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Peter J. Boutros is a PhD candidate in the Johns Hopkins Department of Biomedical Engineering. He received his BS in Biomedical Engineering with concentrations in Electrical Engineering and Mathematics from the University of Connecticut in 2012.
Peter's research interests include characterizing complex neuronal circuits, control system applications to neural networks, and developing prosthetic therapies for neurological pathologies. Peter's doctoral thesis work is aimed at investigating the restoration of the human vestibulo-ocular reflex within the Johns Hopkins Multichannel Vestibular Implant First-in-Human Clinical Trial. As a scientific lead of the study, Peter's work has focused on studying the evoked 3D eye movement responses to electrical stimulation of primary vestibular afferents in subjects affected by profound bilateral vestibular loss. This work characterizes both the acute responses during device fitting and the longitudinal results during chronic prosthetic vestibular stimulation.
Additionally, Peter's work has investigated the development of signal processing strategies for vestibular implant technology. His projects have included the optimization of stimulus encoding in the vestibular nerve, characterization of temporal resolution necessary to encode head velocity with a pulse-frequency modulation (PFM) modulation scheme, and the use of pulsed infrared light to modulate vestibular afferent activity. Peter's work in VNEL has resulted in multiple abstracts presented at scientific conferences, invited talks, and peer reviewed publications.
----------Peer-Reviewed Publications----------
Rabbitt, R.D., Brichta, A.M., Tabatabaee, H., Boutros, P.J., Ahn, J.H., Della Santina, C.C., Poppi, L., and Lim, R., 2016, “Heat pulse excitability of vestibular hair cells and afferent neurons,” J. Neurophysiol., 2016, p. jn.00110.2016.
Boutros P.J., Valentin N., Hageman K.N., Roberts D., Dai C., Della Santina C.C. “Temporal Discretization Errors Produce Minimal Effects on Vestibular Prosthesis Performance” ASME Journal of Medical Devices, Accepted Jan 2016.
Hageman K.N., Chow M.R., Boutros P.J., Roberts D., Tooker A., Lee K., Felix S., Pannu S.S., Della Santina C.C. “Design of a Vestibular Prosthesis for Sensation of Gravitoinertial Acceleration.” ASME Journal of Medical Devices, Accepted Jan 2016.
----------Talks----------
Boutros, P.J., Rahman, M., Valentin N.S., Schoo D., Tan G., Gimmon Y., Chow M., Hofner A., Morillo Rascon A., Marx A., Deas R., De Marzo A., Rodriquez F., Strasser S., Fridman G. Y., Dai C., Ward B., Schubert M., Bowditch S., Jaeger A., Carey J. P., Della Santina C. C. “Continuous Restoration of the Human Vestibulo-Ocular Reflex via a Multichannel Vestibular Implant” Neuromodulation Symposium 2017, Minneapolis, MN, April 2017. MNS2017-240
-----------------Conference Posters-----------------
Boutros, P.J., Rahman, M., Valentin N.S., Schoo D., Gimmon Y., Chow M., Hofner A., Morillo Rascon A., Marx A., Deas R., Fridman G. Y., Davidovics N. S., Ward B. K., Treviño C., Bowditch S.,Roberts D.C., Schubert M., Jaeger A., Carey J. P., Della Santina C. C. "First-in-Human Clinical Trial of the MVI™ Multichannel Vestibular Implant: Continuous Restoration of the Human Vestibulo-Ocular Reflex" Association for Research in Otolaryngology Mid-Winter Meeting 2018, San Diego, CA, February 2018.
Chow, M., Gimmon, Y., Schoo, D.P., Trevino, C., Boutros, P.J., Rahman, M., Valentin, N., Hofner, A., Morillo Rascon, A., Marx, A., Deas, R., Fridman, G.Y., Jaeger, A., Schubert, M.C., Carey, J., Della Santina, C.C. "First-in-Human Clinical Trial of the MVI™ Multichannel Vestibular Implant in Individuals with Bilateral Sensorineural Vestibular Loss: Effects on Gait and Posture" Association for Research in Otolaryngology Mid-Winter Meeting 2018, San Diego, CA, February 2018.
