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Experimental Evolution Publications by Ted Garland: Artificial Selection for High Voluntary Wheel-Running Behavior in House Mice
Experimental Evolution Publications by Ted Garland: Artificial Selection for High Voluntary Wheel-Running Behavior in House Mice
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Inquiry-Based Middle School Lesson Plan -- "Born to Run: Artificial Selection Lab"
Table of Contents for:
Garland, T., Jr., and M. R. Rose, eds. 2009. Experimental evolution: concepts, methods, and applications of selection experiments. University of California Press, Berkeley, California. xvii + 730 pages.
Entire Book is Available Here as a fairly large PDF file
Network for Experimental Research in Evolution
Intercampus Research Program on Experimental Evolution (UCIRPEE) (previous incarnation of NERE)
Stories on the High Runner Mice as Exercise Addicts:
Stories on the High Runner Mice as Exercise Addicts:
"Fit and Dim?" by Lee Dye for ABCNews.com
Holden, C. 2001. 'Behavioral' Addictions: Do They Exist? Science 294:980-982. or view PDF file here
Brain study shows some animals crave exercise (December 1, 2003)
Other Stories on the High Runner Mice:
Other Stories on the High Runner Mice:
In for the long run: Focus on "Lifelong voluntary exercise in the mouse prevents age-related alterations in gene expression in the heart"
lifelines: "Running mice are leaner" by Henry Gee for Nature
"Fitness fanatic or couch potato? Blame your DNA" by Christie Aschwanden for the Los Angeles Times
Sports Illustrated article on "Sports Genes" by David Epstein -- mice are mentioned on last page
Ted Garland quoted in The Sports Gene: Inside the Science of Extraordinary Athletic Performance (2013) by David Epstein
What happens if you give a mouse a Red Bull? UC Riverside researchers find out (The Press-Enterprise 24 Jan. 2017)
Textbook Features on the High Runner Mice:
Textbook Features on the High Runner Mice:
Two-page Box on the mouse selection experiment in 2006 Comparative Physiology text by Moyes and Schulte
Two-pages on the mouse selection experiment in 2014 Evolutionary Analysis text by Herron and Freeman (with contributions by Hodin, Miner, Sidor)
Page discussing a selection experiment on mouse maternal aggression by Stephen Gammie that Ted Garland helped with in 2014 Evolutionary Analysis text by Herron and Freeman
Page 594 in Emlen, D. J., and C. Zimmer. 2020. Evolution: making sense of life, 3rd edition. 3rd ed. Macmillan Learning, Austin, Texas.
Publications on Hsd:ICR Mice before the Selection Experiment:
Publications on Hsd:ICR Mice before the Selection Experiment:
25. Hayes, J. P., T. Garland, Jr., and M. R. Dohm. 1992. Individual variation in metabolism and reproduction of Mus: are energetics and life history linked? Functional Ecology 6:5-14. [PDF file] [Drive PDF file]
26. Friedman, W. A., T. Garland, Jr., and M. R. Dohm. 1992. Individual variation in locomotor behavior and maximal oxygen consumption in mice. Physiology & Behavior 52:97-104. Abstract [PDF file] [Drive PDF file]
40. Richardson, C. S., M. R. Dohm, and T. Garland, Jr. 1994. Metabolism and thermoregulation in crosses between wild and random-bred laboratory house mice (Mus domesticus). Physiological Zoology 67:944-975. Abstract [PDF file] [Drive PDF file]
41. Dohm, M. R., C. S. Richardson, and T. Garland, Jr. 1994. Exercise physiology of wild and random-bred laboratory house mice and their reciprocal hybrids. American Journal of Physiology 267 (Regulatory, Integrative and Comparative Physiol. 36):R1098-R1108. Abstract [PDF file] [Drive PDF file]
42. Garland, T., Jr., T. T. Gleeson, B. A. Aronovitz, C. S. Richardson, and M. R. Dohm. 1995. Maximal sprint speeds and muscle fiber composition of wild and laboratory house mice. Physiology & Behavior 58:869-876. Abstract [PDF file] [Drive PDF file]
49. Dohm, M. R., J. P. Hayes, and T. Garland, Jr. 1996. Quantitative genetics of sprint running speed and swimming endurance in laboratory house mice (Mus domesticus). Evolution 50:1688-1701. Abstract [PDF file] [Drive PDF file]
54. Coleman, M. A., T. Garland, Jr., C. A. Marler, S. S. Newton, J. G. Swallow, and P. A. Carter. 1998. Glucocorticoid response to forced exercise in laboratory house mice (Mus domesticus). Physiology & Behavior 63:279-285. Abstract [PDF file] [Drive PDF file]
64. Carter, P. A., T. Garland, Jr., M. R. Dohm, and J. P. Hayes. 1999. Genetic variation and correlations between genotype and locomotor physiology in outbred laboratory house mice (Mus domesticus). Comparative Biochemistry and Physiology A 123:155-162. Abstract [PDF file] [Drive PDF file]
88. Dohm, M. R., J. P. Hayes, and T. Garland, Jr. 2001. The quantitative genetics of maximal and basal rates of oxygen consumption in mice. Genetics 159:267-277. Abstract [PDF file] [Drive PDF file]
112. Zelditch, M. L., B. L. Lundrigan, H. D. Sheets, and T. Garland, Jr. 2003. Do precocial mammals develop at a faster rate? A comparison of rates of skull development in Sigmodon fulviventer and Mus musculus domesticus. Journal of Evolutionary Biology 16:708-720. [PDF file] [Drive PDF file]
123. Zelditch, M. L., B. L. Lundrigan, and T. Garland, Jr. 2004. Developmental regulation of skull morphology I: Ontogenetic dynamics of variance. Evolution & Development 6:194-206. [PDF file] [Drive PDF file]
134. Zelditch, M. L., J. Mezey, H. D. Sheets, B. L. Lundrigan, and T. Garland, Jr. 2006. Developmental regulation of skull morphology II: ontogenetic dynamics of covariance. Evolution & Development 8:46-60. [PDF file] [Drive PDF file]
Master's Theses and Ph.D. Dissertations on the High Runner Mice from Outside the Garland Lab (in progress):
Master's Theses and Ph.D. Dissertations on the High Runner Mice from Outside the Garland Lab (in progress):
Copes
Schwartz
Vaanholt
Valencia
Jónás, I. 2009. Mice selectively bred for high wheel running activity have increased growth efficiency during lactation. Chapter 5 = pages 67-84. University of Groningen.
Smolinsky, A. N. 2018. Plastic and evolved morphological responses of the hind limb skeleton to mechanical loading in mice. University of Missouri-Columbia, Missouri.
Publications on the High Runner Mice:
Publications on the High Runner Mice:
53. Swallow, J. G., T. Garland, Jr., P. A. Carter, W.-Z. Zhan, and G. C. Sieck. 1998. Effects of voluntary activity and genetic selection on aerobic capacity in house mice (Mus domesticus). Journal of Applied Physiology 84:69-76. [PDF file] [Drive PDF file]
54. Coleman, M. A., T. Garland, Jr., C. A. Marler, S. S. Newton, J. G. Swallow, and P. A. Carter. 1998. Glucocorticoid response to forced exercise in laboratory house mice (Mus domesticus). Physiology & Behavior 63:279-285. Abstract [PDF file] [Drive PDF file]
57. Swallow, J. G., P. A. Carter, and T. Garland, Jr. 1998. Artificial selection for increased wheel-running behavior in house mice. Behavior Genetics 28:227-237. [PDF file] [Drive PDF file]
58. Krugner-Higby, L., A. Gendron, T. Garland, Jr., P. A. Carter, J. G. Swallow, and J. J. Lee. 1998. Eosinophylic polymyositis in a mouse. Contemporary Topics in Laboratory Animal Science 37:94-97. [PDF file] [Drive PDF file]
62. Koteja, P., J. G. Swallow, P. A. Carter, and T. Garland, Jr. 1999. Energy cost of wheel running in house mice: implications for coadaptation of locomotion and energy budgets. Physiological and Biochemical Zoology 72:238-249. [PDF file] [Drive PDF file]
67. Swallow, J. G., P. Koteja, P. A. Carter, T. Garland, Jr. 1999. Artificial selection for increased wheel-running activity in house mice results in decreased body mass at maturity. Journal of Experimental Biology 202:2513-2520. Abstract [PDF file] [Drive PDF file]
68. Koteja, P., T. Garland, Jr., J. K. Sax, J. G. Swallow, and P. A. Carter. 1999. Behaviour of house mice artificially selected for high levels of voluntary wheel running. Animal Behaviour 58:1307-1318. Abstract [PDF file] [Drive PDF file]
69. Zhan, W.-Z., J. G. Swallow, T. Garland, Jr., D. N. Proctor, P. A. Carter, and G. C. Sieck. 1999. Effects of genetic selection and voluntary activity on the medial gastrocnemius muscle in house mice. Journal of Applied Physiology 87:2326-2333. Abstract [PDF file] [Drive PDF file]
70. Rhodes, J. S., P. Koteja, J. G. Swallow, P. A. Carter, and T. Garland, Jr. 2000. Body temperatures of house mice artificially selected for high voluntary wheel-running behavior: repeatability and effect of genetic selection. Journal of Thermal Biology 25:391-400. Abstract [PDF file] [Drive PDF file]
71. Carter, P. A., J. G. Swallow, Sarah J. Davis, and T. Garland, Jr. 2000. Nesting behavior of house mice (Mus domesticus) selected for increased wheel-running activity. Behavior Genetics 30:85-94. Abstract [PDF file] [Drive PDF file]
74. Houle-Leroy, P., T. Garland, Jr., J. G. Swallow, and H. Guderley. 2000. Effects of voluntary activity and genetic selection on muscle metabolic capacities in house mice Mus domesticus. Journal of Applied Physiology 89:1608-1616. Abstract [PDF file] [Drive PDF file]
76. Koteja, P., J. G. Swallow, P. A. Carter, and T. Garland, Jr. 2000. Individual variation and repeatability of maximum cold-induced energy assimilation in house mice. Acta Theriologica 45:455-470. Abstract [PDF file] [Drive PDF file]
77. Koteja, P., and T. Garland, Jr. 2001. Response to R. Eikelboom. Animal Behaviour 61:F25-F26. [PDF file]
Eikelboom, R. 2001. Bins, bouts and wheel running speed. Animal Behaviour 61:679-681. [PDF file] [Drive PDF file]
78. Koteja, P., J. G. Swallow, P. A. Carter, and T. Garland, Jr. 2001. Maximum cold-induced food consumption in mice selected for high locomotor activity: implications for the evolution of endotherm energy budgets. Journal of Experimental Biology 204:1177-1190. [PDF file] [Drive PDF file]
83. Swallow, J. G., P. Koteja, P. A. Carter, and T. Garland, Jr. 2001. Food consumption and body composition in mice selected for high wheel-running activity. Journal of Comparative Physiology B: Biochemical, Systemic, and Environmental Physiology 171:651–659. [Drive PDF file]
84. Dumke, C. L., J. S. Rhodes, T. Garland, Jr., E. Maslowski, J. G. Swallow, A.C. Wetter, and G. D. Cartee. 2001. Genetic selection of mice for high voluntary wheel-running: effect on skeletal muscle glucose uptake. Journal of Applied Physiology 91:1289-1297. Abstract [PDF file] [Drive PDF file]
85. Bronikowski, A. M., P. A. Carter, J. G. Swallow, I. A. Girard, J. S. Rhodes, and T. Garland, Jr. 2001. Open-field behavior of house mice selectively bred for high voluntary wheel running. Behavior Genetics 31:309-316. Abstract [PDF file] [Drive PDF file]
86. Rhodes, J. S., G. R. Hosack, I. Girard, A. E. Kelley, G. S. Mitchell, and T. Garland, Jr. 2001. Differential sensitivity to acute administration of cocaine, GBR 12909, and fluoxetine in mice selectively bred for hyperactive wheel-running behavior. Psychopharmacology 158:120-131. Abstract [PDF file] [Drive PDF file]
87. Girard, I., M. W. McAleer, J. S. Rhodes, and T. Garland, Jr. 2001. Selection for high voluntary wheel running increases intermittency in house mice (Mus domesticus). Journal of Experimental Biology 204:4311-4320. [PDF file] [Drive PDF file] Movie See also "In this issue" pages i-ii.
