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Science Magazine Cover
Science Magazine Cover
Volume 380 | Issue 6652 | 30 June 2023
"Vapor from liquid nitrogen wafts over a rat kidney awaiting a groundbreaking preservation method at the University of Minnesota. Scientists there have learned how to cool the organ to –150°C and rewarm it while minimizing freezing damage, enabling it to work after being transplanted. This laboratory and others are harnessing extreme cold to preserve everything from organs to endangered coral to fresh tomatoes."
Recent Articles in Peer-Reviewed Journals
Recent Articles in Peer-Reviewed Journals
Brister E, Gammon AR, Thompson PB, Tiersch TR, Zuchowicz N. Manipulating Time by Cryopreservation: Designing an Environmental Future by Maintaining a Portal to the Past. Journal of Law, Medicine & Ethics. 2024;52(3):637-647. doi:10.1017/jme.2024.130
Childress JF, Brister E, Thompson PB, et al. Ethical Issues in Emerging Technologies to Extend the Viability of Biological Materials Across Time and Space. Journal of Law, Medicine & Ethics. 2024;52(3):570-584. doi:10.1017/jme.2024.139
Hyun I, Bischof J, Callier SL, et al. The Need for Early Engagement with Interested Groups on Advanced Biopreservation. Journal of Law, Medicine & Ethics. 2024;52(3):585-594. doi:10.1017/jme.2024.134
Thompson PB, Bischof J, Powell-Palm MJ, Smith K, Tiersch TR. Biopreservation in Agriculture and Food Systems: A Summary of Ethical Issues. Journal of Law, Medicine & Ethics. 2024;52(3):666-678. doi:10.1017/jme.2024.149
Safeguarding Earth's biodiversity by creating a lunar biorepository. BioScience. 2024;0(0): 1–6. Hagedorn M, Parenti LR, Craddock RA, Comizzoli P, Mabee P, Meinke B, Wolf SM, Bischof JC, Sandlin RD, Tessier SN, Toner M.
3D Printed Organisms Enabled by Aspiration-Assisted Adaptive Strategies. Advanced Science. 11 (32), [2404617]. Han, G., Khosla, K., Smith, K.T., Ng, D.W.H., Lee, J.Y., Ouyang, X., Bischof, J.C., McAlpine, M.C. (2024).
A Low-Cost, Tabletop LOD-EPR System for Nondestructive Quantification of Iron Oxide Nanoparticles in Tissues. ACS Sensors. 9 (1), [262-271]. Kantesaria, S.A., Tang, X., Suddarth, S., Pasek-Allen, J.L., Namsrai, B.E., Goswitz, A., Hintz, M., Bischof, J., Garwood, M. (2024).
Engineering Magnetic Nanoclusters for Highly Efficient Heating in Radio-Frequency Nanowarming. Nano letters. 24 (15), [4588-4594]. Ye, Z., Tai, Y., Han, Z., Liu, S., Etheridge, M.L., Pasek-Allen, J.L., Shastry, C., Liu, Y., Li, Z., Chen, C., Wang, Z., Bischof, J.C., Nam, J., Yin, Y. (2024).
Irreversible Electroporation has More Synergistic Effect with Anti‐PD‐1 Immunotherapy than Thermal Ablation or Cryoablation, in a Colorectal Cancer Model. Advanced Therapeutics, 2400068. Jiang, M., Shao, Q., Slaughter, J., & Bischof, J. (2024).
Magnetic-Nanorod-Mediated Nanowarming with Uniform and Rate-Regulated Heating. Nano Letters. Liu, S., Han, Z., Ye, Z., Jiang, M., Etheridge, M. L., Bischof, J. C., & Yin, Y. (2024).
CPA toxicity screening of cryoprotective solutions in rat hearts. Kraft, C.J., Namsrai, B., Tobolt, D. Etheridge, M., Finger, E., Bischof, J. Cryobiology, 2024.
