研究業績

学術論文・総説

（欧文）

【2024】

HIF-1 inhibition reverses opacity in a rat model of galactose-induced cataract.

Takashima M, Nagaya M, Takamura Y, Inatani M, Oki M. 

PLoS One. 2024 Feb 28;19(2):e0299145. doi: 10.1371/journal.pone.0299145. eCollection 2024.

Taniguchi K, Kajitani T, Ayano T, Yoshida T, Oki M. 

A novel tracking and analysis system for time-lapse cellular imaging of Schizosaccharomyces pombe.

Genes Genet Syst. 2024 Mar 26;99. doi: 10.1266/ggs.23-00239. Epub 2024 Feb 21.

Ayano T, Oki M. 

IMD2, located near the boundary of heterochromatin regions, is regulated by multiple HAT-related factors.

Genes Genet Syst. 2024 Mar 26;99. doi: 10.1266/ggs.23-00284. Epub 2024 Feb 21.

Tsuji G, Shimomura A, Fukuoka S, Oki M. 

RNA synthesis in liposomes with negatively charged lipids after fusion via freezing-thawing.

Genes Genet Syst. 2024 Mar 26;99. doi: 10.1266/ggs.23-00297. Epub 2024 Feb 21.

Ayano T, Yokosawa T, Oki M. 

GTP-dependent regulation of heterochromatin fluctuations at subtelomeric regions in Saccharomyces cerevisiae.

Genes Cells. 2024 Mar;29(3):217-230. doi: 10.1111/gtc.13094. Epub 2024 Jan 16. 

Takashima M, Yamamura S, Tamiya C, Inami M, Takamura Y, Inatani M, Oki M. 

Glutamate is effective in decreasing opacity formed in galactose-induced cataract model.

Sci Rep. 2024 Feb 19;14(1):4123. doi: 10.1038/s41598-024-54559-y. 

【2023】

Takashima M, Taniguchi K, Nagaya M, Yamamura S, Takamura Y, Inatani M, Oki M. 

Gene profiles and mutations in the development of cataracts in the ICR rat model of hereditary cataracts.

Sci Rep. 2023 Oct 24;13(1):18161. doi: 10.1038/s41598-023-45088-1. 

Kamata K, Ayano T, Oki M (2023) 

Spt3 and Spt8 are involved in the formation of a silencing boundary by interacting with TATA-binding protein.

Biomolecules, 13 (4): 619

Arimura S, Iwasaki K, Neo T, Orii Y, Matsumura T, Takamura Y, Oki M, Inatani M (2023)

Chronic antioxidant capacity loss in anterior chamber environment after iridectomy.

Transl Vis Sci Technol. 2023 May 1;12(5):4 

【2022】

Yamaoka R, Kanada F, Nagaya M, Takashima M, Takamura Y, Inatani M, Oki M. 

Analysis of cataract-regulated genes using chemical DNA damage induction in a rat ex vivo model

PLoS One. 2022 Dec 7;17(12):e0273456. 

Nagaya M, Yamaoka R, Kanada F, Sawa T, Takashima M, Takamura Y, Inatani M, Oki M. 

Histone acetyltransferase inhibition reverses opacity in rat galactose-induced cataract

PLoS One. 2022 Nov 23;17(11):e0273868 

Shimomura A, Ina S, Oki M, Tsuji G. 

Effects of Charged Lipids on Giant Unilamellar Vesicle Fusion and Inner Content Mixing via Freeze-Thawing.

Chembiochem. 2022 Dec 16;23(24):e202200550. 

Nagaya M, Kanada F, Takashima M, Takamura Y, Inatani M, Oki M. 

Atm inhibition decreases lens opacity in a rat model of galactose-induced cataract.

PLoS One. 2022 Sep 23;17(9):e0274735. 

Kajii K, Shimomura A, T Higashide M, Oki M, Tsuji G. 

