Research

Our group studies the structure, dynamics, and function of RNA-protein complexes that regulate gene expression, RNA processing, and cellular defense mechanisms. We employ an integrative approach combining cryogenic electron microscopy (cryo-EM), biochemistry, and RNA-focused biophysics to underastand how these complexes form, function, and are regulated. A central focus of our research is on proteins and RNAs involved in mitochondrial homeostasis, stress adaptation, and immune responses - systems that are often highly dynamic, transient, and therefore challenging to capture using classical structural biology techniques.

Building on our expertise in RNA biology and macromolecular assemblies, we aim to uncover fundamental principles of RNA recognition and processing, while also identifying new opportunities for therapeutic intervention. Our research bridges basic and translational science, spanning topics from the molecular mechanisms of RNA-guided defense systems to the engineering of RNA molecules for therapeutic applications. As part of the GoRNA Biology community, we foster strong collaborations and a vibrant, interdisciplinary research environment that supports curiosity-driven science and advanced method development.