Pioneering quantitative platforms for stored red blood cell assessment open the door for precision transfusion medicine. Proceedings of the National Academy of Sciences of the United States of America. 121 (11), [e2320521121]. Isiksacan, Z., Alessandro, A.D., McKenna, D.H., Tessier, S.N., Kucukal, E., Aslihan Gokaltun, A., William, N., Sandlin, R.D., Bischof, J., Mohandas, N., Busch, M.P., Elbuken, C., Toner, M., Acker, J.P., Yarmush, M.L., Berk Usta, O., Gurkan, U.A. (2024).
High-throughput genetic manipulation of multicellular organisms using a machine-vision guided embryonic microinjection robot. Genetics. 226 (4), [iyae025]. Alegria, A.D., Joshi, A.S., Mendana, J.B., Khosla, K., Smith, K.T., Auch, B., Donovan, M., Bischof, J., Gohl, D.M., Kodandaramaiah, S.B. (2024).
On Chip Sorting of Stem Cell-Derived β Cell Clusters Using Traveling Surface Acoustic Waves. Langmuir. Published online February 6, 2024. Sethia N, Rao JS, Khashim Z, Schornack AMR, Etheridge ML, Peterson QP, Finger EB, Bischof JC, Dutcher CS.
Conduction-Dominated Cryomesh for Organism Vitrification. Advanced Science. 11 (3), [2303317]. Guo, Z., Zuchowicz, N., Bouwmeester, J., Joshi, A.S., Neisch, A.L., Smith, K., Daly, J., Etheridge, M.L., Finger, E.B., Kodandaramaiah, S.B., Hays, T.S., Hagedorn, M., Bischof, J.C. (2024).
The First Proof of Concept Demonstration of Nanowarming in Coral Tissues. Daly, J., Bouwmeester J., Perry, R., Page, C., Khosla, K., Kangas, J., Lager, C., Hardy, K. Bischof, J., Hagedorn, M., Advanced Sustainable Systems, 2023.
Model-Guided Design and Optimization of CPA Perfusion Protocols for Whole Organ Cryopreservation. Han, Z., Rao, J., Ramesh, S., Hergesell, J., Namsrai, B., Etheridge, M., Finger, E., Bischof, J. Annals of Biomedical Engineering, 2023.
Vitrification and nanowarming enable long-term organ cryopreservation and life-sustaining kidney transplantation in a rat model. Han, Z., Rao, J., Gangwar, L., Namsrai, B., Pasek-Allen, J., Etheridge, M., Wolf, S., Pruett, T., Bischof, J., Finger, E. Nature Communications, 2023.
Tumor therapeutic response monitored by telemetric temperature sensing, a preclinical study on immunotherapy and chemotherapy. Shao, Q. Lundgren, M., Lynch, J., Jiang, M., Mir, M., Biscof, J., Nelson, M. Scientific Reports, 2023.
Combining energy-based focal ablation and immune checkpoint inhibitors: preclinical research and clinical trials. Frontiers in Oncology, 13, 1153066. Jiang, M., Fiering, S., & Shao, Q. (2023).
Cryopreservation of Whole Rat Livers by Vitrification and Nanowarming. Sharma, A., Lee, C., Namsrai, B., Han, Z., Tobolt, D., Rao, J., Gao, Z., Etheridge, M., Garwood, M., Clemens, M., Bischof, J., Finger, E. Annals of Biomedical Engineering, 2023.
Nerve Protection During Prostate Cryosurgery. Ranjbartehrani, P., Ramirez, D., Schmidlin, F., Etheridge, M., Iaizzo, P., Shao, Q., Bischof, J. Annals of Biomedical Engineering, 2023.
The first proof of concept demonstration of nanowarming in coral tissue. Daly, J., Bouwmeester, R.P., Page, C., Khosla, K., Kangas, J., Lager, C., Hardy, K., Bischof, J., Hagedorn, M. Advanced Sustainable Systems, 2023.
Physical Demonstration of Vitrification of Liter Scale CPA Systems and Characterization of 120KW RF Coil for Nanowarming of Liter Scale Systems. Gangwar, L., Han, Z., Hintz, M., Pasek-Allen, J., Etheridge, M., Goldstein, R., Bischof, J. Cryobiology, 2022.
