Dykstra MM, Weskamp K, Gómez NB, Waksmacki J, Tank E, Glineburg MR, Snyder A, Pinarbasi E, Bekier M, Li X, Miller MR, Bai J, Shahzad S, Nedumaran N, Wieland C, Stewart C, Willey S, Grotewold N, McBride J, Moran JJ, Suryakumar AV, Lucas M, Tessier PM, Ward M, Todd PK, Barmada SJ.
Cell Reports 2025 Jan 28;44(1):115113.
Van Deynze K, Mumm C, Maltby CJ, Switzenberg JA, Todd PK, Boyle AP.
Nucleic Acids Resarch 2025 Jan 11;53(2):gkae1202.
Maltby CJ, Krans A, Grudzien SJ, Palacios Y, Muiños J, Suárez A, Asher M, Willey S, Van Deynze K, Mumm C, Boyle AP, Cortese A, Ndayisaba A, Khurana V, Barmada SJ, Dijkstra AA, Todd PK.
Sci ence Advances 2024 Sep 6;10(36):eadn2321.
bioRxiv [Preprint]. 2023 Dec 14:2023.12.13.571345.
Glineburg MR, Yildirim E, Gomez N, Rodriguez G, Pak J, Li X, Altheim C, Waksmacki J, McInerney GM, Barmada SJ, Todd PK.
Nucleic Acids Res. 2024 Sep 9;52(16):9745-9759.
bioRxiv [Preprint]. 2023 Nov 11:2023.11.07.566060.
Tseng YJ, Krans A, Malik I, Deng X, Yildirim E, Ovunc S, Tank EMH, Jansen-West K, Kaufhold R, Gomez NB, Sher R, Petrucelli L, Barmada SJ, Todd PK.
Nucleic Acids Research 2024 Feb 27:gkae137.
Malik I, Tseng YJ, Wieland CM, Green KM, Zheng K, Calleja K, Todd PK.
Neurobiol Dis. 2023 Aug;184:106212
Elife. 2023 Mar 20;12:e84043.
Wang ET, Freudenreich CH, Gromak N, Jain A, Todd PK, Nagai Y.
Molecular Cell. 2023 Feb 2;83(3):324-329.
Tassone F, Protic D, Allen EG, Archibald AD, Baud A, Brown TW, Budimirovic DB, Cohen J, Dufour B, Eiges R, Elvassore N, Gabis LV, Grudzien SJ, Hall DA, Hessl D, Hogan A, Hunter JE, Jin P, Jiraanont P, Klusek J, Kooy RF, Kraan CM, Laterza C, Lee A, Lipworth K, Losh M, Loesch D, Lozano R, Mailick MR, Manolopoulos A, Martinez-Cerdeno V, McLennan Y, Miller RM, Montanaro FAM, Mosconi MW, Potter SN, Raspa M, Rivera SM, Shelly K, Todd PK, Tutak K, Wang JY, Wheeler A, Winarni TI, Zafarullah M, Hagerman RJ.
Cells. 2023 Sep 21;12(18):2330.
Wright SE, Rodriguez CM, Monroe J, Xing J, Krans A, Flores BN, Barsur V, Ivanova MI, Koutmou KS, Barmada SJ, Todd PK.
Nucleic Acids Research. 2022 Jul 29:gkac626.
Hessl D, Rosselot H, Miller R, Espinal G, Famula J, Sherman SL, Todd PK, Cabal Herrera AM, Lipworth K, Cohen J, Hall DA, Leehey M, Grigsby J, Weber JD, Alusi S, Wheeler A, Raspa M, Hudson T, Sobrian SK.
J Med Genetics. 2022 Jun 14:jmedgenet-2022-108568.
Tosin MHS, Stebbins GT, Goetz CG, Hagerman RJ, Hessl D, Zolecki MA, Todd PK, Leehey MA, Hall DA.
Front Neurology. 2022 Sep 14;13:977380. 2022.
Reyes CJ, Asano K, Todd PK, Klein C, Rakovic A.
Mov Disorders. 2022 Nov;37(11):2284-2289.
Kong HE, Lim J, Linsalata A, Kang Y, Malik I, Allen EG, Cao Y, Shubeck L, Johnston R, Huang Y, Gu Y, Guo X, Zwick ME, Qin Z, Wingo TS, Juncos J, Nelson DL, Epstein MP, Cutler DJ, Todd PK, Sherman SL, Warren ST, Jin P.