Effects of Sugars on Giant Unilamellar Vesicle Preparation, Fusion, PCR in Liposomes, and Pore Formation.

Langmuir, 2022 Jul 26;38(29):8871-8880. 

【2021】

Oki M and Masai H. (2021)

Regulation of HP1 protein by phosphorylation during transcriptional repression and cell cycle.

J. Biochem., 2021 Sep 7;169(6):629-632 

Tsuji G, Sunami T, Oki M, Ichihashi N.(2021)

Exchange of proteins in liposomes through streptolysin O pores.

Chembiochem, 2021 Jun 2;22(11):1966-1973 

【2020】

Bandaru S, Higashide TM, Shimizu Y, Usami K, Lee S, Takei NK, Yoshitome K, Nishimura Y, Otsuki T, Ito T. (2020)

Structure-based design of gRNA for Cas13 

Sci Rep. 2020 Jul 14;10(1):11610

Neo T, Gozawa M, Takamura Y, Inatani M, Oki M. (2020)

Gene expression profile analysis of the rabbit retinal vein occlusion model.

PLOS ONE, 2020 Jul 31;15(7):e0236928 

Kanada F, Ogino Y, Yoshida T, Oki M. (2020) 

A novel tracking and analysis system for time-lapse cell imaging of Saccharomyces cerevisiae.

Genes Genet. Syst., 95 (2), 75-83. PMID: 32249245

Hayashi N and Oki M. (2020)

Altered metabolic regulation owing to gsp1 mutations encoding the nuclear small G protein in Saccharomyces cerevisiae.

Curr Genet. 66 (2), 335-344. PMID: 31372715

【2019】

Kanada F, Takamura Y, Miyake S, Kamata K, Inami M, Inatani M, Oki M. (2019) 

Histone acetyltransferase and Polo-like kinase3 inhibitors prevent rat galactose-induced cataract.

Sci. Rep., Dec 27;9(1):20085. PMID: 31882756 

Hamdani O, Dhillon N, Hsieh TS, Fujita T, Ocampo J, Kirkland JG, Lawrimore J, Kobayashi   TJ,  Friedman B, Fulton D, Wu KY, Chereji RV, Oki M, Bloom K, Clark DJ, Rando OJ, Kamakaka RT. (2019)

tRNA Genes Affect Chromosome Structure and Function via Local Effects.

Mol. Cell. Biol., 39(8). pii: e00432-18.  PMID:30718362

Doubayashi D, Oki M, Mikami B, Uchida H. (2019)

The microenvironment surrounding FAD mediates its conversion to 8-formyl-FAD in Aspergillus oryzae RIB40 formate oxidase.

J. Biochem., 166(1), 67-75. PMID:30715389

【2018】

Uchida H, Mikami B, Yamane-Tanabe A, Ito A, Hirano K, Oki M. (2018)

Crystal structure of an aldehyde oxidase from Methylobacillus sp. KY4400.

J. Biochem., 163 (4), 321-328. PMID: 29319807

Sunami T, Shimada K, Tsuji G, and Fujii S

Flow Cytometric Analysis To Evaluate Morphological Changes in Giant Liposomes As Observed in Electrofusion Experiments

Langmuir. 2018; vol. 34(1) : pp. 88-96

Murase Y, Nakanishi H, Tsuji G, Sunami T, Ichihashi N.

In vitro evolution of unmodified 16S rRNA for simple ribosome reconstitution

ACS Synth Biol. 2018; vol. 7(2) : pp.576-583

Tsuji G, Sunami T, Ichihashi N.

Production of giant unilamellar vesicles by the water-in-oil emulsion-transfer method without high internal concentrations of sugars

J Biosci Bioeng. 2018; vol. 126 (4): pp.540-545

【2016】

Aihara H, Nakagawa T, Mizusaki H, Yoneda M, Kato M, Doiguchi M, Imamura Y, Higashi M, Ikura T, Hayashi T, Kodama Y, Oki M, Nakayama T, Cheung E, Aburatani H, Takayama KI, Koseki H, Inoue S, Takeshima Y, Ito T. (2016) 

Histone H2A T120 Phosphorylation Promotes Oncogenic Transformation via Upregulation of Cyclin D1.      