90. Garland, T., Jr. 2001. Phylogenetic comparison and artificial selection: two approaches in evolutionary physiology. Pages 107-132 in R. C. Roach, P. D. Wagner, and P. H. Hackett, eds. Hypoxia: From Genes to the Bedside. Advances in Experimental Biology and Medicine, volume 502. Kluwer Academic/Plenum Publishers, New York. [PDF file] [Drive PDF file]
92. Thomson, S. L., T. Garland, Jr., J. G. Swallow, and P. A. Carter. 2002. Response of Sod-2 enzyme activity to selection for high voluntary wheel running. Heredity 88:52-61. Abstract [PDF file] [Drive PDF file]
93. Girard, I., and T. Garland, Jr. 2002. Plasma corticosterone response to acute and chronic voluntary exercise in female house mice. Journal of Applied Physiology 92:1553-1561. [PDF file] [Drive PDF file]
94. Girard, I., J. G. Swallow, P. A. Carter, P. Koteja, J. S. Rhodes, and T. Garland, Jr. 2002. Maternal-care behavior and life-history traits in house mice (Mus domesticus) artificially selected for high voluntary wheel-running activity. Behavioural Processes 57:37-50. [PDF file] [Drive PDF file]
95. Garland, T., Jr. 2003. Selection experiments: an under-utilized tool in biomechanics and organismal biology. Pages 23-56 in V. L. Bels, J.-P. Gasc, and A. Casinos, eds. Vertebrate Biomechanics and Evolution. BIOS Scientific Publishers, Oxford, U.K. [PDF file] [Drive PDF file]
96. Garland, T., Jr., M. T. Morgan, J. G. Swallow, J. S. Rhodes, I. Girard, J. G. Belter, and P. A. Carter. 2002. Evolution of a small-muscle polymorphism in lines of house mice selected for high activity levels. Evolution 56:1267-1275. [PDF file] [Drive PDF file]
97. Klomberg, K. L., T. Garland, Jr., J. G. Swallow, and P. A. Carter. 2002. Dominance, plasma testosterone levels, and testis size in mice artificially selected for high activity levels. Physiology & Behavior 77:27-38. Abstract [PDF file] [Drive PDF file]
98. Bronikowski, A. M., T. J. Morgan, T. Garland Jr., and P. A. Carter. 2002. Antioxidant gene expression in active and sedentary house house mice (Mus domesticus) selected for high voluntary wheel-running behavior. Genetics 161:1763-1769. [PDF file] [Drive PDF file]
102. Houle-Leroy, P., T. Garland, Jr., J. G. Swallow, and H. Guderley. 2003. Artificial selection for high activity favors mighty mini-muscles in house mice. American Journal of Physiology Regulatory Integrative Comparative Physiology 284:R433-R443. [PDF file] [Drive PDF file]
103. Morgan, T. J., T. Garland, Jr., and P. A. Carter. 2003. Ontogenies in mice selected for high voluntary wheel-running activity. I. Mean ontogenies. Evolution 57:646-657. [PDF file] [Drive PDF file]
104. Bronikowski, A. M., P. A. Carter, T. J. Morgan, T. Garland, Jr., N. Ung, T. D. Pugh, R. Weindruch, and T. A. Prolla. 2003. Lifelong voluntary exercise in the mouse prevents age-related alterations in gene expression in the heart. Physiological Genomics 12:129-138. [PDF file] [Drive PDF file] [Welle, S., and S. B. Glueck. 2003. In for the long run: Focus on "Lifelong voluntary exercise in the mouse prevents age-related alterations in gene expression in the heart." Physiological Genomics 12:71-72.]
106. Rhodes, J. S., and T. Garland, Jr. 2003. Differential sensitivity to acute administration of Ritalin, apomorphine, SCH 23390, and raclopride in mice selectively bred for hyperactive wheel-running behavior. Psychopharmacology 167:242-250. PDF file] [Drive PDF file]
107. Morgan, T. J., T. Garland, Jr., B. L. Irwin, J. G. Swallow, and P. A. Carter. 2003. The mode of evolution of molecular markers in populations of house mice under artificial selection for locomotor behavior. Journal of Heredity 94:236-242. [PDF file] [Drive PDF file]
109. Rhodes, J. S., H. van Praag, S. Jeffrey, I. Girard, G. S. Mitchell, T. Garland, Jr., and F. H. Gage. 2003. Exercise increases hippocampal neurogenesis to high levels but does not improve spatial learning in mice bred for increased voluntary wheel running. Behavioral Neuroscience 117:1006-1016. [PDF file] [Drive PDF file]
111. Johnson, R. A., J. S. Rhodes, S. L. Jeffrey, T. Garland, Jr., and G. S. Mitchell. 2003. Hippocampal brain-derived neurotrophic factor but not neurotrophin-3 increases more in mice selected for increased voluntary wheel running. Neuroscience 121:1-7. [PDF file] [Drive PDF file]
113. Hochstetler, K. J., T. Garland, Jr., J. G. Swallow, P. A. Carter, and A. Bult-Ito. 2004. Number of arginine-vasopressin neurons in the suprachiasmatic nuclei is not related to level or circadian characteristics of wheel-running activity in house mice. Behavior Genetics 34:131-136. [PDF file] [Drive PDF file]
114. Gammie, S. C., N. S. Hasen, J. S. Rhodes, I. Girard, and T. Garland, Jr. 2003. Predatory aggression, but not maternal or intermale aggression, is associated with high voluntary wheel-running behavior in mice. Hormones and Behavior 44:209-221. [PDF file] [Drive PDF file]
116. Rhodes, J. S., T. Garland, Jr., and S. C. Gammie. 2003. Patterns of brain activity associated with variation in voluntary wheel-running behavior. Behavioral Neuroscience 117:1243-1256. [PDF file] [Drive PDF file]
117. Koteja, P., J. G. Swallow, P. A. Carter, and T. Garland, Jr. 2003. Different effects of intensity and duration of locomotor activity on circadian period. Journal of Biological Rhythms 18:491-501. [Abstract] [PDF file] [Drive PDF file]
118. Koteja, P., P. A. Carter, J. G. Swallow, and T. Garland, Jr. 2003. Food wasting in house mice: variation among individuals, families, and genetic lines. Physiology & Behavior 80:375-383. [PDF file] [Drive PDF file]
121. Belter, J. G., H. V. Carey, and T. Garland, Jr. 2004. Effects of voluntary exercise and genetic selection for high activity levels on HSP70 expression in house mice. Journal of Applied Physiology 96:1270-1276. [PDF file] [Drive PDF file]
124. Bronikowski, A. M., J. S. Rhodes, T. Garland, Jr., T. A. Prolla, T. Awad, and S. C. Gammie. 2004. The evolution of gene expression in the hippocampus in response to selective breeding for increased locomotor activity. Evolution 58:2079-2086. [PDF file] [Drive PDF file]
127. Li, G., J. S. Rhodes, I. Girard, S. C. Gammie, and T. Garland, Jr. 2004. Opioid-mediated pain sensitivity in mice bred for high voluntary wheel running. Physiology & Behavior 83:515-524. [PDF file] [Drive PDF file]
129. Morgan, T. J., M. A. Evans, T. Garland, Jr., J. G. Swallow, and P. A. Carter. 2005. Molecular and quantitative genetic divergence among populations of house mice with known evolutionary histories. Heredity 94:518-525. [PDF file] [Drive PDF file]
131. Swallow, J. G., J. S. Rhodes, and T. Garland, Jr. 2005. Phenotypic and evolutionary plasticity of organ masses in response to voluntary exercise in house mice. Integrative and Comparative Biology 45:426-437. [PDF file] [Drive PDF file]
132. Rhodes, J. S., S. C. Gammie, and T. Garland, Jr. 2005. Neurobiology of mice selected for high voluntary wheel-running activity. Integrative and Comparative Biology 45:438-455. [PDF file] [Drive PDF file]
133. Rezende, E. L., M. A. Chappell, F. R. Gomes, J. L. Malisch, and T. Garland, Jr. 2005. Maximal metabolic rates during voluntary exercise, forced exercise, and cold exposure in house mice selectively bred for high wheel-running. Journal of Experimental Biology 208:2447-2458. [PDF file] [Drive PDF file]
135. Syme, D. A., K. Evashuk, B. Grintuch, E. L. Rezende, and T. Garland, Jr. 2005. Contractile abilities of normal and “mini” triceps surae muscles from mice (Mus domesticus) selectively bred for high voluntary wheel running. Journal of Applied Physiology 99:1308-1316. [PDF file] [Drive PDF file]
136. Garland, T., Jr., and P. A. Freeman. 2005. Selective breeding for high endurance running increases hindlimb symmetry. Evolution 59:1851-1854. [PDF file] [Drive PDF file]
137. Rezende, E. L., S. A. Kelly, F. R. Gomes, M. A. Chappell, and T. Garland, Jr. 2006. Effects of size, sex, and voluntary running speeds on costs of locomotion in lines of laboratory mice selectively bred for high wheel-running activity. Physiological and Biochemical Zoology 79:83-99. [PDF file] [Drive PDF file]
139. Rezende, E. L., T. Garland, Jr., M. A. Chappell, J. L. Malisch, and F. R. Gomes. 2006. Maximum aerobic performance in lines of Mus selected for high wheel-running activity: effects of selection, oxygen availability, and the mini-muscle phenotype. Journal of Experimental Biology 209:115-127. [PDF file] [Drive PDF file]
141. Kelly, S. A., P. P. Czech, J. T. Wight, K. M. Blank, and T. Garland, Jr. 2006. Experimental evolution and phenotypic plasticity of hindlimb bones in high-activity house mice. Journal of Morphology 267:360-374. [PDF file] [Drive PDF file]