Proc Natl Acad Sci U S A. 2022 May 31;119(22):e2118124119.
Green KM, Miller SL, Malik I, Todd PK.
Hum Mol Genet. 2022 Feb 26. doi: 10.1093/hmg/ddac021.
Zhang Y, Glineburg MR, Basrur V, Conlon K, Wright SE, Krans A, Hall DA, Todd PK.
Hum Mol Genet. 2022 Feb 8:ddab353.
Bell HN, Rebernick RJ, Goyert J, Singhal R, Kuljanin M, Kerk SA, Huang W, Das NK, Andren A, Solanki S, Miller SL, Todd PK, Fearon ER, Lyssiotis CA, Gygi SP, Mancias JD, Shah YM.
Cancer Cell. 2022 Feb 14;40(2):185-200.e6
Indranil Malik, Yi-Ju Tseng, Shannon E. Wright, Kristina Zheng, Prithika Ramaiyer, Katelyn M. Green, Peter K. Todd .
EMBO Mol Med (2021)13:e14163
Singh CR*, Glineburg MR*, Moore C*, Tani N, Jaiswal R, Zou Y, Aube E, Gillaspie S, Thornton M, Cecil A, Hilgers M, Takasu A, Asano I, Asano M, Escalante CR, Nakamura A, Todd PK, Asano K.
Cell Rep. 2021 Jul 13;36(2):109376.
Malik I.*, Kelley CP*, Wang ET#, Todd PK#.
Nat Rev Mol Cell Biol. 2021 Jun 17.
Mailick MR, Hong J, Movaghar A, DaWalt L, Berry-Kravis EM, Brilliant MH, Boero J, Todd PK, Hall D.
Tseng Y-J, Sandwith SN, Green KM, Chambers AE, Krans A, Raimer HM, Sharlow ME, Reisinger MA, Richardson AE, Routh ED, Smaldino MA, Wang Y-H, Vaughn JP, Todd PK#, Smaldino PJ#.
Journal of Biological Chemistry. 2021 Aug; 297(2): 100914.
Acta Neuropathol Commun 9, 73 (2021).
Dijkstra AA, Haify SN, Verwey NA, Prins ND, van der Toorn EC, Rozemuller AJM, Bugiani M, den Dunnen WFA, Todd PK, Charlet-Berguerand N, Willemsen R, Hukema RK, Hoozemans JJM.
Brain Commun. 2021 Jan 27;3(1):fcab007.
Neurology. 2020 Sep 28:10.1212/WNL.0000000000010959.
Wiley Interdiscip Rev RNA. 2020 Sep 20:e1628.
He F, Flores BN, Krans A, Frazer M, Natla S, Niraula S, Adefioye O, Barmada SJ, Todd PK.
Acta Neuropathol Commun. 2020 Aug 4;8(1):122.
Rodriguez CM#, Wright SE#, Kearse MG, Haenfler JM, Flores BN, Liu Y, Ifrim MF, Glineburg MR, Krans A, Jafar-Nejad P, Sutton MA, Bassell GJ, , Parent JM, Rigo F, Barmada SJ, Todd PK.
Nature Neuroscience, 2020 Mar;23(3):386-397.
Samuel J Mackenzie, Chun Chieh Lin, Peter K Todd, James F Burke, and Brian C Callaghan
Neurology: Genetics April 2020; 6 (2) .
Katelyn M Green, Udit Sheth, Brittany N Flores, Shannon E Wright, Alexandra Sutter, Michael G Kearse, Sami J. Barmada, Magdalena I. Ivanova, and Peter K Todd.
Journal if Biological Chemistry. 2019 Oct 23. PMID: 31649034 doi: 10.1074/jbc.RA119.009951.
Amy Krans, Geena Skariah, Yuan Zhang, Bryana Bayly, Peter K. Todd
Acta Neuropathol Commun. 2019 Oct 30;7(1):152.
Amanda N. Sacino; Stefan Prokop; Meggen A. Walsh; Jennifer Adamson; S H Subramony; Amy Krans; Peter K. Todd; Benoit I. Giasson; Anthony T. Yachnis
Acta Neuropathol Commun. 2019 Oct 30;7(1):158.
Linsalata AE, He F, Malik AM, Glineburg MR, Green KM, Natla S, Flores BN, Krans A, Archbold HC, Fedak SJ, Barmada SJ, Todd PK.
