Chenkai Dai, MD PhD

Dr. Chenkai Dai is an Assistant Professor in the department of Otolaryngology Head and Neck Surgery, Johns Hopkins School of Medicine.Dr. Chenkai Dai completed medical training in 2000 at the Tongji Medical College, Huazhong University of Science & Technology in Wuhan, China, where he also completed specialty training resulting in award of an MS in Otolaryngology Science in 2003. He then completed his PhD in Bioengineering at the University of Oklahoma, where he primarily studied middle ear and cochlear mechanics and worked on development of a middle ear implantable device. He joined the Vestibular NeuroEngineering Lab as a research Fellow since 2008 under the mentorship of Dr. Della Santina. His research focuses on adaptation to chronic stimulation using a multichannel vestibular prosthesis and hearing outcomes after vestibular prosthesis electrode implantation.

Peer Reviewed Articles

Dai C, Fridman GY, Davidovics NS, Chiang B, Ahn JH, Della Santina CC. (2011) Restoration of 3D vestibular sensation in rhesus monkeys using a multichannel vestibular prosthesis. Hear Res. 281(1-2):74-83.

Sun DQ, Rahman MA, Fridman G, Dai C, Chiang B, Della Santina CC. (2011) Chronic stimulation of the semicircular canals using a multichannel vestibular prosthesis: effects on locomotion and angular vestibulo-ocular reflex in chinchillas. Conf Proc IEEE Eng Med Biol Soc.;2011:3519-3523.

Rahman MA, Dai C, Fridman GY, Davidovics NS, Chiang B, Ahn J, Hayden R, Melvin TA, Sun DQ, Hedjoudje A, Della Santina CC. (2011)Restoring the 3D vestibulo-ocular reflex via electrical stimulation: the Johns Hopkins multichannel vestibular prosthesis project. Conf Proc IEEE Eng Med Biol Soc.; 3142-3145.

Chiang B, Fridman GY, Dai C, Rahman MA, Della Santina CC. (2011) Design and performance of a multichannel vestibular prosthesis that restores semicircular canal sensation in rhesus monkey. IEEE Trans Neural Syst Rehabil Eng. 19(5):588-598.

Dai C, Fridman GY, Della Santina CC. (2011) Effects of vestibular prosthesis electrode implantation and stimulation on hearing in rhesus monkeys. Hear Res. 277(1-2):204-210.

Dai C, Fridman GY, Chiang B, Davidovics NS, Melvin TA, Cullen KE, Della Santina CC. (2011) Cross-axis adaptation improves 3D vestibulo-ocular reflex alignment during chronic stimulation via a head-mounted multichannel vestibular prosthesis. Exp Brain Res. 210(3-4):595-606.

Della Santina CC, Migliaccio AA, Hayden R, Melvin TA, Fridman GY, Chiang B, Davidovics NS, Dai C, Carey JP, Minor LB, Anderson ICW, Park H, Lyford-Pike S, Tang S (2010) Current and Future Management of Bilateral Loss of Vestibular Sensation – An update on the Johns Hopkins Multichannel Vestibular Prosthesis Project. Cochlear Implants International (in press)

Fridman GY, Davidovics NS, Dai C, Migliaccio AA, Della Santina CC. Vestibulo-Ocular Reflex Responses to a Multichannel Vestibular Prosthesis Incorporating a 3D Coordinate Transformation for Correction of Misalignment.J Assoc Res Otolaryngol. 2010 Feb 23. [Epub ahead of print]

Gan RZ, Dai C, Wang X, Nakmali D, Wood MW.A totally implantable hearing system - Design and function characterization in 3D computational model and temporal bones. Hear Res. 2009 Sep 20.

Lu, H., Luo, H., Dai, C., and Gan, R. Z. The Young’s modulus of human eardrum at high strain rates. Proceedings of the SEM XI International Congress & Exposition on Experimental and Applied Mechanics, Paper #255, 2008

Luo, H., Lu, H., Dai, C., Gan, R. Z. A comparison of Young’s modulus for normal and diseased human eardrums at high strain sates. International Journal of Experiment and Computational Biomechanics : 1, 1-22, 2009

Luo, H., Dai, C., Gan R. Z. , Lu H. Measurement of Young’s modulus of human tympanic membrane at high strain rates. J Biomech Eng. 2009 Jun; 131(6):064501.