143. Guderley, H., P. Houle-Leroy, G. M. Diffee, D. M. Camp, and T. Garland, Jr. 2006. Morphometry, ultrastructure, myosin isoforms, and metabolic capacities of the "mighty mini muscles" favoured by selection for high activity in house mice. Comparative Biochemistry and Physiology Part B: Biochemistry and Molecular Biol. 144:271-282. [PDF file] [Drive PDF file]
145. Rezende, E. L., F. R. Gomes, J. L. Malisch, M. A. Chappell, and T. Garland, Jr. 2006. Maximal oxygen consumption in relation to subordinate traits in lines of house mice selectively bred for high voluntary wheel running. Journal of Applied Physiology 101:477-485. [PDF file] [Drive PDF file]
146. Zhang, Y., T.-S. Lee, E. M. Kolb, K. Sun, X. Lu, F. M. Sladek, G. S. Kassab, T. Garland, Jr., and J. Y.-J. Shyy. 2006. AMP-activated protein kinase is involved in endothelial nitric-oxide synthase activation in response to shear stress. Arteriosclerosis, Thrombosis, and Vascular Biology 26:1281-1287. [PDF file] [Drive PDF file] Faculty of 1000 Selection!
147. Bronikowski, A. M., T. Morgan, T. Garland, Jr., and P.A. Carter. 2006. The evolution of aging and age-related physical decline in mice selectively bred for high voluntary exercise. Evolution 60:1494-1508. [PDF file] [Drive PDF file]
148. Garland, T., Jr., and S. A. Kelly. 2006. Phenotypic plasticity and experimental evolution. Journal of Experimental Biology 209:2344-2361. [PDF file] [Drive PDF file]
150. Krugner-Higby, L., I. Girard, J. Welter, A. Gendron, J. S. Rhodes, and T. Garland Jr. 2006. Clostridial enteropathy in lactating outbred swiss-derived (ICR) mice. Journal of the American Association for Laboratory Animal Science 45:80-87. [PDF file] [Drive PDF file]
151. Vaanholt, L. M., T. Garland Jr., S. Daan, and G. H. Visser. 2007. Wheel-running activity and energy metabolism in relation to ambient temperature in mice selected for high wheel-running activity. Journal of Comparative Physiology B 177:109-118. [PDF file] [Drive PDF file]
152. Malisch, J. L., W. Saltzman, F. R. Gomes, E. L. Rezende, D. R. Jeske, and T. Garland, Jr. 2007. Baseline and stress-induced plasma corticosterone concentrations of mice selectively bred for high voluntary wheel running. Physiological and Biochemical Zoology 80:146-156. [PDF file] [Drive PDF file]
154. Belke, T. W., and T. Garland, Jr. 2007. A brief opportunity to run does not function as a reinforcer for mice selected for high daily wheel-running rates. Journal of the Experimental Analysis of Behavior 88:199-213. [PDF file] [Drive PDF file]
155. Vaanholt, L. M., P. Meerlo, T. Garland, Jr., G. H. Visser, and G. van Dijk. 2007. Plasma adiponectin is increased in mice selectively bred for high wheel-running activity, but not by wheel running per sé. Hormone and Metabolic Research 39:377-383. [PDF file] [Drive PDF file]
156. Vaanholt, L. M., B. De Jong, T. Garland, Jr., S. Daan, and G. H. Visser. 2007. Behavioural and physiological responses to increased foraging effort in male mice. Journal of Experimental Biology 210:2013-2024. [PDF file] [Drive PDF file]
160. Girard, I., E. L. Rezende, and T. Garland, Jr. 2007. Leptin levels and body composition of mice selectively bred for high voluntary activity. Physiological and Biochemical Zoology 80:568-579. [PDF file] [Drive PDF file]
162. Middleton, K. M., C. E. Shubin, D. C. Moore, P. A. Carter, T. Garland, Jr., and S. M. Swartz. 2008. The relative importance of genetics and phenotypic plasticity in dictating bone morphology and mechanics in aged mice: evidence from an artificial selection experiment. Zoology 111:135-147. [PDF file] [Drive PDF file]
163. Vaanholt, L. M., J. R. Speakman, T. Garland Jr., G. E. Lobley, and G. H. Visser. 2008. Protein synthesis and antioxidant capacity in aging mice: effects of long-term voluntary exercise. Physiological and Biochemical Zoology 81:148-157. [PDF file] [Drive PDF file]
164. Guderley, H., D. R. Joanisse, S. Mokas, G. M. Bilodeau, and T. Garland, Jr. 2008. Altered fiber types in gastrocnemius muscle of high wheel-running selected mice with mini muscle phenotypes. Comparative Biochemistry and Physiology, Part B 149:490-500. [PDF file] [Drive PDF file]
165. Kane, S. L., T. Garland, Jr., and P. A. Carter. 2008. Basal metabolic rate of aged mice is affected by random genetic drift but not by selective breeding for high early-age locomotor activity or chronic wheel access. Physiological and Biochemical Zoology 81:288-300. PDF_file] [Drive PDF file]
166. Hannon, R. M., S. A. Kelly, K. M. Middleton, E. M. Kolb, D. Pomp, and T. Garland, Jr. 2008. Phenotypic effects of the “mini-muscle” allele in a large HR x C57BL/6J mouse backcross. Journal of Heredity 99:349-354. [PDF file] [Drive PDF file]
167. Malisch, J. L., C. W. Breuner, F. R Gomes, M. A. Chappell, and T. Garland, Jr. 2008. Circadian pattern of total and free corticosterone concentrations, corticosteroid-binding globulin, and physical activity in mice selectively bred for high voluntary wheel-running behavior. General and Comparative Endocrinology 156:210-217. [PDF file] [Drive PDF file]
169. Hartmann, J., T. Garland, Jr., R. M. Hannon, S. A. Kelly, G. Muñoz, and D. Pomp. 2008. Fine mapping of "Mini-Muscle", a recessive mutation causing reduced hind-limb muscle mass in mice. Journal of Heredity 99:679-687. [PDF file] [Drive PDF file]
171. Middleton, K. M., S. A. Kelly, and T. Garland, Jr. 2008. Selective breeding as a tool to probe skeletal response to high voluntary locomotor activity in mice. Integrative and Comparative Biology 48:394-410. [PDF file] [Drive PDF file]
172. Vaanholt, L. M., I. Jonas, M. Doornbos, K. A. Schubert, C. Nyakas, T. Garland, Jr., G. H. Visser, and Gertjan van Dijk. 2008. Metabolic and behavioral responses to high-fat feeding in mice selectively bred for high wheel-running activity. International Journal of Obesity 32:1566-1575. [PDF file] [Drive PDF file]
173. Yan, R. H., J. L. Malisch, R. M. Hannon, P. L. Hurd, and T. Garland, Jr. 2008. Selective breeding for a behavioral trait changes digit ratio. PLoS ONE 3(9):e3216. doi:10.1371/journal.pone.0003216. [PDF file] [Drive PDF file]
175. Keeney, B. K., D. A. Raichlen, T. H. Meek, R. S. Wijeratne, K. M. Middleton, G. L. Gerdeman, and T. Garland, Jr. 2008. Differential response to a selective cannabinoid receptor antagonist (SR141716: rimonabant) in female mice from lines selectively bred for high voluntary wheel-running behavior. Behavioural Pharmacology 19:812-820. [PDF file] [Drive PDF file]
176. Malisch, J. L., S. A. Kelly, A. Bhanvadia, K. M. Blank, R. L. Marsik, E. G. Platzer, and T. Garland, Jr. 2009. Lines of mice with chronically elevated baseline corticosterone are more susceptible to a parasitic nematode infection. Zoology 112:316-324. [PDF file] [Drive PDF file]
177. Gomes, F. R., E. L. Rezende, J. L. Malisch, S. K. Lee, D. A. Rivas, S. A. Kelly, C. Lytle, B. B. Yaspelkis III, and T. Garland, Jr. 2009. Glycogen storage and muscle glucose transporters (GLUT-4) of mice selectively bred for high voluntary wheel running. Journal of Experimental Biology 212:238-248. [PDF file] [Drive PDF file]
178. Malisch, J. L., C. W. Breuner, E. M. Kolb, H. Wada, R. M. Hannon, M. A. Chappell, K. M. Middleton, and T. Garland, Jr. 2009. Behavioral despair and home-cage activity in mice with chronically elevated baseline corticosterone concentrations. Behavior Genetics 39:192-201. [PDF file] [Drive PDF file]
179. Bilodeau, G. M., H. Guderley, D. R. Joanisse, and T. Garland, Jr. 2009. Reduction of type IIb myosin and IIB fibers in tibialis anterior muscle of mini-muscle mice from high-activity lines. Journal of Experimental Zoology Part A: Ecological Genetics and Physiology 311A:189-198. [PDF file] [Drive PDF file]
180. McGillivray, D. G., T. Garland, Jr., E. M. Dlugosz, M. A. Chappell, and D. A. Syme. 2009. Changes in efficiency and myosin expression in the small-muscle phenotype of mice selectively bred for high voluntary running activity. Journal of Experimental Biology 212:977-985. [PDF file] [Drive PDF file]
181. Young, N. M., B. Hallgrímsson, and T. Garland, Jr. 2009. Epigenetic effects on integration of limb lengths in a mouse model: selective breeding for high voluntary locomotor activity. Evolutionary Biology 36:88-99. [PDF file] [Drive PDF file]
183. Nehrenberg, D. L., K. Hua, D. Estrada-Smith, T. Garland, Jr., and D. Pomp. 2009. Voluntary exercise and its effects on body composition depend on genetic selection history. Obesity 17:1402-1409. [PDF file][Drive PDF file]
184. Wong, L. E., T. Garland, Jr., S. Rowan, and R. T. Hepple. 2009. Anatomic capillarization is elevated in the medial gastrocnemius muscle of mighty mini mice. Journal of Applied Physiology 106:1660-1667. [PDF file] [Drive PDF file]