Biological Characterization of Vitrified Pancreatic Islets and Transplantation. Rao, J., Zhan, L., Sethia, N., Slama, M., Han, Z., Tobolt, D., Etheridge, M., Peterson, Q., Dutcher, C., Bischof, J., Finger, E. Cryobiology, 2022.
Vitrification and Rewarming of Magnetic Nanoparticle-Loaded Rat Hearts. Namsrai, B., Gao, Z., Han, Z., Joshi, P., Rao, J., Ravikumar, V., Sharma, A., Ring, H., Idiyatullin, D., Magnuson, E., Iaizzo, P. A., Tolkacheva, E.G., Garwood, M., Rabin, Y., Etheridge, M., Finger, E., Bischof, J.C. Cyrobiology, 2022.
High and low subzero engineering approaches for organ preservation. Bischof, J.C. Cryobiology, vol. 109, 1 Dec 2022, pp. 2-3.
Tumor Ablation by Irreversible Electroporation Augments PD-1 Checkpoint Inhibitor Immunotherapy in Color Adenocarcinoma. Slaughter, J., Shao, Q., Jiang, M., Bischof, J.C. Journal of the American College of Surgeons, 2022.
Rapid Joule Heating Improves Vitrification Based Cryopreservation. Zhan, L., Han, Z., Shao, Q., Etheridge, M., Hays, T., Bischof, J. C. Nature Communications, 2022.
Injectable and Repeatable Inductive Heating of Iron Oxide Nanoparticle-Enhanced “PHIL” Embolic toward Tumor Treatment. Pasek-Allen, J. L., Kantesaria, S., Gangwar, L., Shao, Q., Gao, Z., Idiyatullin, D., ... & Bischof, J. C. ACS Applied Materials & Interfaces, 2022.
Fast and ultrafast thermal contrast amplification of gold nanoparticle-based immunoassays. Liu, Y., Zhan, L., Kangas, J., Wang, Y., & Bischof, J. Scientific reports, 2022.
Characterization of Miniature Probes for Cryosurgery, Thermal Ablation, and Irreversible Electroporation on Small Animals. Ranjbartehrani, P., Etheridge, M., Ramadhyani, S., Natesan, H., Bischof, J., & Shao, Q. Advanced Therapeutics, 2022.
Pancreatic islet cryopreservation by vitrification achieves high viability, function, recovery and clinical scalability for transplantation. Zhan, L., Rao, J. S., Sethia, N., Slama, M. Q., Han, Z., Tobolt, D., ... & Finger, E. B. , Nature Medicine, 2022.
Supplemented phase diagrams for vitrification CPA cocktails: DP6, VS55 and M22, Han, Z., Gangwar, L., Magnuson, E., Etheridge, M. L., Pringle, C. O., Bischof, J. C., & Choi, J. Cryobiology, 2022.
Book Chapters Archives (Pre-2022)
Book Chapters Archives (Pre-2022)
Natesan, H. Bischof, J., 2018. Micro‐and Nanoscale Calorimetry for Biomedical Applications. In Theory and Applications of Heat Transfer in Humans 1, 393-431.
Natesan, H., Choi, J., Lubner, S., Dames, C. and Bischof, J., 2016. Multi-scale thermal conductivity measurements for cryobiological applications. In Multiscale Technologies for Cryomedicine: Implementation from Nano to Macroscale (pp. 125-171).
Choi, J., Kumar, S.B., Jiang-Hughes, S. and Bischof, J.C., 2016. The Effect of Cold Temperatures on Biological Systems. In Dermatological Cryosurgery and Cryotherapy (pp. 19-36). Springer London.
Jordan, A., Etheridge, M.L. and Bischof, J.C., 2012. Magnetic nanoparticles for cancer therapy. In Physics of Thermal Therapy: Fundamentals and Clinical Applications (pp. 293-318). Taylor & Francis.
Qin, Z. and Bischof, J.C., 2012. Application of Gold Nanoparticle in Laser Thermal Therapy, Ch. 17. In Physics of Thermal Therapy. CRC Press, New York, NY. Edited by Moros EG. (pp. 319–338).
Publication Archives (Pre-2022)
Publication Archives (Pre-2022)
Vitrification and nanowarming of kidneys, Sharma, A., Rao, J. S., Han, Z., Gangwar, L., Namsrai, B., Gao, Z., ... & Bischof, J. C., Advanced Science, 2021.
