Jakimowicz
group
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Our main topics:
Our main topics:
Chromosome segregation and its coordination with cell division and other cell cycle processes
Chromosome segregation and its coordination with cell division and other cell cycle processes
We focus on the function of the chromosome segregation proteins ParA and ParB in Streptomyces and Mycobacterium . We found that segregation protein ParA interacts with polar proteins, Scy in Streptomyces and DivIVA in Mycobacterium. Studying the ParA and ParB interactions we explore the coordination of chromosome segregation with the other bacterial cell processes - cell elongation and cell division.
Chromosome topology and gene transcription
Chromosome topology and gene transcription
Chromosome topology is controlled by topoisomerases and nucleoid associated proteins (NAPs). We have established the role of highly processive topoisomerase I (TopA) in Streptomyces chromosome organisation and we examined its cooperation with NAPS. We also focus on the role of chromosome topology in regulation of gene expression.
The chromosome organisation during Streptomyces cell cycle
The chromosome organisation during Streptomyces cell cycle
Our recent studies have revealed how the linear chromosome of S. venezuelae is folded and provided the first evidence of profound rearrangement of the bacterial chromosome during sporulation. We have also showed the role of segregation proteins, condesins and NAPs in chromosome folding.
room 3.20
phone: (+48)71-375-29-26
dagmara.jakimowicz(at)uwr.edu.pl
prof. Dagmara Jakimowicz
prof. Dagmara Jakimowicz
Brief CV
Brief CV
since 2024: Head of Department of Molecular Microbiology, Faculty of Biotechnology, University of Wroclaw,
2018: Professor
Since 2009: Associate Professor at Faculty of Biotechnology, University of Wroclaw, Poland
2008: Habilitation, Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, Wroclaw, Poland
2005 - 2008: Assistatnt Professor at Institute of Immunology and Experimental Therapy, Wroclaw, Poland
2001 - 2005: PostDoc, Marie Curie fellowship, prof. Keith Chater's group, John Innec Centre, Noriwch, UK
2000: PhD, supervisor: prof. Jolanta Zakrzewska-Czerwińska, Institute of Immunology and Experimental Therapy, Wroclaw, Poland
1996: MSc, Biotechnology, University of Wroclaw
... and the team
... and the team
PhDs
PhDs
room 3.13
phone: (+48)71-375-62-47
agnieszka.strzalka(at)uwr.edu.pl
Agnieszka Strzałka
Agnieszka Strzałka
Brief CV
Since 2018: PostDoc - Department of Molecular Microbiology, Faculty of Biotechnology at University of Wroclaw
2017: PhD in Department of Molecular Microbiology, Faculty of Biotechnology, University of Wroclaw
2012: MSc in Molecular Microbiology, Faculty of Biotechnology, University of Wroclaw
2011: BSc in Biotechnology, University of Wroclaw
Research interests/projects
Chromosome dynamics in Streptomyces coelicolor
room 3.17
phone: (+48)71-375-23-93
monika.pioro(at)uwr.edu.pl
Monika Pióro
Monika Pióro
Brief CV
Since 2018: PostDoc - Department of Molecular Microbiology, Faculty of Biotechnology at University of Wroclaw
2018: PhD in Molecular Biology, Ludwik Hirszfeld Institute of Immunology and Experimental Therapy, Laboratory of Molecular Biology of Microorganisms
2013: MSc in Molecular Microbiology, University of Wroclaw
2011: BSc in Biotechnology, Faculty of Biotechnology, University of Wroclaw
Research interests/projects
Analysis of species-specific interactions of proteins involved in segregation of bacterial chromosome
PhD students
PhD students
Katarzyna Pawlikiewicz
Katarzyna Pawlikiewicz
Research interests/projects
Spatial organisation of Streptomyces venezuelae chromosome during sporulation and germination of spores - the role of nucleoid-binding proteins.
room 3.18
phone: (+48)71-375-26-40
katarzyna.pawlikiewicz(at)uwr.edu.pl
Jakub Mikołajczyk
Jakub Mikołajczyk
Research interests/projects
Influence of changes in chromosome topology and stress conditions on gene expression during sporulation and dermination of spores.
room 2.24
phone: (+48)71-375-70-62
jakub.mikolajczyk2(at)uwr.edu.pl
Elżbieta Kryska
Elżbieta Kryska
Research interests/projects
The role of ParA homolog in Mycobacterium
room 2.25
phone: (+48) 71-375-70-62
elzbieta.kryska(at)uwr.wedu.pl
Kinga Klich
Kinga Klich
Research interests/projects
The role of NAP proteins in chromosome organization and regulation of gene expression in Streptomyces venezuelae
room 2.25
phone: (+48)71-375-70-62
kinga.klich(at)uwr.edu.pl
- Former PhD students
- Izabela Matusiak (graduated in 2023)
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