185. Eisenmann, J. C., E. E. Wickel, S. A. Kelly, K. M. Middleton, and T. Garland, Jr. 2009. Day-to-day variability in voluntary wheel running among genetically differentiated lines of mice that vary in activity level. European Journal of Applied Physiology 106:613-619. [PDF file] [Drive PDF file]
188. Dlugosz, E. M., M. A. Chappell, D. G. McGillivray, D. A. Syme, and T. Garland, Jr. 2009. Locomotor trade-offs in mice selectively bred for high voluntary wheel running. Journal of Experimental Biology 212:2612-2618. [PDF file] [Drive PDF file]
189. Meek, T. H., B. P. Lonquich, R. M. Hannon, and T. Garland, Jr. 2009. Endurance capacity of mice selectively bred for high voluntary wheel running. Journal of Experimental Biology 212: 2908-2917. [PDF file] [Drive PDF file]
191. Swallow, J. G., J. P. Hayes, P. Koteja, and T. Garland, Jr. 2009. Selection experiments and experimental evolution of performance and physiology. Pages 301-351 in Experimental Evolution: Concepts, Methods, and Applications of Selection Experiments, T. Garland, Jr., and M. R. Rose, eds. University of California Press, Berkeley, California. [PDF file] [Drive PDF file]
192. Rezende, E. L., F. R. Gomes, M. A. Chappell, and T. Garland, Jr. 2009. Running behavior and its energy cost in mice selectively bred for high voluntary locomotor activity. Physiological and Biochemical Zoology 82:662-679. [PDF file] [Drive PDF file]
193. Nehrenberg, D. L., S. Wang, R. M. Hannon, T. Garland, Jr., and D. Pomp. 2010. QTL underlying voluntary exercise in mice: interactions with the “mini muscle” locus and sex. Journal of Heredity 101:42-53. [PDF file] [Drive PDF file]
195. Feder, M. E., T. Garland, Jr., J. H. Marden, and A. J. Zera. 2010. Locomotion in response to shifting climate zones: not so fast. Annual Review of Physiology 72:167-190. [PDF file] [Drive PDF file] (includes review of rodent selection experiments)
196. Vaanholt, L. M., S. Daan,T. Garland, Jr., and G. H. Visser. 2010. Exercising for life? Energy metabolism, body composition, and longevity in mice exercising at different intensities. Physiological and Biochemical Zoology 83:239-251. [PDF file] [Drive PDF file]
198. Kolb, E. M., S. A. Kelly, K. M. Middleton, L. S. Sermsakdi, M. A. Chappell, and T. Garland, Jr. 2010. Erythropoietin elevates VO2,max but not voluntary wheel running in mice. Journal of Experimental Biology 213:510-519. [PDF file] [Drive PDF file]
200. Middleton, K. M., T. Garland, Jr., B. D. Goldstein, P. R. Guduru, S. A. Kelly, and S. M. Swartz. 2010. Variation in within-bone stiffness measured by nanoindentation in mice bred for high levels of voluntary wheel running. Journal of Anatomy 216:121-131. [PDF file] [Drive PDF file]
201. Kelly, S. A., D. L. Nehrenberg, K. Hua, R. R. Gordon, T. Garland, Jr., and D. Pomp. 2010. Parent-of-origin effects on voluntary exercise levels and body composition in mice. Physiological Genomics 40:111-120. [PDF file] [Drive PDF file]
202. Meek, T. H., J. C. Eisenmann, and T. Garland, Jr. 2010. Western diet increases wheel running in mice selectively bred for high voluntary wheel running. International Journal of Obesity 34:960-969. [PDF file] [Drive PDF file]
203. Jonas, I., M. Doornbos, L. Vaanholt, T. Garland, Jr, A. J. W. Scheurink, C. Nyakas, and G. van Dijk. 2010. Effects of selective breeding for increased wheel running behavior on circadian timing of substrate oxidation and ingestive behavior. Physiology & Behavior 99:549-554. [PDF file] [Drive PDF file]
204. Wallace, I. J., K. M. Middleton, S. Lublinsky, S. A. Kelly, S. Judex, T. Garland, Jr., and B. Demes. 2010. Functional significance of genetic variation underlying limb bone diaphyseal structure. American Journal of Physical Anthropology 143:21-30. [PDF file] [Drive PDF file]
205. Mathes, W. F., D. L. Nehrenberg, R. Gordon, K. Hua, T. Garland, Jr., and D. Pomp. 2010. Dopaminergic dysregulation in mice selectively bred for excessive exercise or obesity. Behavioural Brain Research 210:155-163. [PDF file] [Drive PDF file]
206. Jonas, I., K. A. Schubert, A. C. Reijne, J. Scholte, T. Garland, Jr., M. P. Gerkema, A. J. W. Scheurink, C. Nyakas, and G. van Dijk. 2010. Behavioral traits are affected by selective breeding for increased wheel-running behavior in mice. Behavior Genetics 40:542-550. [PDF file] [Drive PDF file]
207. Kelly, S. A., D. L. Nehrenberg, J. L. Peirce, K. Hua, B. M. Steffy, T. Wiltshire, F. Pardo Manuel de Villena, T. Garland, Jr., and D. Pomp. 2010. Genetic architecture of voluntary exercise in an advanced intercross line of mice. Physiological Genomics 42:190-200. [PDF file] [Drive PDF file]
211. Garland, T., Jr., S. A. Kelly, J. L. Malisch, E. M. Kolb, R. M. Hannon, B. K. Keeney, S. L. Van Cleave, and K. M. Middleton. 2011. How to run far: Multiple solutions and sex-specific responses to selective breeding for high voluntary activity levels. Proceedings of the Royal Society B 278:574-581. [PDF file] [Drive PDF file] UCR Press Release To see a video of Dr. Garland discussing the research, click here.xx
212. Robertson, H. T., D. L. Smith, N. M. Pajewski, R. H. Weindruch, T. Garland, Jr., G. Argyropoulos, A. Bokov, and D. B. Allison. 2011. Can rodent longevity studies be both short and powerful? The Journals of Gerontology, Series A: Biological Sciences, Medical Sciences 66:279-286. [PDF file] [Drive PDF file]
213. Garland, T., Jr., H. Schutz, M. A. Chappell, B. K. Keeney, T. H. Meek, L. E. Copes, W. Acosta, C. Drenowatz, R. C. Maciel, G. van Dijk, C. M. Kotz, and J. C. Eisenmann. 2011. The biological control of voluntary exercise, spontaneous physical activity, and daily energy expenditure in relation to obesity: human and rodent perspectives. Journal of Experimental Biology 214:206-229. [PDF file] [Drive PDF file]
214. Hannon, R. M., T. H. Meek, W. Acosta, R. C. Maciel, H. Schutz, and T. Garland, Jr. 2011. Sex-specific heterosis in line crosses of mice selectively bred for high locomotor activity. Behavior Genetics 41:615-624. [PDF file] [Drive PDF file]
215. Kelly, S. A., D. L. Nehrenberg, K. Hua, T. Garland, Jr., and D. Pomp. 2011. Exercise, weight loss, and changes in body composition in mice: phenotypic relationships and genetic architecture. Physiological Genomics 43:199-212. [PDF file] [Drive PDF file]
220. Farber, C. R., S. A. Kelly, E. Baruch, D. Yu, K. Hua, D. L. Nehrenberg, F. Pardo-Manuel de Villena, R. J. Buus, T. Garland, Jr., and D. Pomp. 2011. Identification of quantitative trait loci influencing skeletal architecture in mice: emergence of Cdh11 as a primary candidate gene regulating femoral morphology. Journal of Bone and Mineral Research 26:2174-2183. [PDF file] [Drive PDF file]
222. Audet, G. N., T. H. Meek, T. Garland, Jr., and I. M. Olfert. 2011. Expression of angiogenic regulators and skeletal muscle capillarity in selectively bred high aerobic capacity mice. Experimental Physiology 96.11:1138-1150. [PDF file] [Drive PDF file] Commentary Viewpoint by Birot, O. 2011. Genetic background, endurance performance and muscle capillarization: lessons from the “mini mice.” Experimental Physiology 96:1116–1117. [PDF file] [Drive PDF file]
225. Wallace, I. J., S. M. Tommasini, S. Judex, T. Garland, Jr., and B. Demes. 2012. Genetic variations and physical activity as determinants of limb bone morphology: an experimental approach using a mouse model. American Journal of Physical Anthropology 148:24-35. [PDF file] [Drive PDF file]
226. Downs, C. J., H. Schutz, T. H. Meek, E. M. Dlugosz, W. Acosta, K. S. de Wolski, J. L. Malisch, J. P. Hayes, and T. Garland, Jr. 2012. Within life-time trade-offs but evolutionary freedom for hormonal and immunological traits: evidence from mice bred for high voluntary exercise. Journal of Experimental Biology 215:1651-1661. [PDF file] [Drive PDF file]
227. Meek, T. H., E. M. Dlugosz, K. T. Vu, and T. Garland, Jr. 2012. Effects of leptin treatment and Western diet on wheel running in selectively bred high runner mice. Physiology & Behavior 106:252-258. [PDF file] [Drive PDF file]
228. Keeney, B. K., T. H. Meek, K. M. Middleton, L. F. Holness, and T. Garland, Jr. 2012. Sex differences in cannabinoid receptor-1 (CB1) pharmacology in mice selectively bred for high voluntary wheel-running behavior. Pharmacology, Biochemistry and Behavior 101:528-537. [PDF file] [Drive PDF file]
229. Kelly, S. A., D. L. Nehrenberg, K. Hua, T. Garland, Jr., and D. Pomp. 2012. Functional genomic architecture of predisposition to voluntary exercise in mice: expression QTL in the brain. Genetics 191:643-654. [PDF file] [Drive PDF file]
232. Careau, V. C., O. R. P. Bininda-Emonds, G. Ordonez, and T. Garland, Jr. 2012. Are voluntary wheel running and open-field behavior correlated in mice? Different answers from comparative and artificial selection approaches. Behavior Genetics 42:830-844. [PDF file] [Drive PDF file]