Dai, C., Gan, R.Z. Change of cochlear response in animal model of otitis media with effusion. Audiol Neurootol. 2009 Sep 24;15(3):155-167.

Gan, R. Z., Cheng, T., Dai, C., and Wood, M. W. 3D computational model for prediction of hearing loss in perforations of tympanic membrane. J Acoust Soc Am. 2009 Jul;126(1):243-53.

Dai, C., Gan, R.Z. Change of middle ear transfer function in otitis media with effusion model of guinea pigs. Hear Res. 2008;243(1-2):78-86.

Daphalapurkar, NP., Dai C., Gan, R.Z., and Lu, H. Characterization of the linearly viscoelastic behavior of human tympanic membrane using nanoindentation technique. J Mech Behav Biomed Mater. 2009 Jan;2(1):82-92.

Dai, C., Wood, M.W., Gan, R. Z., Combined effect of fluid and pressure on middle ear function. Hear Res. 2008; 236(1-2):22-32.

Dai, C, Cheng, T., Wood, M.W., Gan, R.Z. Detachment and fixation of superior and anterior malleus ligament: experiment and modeling. Hear Res. 2007;230(1-2):24-33.

Dai, C., Gan, R.Z., Wood, M.W. Tympanometry and laser Doppler interferometry measurements on otitis media with effusion model in human temporal bones. Otol Neurotol. 2007;28(4):551-8.

Gan, R.Z., Dai, C., Wood, M.W. Laser interferometry measurements of middle ear fluid and pressure effects on sound transmission. J Acoust Soc Am. 2006;12 (6):3799-810.

Cheng, T., Dai, C, Gan, RZ. Viscoelastic properties of human tympanic membrane. Ann Biomed Eng. 2007;35(2):305-14.

Gan, RZ., Dai, C., and Wang, X. Biomechanics of otitis media with effusion in human ear. In: The Fifth World Congress of Biomechanics (Dieter Liepsch ed.), Medimond Publishing, pp. 527-533, 2006.

Kong, W., Ma, H., Han, P., Yue, J., Xiong, X., Zhu, L., and Dai, C.. Image examination of postoperative evaluation for the cochlear implanted electrode. Chin J. Otorhinolaryngol, Vol 39, No 2: 81-84, 2004.

Kong, W., Yue, J., Xiong, X., Zhu, L., Kong, X., Han, P., Ma, H., Duan, J., Dai, C., and Chen, H. Integrated methods for assessing auditory nerve–auditory pathway integrity. Chin Clinical Otorhinolaryngol, Vol 17, No. 12: 705-708, 2003.

Dai, C. and Kong, W. The method of isolating Deiters cell from guinea pig and the criterion of cell judgment. Journal of Hearing & Speech Pathology, 11(2):115-117, 2003.

Conference Abstracts & Presentations

Dai C, Fridman GY, Chiang B, Davidovics NS, Della Santina CC, “3D aVOR adaptation to chronic motion-modulated multi-channel prosthetic stimulation of semicircular canal ampullary nerves,” ARO 2010

Fridman GY, Davidovics ND, Dai C, Migliaccio AA, Della Santina CC, “Multichannel vestibular prosthesis using linear coordinate axis transformation stabilizes eyes for head rotation about any axis,” ARO 2010

Dai C, Fridman GY, Della Santina CC, “Effects of vestibular electrode implantation and prosthetic stimulation on hearing in rhesus monkeys,” ARO 2010

Gan, R. Z., Dai, Chenkai, Nakmali, D., and Wood, M. W. A totally implantable hearing system - TIHS. 5^th International Symposium on Middle Ear Mechanics in Research and Otology, Stanford University, June 24-28, 2009.

Gan, R.Z., Li W., Dai, C. Middle ear transfer function measured in acute otitis media model of guinea pig. Association for Research in Otolaryngology (ARO) - Midwinter Meeting, Vol.33:269, 2009.

