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Meg (Margaret) Chow is currently a PhD student in the Johns Hopkins Department of Biomedical Engineering. She received her BS in Biomedical Engineering from Johns Hopkins University in 2014 with a focus in instrumentation and micro/nano technology.
Meg has been with VNEL since 2015, where her research is focused on the development of the future generations of VNEL's Multichannel Vestibular Prosthesis (MVP) via improved application-specific integrated circuit (ASIC) design as well as improved stimulation paradigms. This work includes studying the effects of utricle and saccule stimulation combined with semi-circular canal (SCC) stimulation.
Meg is also a member on the Multichannel Vestibular Implant (MVI) clinical trial team, focusing on postural and gait effects of the MVI using standard clinical assessments.
----------Honors/Awards----------
Won-Sang Lee Award, Barany Society Meeting, Uppsala, Sweden Jun 2018
Association for Research in Otolaryngology Travel Award, San Diego, CA Dec 2017
----------Peer-Reviewed Publications----------
Chow M.R., Fernandez Brillet C, Hageman K.N., Roberts D.C., Ayiotis A.I., Haque R.M., Della Santina C.C.. "Binocular 3D otolith-ocular reflexes: responses of chinchillas to natural and prosthetic stimulation after ototoxic injury and vestibular implantation" Journal of Neurophysiology (in press). 05 Apr 2023.
Chow, M.R.*, Ayiotis, A.I.*, Schoo, D.P.*, Gimmon, Y.G.*, Lane, K.E., Morris, B.J., Rahman, M.A., Valentin, N.S., Boutros, P.J., Ward, B.K., Sun, D.Q., Trevino Guajardo, C., Schubert, M.C., Carey, J.P., Della Santina, C.C. “Regaining Balance with Vestibular Implants: Posture, Gait, Quality of Life." New England Journal of Medicine. 11 Feb 2021.
Hageman, K.N., Chow, M.R., Roberts, D.C., Della Santina, C.C. “Low-Noise Magnetic Coil System for Recording 3-D Eye Movements.” IEEE Transactions on Instrumentation and Measurement, vol.70 31 Aug 2020.
Hageman, K.N., Chow, M.R., Roberts, D., Della Santina, C.C. “Binocular 3D otolith-ocular reflexes: responses of chinchillas to prosthetic electrical stimulation targeting the utricle and saccule.” Journal of Neurophysiology,vol.123,no.1 1 Jan 2020.
Hageman, K.N., Chow, M.R., Roberts, D., Della Santina, C.C. “Binocular 3D otolith-ocular reflexes: responses of normal chinchillas to tilt and translation.” Journal of Neurophysiology,vol.123,no.1 1 Jan 2020.
Boutros, P.J., Schoo, D.P., Rahman, M., Valentin, N.S., Chow, M.R., Ayiotis, A.I., Morris, B.J., Hofner, A., Morillo Rascon, A., Marx, A., Deas, R., Fridman, G.Y., Davidovics, N.S., Ward, B.K., Treviño, C., Bowditch, S.P., Roberts, D.C., Lane, K.E., Gimmon, Y., Schubert, M.C., Carey, J.P., Jaeger, A., Della Santina, C.C. “Continuous vestibular implant stimulation partially restores eye-stabilizing reflexes.” JCI Insight,vol.4,no.22 14 Nov 2019.
Hageman, K.N., Chow, M.R., Boutros, P.J., Roberts, D., Tooker, A., Lee, K., Felix, S., Pannu, S.S., Della Santina, C. C. “Design of a Vestibular Prosthesis for Sensation of Gravitoinertial Acceleration.” ASME Journal of Medical Devices, vol.10, no.3, 1 Aug 2016. doi: 10.1115/1.4033759.
-----------------Presentations/Talks-----------------
Chow, M. “Extending Vestibular Implants to 6D: Micromachined Electrode Arrays Enable Selective Stimulation of Otolith End Organs.” Lawrence Livermore National Laboratory Neural Interfaces Workshop, San Francisco, CA, Aug 2019.
Chow, M., Hageman, K., Roberts, D., Della Santina, C. “Temporal Dynamics of Eye Movements Elicited by Combined Otolith and Semicircular Canal Stimulation.” Barany Society Meeting 2018, Uppsala, Sweden, June 2018.
Chow, M., Hageman, K., Roberts, D., Della Santina, C. “Spatial Selectivity of Eye Movements elicited by combined Otolith and Semicircular Canal Stimulation.” Barany Society Meeting 2018, Uppsala, Sweden, June 2018.
Chow, M., et al. “Multichannel Vestibular Implant Early Feasibility Study: Gait and Posture Outcomes.” Barany Society Meeting 2018, Uppsala, Sweden, June 2018.
Boutros, P.J., School, D.P., Rahman, M., Valentin, N.S., Chow, M.R., et al. “First-in-human Safety and Preliminary Efficacy Results for the MVI Multichannel Vestibular Implant.” Barany Society Meeting 2018, Uppsala, Sweden, June 2018.
Schoo, D.P., Boutros, P.J., Chow, M.R., et al. “Multichannel Vestibular Implant Early Feasibility Study: Safety and Audiometric Outcomes.” Barany Society Meeting 2018, Uppsala, Sweden, June 2018.
