Acute Kidney Injury

Acute Kidney Injury in paediatric cancer patients

Background

Over the last few decades, cancer therapy has been improved by the introduction of intensified treatment protocols and advanced supportive therapy. As a consequence, outcomes for children diagnosed with cancer have progressed from an estimated 80% mortality in the late 80’s to an 80% survival at this time. However, these developments have also increased morbidity, including the incidence of disease- or treatment-associated complications, many of which require intensive care treatment.  Renal failure is one of these serious complications.

Relevance for cancer research

Studies on outcome assessment in paediatric cancer and hematopoietic stem cell transplant (HSCT) patients are scarce. Acute kidney injury (AKI) is common in the post-HSCT phase and contributes to morbidity in these critically ill children. Continuous renal replacement therapy (CRRT) has become the most widely used renal support modality for use in the AKI population. A better understanding of the impact of CRRT on short- and long-term outcomes is hence essential for an optimal CRRT implementation. Furthermore, early detection of AKI is critical.  The diagnosis of AKI is currently based on an increase in serum creatine (SCr), which is a marker of glomerular filtration rate (GFR) and the presence of oliguria. Our recently study showed Serum creatinine and oliguria seem to be not sensitive markers for timely detection of AKI in this population. 


Aims

Within this project we will investigate:


Project Outcomes


Team

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