Imaging the distribution of iron oxide nanoparticles in hypothermic perfused tissues. HL Ring, Z Gao, A Sharma, Z Han, C Lee, KGM Brockbank, ED Greene, KL Helke, Z Chen, LH Campbell, B Weegman, M Davis, M Taylor, S Giwa, GM Fahy, B Wowk, R Pagotan, JC Bischof, M Garwood, Magnetic resonance in medicine, 2020, 83(5), 1750-1757.
Preparation of Scalable Silica‐Coated Iron Oxide Nanoparticles for Nanowarming. Z Gao, HL Ring, A Sharma, B Namsrai, N Tran, EB Finger, M Garwood, CL Haynes, JC Bischof, Advanced Science, 2020.
Optimizing Integrated Electrode Design for Irreversible Electroporation of Implanted Polymer Scaffolds. F Pelaez, Q Shao, P Ranjbartehrani, T Lam, HR Lee, S O’Flanagan, A Silbaugh, JC Bischof, SM Azarin, Annals of Biomedical Engineering, 2020.
Liver Cryopreservation for Regenerative Medicine Applications. A Sharma, JC Bischof, EB Finger, Regenerative Engineering and Translational Medicine, 2019.
Nanowarming using Au-tipped Co 35 Fe 65 ferromagnetic nanowires. Daniel Shore, Adrian Ghemes, Oana Dragos-Pinzaru, Zhe Gao, Qi Shao, Anirudh Sharma, Joseph Um, Ibro Tabakovic, John C Bischof, Bethanie JH Stadler, Nanoscale, 2019, 11 (31), 14607-14615.
Improved detection of Group A streptococcus during thermal contrast amplification vs. visual reading of clinical rapid diagnostic tests. Anal. Methods, 2019, 11, 2013-2017.
Engineering T Cell Response to Cancer Antigens by Choice of Focal Therapeutic Conditions. Q Shao, S O'Flanagan, T Lam, P Roy, F Pelaez, BJ Burbach, SM Azarin,Y Shimizu, JC Bischof, International Journal of Hyperthermia, 2019, 1-9.
Mapping Electrical Properties Heterogeneity of Tumor Using Boundary Informed Electrical Properties Tomography (BIEPT) at 7T. Y Wang, Q Shao, PF Van de Moortele, E Racila, J Liu, JC Bischof, B He, Magnetic resonance in medicine,2018, 81 (1), 393-409.
Characterization of Laser Gold Nanowarming: A Platform for Millimeter-Scale Cryopreservation. K Khosla, L Zhan, A Bhati, A Carley-Clopton, M Hagedorn, JC Bischof, Langmuir, 2018.
A Three-dimensional Transient Computational Study of 532-nm Laser Thermal Ablation in a Geometrical Model Representing Prostate Tissue. H Elkhalil, A Alshare, G Shafirstein, JC Bischof, International Journal of Hyperthermia, 1-10.
Measurement of Specific Heat and Crystallization in VS55, DP6, and M22 Cryoprotectant Systems With and Without Sucrose. S Phatak, H Natesan, J Choi, KGM Brockbank, JC Bischof, Biopreservation and Biobanking, 2018.
Ferrozine Assay for Simple and Cheap Iron Analysis of Silica-Coated Iron Oxide Nanoparticles. H Ring, Z Gao, ND Klein, M Garwood, JC Bischof, CL Haynes.ChemRxiv, 2018.
Ultrarapid Inductive Rewarming of Vitrified Biomaterials with Thin Metal Forms. N Manuchehrabadi, M Shi, P Roy, Z Han, J Qiu, F Xu, TJ Lu, J Bischof, Annals of Biomedical Engineering, 2018,1-13.
From Nanowarming to Thermoregulation: New Multiscale Applications of Bioheat Transfer. JC Bischof, KR Diller, Annual review of biomedical engineering, 2018, 20, 301-327.
Cryopreservation by Vitrification: A Promising Approach for Transplant Organ Banking. EB Finger, JC Bischof, Current Opinion in Organ Transplantation, 2018, 23 (3), 353-360.