Boutros, P.J., Schoo, D.P., Rahman, M., Valentin, N.S., Chow, M.R., et al. “Multichannel Vestibular Implant: Continuous Restoration of the Human Vestibulo-Ocular Reflex.” Barany Society Meeting 2018, Uppsala, Sweden, June 2018.
-----------------Conference Posters-----------------
Chow, M.R., Hageman, K.N., Boutros, P.J., Morris, B.J., Tooker, A., Roberts, D., Haque, R., Della Santina, C.C. “The Effect of Stimulation and Reference Electrode Location on Electrically-evoked Vestibulo-Ocular Reflex Eye Movements in Chinchillas.” Association for Research in Otolaryngology Mid-Winter Meeting 2019, Baltimore, MD, Feb 2019.
Morris, B.J., Chow, M.R., Hedjoudje, A., Cullen, K.E., Hessler, R., Della Santina, C.C. “The Effect of Common Crus Reference Electrode Depth on Electrically-evoked Vestibulo-Ocular Reflex Eye Movements in Rhesus Macaque.” Association for Research in Otolaryngology Mid-Winter Meeting 2019, Baltimore, MD, Feb 2019.
Chow, M., Hageman, K., Roberts, D., Della Santina, C. “Temporal Dynamics of Electrically-Evoked Eye Movements Elicited by a Vestibular Prosthesis Designed to Restore Sensation of Gravitoinertial Acceleration.” Association for Research in Otolaryngology Mid-Winter Meeting 2018, San Diego, CA, Feb 2018.
Hageman, K., Chow, M., Roberts, D., Della Santina, C. “Spatial Selectivity of Electrically-Evoked Eye Movements Elicited by a Vestibular Prosthesis Designed to Restore Sensation of Gravitoinertial Accerlation.” Association for Research in Otolaryngology Mid-Winter Meeting 2018, San Diego, CA, Feb 2018.
Chow, M., et al. “First-in-Human Trial of the MVI™ Multichannel Vestibular Implant in Individuals with Bilateral Vestibular Loss: Effects on Gait and Posture.” Association for Research in Otolaryngology Mid-Winter Meeting 2018, San Diego, CA, Feb 2018.
Schoo, D.P., Bowditch, S., Marsiglia, D., Boutros, P., Chow, M., et al. “Long-term Audiometric Results from the first 3 subjects of the MVI™ Multichannel Vestibular Implant Early Feasibility Study.” Association for Research in Otolaryngology Mid-Winter Meeting 2018, San Diego, CA, Feb 2018.
Boutros, P.J., Rahman, M., Valentin, N.S., Schoo, D.P., Gimmon, Y., Chow, M.R., et al. “First-in-Human Clinical Trial of the MVI™ Multichannel Vestibular Implant: Continuous Restoration of the Human Vestibulo-Ocular Reflex.” Association for Research in Otolaryngology Mid-Winter Meeting 2018, San Diego, CA, Feb 2018.
Hageman, K.N., Chow, M.R., Boutros, P.J., Roberts, D., Della Santina, C.C., “Electrically-Evoked Eye Movements using a Vestibular Prosthesis Designed to Restore Sensation of Gravitoinertial Acceleration.” Neuromodulation Symposium 2017, Minneapolis, MN, Apr 2017.
Boutros, P.J., Rahman, M., Valentin, N.S., Schoo D., Tan G., Gimmon Y., Chow, M., Hofner, A., Rascon, A.M., Marx, A., Deas, R., De Marzo, A., Rodriquez, F., Strasser, S., Fridman, G.Y., Da, C., Ward, B., Schubert, M., Bowditch, S., Jaeger, A., Carey, J.P., Della Santina, C.C. “Continuous Restoration of the Human Vestibulo-Ocular Reflex via a Multichannel Vestibular Implant.” Neuromodulation Symposium 2017, Minneapolis, MN, Apr 2017.
Hageman, K.N., Yuen Lim, K., Chow, M.R., Kalayjian, Z.K., Andreou, A.G., Wang, X., Della Santina, C.C., "Versatile Stimulation Circuitry for Neural Applications: Use in Vestibular and Cochlear Stimulation." North American Neuromodulation Society-Neural Interfaces Conference, Baltimore, MD, June 2016.
Hageman, K.N., Chow, M.R., Boutros, P.J., Roberts, D., Tooker, A., Lee, K., Felix, S., Pannu, S.S., Della Santina, C.C. “Design of a Vestibular Prosthesis for Sensation of Gravitoinertial Acceleration.” Design of Medical Devices Conference 2016 and Neuromodulation Symposium 2016, Minneapolis, MN, Apr 2016.
Hageman, K.N., Chow, M.R., Roberts, D., Ren, P. Boutros, P.J., Dai, C., Della Santina, C.C. “Characterization of Normal 3D Binocular Chinchilla Otolith-Ocular Reflexes as a Metric to Study Otolith Stimulation using a Multichannel Vestibular Prosthesis.” Association for Research in Otolaryngology Mid-Winter Meeting 2016, San Diego, CA, Feb 2016.
Keenan T, Smith K, Bertagnolli D, Goldy J, Miller J, Menon V, Chow M, et. Al. “Development of an integrated platform for standardized, high-throughput single cell transcriptional profiling.” Allen Institute for Brain Science. Society for Neuroscience. San Diego, CA, Nov. 2013.
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