Mol Cell. 64(1), 176-188. PMID: 27716482

Kamata K, Shinmyozu K, Nakayama JI, Hatashita M, Uchida H, Oki M. (2016)

Four domains of Ada1 form a heterochromatin boundary through different mechanisms.

Genes Cells. 21(10), 1125-1136. PMID: 27647735

Mitsumori R, Shinmyozu K, Nakayama J, Uchida H and Oki M. (2016)

Gic1 is a novel heterochromatin boundary protein in vivo.

Genes Genet. Syst., 91(3):151-159. PMID: 27301280 

Mitsumori R*, Ohashi T*, Kazuto K, Ichino A, Kei Taniguchi, Kunihiro Ohta, Uchida H and Oki M. (2016)

Analysis of novel Sir3 binding regions in Saccharomyces cerevisiae.

J. Biochem., 160 (1), 11-17. PMID: 26957548

*These two authors contributed equally to this work.

Gakushi Tsuji, Satoshi Fujii, Takeshi Sunami, and Tetsuya Yomo

Sustainable proliferation of liposomes compatible with inner RNA replication

Proc Natl Acad Sci U S A. 2016; vol. 113(3) : pp. 590-595

【2014】

Kamata K*, Goswami G*, Kashio S, Urano T, Nakagawa R, Uchida H and Oki M. (2014) 

The N-terminus and Tudor domains of Sgf29 are important for its heterochromatin boundary formation function.

J. Biochem., 155 (3), 159-171. 

*These two authors contributed equally to this work.

【2013】

Kamata K*, Hatanaka A*, Goswami G, Shinmyozu K, Nakayama J, Urano T, Hatashita, M, Uchida H and Oki M. (2013) 

The C-terminus of the Sgf73 subunit of SAGA and SLIK is important for retention in the larger complex and for heterochromatin boundary  function.

Genes to cells, 18(9), 823-837. PMID: 23819448

*These two authors contributed equally to this work.

Mano Y, Kobayashi TJ, Nakayama J, Uchida H and Oki M.(2013) 

Single cell visualization of yeast gene expression shows correlation of epigenetic switching between multiple heterochromatic regions through multiple generations.

PLOS Biology, Jul;11(7):e1001601. PMID: 23843746

【2011】

Hatanaka A, Chen B, Sun JQ, Mano Y, Funakoshi M, Kobayashi H, Ju Y, Mizutani T,  Shinmyozu K, Nakayama J, Miyamoto K, Uchida H and Oki M. (2011)

Fub1, a novel protein isolated by boundary screening, binds the proteasome complex.

Genes Genet. Syst., 86, 305-314.  PMID: 22362029

Doubayashi D, Ootake T, Maeda Y, Oki M, Tokunaga Y, Sakurai A, Nagaosa Y, Mikami B, Uchida H. (2011) 

Formate oxidase, an enzyme of the glucose-methanol-choline oxidoreductase family, has His-Arg pair and 8-formyl-FAD in catalytic site. 

Biosci. Biotechnol. Biochem., 75, 1662-1667.  PMID: 21897046

Sun JQ, Hatanaka A and Oki M. (2011)

Boundaries of transcriptionally silent chromatin in Saccharomuces cerevisiae.

Genes Genet. Syst., 86, 73-81. (Review)  PMID: 21670546

【2010】

Maeda Y, Dobayashi D, Ootake T, Oki M, Mikami B and Uchida H. (2010)

Crystallization and preliminary X-ray analysis of formate oxidase, an enzyme of the glucose-methanol-choline oxidoreductase family. 

