTP regulates ParB function during Streptomyces growth and how ParB function is correlated with the CTP synthase (PyrG) activity.
room 3.18
phone: (+48)71-375-26-40
marcin.szafran(at)uwr.edu.pl
dr hab. Marcin Szafran
dr hab. Marcin Szafran
Brief CV
Brief CV
2024: Habilitation, Faculty of Biotechnology, University of Wroclaw
since 2014: Assistant Professor, Department of Molecular Microbiology, Faculty of Biotechnology, University of Wroclaw
2014: PhD in Biochemistry, Faculty of Biotechnology, University of Wroclaw
2008: MSc, Biotechnology of Proteins and Peptides, Faculty of Biotechnology, University of Wroclaw
2006: BSc, Biotechnology, Faculty of Biotechnology, University of Wroclaw
... and the team
... and the team
PhD students
PhD students
Dominik Bania, Msc
Dominik Bania, Msc
Research interests/projects
The role of ParB in chromosome rearrangements during S. venezuelae development
room 2.24
phone: (+48) 71-375-26-40
dominik.bania(at)uwr.edu.pl
Aleksandra Jakubowska, Msc
Aleksandra Jakubowska, Msc
Research interests/projects
The role of ParA protein in the regulation of the life cycle and chromosome organization during S. venezuelae development
room 2.25
phone: (+48) 71-375-26-40
aleksandra.jakubowska2(at)uwr.edu.pl
Former PhD students
Former PhD students
Julia Duława-Kobeluszczyk (graduated in 2024)
Julia Duława-Kobeluszczyk (graduated in 2024)
Justyna Szymczak (graduated in 2023)
Justyna Szymczak (graduated in 2023)
Research projects
Research projects
2024-2028: National Science Center; OPUS 25 (2023/49/NZ1/00781) "Exploring unknown molecular mechanisms controlling ParB-dependent chromosome rearrangements in Streptomyces".
2019-2024: National Science Center; SONATA 14 (2018/31/D/NZ1/00287) “Two lysine posttranslational modifications, acetylation and pupylation and their role in regulation of Streptomyces chromosome topology”
2017-2022: National Science Center; HARMONIA 8 (2016/22/M/NZ1/00122) “The architecture of bacterial segrosome - the cooperation of topoisomerase I and segregation protein ParB in Streptomyces”
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