233. Templeman, N. M., H. Schutz, T. Garland, Jr., and G. B. McClelland. 2012. Do mice bred selectively for high locomotor activity have a greater reliance on lipids to power submaximal aerobic exercise? American Journal of Physiology Regulatory Integrative and Comparative Physiology 303:R101-R111. [PDF file] [Drive PDF file]
236. Kolb, E. M., E. L. Rezende, L. Holness*, A. Radtke*, S. K. Lee*, A. Obenaus, and T. Garland, Jr. 2013. Mice selectively bred for high voluntary wheel running have larger midbrains: support for the mosaic model of brain evolution. Journal of Experimental Biology 216:515-523. [PDF file] [Drive PDF file] [UCR Today] [Science Daily news story] [Deccan Herald] [NBC Los Angeles] [Animal Abstracts] [Medical News Today] [Many Years Young] [Indian Express] [moneycontrol.com] [Business Standard]
237. Waters, R. P., R. B. Pringle, G. L. Forster, K. J. Renner, J. L. Malisch, T. Garland, Jr., and J. G. Swallow. 2013. Selection for increased voluntary wheel-running affects behavior and brain monoamines in mice. Brain Research 1508:9-22. [PDF file] [Drive PDF file]
238. Burniston, J. G., T. H. Meek, S. N. Pandey, G. Broitman-Maduro, M. F. Maduro, A. M. Bronikowski, T. Garland, Jr., and Y.-W. Chen. 2013. Gene expression profiling of gastrocnemius of "minimuscle" mice. Physiological Genomics 45:228-236. [PDF file] [Drive PDF file]
239. Kolb, E. M., S. A. Kelly, and T. Garland, Jr. 2013. Mice from lines selectively bred for high voluntary wheel running exhibit lower blood pressure during withdrawal from wheel access. Physiology & Behavior 112-113:49-55. [PDF file] [Drive PDF file]
240. Careau, V., M. E. Wolak, P. A. Carter, and T. Garland, Jr. 2013. Limits to behavioral evolution: the quantitative genetics of a complex trait under directional selection. Evolution 67:3102-3119. [PDF file] [Drive PDF file]
242. Dlugosz, E. M., H. Schutz, T. H. Meek, W. Acosta, C. J. Downs, E. G. Platzer, M. A. Chappell, and T. Garland, Jr. 2013. Immune response to a Trichinella spiralis infection in house mice from lines selectively bred for high voluntary wheel running. Journal of Experimental Biology 216:4212-4221. [PDF file] [Drive PDF file]
243. Dlugosz, E. M., M. A. Chappell, T. H. Meek, P. Szafrañska, K. Zub, M. Konarzewski, J. H. Jones, J. E. P. W. Bicudo, V. Careau, and T. Garland, Jr. 2013. Phylogenetic analysis of mammalian maximal oxygen consumption during exercise. Journal of Experimental Biology 216:4712-4721. [PDF File] [Drive PDF file]
244. Kelly, S. A., T. A. Bell, S. R. Selitsky, R. J. Buus, K. Hua, G. M. Weinstock, T. Garland, Jr., F. Pardo-Manuel de Villena, and D. Pomp. 2013. A novel intronic SNP in the Myosin heavy polypeptide 4 gene is responsible for the Mini-Muscle phenotype characterized by major reduction in hindlimb muscle mass in mice. Genetics 195:1385-1395. [PDF file] [Drive PDF file]
245. Guidotti, S., I. Jonas, K. M. Schubert, T. Garland, Jr., H. A. J. Meijer, A. J. W. Scheurink, and G van Dijk. 2013. High-saturated fat-sucrose feeding affects lactation energetics in control mice and mice selectively bred for high wheel-running behavior. American Journal of Physiology-Regulatory, Comparative and Integrative Physiology. 305:R1433-440. [PDF File] [Drive PDF file]
247. Meek, T. H., J. C. Eisenmann, B. K. Keeney, R. M. Hannon, E. M. Dlugosz, and T. Garland, Jr. 2014. Effects of early- life exposure to Western diet and wheel access on Metabolic Syndrome profiles in mice bred for high voluntary exercise. Genes, Brain and Behavior 13:322-332. [PDF file] [Drive PDF file]
248. Kelly, S. A., E. L. Rezende, M. A. Chappell, F. R. Gomes, E. M. Kolb, J. L. Malisch, J. S. Rhodes, G. S. Mitchell, and T. Garland, Jr. 2014. Exercise training effects on hypoxic and hypercapnic ventilatory responses in mice selected for increased voluntary wheel running. Experimental Physiology 99:403-413. [PDF File] [Drive PDF file]
251. Radojcic, T., and T. Garland, Jr. 2014. Born to run: Experimental evolution of high voluntary exercise in mice. Science Scope 37:51-60. [PDF File] [Drive PDF file] This is about the active-learning, middle-school lesson plan.
253. Kelly, S. A., D. L. Nehrenberg, K. Hua, T. Garland, Jr., and D. Pomp. 2014. Quantitative genomics of voluntary exercise in mice: transcriptional analysis and mapping of expression QTL in muscle. Physiological Genomics 46:593-601. [PDF File] [Drive PDF file]
256. Schutz, H., H. A. Jamniczky, B. Hallgrímsson, and T. Garland, Jr. 2014. Shape-shift: semicircular canal morphology responds to selective breeding for increased locomotor activity. Evolution 68:3184-3198. [PDF file] [Drive PDF file]
257. Talmadge, R. J., W. Acosta, and T. Garland, Jr. 2014. Myosin heavy chain isoform expression in adult and juvenile mini-muscle mice bred for high-voluntary wheel running. Mechanisms of Development 134:16-30. [PDF file] [Drive PDF file]
259. Didion, J. P., A. P. Morgan, A. M.-F. Clayshulte, R. C. Mcmullan, L. Yadgary, P. M. Petkov, T. A. Bell, D. M. Gatti, J. J. Crowley, K. Hua, D. L. Aylor , L. Bai, M. Calaway, E. J. Chesler, J. E. French, T. R. Geiger, T. J. Gooch, T. Garland, Jr., A. H. Harrill, K. Hunter, L. McMillan, M. Holt, D. R. Miller, D. A. O'Brien, K. Paigen, W. Pan, L. B. Rowe, G. D. Shaw, P. Simecek, P. F. Sullivan, K. L. Svenson, G. M. Weinstock, D. W. Threadgill, D. Pomp, G. A. Churchill. and F. Pardo-Manuel de Villena. 2015. A multi-megabase copy number gain causes maternal transmission ratio distortion on mouse Chromosome 2. PLoS Genetics. 11(2): e1004850. doi:10.1371/journal.pgen.1004850 [PDF file] [Drive PDF file]
261. Copes, L. E., H. Schutz, E. M. Dlugosz, W. Acosta, M. A. Chappell, and T. Garland, Jr. 2015. Effects of voluntary exercise on spontaneous physical activity and food consumption in mice: Results from an artificial selection experiment. Physiology & Behavior 149:86-94. [PDF file] [Drive PDF file]
262. Acosta, W., T. H. Meek, H. Schutz, E. M. Dlugosz, K. T. Vu, and T. Garland, Jr. 2015. Effects of early-onset voluntary exercise on adult physical activity and associated phenotypes in mice. Physiology & Behavior 149:279-286. [PDF file] [Drive PDF file] UCR press release
263. Storz, J. F., J. T. Bridgham, S. A. Kelly, and T. Garland, Jr. 2015. Genetic approaches in comparative and evolutionary physiology. American Journal of Physiology (Regulatory, Integrative and Comparative Physiology) 309:R197-R214. [PDF file] [Drive PDF file]
267. Careau, V., M. E. Wolak, P. A. Carter, and T. Garland, Jr. 2015. Evolution of the additive genetic variance-covariance matrix under continuous directional selection on a complex behavioral phenotype. Proceedings of the Royal Society B 282:20151119. http://dx.doi.org/10.1098/rspb.2015.1119. [PDF file] [Drive PDF file]
270. Guidotti, S., N. Meyer, E. Przybyt, A. J. W. Scheurink, M. C. Harmsen, T. Garland, Jr., and G. van Dijk. 2016. Diet-induced obesity resistance of adult female mice selectively bred for increased wheel-running behavior is reversed by single perinatal exposure to a high-energy diet. Physiology & Behavior 157:246-257. [PDF file] [Drive PDF file]
271. Didion, J. P., A. P Morgan, L. Yadgary, T. A. Bell, R.l C. McMullan, L. Ortiz de Solorzano, J. Britton-Davidian, C. J. Bult, K. J. Campbell, R. Castiglia, Y.-H. Ching, A. J. Chunco, J. J. Crowley, E. J. Chesler, J. E. French, S. I. Gabriel, D. M. Gatti, T. Garland Jr., E. B. Giagia-Athanasopoulou, M. D. Giménez, S. A. Grize, İ. Gündüz, A. Holmes, H. C. Hauffe, J. S. Herman, J. M. Holt, K. Hua, W. J. Jolley, A. K. Lindholm, M. J. López-Fuster, G. Mitsainas, M. Mathias, L. McMillan, M. Graça Ramalhinho, B. Rehermann, S. P. Rosshart, J. B. Searle, M.-S. Shiao, E. Solano, K. L. Svenson, P. Thomas-Laemont, D. W. Threadgill, J. V. Queija, G. M. Weinstock, D. Pomp, G. A. Churchill, and F. Pardo-Manuel de Villena. 2016. R2d2 drives selfish sweeps in the house mouse. Molecular Biology and Evolution 33:1381-1395. [PDF file] [Drive PDF file]
272. Claghorn, G. C., I. A. T. Fonseca, Z. Thompson, C. Barber, and T. Garland, Jr. 2016. Serotonin-mediated central fatigue underlies increased endurance capacity in mice from lines selectively bred for high voluntary wheel running. Physiology & Behavior 161:145-154. [PDF file] [Drive PDF file] Blog by Chris Perry: "It’s what’s inside that counts. But what’s inside? The role of serotonin and central fatigue." https://medsportsnutrition.com/2016/05/31/its-whats-inside-that-counts-but-whats-inside-the-role-of-serotonin-and-central-fatigue/
273. Wallace, I. J., and T. Garland, Jr. 2016. Mobility as an emergent property of biological organization: insights from experimental evolution. Evolutionary Anthropology 25:98-104. [PDF file] [Drive PDF file]