Acta. Crystallogr. Sect. F. Struct. Biol. Cryst. Commun., 66, 1064-1066. PMID: 20823527

Mizutani T, Yazawa T, Ju Y, Imamichi Y, Uesaka M, Inaoka Y, Matsuura K, Kamiki Y, Oki M , Umezawa A and Miyamot K. (2010)

Identification of a novel distal control region upstream of the human steroidogenic acute regulatory protein (STAR) gene that participates in SF-1 dependent chromatin architecture. 

J. Biol. Chem., 285, 28240-28251.  PMID: 20601698

【2009】

Maeda Y, Dobayashi D, Oki M, Nose H, Sakurai A, Isa K, Fujii Y and Uchida H. (2009) 

Expression in Escherichia coli of an unnamed protein gene from Aspergillus oryzae RIB40 and cofactor analyses of the gene product as     formate oxidase. 

Biosci. Biotechnol. Biochem., 73 2645-2649.  PMID: 19966484

【2008】

Maeda Y, Oki M, Fujii Y, Hatanaka A, Hojo M, Hirano K and Uchida H. (2008) 

Cloning and expression of three formate oxidase genes from Debaryomyces vanrijiae MH201.

Biosci. Biotechnol. Biochem., 72, 1999-2004.  PMID: 18685206

【2007】

Oki M, Ma L, Wang Y, Hatanaka A, Miyazato C, Tatebayashi K, Nishitani H, Uchida H and Nishimoto T. (2007) 

Identification of novel suppressors for Mog1 implies its involvement in RNA metabolism, lipid metabolism and signal transduction. 

Gene, 400, 114-121.  PMID: 17651922

Oki M, Aihara H and Ito T. (2007) 

Role of histone phosphorylation in chromatin dynamics and its implications in diseases. 

Subcell Biochem., 41, 319-336. (Review)  PMID: 17484134

Hayashi N, Murakami S, Tsurusaki S, Nagaura Z, Oki M, Nishitani H, Kobayashi M, Shimizu H, Yamamoto K and Nishimoto T. (2007) 

Temperature-sensitive defects of the GSP1 gene, yeast Ran homologue, activeate the Tel1-dependent pathway.          

Biochem.Biophys.Res.Commun., 355, 330-336.  PMID: 17187759

【2006】

Valencia-Burton M, Oki M, Johnson J, Seier TA, Kamakaka RT and Haber JE. (2006) 

Different mating-type-regulated genes affect the DNA repair defects of Saccharomyces RAD51, RAD52 and RAD55 mutants. 

Genetics, 174, 41-55.  PMID: 16782999

Dhillon N, Oki M, Szyjka SJ, Aparicio OM and Kamakaka RT. (2006) 

H2A.Z functions to regulate progression through the cell cycle.  

Mol. Cell. Biol., 26, 489-501.  PMID: 16382141

【2005】

Oki M and Kamakaka RT. (2005) 

Barrier function at HMR.  

Mol. Cell, 19, 707-716.  PMID: 16137626

【2004】

Oki M, Valenzuela L, Chiba T, Ito T and Kamakaka RT. (2004) 

Barrier proteins remodel and modify chromatin to restrict silenced domains.  

Mol. Cell. Biol., 24, 1956-1967.  PMID: 14966276

【2002】

Oki M and Kamakaka RT. (2002)  Blockers and barriers to transcription :   competing activities.  

Curr. Opin. Cell. Biol., 14, 299-304. (Review)  PMID: 12067651

【2001】

Suzuki N, Noguchi E, Nakashima N, Oki M, Ohba T, Tartakoff A, Ohishi M, and Nishimoto T. (2001) 

The Saccharomyces cerevisiae small GTPase, Gsp1p/Ran , is involved     in 3' processing of 7S-to-5.8S rRNA and in degradation of the excised  5'-A0 fragment of 35S pre-rRNA, both of which are carried out by the exosome.  

Genetics, 158, 613-625.  PMID: 11404326

【2000】

Oki M and Nishimoto T. (2000).  

Yrb1p interaction with the Gsp1p C terminus blocks Mog1p stimulation of GTP release from Gsp1p.  