Dai, C., Li W., Gan, R.Z. Change of Cochlear Mechanics in Acute Otitis Media and Otitis Media with Effusion. Association for Research in Otolaryngology (ARO) - Midwinter Meeting, Vol.33:984, 2009.

Dai, C., and Gan, R. Z. Measurement and modeling of cochlear mechanics in otitis media with effusion Proceedings of the Biomedical Engineering Society 2008 Annual Fall Meeting, St. Luis, MO, September, 2008.

Gan, R. Z., Dai, C., Yang, F. and Nakmali, D. Effect of stapedial annular ligament on sound transmission in human ear. Proceedings of the Biomedical Engineering Society 2008 Annual Fall Meeting, St. Louis, MO, October 2-4, 2008.

Gan, R. Z., Dai, C., Nakmali, D. and Wood, M. W. A totally implantable hearing device for restoration of hearing. ASME J. Medical Devices, Vol. 2, No. 2: Paper 027521-1, 2008.

Dai, C., Gan, R..Z. Change of Cochlea mechanics and auditory brainstem response in animal model of otitis media with effusion. Association for Research in Otolaryngology (ARO) - Midwinter Meeting, Vol.31:506, 2008.

Gan, R. Z., Dai, C., Nakmali D., Wood, M. W. Characterization of performance for an implantable hearing device in human temporal bones. Association for Research in Otolaryngology (ARO)- Midwinter Meeting, Vol. 31: 544, 2008.

Gan, R. Z., Cheng, T. and Dai, C. Mechanical properties and microstructures of human middle ear tissues. Proceedings of the Biomedical Engineering Society 2007 Annual Fall Meeting, Los Angeles, CA, September 26-29, 2007.

Dai, C., Nakmali, D. and Gan, R. Z. Change of middle ear and cochlea mechanics in animal model of otitis media with effusion. Proceedings of the Biomedical Engineering Society 2007 Annual Fall Meeting, Los Angeles, CA, September 26-29, 2007.

Gan, R. Z., Cheng, T., Dai, C., and Nakmali, D. Mechanical properties of ligaments in human middle ear ¨C measurement and modeling. Proceedings of WACBE World Congress on Bioengineering, 7.1-3: pp. 1-4, 2007.

Dai, C. and Gan, R. Z. Animal model of otitis media with effusion for measurements in middle ear transfer function. 27th Oklahoma AIAA/ASME Symposium, March 31, 2007

Dai, C., Cheng, T., and Gan, R.Z., Disconnection and fixation of anterior and superior mallear ligaments in middle ear. Proceeding of the Biomedical Engineering Society 2006 Annual Fall Meeting, 709, Chicago, October, 2006

Gan, R.Z., Dai, C. and Wang X. Biomechanics of otitis media with effusion in human ear. The 5th World Congress of Biomechanic - Munich, August, 2006

Dai, C. and Gan, R.Z. Tympanometry and laser Interferometry measurements in human temporal bones. 25th Oklahoma AIAA/ASME Symposium, April , 2006.

Gan, R.Z., Dai, C., Nakmali, D., Wood, M.W. Measurements of the effects of middle ear fluid on acoustic-mechanical transmission in human ear. Association for Research in Otolaryngology (ARO) - Midwinter Meeting, Vol. 29: 645, 2006.

Gan, R.Z., Cheng, T., Dai, C., and Nakmali, D. Effect of rheological properties of middle ear tissues on sound transmission. Biorheology, Vol. 42 (5): S28, P. 680, 2005.

Gan, R.Z., Cheng, T., Dai, C., and Nakmali, D. Measurements of viscoelastic properties of ear tissues and their effect on acoustic transmission, Proceeding of the Biomedical Engineering Society 2005 Annual Fall Meeting, Baltimore, October, 2005.

Dai C. and Gan R.Z. Middle ear transfer function measured in guinea pigs with laser Doppler interferometry. 25th Oklahoma AIAA/ASME Symposium, February 12, 2005.

Dai, C. and Kong, W. The ion current induced by ATP and GABA on isolated Deiters cells. The Eighth Otorhinolaryngology-Head & Neck Surgery Academic Meeting of Six Provinces in South-Central China, Wuhan, P. 130, 2002.