Biomaterial Scaffolds for Non-invasive Focal Hyperthermia as A Potential Tool to Ablate Metastatic Cancer Cells. F Pelaez, N Manuchehrabadi, P Roy, H Natesan, Y Wang, E Racila, H Fong, K Zeng, AM Silbaugh, JC Bischof, SM Azarin, Biomaterials, 2018, 166, 27-37.
The Role of Protein Loss and Denaturation in Determining Outcomes of Heating, Cryotherapy, and Irreversible Electroporation on Cardiomyocytes. F Liu, P Roy, Q Shao, C Jiang, J Choi, C Chung, D Mehra, JC Bischof, Journal of biomechanical engineering, 2018, 140 (6), 061007.
In vivo Imaging of Electrical Properties of An Animal Tumor Model with An 8‐channel Transceiver Array at 7 T Using Electrical Properties Tomography. J Liu, Q Shao, Y Wang, G Adriany, J Bischof, V de Moortele, B He, Magnetic resonance in medicine, 2017, 78 (6), 2157-2169.
The role of nanoparticle design in determining analytical performance of lateral flow immunoassays. L Zhan, S Guo, F Song, Y Gong, F Xu, DR Boulware, MC McAlpine, WC Wang, JC Bischof Nano letters, 2017,17(12), pp.7207-7212.
Physical and Chemical Enhancement of and Adaptive Resistance to Irreversible Electroporation of Pancreatic Cancer. Q Shao, F Liu, C Chung, K Elahi-Gedwillo, PP Provenzano, B Forsyth, JC Bischof, Ann Biomed Eng. 2017. 46 (1), 25-36.
Gold Nanorod Induced Warming of Embryos from the Cryogenic State Enhances Viability. K Khosla, Y Wang, M Hagedorn, Z Qin, J Bischof, ACS Nano, 2017, 11 (8), 7869-7878.
Thermal thresholds of cardiovascular HL-1 cell destruction by cryothermal exposure. J Choi, J Bischof, Cryobiology, 2017, 78, 115-118.
Improved tissue Cryopreservation Using Inductive Heating of Magnetic Nanoparticles. N Manuchehrabadi, Z Gao, J Zhang, HL Ring, Q Shao, F Liu, M Mcdermott, A Fok, Y Rabin, KG Brockbank, M Garwood, CJ Haynes, JC Bischof, Science translational medicine, 2017, 9(379).
Determination of Cryothermal Injury Thresholds in Tissues Impacted by Cardiac Cryoablation. RP Goff, SG Quallich, RA Buechler, JC Bischof, PA Iaizzo, Cryobiology, 2017, 75, 125-133.
Multi-Scale Thermal Property Measurements for Biomedical Application. H Natesan, JC Bischof, ACS Biomaterials Science & Engineering, 2016. 3 (11), 2669-2691.
Thermal Contrast Amplification Reader Yielding 8-Fold Analytical Improvement for Disease Detection with Lateral Flow Assays. Y Wang, Z Qin, DR Boulware, BS Pritt, LM Sloan, IJ González, D Bell, RR Rees-Channer, P Chiodini, WC Wang, JC Bischof, Analytical Chemistry, 2016, 88(23), pp.11774-11782.
Predictable heating and positive MRI contrast from a mesoporous silica-coated iron oxide nanoparticle. KR Hurley, HL Ring, M Etheridge, J Zhang, Z Gao, Q Shao, ND Klein, VM Szlag, Chung, C. TM Reineke, M Garwood, JC Bischof, CJ Haynes, Molecular pharmaceutics, 2016, 13(7), pp.2172-2183.
Quantitative Comparison of Photothermal Heat Generation between Gold Nanospheres and Nanorods. Z Qin, Y Wang, J Randrianalisoa, V Raeesi, WCW Chan, W Lipiński, JC bischof, Scientific Reports, 2016, 6, 29836.
A Micro-Thermal Sensor for Focal Therapy Applications. H Natesan, W Hodges, J Choi, S Lubner, C Dames, J Bischof, Scientific reports, 2016, 6, 21395.
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