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Many people need to realize how genetics and cancer are linked together. In this blog, urologist Cletus Georges MD discusses genetics as it relates to prostate cancer.
Many people need to realize how genetics and cancer are linked together. In this blog, urologist Cletus Georges MD discusses genetics as it relates to prostate cancer.
Recent studies have indicated that up to 10% of men with prostate cancer have the condition due to an inherited genetic mutation. The fact is, there are national guidelines that aim to determine which men who suffer from prostate cancer should undergo genetic counseling and testing. This instrument was created in the interest of addressing cancer in general, which has been one of the most elusive medical issues known to man for decades.
Recent studies have indicated that up to 10% of men with prostate cancer have the condition due to an inherited genetic mutation. The fact is, there are national guidelines that aim to determine which men who suffer from prostate cancer should undergo genetic counseling and testing. This instrument was created in the interest of addressing cancer in general, which has been one of the most elusive medical issues known to man for decades.
Following said guidelines, men with prostate cancer are advised to speak with a genetics expert if any of the following are true to their condition, as Cletus Georges MD details:
Following said guidelines, men with prostate cancer are advised to speak with a genetics expert if any of the following are true to their condition, as Cletus Georges MD details:
1. A tumor test that suggests a hereditary condition
1. A tumor test that suggests a hereditary condition
2. A blood relative has tested positive for an inherited mutation pointing to a gene linked to prostate cancer
2. A blood relative has tested positive for an inherited mutation pointing to a gene linked to prostate cancer
3. Metastatic prostate cancer diagnosed at any age
3. Metastatic prostate cancer diagnosed at any age
4. An indication based on pathology that the cancer is considered very-high or high-risk
4. An indication based on pathology that the cancer is considered very-high or high-risk
5. Eastern European (Ashkenazi) Jewish ancestry
5. Eastern European (Ashkenazi) Jewish ancestry
6. A blood relative having been diagnosed with breast cancer at age 50 or younger, or ovarian, pancreatic or metastatic prostate cancer, or high-grade prostate cancer at any age
6. A blood relative having been diagnosed with breast cancer at age 50 or younger, or ovarian, pancreatic or metastatic prostate cancer, or high-grade prostate cancer at any age
7. Two or more close relatives diagnosed with breast or prostate cancer at any age
7. Two or more close relatives diagnosed with breast or prostate cancer at any age
In the case of prostate cancer, the relevant genetic tests that are administered are Germline and Somatic testing, which work to identify unique target therapies, shares Cletus Georges MD.
In the case of prostate cancer, the relevant genetic tests that are administered are Germline and Somatic testing, which work to identify unique target therapies, shares Cletus Georges MD.
Genetic testing may be cumbersome to the patient, as it already is tough to have cancer in the first place. However, the benefit of testing lies in its ability to identify gene mutations that can impact patients and their families.
Genetic testing may be cumbersome to the patient, as it already is tough to have cancer in the first place. However, the benefit of testing lies in its ability to identify gene mutations that can impact patients and their families.
After graduating from Andrews University with a Bachelor’s Degree in Zoology with a Biomedical option in 1997, Cletus Georges MD completed his residency in Urology at Northwestern University McGaw Medical Center in 1997. He has helped many individuals who have problems that affect the urinary tract. For more information, please visit this page.
After graduating from Andrews University with a Bachelor’s Degree in Zoology with a Biomedical option in 1997, Cletus Georges MD completed his residency in Urology at Northwestern University McGaw Medical Center in 1997. He has helped many individuals who have problems that affect the urinary tract. For more information, please visit this page.
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