275. Malisch, J. L., K. deWolski*, T. H. Meek, W. Acosta, K. M. Middleton, O. L. Crino, and T. Garland, Jr. 2016. Acute restraint stress alters wheel-running behavior immediately following stress and up to 20 hours later in house mice. Physiological and Biochemical Zoology 89:546-552. [PDF file] [Drive PDF file]
276. Garland, T., Jr., M. Zhao, and W. Saltzman. 2016. Hormones and the evolution of complex traits: insights from artificial selection on behavior. Integrative and Comparative Biology 56:207-224. [PDF file] [Supplemental Excel file] [Drive PDF file]
277. Caetano-Anollés, K., J. S. Rhodes, T. Garland, Jr., S. D. Perez, A. G. Hernandez, B. R. Southey, S. L. Rodriguez-Zas. 2016. Cerebellum transcriptome of mice bred for high voluntary activity offers insights into locomotor control and reward-dependent behaviors. PloS ONE. 11(11): e0167095. doi:10.1371/journal.pone.0167095. [PDF file] [Drive PDF file]
278. Claghorn, G. C., Z. Thompson, K. Wi*, L. Van*, and T. Garland, Jr. 2017. Caffeine stimulates voluntary wheel running in mice without increasing aerobic capacity. Physiology & Behavior 170:133-140. [PDF file] [Drive PDF file]
279. Saul, M., P. Majdak, S. D. Perez, T. Garland, Jr., and J. S. Rhodes. 2017. High motivation for exercise is associated with altered chromatin regulators of monoamine receptor gene expression in the striatum of selectively bred mice. Genes, Brain and Behavior 16: 328-341. [PDF file] [Drive PDF file]
280. Marck, A., G. Berthelot, V. Foulonneau, A. Marc, J. Antero-Jacquemin, P. Noirez, A. M. Bronikowski, T. J. Morgan, T. Garland, Jr., P. A. Carter, P. Hersen, J.-M. Di Meglio, and J.-F. Toussaint. 2017. Age-related changes in locomotor performance reveal a similar pattern for Caenorhabditis elegans, Mus domesticus, Canis familiaris, Equus caballus, and Homo sapiens. Journals of Gerontology: Biological Sciences 72:455-463. [PDF file] [Drive PDF file]
281. Acosta, W., T. H. Meek, H. Schutz, E. M. Dlugosz, and T. Garland, Jr. 2017. Preference for Western diet coadapts in High Runner mice and affects voluntary exercise and spontaneous physical activity in a genotype-dependent manner. Behavioural Processes 135:56-65. [PDF file] [Drive PDF file]
282. Thompson, Z., D. Argueta, T. Garland, Jr., and N. DiPatrizio. 2017. Circulating levels of endocannabinoids respond acutely to voluntary exercise, are altered in mice selectively bred for high voluntary wheel running, and differ between the sexes. Physiology & Behavior 170:141-150. [PDF file] [Drive PDF file]
283. Garland, T., Jr., M. D. Cadney, and R. A. Waterland. 2017. Early-life effects on adult physical activity: concepts, relevance, and experimental approaches. Physiological and Biochemical Zoology 90:1-14. [PDF file] [Drive PDF file]
284. Kelly, S. A., F. R. Gomes, E. M. Kolb, J. L. Malisch, and T. Garland, Jr. 2017. Effects of activity, genetic selection and their interaction on muscle metabolic capacities and organ masses in mice. Journal of Experimental Biology 220:1038-1047. [PDF file] [Drive PDF file]
286. Hiramatsu, L., J. C. Kay, Z. Thompson, J. M. Singleton, G. C. Claghorn, R. L. Albuquerque, B. Ho*, B. Ho*, G. Sanchez*, and T. Garland, Jr. 2017. Maternal exposure to Western diet affects adult body composition and voluntary wheel running in a genotype-specific manner in mice. Physiology & Behavior 179:235-245. [PDF file] [Drive PDF file]
287. Claghorn, G. C., Z. Thompson, J. C. Kay, G. Ordonez, T. G. Hampton, and T. Garland, Jr. 2017. Selective breeding and short-term access to a running wheel alter stride characteristics in house mice. Physiological and Biochemical Zoology 90:533-545. [PDF file] [Drive PDF file]
291. Xu, S., and T. Garland, Jr. 2017. A mixed model approach to genome-wide association studies for selection signatures, with application to mice bred for voluntary exercise behavior. Genetics 207:785-799. [PDF file] [Drive PDF file]
293. Thompson, Z., E. M. Kolb, and T. Garland, Jr. 2018. High-runner mice have reduced incentive salience for a sweet-taste reward when housed with wheel access. Behavioural Processes 146:46-53. [PDF file] [Drive PDF file]
295. Peacock, S. J., B. R. Coats, J. K. Kirkland, C. A. Tanner, T. Garland, Jr., K. M. Middleton. 2018. Predicting the bending properties of long bones: insights from an experimental mouse model. American Journal of Physical Anthropology 165:457-470. [PDF file] [Drive PDF file]
296. Lightfoot, J. T., E. J. C. De Geus, F. W. Booth, M. S. Bray, M. den Hoed, J. Kaprio, S. A. Kelly, D. Pomp, M. C. Saul, M. A. Thomis, T. Garland, Jr., and C. Bouchard. 2018. Biological / genetic regulation of physical activity level: consensus from GenBioPAC. Medicine and Science in Sports and Exercise 50:863-873. [PDF file] [Drive PDF file]
299. Copes, L. E., H. Schutz, E. M. Dlugsoz, and T. Garland, Jr. 2018. Locomotor activity, hormones, and systemic robusticity: an investigation of cranial vault thickness in mouse lines bred for high endurance running. American Journal of Physical Anthropology 166:442-458. [PDF file] [Drive PDF file] [https://www.academia.edu/ai_podcast/115092860]
300. Biro, P. A., T. Garland, Jr., C. Beckmann, B. Ujvari, F. Thomas, and J. R. Post. 2018. Metabolic scope as a proximate constraint on individual behavioral variation: effects on 'personality', plasticity, and predictability. American Naturalist 192:142-154. [PDF file] [Drive PDF file]
301. Hiramatsu, L., and T. Garland, Jr. 2018. Mice selectively bred for high voluntary wheel-running behavior conserve more fat despite increased exercise. Physiology & Behavior 194:1-8. [PDF file] [Drive PDF file]
302. Castro, A. A., and T. Garland, Jr. 2018. Evolution of hindlimb bone dimensions and muscle masses in house mice selectively bred for high voluntary wheel-running behavior. Journal of Morphology 279:766-779. [PDF file] [Drive PDF file]
303. Schwartz, N. L., B. A. Patel, T. Garland, Jr., and A. M. Horner 2018. Effects of selective breeding for high voluntary wheel-running behavior on femoral nutrient canal size and abundance in house mice. Journal of Anatomy 233:193-203. [PDF file] [Drive PDF file]
304. Peacock, S. J., T. Garland, Jr., and K. M. Middleton. 2018. Reply to Ruff, Warden, and Karlson. American Journal of Physical Anthropology 167:190-193. [PDF file] [Drive PDF file]
305. Zhang, P., J. S. Rhodes,T. Garland, Jr., S. Perez, B. Southey, and S. L. Rodriguez-Zas. 2018. Brain region-dependent gene networks associated with selective breeding for increased voluntary wheel-running behavior. PLoS ONE. 13(8):e0201773. [PDF file] [Drive PDF file]
306. Kay, J. C., J. Ramirez, E. Contreras, and T. Garland, Jr. 2018. Reduced non-bicarbonate skeletal muscle buffering capacity in mice with the mini-muscle phenotype. Journal of Experimental Biology 221:jeb172478. [PDF file] [Drive PDF file]
308. Singleton, J. S., and T. Garland, Jr. 2019. Influence of corticosterone on growth, home-cage activity, wheel running, and aerobic capacity in house mice selectively bred for high voluntary wheel-running behavior. Physiology & Behavior 198:27-41. [PDF file] [Drive PDF file]
309. Kay, J. C., G. C. Claghorn, Z. Thompson, T. G. Hampton, and T. Garland, Jr. 2019. Electrocardiograms of mice selectively bred for high levels of voluntary exercise: Effects of short-term exercise training and the mini-muscle phenotype. Physiology & Behavior 199:322-332. [PDF file] [Drive PDF file]
310. Dewan, I.*, T. Garland, Jr., L. Hiramatsu, and V. Careau. 2019. I smell a mouse: indirect genetic effects on voluntary wheel-running distance, duration and speed. Behavior Genetics 49:49-59. [PDF file] [Drive PDF file]
311. Wone, B., W. C. Kim, H. Schutz, T. H. Meek, and T. Garland, Jr. 2019. Mitochondrial haplotypes are not associated with mice selectively bred for high voluntary wheel running. Mitochondrion 46:134-139. [PDF file] [Drive PDF file]
312. Lewton, K. L., T. Ritzman, L. E. Copes, T. Garland, Jr., and T. D. Capellini. 2019. Exercise-induced loading increases ilium cortical area in a selectively-bred mouse model. American Journal of Physical Anthropology 168:543-551. [PDF file] [Drive PDF file]
321. Schmill, M. P., M. D. Cadney, Z. Thompson, L. Hiramatsu, R. L. Albuquerque, M. P. McNamara, A. A. Castro, J. C. Kay, D. G. Buenaventura, J. L. Ramirez, J. S. Rhodes, and T. Garland, Jr. 2020. Conditioned place preference for cocaine and methylphenidate in female mice from lines selectively bred for high voluntary wheel-running behavior. Genes, Brain and Behavior. Sep 9;e12700. https://doi.org/10.1111/gbb.12700. [PDF file] [Drive PDF file]
322. Hillis, D. A., L. Yadgary, G. M. Weinstock, F. Pardo-Manuel de Villena, D. Pomp, A. S. Fowler*, S. Xu, F. Chan, and T. Garland, Jr. 2020. Genetic basis of aerobically supported voluntary exercise: results from a selection experiment with house mice. Genetics 216:781-804. [PDF file] [Drive PDF file] HIGHLIGHTED ARTICLE!
