Computational chronobiology

We are interested in studying the human "body clock" with advanced computational methods and over a range of timescales.

In healthy humans, we are interested in how our lifestyle and behaviour impacts and interacts with out body clock. As part of this, we are currently running wearable-based studies with healthy volunteers. Take a look here if you want to take part!

Additionally, in many neurological and psychiatric processes fluctuate over time, following biological rhythms on circadian (daily) and longer (multidien) timescales. We study how these rhythms are expressed in the brain and body, and how they relate to disease. Using long-term intracranial EEG, we have shown that circadian and ultradian rhythms of brain activity are diminished in pathological tissue. Using wearable sensors, we have found that circadian rhythms estimated from long-term heart rate are more variable in people with epilepsy. We have also shown that fluctuations in interictal EEG over minutes to days can explain how seizures change over time.