Embedded Files
Ongoing Projects
Ongoing Projects
The PACT-ES study
The PACT-ES study
This research project aims to employ advanced medical statistics methodology to develop a novel Personalised Approach to Chemotherapy Treatment for Ewing’s Sarcoma (PACT-ES). PACT-ES will investigate the longitudinal relationship between dose-reductions/delays in chemotherapy and multiple side effects, and their impact on survival outcomes.
The INDICATES study
The INDICATES study
This study aims to develop a user-friendly prediction tool to assist the multidisciplinary team in the decision-making process on INDIvidualized loCAl Therapy for patients with Ewing Sarcoma (INDICATES).
Prediction and validation using PERSARC (PERsonalized SARcoma Care)
Prediction and validation using PERSARC (PERsonalized SARcoma Care)
The PERSARC app represents an informative support tool for the dynamic prediction of overall survival (OS) and local recurrence (LR) in high-grade Soft-Tissue Sarcomas of the extremity (eSTS), using patient-, tumour- and treatment-related characteristics. It is currently used by many physicians in their daily practice to assess a more realistic prognosis of expected recurrence rates and life expectancy, improving their clinical-based predictive capability. Furthermore, given its established validity, it can serve as a tool for the validation and comparison of new models for OS and/or LR in eSTS.
Imputation in cure models
Imputation in cure models
The aim of this project is to extend the methodology of mixture cure models by incorporating a multiple imputation framework. The proposed approach differentiates between covariates affecting cure probability and those influencing survival, accommodating scenarios with missing covariates. Simulation studies and an application to osteosarcoma will illustrate its benefits and practical implications.
Multistate cure analysis
Multistate cure analysis
The aim of this project is to develop a more generalized and user-friendly algorithm to fit a multistate cure model, on top of the current framework of multistate model and mixture cure model. The proposed algorithm will be applied on a study of childhood osteosarcoma as an example.
Evaluating MUTARS® mega-endoprostheses
Evaluating MUTARS® mega-endoprostheses
The aim of this project is to perform a qualitative evaluation of MUTARS® mega-endoprostheses survival in patients with extensive bone defects, describing failure types, mechanical/non-mechanical complications (according to the Henderson classification), and risk factors for complications.
The PRIME-ROSE study
The PRIME-ROSE study
The aim of PRIME-ROSE is to enable cross-border data sharing by combining the data from DRUP-like trials in Europe. First, it builds synthetic randomized trials resembling a randomized control trial to evaluate clinical benefit. Second, the project plans to design and conduct pragmatic clinical trials, provide implementation data, effectively involve patients, focus on multi-stakeholder collaboration and continuous knowledge transfer and training of DRUP-like trials.
The SCOPES study
The SCOPES study
The aim of the KWF-funded study is to compare the wound healing complication rates and local control between the two different treatment schedules in soft tissue sarcomas, as well as the treatment-related burden for patients and the cost-effectiveness of the two regimens.
The DRUP (Drug Rediscovery Protocol) study
The DRUP (Drug Rediscovery Protocol) study
The aim of this project is to elaborate the use of statistical methods within the long-standing DRUP trial. First, the pooling of information across the different cohorts will be investigated to better analyze the effectiveness of targeted therapy in DRUP. Secondly, the absence of a control group shall be addressed by examining the application of survival models with historical data.
Pathological diagnosis of solid pediatric tumors
Pathological diagnosis of solid pediatric tumors
The aims of the this project are: (i) to evaluate the diagnostic value and accuracy of current pathological techniques in the diagnosis of solid pediatric tumors; (ii) to investigate the prognostic value of molecular aberrations in (non-high-risk) neuroblastoma to improve current risk-stratification and thereby improving outcome of neuroblastoma patients.
Acute Kidney Injury in paediatric cancer patients
Acute Kidney Injury in paediatric cancer patients
This project focuses on investigating (i) the applicability of non-invasive biomarkers to identify early Acute Kidney Injury (AKI) in paediatric cancer patients, and (ii) the impact of continuous renal replacement therapy on both short- and long-term outcomes among these children and factors that influence these outcomes.
The PASART-II clinical trial
The PASART-II clinical trial
In the phase 2 PASART-II clinical trial, the efficacy, feasibility and safety of the neo-adjuvant combination of pazopanib and radiotherapy will be examined in high-risk, localized soft tissue sarcoma. If the results of this trial are positive, oncologists could be provided with a new treatment modality for this rare type of tumours, decreasing treatment side-effects, and improving patient survival and quality of life.
Liquid biopsies in pediatric solid tumors
Liquid biopsies in pediatric solid tumors
This project focuses on investigating the clinical significance of (i) minimal residual disease in bone marrow and blood and (ii) cell free DNA tumor markers in patients with neuroblastoma and other pediatric solid tumors.
Past Projects
Past Projects
Critically ill pediatric oncology patients
Critically ill pediatric oncology patients
Fluorescence Guided Surgery for Pediatric Oncology
Fluorescence Guided Surgery for Pediatric Oncology
Long term survival after childhood osteosarcoma: cure models
Long term survival after childhood osteosarcoma: cure models
Time-varying covariates for survival models
Time-varying covariates for survival models
Predicting cancer survival with machine learning
Predicting cancer survival with machine learning
Personalised Sarcoma Care (PERSARC)
Personalised Sarcoma Care (PERSARC)
Validating the Adjusted Clinical Groups (ACG) Risk Stratification Tool for Dutch Primary Care
Validating the Adjusted Clinical Groups (ACG) Risk Stratification Tool for Dutch Primary Care
Meta-analysis of individual patient data to investigate dose-intensity relation with survival outcome for osteosarcoma patients
Meta-analysis of individual patient data to investigate dose-intensity relation with survival outcome for osteosarcoma patients
Individual Clinical Advanced decision-making and Risk Evaluation for Ewing sarcoma (iCare 4 Ewing)
Individual Clinical Advanced decision-making and Risk Evaluation for Ewing sarcoma (iCare 4 Ewing)
Impact of Surgery for Neuroblastoma
Impact of Surgery for Neuroblastoma
The OPTIMAL study: Optimizing the treatment of patients with bone metastases
The OPTIMAL study: Optimizing the treatment of patients with bone metastases
Dose-intensity relation with survival outcomes in Acute Lymphoblastic Leukaemia
Dose-intensity relation with survival outcomes in Acute Lymphoblastic Leukaemia
Google Sites
Report abuse