323. Nguyen, Q. A. T., D. Hillis, S. Katada, T. Harris, C. Pontrello, T. Garland, Jr., and S. Haga-Yamanaka. 2020. Coadaptation of the chemosensory system with voluntary exercise behavior in mice. PLoS ONE 15(11):e0241758. [PDF file] [Drive PDF file] UCR Press Release Psychology Today BBC Science Focus Magazine Ladders Chemical & Engineering News Uncover Reality
325. Castro, A. A., H. Rabitoy*, G. C. Claghorn, and T. Garland, Jr. 2021. Rapid and longer-term effects of selective breeding for voluntary exercise behavior on skeletal morphology in house mice. Journal of Anatomy 238:720-742. [PDF file] [Drive PDF file]
327. McNamara, M. P., J. M. Singleton, M. D. Cadney, P. M. Ruegger, J. Borneman, and T. Garland, Jr. 2021. Early-life effects of juvenile Western diet and exercise on adult gut microbiome composition in mice. Journal of Experimental Biology 224:jeb.239699. [PDF file] [Drive PDF file] UCR News Release Science Daily Reddit yahoo!style
Live, 4-minute radio interview with KCBS (San Francisco)
328. Cadney, M. D., L. Hiramatsu, Z. Thompson, M. Zhao, J. C. Kay, J. M. Singleton, R. L. Albuquerque, M. P. Schmill, W. Saltzman, and T. Garland, Jr. 2021. Effects of early-life exposure to Western diet and voluntary exercise on adult activity levels, exercise physiology, and associated traits in selectively bred High Runner mice. Physiology & Behavior 234:113389. [PDF file] [Drive PDF file] [Supplemental Table 1 Excel file]
329. Han, Y., M. He, T. Marin, H. Shen, W.-T. Wang, T.-Y. Lee, H.-C. Hong, Z.-L. Jiang, T. Garland, Jr., J. Y.-J. Shyy, B. Gongol, and S. Chien. 2021. Roles of KLF4 and AMPK in the inhibition of glycolysis by pulsatile shear stress in endothelial cells. PNAS 118: No. 21 e2103982118. [PDF file] [Drive PDF file]
330. Cadney M.D., N.E. Schwartz, M.P. McNamara, M.P. Schmill, A.A. Castro, D.M. Hillis, and T. Garland, Jr. 2021. Cross-fostering selectively bred High Runner mice affects adult body mass but not voluntary exercise. Physiology & Behavior 241:113569. [PDF file] [Drive PDF file]
332. Castro A. A., F. A. Karakostis, L. E. Copes, H. E. McClednon*, A. P. Trivedi*, N. E. Schwartz, and T. Garland, Jr. 2022. Effects of selective breeding for voluntary exercise, chronic exercise, and their interaction on muscle attachment site morphology in house mice. Journal of Anatomy 240:279-295. [Drive PDF file]
334. Schmill, M. P., Z. Thompson, D. A. Argueta, N. V. DiPatrizio, and T. Garland, Jr. 2022. Effects of selective breeding, voluntary exercise, and sex on endocannabinoid levels in the mouse small-intestinal epithelium. Physiology & Behavior 245:113675. [Drive PDF file]
336. McNamara, M. P., M. D. Cadney, A. A. Castro, D. A. Hillis, K. M. Kallini, J. C. Macbeth, M. P. Schmill, N. E. Schwartz, A. Hsiao, and T. Garland, Jr. 2022. Oral antibiotics reduce voluntary exercise behavior in athletic mice. Behavioural Processes 199:104650. [Drive PDF file] [https://doi.org/10.1016/j.beproc.2022.104650]
[write-up in Outdoor Magazine] [Washington Post]
337. Latchney, S. E., M. D. Cadney, A. Hopkins, and T. Garland, Jr. 2022. DNA methylation analysis of imprinted genes in the cortex and hippocampus of cross-fostered mice selectively bred for increased voluntary wheel-running. Behavior Genetics. 52:281-297. [Drive PDF file] https://doi.org/10.1007/s10519-022-10112-z
338. Wang, Z., A. Emmerich, N. J. Pillon, T. Moore, D. Hemerich, M. C. Cornelis, E. Mazzaferro, S. Broos, T. S. Ahluwalia, T. M. Bartz, A. R. Bentley, L. F. Bielak, M. Chong, A. Y. Chu, D. Berry, R. Dorajoo, N. D. Dueker, E. Kasbohm, B. Feenstra, M. F. Feitosa, C. Gieger, M. Graff, L. M. Hall, T. Haller, F. P. Hartwig, D. A. Hillis, V. Huikari, N. Heard-Costa, C. Holzapfel, A. U. Jackson, Å. Johansson, A. M. Jørgensen, M. A. Kaakinen, R. Karlsson, K. F. Kerr, B. Kim, C. M. Koolhaas, Z. Kutalik, V. Lagou, P. A. Lind, M. Lorentzon, L.-P. Lyytikäinen, M. Mangino, C. Metzendorf, K. R. Monroe, A. Pacolet, L. Pérusse, R. Pool, R. C. Richmond, N. V. Rivera, S. Robiou-du-Pont, K. E. Schraut, C.-A. Schulz, H. M. Stringham, T. Tanaka, A. Teumer, C. Turman, P. J. van der Most, M. Vanmunster, F. J. A. van Rooij, J. V. van Vliet-Ostaptchouk, X. Zhang, J.-H. Zhao, W. Zhao, Z. Balkhiyarova, M. N. Balslev-Harder, S. E. Baumeister, J. Beilby, J. Blangero, D. I. Boomsma, S. Brage, P. S. Braund, J. A. Brody, M. Bruinenberg, U. Ekelund, C.-T. Liu, J. W. Cole, F. S. Collins, L. A. Cupples, T. Esko, S. Enroth, J. D. Faul, L. Fernandez-Rhodes, A. E. Fohner, O. H. Franco, T. E. Galesloot, S. D. Gordon, N. Grarup, C. A. Hartman, G. Heiss, J. Hui, T. Illig, R. Jago, A. James, P. K. Joshi, T. Jung, M. Kähönen, T. O. Kilpeläinen, W.-P. Koh, I. Kolcic, P. P. Kraft, J. Kuusisto, L. J. Launer, A. Li, A. Linneberg, J. Luan, P. M. Vidal, S. E. Medland, Y. Milaneschi, A. Moscati, B. Musk, C. P. Nelson, I. M. Nolte, N. L. Pedersen, A. Peters, P. A. Peyser, C. Power, O. T. Raitakari, M. Reedik, A. P. Reiner, P. M. Ridker, I. Rudan, K. Ryan, M. A. Sarzynski, L. J. Scott, R. A. Scott, S. Sidney, K. Siggeirsdottir, A. V. Smith, J. A. Smith, E. Sonestedt, M. Strøm, E. S. Tai, K. K. Teo, B. Thorand, A. Tönjes, A. Tremblay, A. G. Uitterlinden, J. Vangipurapu, N. van Schoor, U. Völker, G. Willemsen, K. Williams, Q. Wong, H. Xu, K. L. Young, J. M. Yuan, M. C. Zillikens, A. B. Zonderman, A. Ameur, S. Bandinelli, J. C. Bis, M. Boehnke, C. Bouchard, D. I. Chasman, G. D. Smith, E. J. C. de Geus, L. Deldicque, M. Dörr, M. K. Evans, L. Ferrucci, M. Fornage, C. Fox, T. Garland, Jr., V. Gudnason, U. Gyllensten, T. Hansen, C. Hayward, B. L. Horta, E. Hyppönen, M.-R. Jarvelin, W. C. Johnson, S. L. R. Kardia, L. A. Kiemeney, M. Laakso, C. Langenberg, T. Lehtimäki, L. L. Marchand, P. K. E. Magnusson, N. G. Martin, M. Melbye, A. Metspalu, D. Meyre, K. E. North, C. Ohlsson, A. J. Oldehinkel, M. Orho-Melander, G. Pare, T. Park, O. Pedersen, B. W. J. H. Penninx, T. H. Pers, O. Polasek, I. Prokopenko, C. N. Rotimi, N. J. Samani, X. Sim, H. Snieder, T. I. A. Sørensen, T. D. Spector, N. J. Timpson, R. M. van Dam, N. van der Velde, C. M. van Duijn, P. Vollenweider, H. Völzke, T. Voortman, G. Waeber, N. J. Wareham, D. R. Weir, H.-E. Wichmann, J. F. Wilson, A. L. Hevener, A. Krook, J. R. Zierath, M. A. I. Thomis, R. J. F. Loos, and M. den Hoed. 2022. Genome-wide association analyses of physical activity and sedentary behavior provide insights into underlying mechanisms and roles in disease prevention. Nature Genetics 54:1332-1344. [Drive PDF file]
339. Cadney, M. D., R. L. Albuquerque, N. E. Schwartz, M. P. McNamara, A. A. Castro, M. P. Schmill, and T. Garland, Jr. 2022. Effects of early-life voluntary exercise and fructose on adult activity levels, body composition, aerobic capacity, and organ masses in mice bred for high voluntary wheel-running behavior. Journal of Developmental Origins of Health and Disease. In press. [Drive PDF file] https://doi.org/10.1017/S204017442200054X
340. Castro, A. A., T. Garland, Jr., S. Ahmed*, and N. C. Holt. 2022. Trade-offs in muscle physiology in selectively bred High Runner mice. Journal of Experimental Biology. 225(23):jeb244083. [Drive PDF file] https://doi.org/10.1242/jeb.244083
341. Hillis, D. A., and T. Garland, Jr. 2023. Multiple solutions at the genomic level in response to selective breeding for high locomotor activity. Genetics. 223(1): iyac165. [Drive PDF file]
