We are a group of science enthusiasts driven by curiosity and a desire to understand how biological systems work at the molecular level. Our research focuses on mitochondria and the RNA metabolism that takes place within them, including its connections and cross-regulation with the rest of the cell. We are particularly interested in the complex networks of proteins and RNA molecules that collectively maintain cellular homeostasis.
A key aspect of our work is the study of proteins for which little or no structural information is currently available. By uncovering their structures, we aim to answer fundamental questions about their activity, mechanism, and biological function. We investigate structure-function relationships using a range of structural biology methods, with cryogenic electron microscopy (cryo-EM) as our preferred approach. To complement structural studies, we employ a broad set of biophysical techniques and functional assays, allowing us to develop a comprehensive and mechanistic understanding of molecular interactions and regulatory processes within mitochondria.