EMBO Rep. 2019 Jul 25:e47498. LINK
Neurobiol Dis. 2019 Oct;130:104515. Epub 2019 Jun 21. Review. LINK
Kearse MG, Goldman DH, Choi J, Nwaezeapu C, Liang D, Green KM, Goldstrohm AC, Todd PK, Green R, Wilusz JE.
Genes Dev. 2019 Jul 1;33(13-14):871-885. Epub 2019 Jun 6. LINK
Translation of upstream open reading frames in a model of neuronal differentiation
Rodriguez, C.M., Chun, S.Y., Mills, R.E., Todd, P.K.
BMC Genomics. 2019 May 20;20(1):391. doi: 10.1186/s12864-019-5775-1. LINK
Targeted Reactivation of FMR1 Transcription in Fragile X Syndrome Embryonic Stem Cells.
Jill Haenfler, Geena Skariah, Caitlin M Rodriguez, Andre Monteiro Da Rocha, Jack Parent, Gary D Smith, Peter K Todd
Front Mol Neurosci. 2018 Aug 15;11:282. Link
Repeat-associated non-AUG (RAN) translation and other molecular mechanisms in Fragile X Tremor Ataxia Syndrome.
Glineburg MR, Todd PK, Charlet-Berguerand N, Sellier C.
Brain Research, 2018 Feb 14. pii: S0006-8993(18)30064-7. Link
RAN translation at C9orf72- associated repeat expansions is selectively enhanced by the integrated stress response.
Green KM, Glineburg MR*, Kearse MG*, Flores BN, Linsalata AE, Fedak SJ, Goldstrohm AC, Barmada SJ, Todd PK.
Nature Communications, 2017. Link
*discussed on ALZforum: Link
Translation of expanded CGG repeats into FMRpolyG is pathogenic and may contribute to Fragile X Tremor Ataxia Syndrome.
Sellier C, Buijsen RA, He F, Natla S, Jung L, Tropel P, Gaucherot A, Jacobs H, Meziane H, Vincent A, Champy MF, Sorg T, Pavlovic G, Wattenhofer-Donze M, Birling MC, Oulad- Abdelghani M, Eberling P, Ruffenach F, Joint M, Anheim M, Martinez-Cerdeno V, Tassone F, Willemsen R, Hukema RK, Viville S, Martinat C, Todd PK, Charlet-Berguerand N.
Neuron. 2017 Jan 18;93(2):331-347. Link
*previewed in Neuron: Link
SPECtre: a spectral coherence--based classifier of actively translated transcripts from ribosome profiling sequence data.
Chun SY, Rodriguez CM, Todd PK, Mills RE.
BMC Bioinformatics. 2016 Nov 25;17(1):482. Link
RAN translation from antisense CCG repeats in Fragile X Tremor/Ataxia Syndrome
Krans A, Kearse MG, Todd PK.
Annals of Neurology Oct 2016
Distinct C9orf72 associated dipeptide repeat structures correlate with neuronal toxicity
Flores BN, Dulchavsky ME, Krans A, Sawaya MR, Paulson HL, Todd PK, Barmada SJ, Ivanova MI
PLoS One, 2016 Oct 24;11(10):e0165084. Link
CGG Repeat associated non-AUG translation utilizes a cap-dependent, scanning mechanism of initiation to produce toxic proteins.
Kearse MG, Green KM, Krans A, Rodriguez CM, Linsalata AE, Goldstrohm AC, Todd PK.
Molecular Cell 2016. 62(2), Pages 155–156. Link
*Previewed in Molecular Cell: Link
*Highlighted in Nature Reviews Molecular & Cellular Biology: Link
Small Molecule Recognition and Tools to Study Modulation of r(CGG)exp in Fragile X-Associated Tremor Ataxia Syndrome.
Yang WY, He F, Strack RL, Oh SY, Frazer M, Jaffrey SR, Todd PK, Disney MD.
ACS Chemical Biology 2016 Sep 16;11(9):2456-65. Link
A Screen for Novel Hexanucleotide Repeat Expansions at ALS and FTD Associated Loci.
He F, Jones JB, Figueroa-Romero C, Zhang D, Feldman EL, Goutman SA, Meisler MH, Callaghan BC, and Todd PK.