342. Kay, J. C., J. Colbath*, R. J. Talmadge, T. Garland, Jr. 2022. Mice from lines selectively bred for voluntary exercise are not more resistant to muscle injury caused by either contusion or wheel running. PLoS ONE 17(11):e0278186. [Drive PDF file] https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0278186
344. McNamara, M. P., E. M. Venable, M. D. Cadney, A. A. Castro, M. P. Schmill, L. Kazzazi*, R. N. Carmody, and T. Garland, Jr. 2022. Weanling gut microbiota composition of a mouse model selectively bred for high voluntary wheel-running behavior. Journal of Experimental Biology 226: jeb245081. doi:10.1242/jeb.245081. [Drive PDF file]
349. Leszczynski, E. C., N. E. Schwartz, A. C. McPeek, K. D. Currie, D. P. Ferguson, and T. Garland, Jr. 2023. Selectively breeding for high voluntary physical activity in female mice does not bestow inherent characteristics that resemble eccentric remodeling of the heart, but the mini-muscle phenotype does. Sports Medicine and Health Science 5:205-212. [Drive PDF file] [Link to Open Access paper]
348. Schwartz, N. E., M. McNamara, J. M. Orozco, J. O. Rashid, A. P. Thai, and T. Garland, Jr. 2023. Selective breeding for high voluntary exercise in mice increases maximal (V̇O2,max) but not basal metabolic rate. Journal of Experimental Biology 226:jeb245256. doi:10.1242/jeb.245256 [Drive PDF file]
349. Latchney, S. E., M. D. Cadney, A. Hopkins, and T. Garland, Jr. 2023. Maternal upbringing and selective breeding for voluntary exercise behavior modify patterns of DNA methylation and expression of genes in the mouse brain. Genes, Brain and Behavior. [Drive PDF file] 2023:e12858. doi:10.1111/gbb.12858
350. Schmill, M. P., Z. Thompson, D. Lee*, L. Haddadin*, S. Mitra*, R. Ezzat*, S. Shelton*, P. Levin*, S. Benham*, K. J. Huffman, and T. Garland, Jr. 2023. Hippocampal, whole midbrain, red nucleus, and ventral tegmental area volumes are increased by selective breeding for high voluntary wheel-running behavior. Genes, Brain and Behavior 98:245-263. [Drive PDF file] https://doi.org/10.1159/000533524
352. Whitehead, N. N., S. A. Kelly, J. S. Demes*, N. E. Schwartz, and T. Garland, Jr. 2023. Locomotor play behavior evolves by random genetic drift but not as a correlated response to selective breeding for high voluntary wheel-running behavior. Behavioural Processes 213:104973. [Drive PDF file]
354. Tan, B. B., N. E. Schwartz, L. E. Copes, and T. Garland, Jr. 2024. Effects of long-term voluntary wheel running and selective breeding for wheel running on femoral nutrient canals. Journal of Anatomy 244:1015-1029. [Drive PDF file]
355. Khan, R. H., J. S. Rhodes, I. A. Girard, N. E. Schwartz, and T. Garland, Jr. 2024. Does behavior evolve first? Correlated responses to selection for voluntary wheel-running behavior in house mice. Ecological and Evolutionary Physiology 97:97-117. [Drive PDF File]
356. Thompson, Z, I. A. T. Fonseca, W. Acosta, L. Idarraga*, and T. Garland, Jr. 2024. Effects of food restriction on voluntary wheel-running behavior and body mass in selectively bred High Runner lines of mice. Physiology & Behavior 282:114582. [UCR news article] [Muscle & Fitness] [Fitness School YouTube] [Drive PDF file]
357. Castro, A. A., A. Nguyen, S. Ahmed*, T. Garland, Jr., and N. C. Holt. 2024. Muscle-tendon unit properties in mice selected for high levels of voluntary running: novel physiologies, co-adaptation, trade-offs, and multiple solutions in the evolution of cursoriality. Ecological and Evolutionary Physiology. 97:191-208. https://doi.org/10.1086/731307 [Drive PDF file]
358. Hillis, D. A., L. Yadgary, G. M. Weinstock, F. Pardo-Manuel de Villena, D. Pomp, and T. Garland, Jr. 2023. Large changes in detected selection signatures after a selection limit in mice bred for voluntary wheel-running behavior. PLoS ONE 19:e0306397. https://doi.org/10.1371/journal.pone.0306397 [Drive PDF file]
360. Schwartz, N. and T. Garland, Jr. 2024. A meta-analysis of whole-body and heart mass effect sizes from a long-term artificial selection experiment for high voluntary exercise. Journal of Experimental Biology 227:jeb249213. 10.1242/jeb.249213 [Drive PDF file]
361. Phan, J. M.-P., J. Yi, J. H. A. Foote, A. R. K. Ayabe, K. Guan, T. Garland, Jr., and K. D. Parfitt. 2024. Hippocampal long-term potentiation is modulated by exercise-induced alterations in dopamine synaptic transmission in mice selectively bred for high voluntary wheel running. Restorative Neurology and Neuroscience 42:193-208. [Drive PDF file] https://doi.org/10.1177/09226028241290400
362. Hiramatsu, L., V. Careau, and T. Garland, Jr. 2024. Can a hybrid line break a selection limit on behavioral evolution in mice? Behavior Genetics 55:43-58. [Drive PDF file] Supplemental Table S2 https://doi.org/10.1007/s10519-024-10209-7
363. Hagan, M. L., A. Tuladhar, K. Yu, D. W. Alhamad, H. Bensreti, J. Dorn, V. M. Piedra, N. Cantu, E. G. Stokes, D. Blumenthal, R. L. Roberts, V. Balayan, S. M. Bass, T. Dickerson, A. L. Cartelle, M. Montesinos-Cartagena, M. E. Awad, A. A. Castro, T. Garland, M. A. Cooley, M. Johnson, M. W. Hamrick, P. L. McNeil, and M. E. McGee-Lawrence. 2024. Osteocyte Sptbn1 deficiency alters cell survival and mechanotransduction following formation of plasma membrane disruptions (PMD) from mechanical loading. Calcified Tissue International 115:725–743. [Drive PDF file] https://link.springer.com/article/10.1007/s00223-024-01285-2
364. Schwartz, N. E., M. P. Schmill, M. D. Cadney, A. A. Castro, D. A. Hillis, M. P. McNamara, J. O. Rashid, W. Lampman, D. F. DeLaCruz, B. D. Tran, N. L. Trutalli, and T. Garland, Jr. 2025. Maternal exercise opportunity before, during, and after pregnancy alters maternal care behavior, offspring development, and offspring survival, but has few effects on offspring adult physical activity or body composition. Physiology & Behavior 291:114752. [Drive PDF file] https://www.sciencedirect.com/science/article/pii/S0031938424003007?via%3Dihub
365. Valencia, M., J. Monroy, T. Garland, Jr., and A. M. Horner. 2025. Early-life exercise effects on Achilles tendon in mice selectively bred for high voluntary wheel-running behavior. Physiological Reports 13:e70515. [Drive PDF file]
366. Schwartz, N. E., M. R. Alva, and T. Garland, Jr. 2025. Differential effects of acute total water deprivation on voluntary exercise behavior and body mass in laboratory house mice. Physiology & Behavior. In revision.
367. Wolak, M. E., A. J. Wilson, L. Hiramatsu, T. Garland, Jr., and V. Careau. 2025. How do trade-offs emerge across populations, while being absent within? A replicated selection experiment suggests all four evolutionary mechanisms are at play. Current Biology. In review.
368. Whitehead, N. N., N. E. Schwartz, C. Jiang, H. M. Read, N. C. Holt, and T. Garland, Jr. 2025. Selective breeding for high levels of physical activity in mice does not reduce lifetime reproductive success or lifespan. Evolution. In review.
369. Sleep manuscript ...
Alva M. R. 2021. Effects of dehydration on voluntary wheel-running behavior and body mass in laboratory house mice (Capstone Project, Senior Thesis). University of California, Riverside. 32 pages.
NEWish!!! Garland, Jr., T. 2022. Born to Run: Experimental Evolution of Exercise Behavior and Physiology in a Vertebrate Model Organism. In preparation. Riverside, California. [Draft of Chapter 1]
UCR Department of Evolution, Ecology, and Organismal Biology
Publications on the High Runner Mice
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