Schoo, D.P., Bowditch, S., Marsiglia, D., Boutros, P.J., Chow, M., Gimmon, Y., Rahman, M., Valentin, N., Ward B. K., Trevino, C., Davidovics N. S., Hofner, A., Morillo Rascon, A., Marx, A., Deas, R., Fridman, G.Y., Jaeger, A., Carey, J., Della Santina, C.C. "Long-term Audiometric Results from the first 3 subjects of the MVI™ Multichannel Vestibular Implant Early Feasibility Study" Association for Research in Otolaryngology Mid-Winter Meeting 2018, San Diego, CA, February 2018.
Boutros P.J., Valentin N., Roberts D., Hageman K.N., Dai C., Della Santina C.C. “Temporal Discretization Errors Produce Minimal Effects on Vestibular Prosthesis Performance” Design of Medical Devices Conference 2016, Minneapolis, MN, April 2016.
Hageman K.N., Chow M.R., Boutros P.J., Roberts D., Tooker A., Lee K., Felix S., Pannu S.S., Della Santina C.C. “Design of a Vestibular Prosthesis for Sensation of Gravitoinertial Acceleration.” Design of Medical Devices Conference 2016, Minneapolis, MN, April 2016.
Hageman K.N., Chow M.R., Roberts D., Ren P., Boutros, P.J., Dai, C., Della Santina C.C. “Characterization of Normal 3D Binocular Chinchilla Otolith-Ocular Reflexes as a Metric to Study Otolith Stimulation using a Multichannel Vestibular Prosthesis.” Association for Research in Otolaryngology Mid-Winter Meeting 2016, San Diego, CA, February 2016.
Boutros P.J., Valentin N., Roberts D., Hageman K.N., Dai C., Della Santina C.C. “Temporal Discretization Inherent to Continuous Interleaved Sampling Stimulation Causes Negligible Effects on Vestibulo-Ocular Reflex Responses Elicited in Rhesus Monkeys.” Association for Research in Otolaryngology Mid-Winter Meeting 2016, San Diego, CA, February 2016.
Rabbitt R., Brichta A., Tabatabaee T., Boutros P.J., Ahn JH., Della Santina C.C., Poppi L., Lim R. "Excitation and Inhibition of Semicircular Canal Type II Hair Cells by Pulsed Infrared Light" Association for Research in Otolaryngology Mid-Winter Meeting 2016, San Diego, CA, February 2016.
Boutros P.J., Hageman K.N., Tooker A., Lee K., Felix S., Dai C., Pannu S., Della Santina C.C. "High Density Micromachined Polyimide Electrode Arrays for Vestibular Implants." ARO Mid-Winter Meeting 2015, Baltimore, MD, February 2015.
Boutros P.J., Ahn JH., Fridman G.Y., Dai C., Lasker D., Della Santina C.C. "Vestibular Primary Afferent and Vestibulo-Ocular Reflex Eye Movement Responses to Infrared Laser Stimulation of the Mammalian Labyrinth" ARO Mid-Winter Meeting 2013, Baltimore, MD. February 2013.
Boutros P.J., Kim D., Kuwada S., Escabi M. "Temporal Nonlinearities for Amplitude Modulation Coding in the Unanesthesized Rabbit Inferior Colliculus" Society for Neuroscience 2012. New Orleans, LA. November 2012
Boutros P.J., Lee C., Mathews S., Wilkens P., Peterson D., McIsaac J. "Novel 3-D Brachial Plexus Reconstruction from 2-D Ultrasound Using XBOX Kinect Tracking" 2012 Biomedical Engineering Society Annual Meeting. Atlanta, GA. October 2012
Boutros P.J., Kim D., Kuwada S., Escabi M. "Temporal Nonlinearities for Amplitude Modulation Coding in the Unanesthesized Rabbit Inferior Colliculus" ARO Mid-Winter Meeting 2012. San Diego, CA, February 2012
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