J. Biol Chem., 275, 32894-32900.  PMID: 10921930

【1998】

Oki M and Nishimoto T. (1998).  

A protein required for nuclear-protein import, Mog1p,  directly interacts with GTP-Gsp1p, the Saccharomyces  cerevisiae Ran homologue.  

Proc. Natl. Acad. Sci. USA, 95, 15388-15393.  PMID: 9860978

Oki M, Noguchi E, Hayashi N, Nishimoto T. (1998) 

Nuclear protein import, but not mRNA export, is defective  in all Saccharomyces cerevisiae  mutants that produce temperature-sensitive forms of the Ran GTPase homologue Gsp1p.  

Mol. Gen. Genet., 257, 624-634.  PMID: 9604885

Kakikawa M, Watanabe N, Funawatashi T, Oki M, Yasukawa H, Taketo A, Kodaira K. (1998). 

Promoter/repressor system in Lactobacillus plantarum  phage fg1e:characterization of the promoter pR49-pR-pL and overproduction of the cro-like protein Cng in Eschrichia coli. 

Gene, 215, 371-379.  PMID: 9714836

【1997】

Oki M, Kakikawa M, Nakamura S, Yamamura E, Watanabe N, Sasamoto M, Taketo A, Kodaira K. (1997) 

Fanctional and structural features of the holin HOL protein of the Lactobacillus plantarum phage fg1e: analysis in Escherishia coli system. 

Gene, 197, 137-145.  PMID: 9332359

Kodaira K, Oki M, Kakikawa M, Watanabe N, Hirakawa M, Yamada K, Taketo A. (1997)  

Genome structure of the Lactobacillus temperate phage fg1e: the whole genome sequence and the putative promoter/repressor system. 

Gene, 187, 45-53.  PMID: 9073065

Kakikawa M, Oki M, Watanabe N, Yasukawa H, Masamune Y, Taketo A, Kodaira K. (1997) 

Characterization of the genes encoding integrative and excisive functions of Lactobacillus phage fg1e: clonig,sequence analysis, and expression in Escherishia coli . 

Gene, 185, 119-125.  PMID: 9034322

【1996】

Oki M, Kakikawa M, Taketo A, Kodaira K. (1996) 

Cloning, sequence analysis, and expression of the genes encoding lytic functions of Lactobacillus bacteriophage fg1e.  

Gene, 176, 215-223.  PMID: 8918256

Oki M, Kakikawa M, Taketo A, Kodaira K. (1996) 

Genome structure of a Lactobacillus  plasmid pNMO belonging to the rolling-circle type replicon.  

J. Gen. Appl. Microbiol., 42, 271-283

Kodaira K, Oki M, Kakikawa M, Taketo A. (1996) 

The virion proteins encoded by bacteriophage fK and its host-range mutant fKhT:host-range determination and DNA binding properties.  

J. Biochem., 119, 1062-1069.  PMID: 8827438

Kakikawa M, Oki M, Tadokoro H, Nakamura S, Taketo A, Kodaira K. (1996)  

Cloning and nucleotido sequence of the major capsid protein of Lactobacillus bacteriophage fg1e.  

Gene, 175, 157-165.  PMID: 8917093

【1995】

Kodaira K, Oki M, Taketo A, Yasukawa H, Masamune Y. (1995)  

Determination of the single stranded origin of Shigella sonnei plasmid pKYM.  

Biochimica et Biophysica Acta., 1260, 183-190.  PMID: 7841195

(邦文)

田頭英樹、中川武弥、沖昌也、安井潔、伊藤敬 (2005) p62-72 

バイオ研究マスターシリーズ、転写研究集中マスター 

「クロマチンリモデリング」

中川武弥、 田頭英樹、沖昌也、伊藤敬 (2005) vol 42, No.9, p966-972 

 Molecular Medicine, 転写制御と疾患 「クロマチンと病態」