Research Support

Bioinformatics and Computational Biology

Our researchers work on core computational biology-related problems, including genomics, proteomics, metagenomics, and phylogenomics. We develop novel techniques that combine ideas from mathematics, computer science, probability, statistics, and physics, and we help identify and formalize computational challenges in the biological domain, while experimentally validating novel hypotheses generated by our analyses.

We are developing algorithms with improved accuracy for large-scale and complex estimation problems in phylogenomics (genome-scale phylogeny estimation), multiple sequence alignment, and metagenomics. We are exploring gene regulation—developing advanced techniques to predict the diverse function of noncoding parts of DNA and to relate interspecies and interpersonal differences in DNA to differences in the organism’s form and function. We work broadly in the development of machine learning techniques for computational biology, with research spanning the areas of molecular and structural biology; networks and systems biology; and molecular mechanisms of human disease.

Plant genomics

• To undertake, aid, promote, guide and coordinate research of high caliber in basic and applied plant molecular biology;
• To provide and promote effective linkages on a continuing basis between various scientific and research agencies / laboratories and other organizations working in the country on plant genes, development and related areas;
• To utilize molecular biology approaches along with tissue culture and genetic engineering technology to identify important genes and manipulate these for generating transgenic plants with improved agronomic characters and pathogen / stress resistance;
• To take up any fundamental work related to gene-regulation and mapping that would aid in achieving above mandate;
• Development of molecular markers for monitoring important traits;
• Production and testing of transgenic plants;
• Identification of genes that are vital for the survival of the pathogens so that those could be targeted for pathogen combating;
• To impart advance training at different levels in the field of plant genetic engineering and genome analysis; and
• To undertake collaborative programmes with International Institutes those are engaged in plant genome research and develop close linkages.