Neurology: Genetics. 2016 May 11;2(3):e71. Link
RAN translation: What makes it Run?
Green KM, Linsalata AE, Todd PK.
Brain Research 2016 2016 Sep 15;1647:30-42. Link
RAN translation at CGG repeats induces ubiquitin proteasome system impairment in models of fragile X-associated tremor ataxia syndrome.
Oh S-Y, He F, Krans A, Frazer M, Taylor JP, Paulson HL and Todd PK.
Human Molecular Genetics 2015. 24 (15), 4317-4326. Link
Modifications to toxic CUG RNAs induce structural stability, rescue mis-splicing in amyotonic dystrophy cell model and reduce toxicity in a myotonic dystrophy zebrafish model.
deLorimier E, Coonrod LA, Copperman J, Taber A, Reister EE, Sharma K, Todd PK, Guenza MG, Berglund JA
Nucleic Acids Research 2014 Nov 10; 42(20): 12768–12778. Link
Fragile X mental retardation protein expression in Alzheimer's Disease.
Renoux AJ, Carducci NM, Ahmady AA and Todd PK.
Frontiers in Genetics. 5:630. Link
Discovery of a Biomarker and Lead Small Molecules to Target r(GGGGCC)-Associated Defects in c9FTD/ALS.
Su Z, Zhang Y, Gendron TF, Bauer PO, Chew J, Yang WY, Fostvedt E, Jansen-West K, Belzil VV, Desaro P, Johnston A, Overstreet K, Oh SY, Todd PK, Berry JD, Cudkowicz ME, Boeve BF, Dickson D, Floeter MK, Traynor BJ, Morelli C, Ratti A, Silani V, Rademakers R, Brown RH, Rothstein JD, Boylan KB, Petrucelli L, Disney MD.
Neuron. 2014 Sep 3;83(5):1043-50. Link
Repeat-Associated Non-AUG Translation and Its Impact in Neurodegenerative Disease.
Neurotherapeutics. 2014 Jul 9. Link
Impaired sensorimotor gating in Fmr1 knock out and Fragile X premutation model mice.
Renoux AJ, Sala-Hamrick KJ, Carducci NM, Frazer M, Halsey KE, Sutton MA, Dolan DF, Murphy GG, Todd PK.
Behavioral Brain Research. 2014 Jul 1;267:42-5. Link
TDP-43 Suppresses CGG Repeat-induced Neurotoxicity through Interactions with HnRNP A2/B1.
He F, Krans A, Freibaum BD, Taylor JP, Todd PK.
Human Molecular Genetics 2014 May 8. pii: ddu216. Link
JC Virus Granule Cell Neuronopathy in a patient treated with Rituximab.
Dang L, Dang X, Koralnik IJ, and Todd PK.
JAMA Neurology, 2014 Apr;71(4):487-9. Link
Making sense of the antisense transcripts in C9FTD/ALS.
Acta Neuropathologica. 2013 Dec;126(6):785-7. Link
C9orf72-associated FTD/ALS: when less is more.
Neuron. 2013 Oct 16;80(2):257-8. Link
Transcriptional changes and developmental abnormalities in a zebrafish model of myotonic dystrophy type 1.
Todd PK, Ackall FY, Hur J, Sharma K, Paulson HL, Dowling JJ.
Disease Models & Mechanisms. 2014 Jan-Feb;7(1):143-55. Link
CGG Repeat Associated Translation Mediates Neurodegeneration in Fragile X Tremor Ataxia Syndrome.
Todd PK, Oh S-Y, Krans A, He F, Sellier C, Frazer MI, Renoux AJ, Chen K-C, Scaglione KM, Basrur V, Elenitoba-Johnson K, Vonsattel JP, Louis ED, Sutton MA, Taylor JP, Mills RE, Charlet-Berguerand N, and Paulson HL.
Neuron. May 8;78(3):440-55. doi: 10.1016/j.neuron.2013.03.026. Link
*Previewed in Neuron 2013 Link
Sequestration of DROSHA and DGCR8 by Expanded CGG RNA Repeats Alters MicroRNA Processingin Fragile X-Associated Tremor/Ataxia Syndrome.
Sellier C, Freyermuth F, Tabet R, Tran T, He F, Ruffenach F, Alunni V, Moine H, Thibault H, Page A, Tassone F, Willemsen R, Disney M, Hagerman P, Todd P, Charlet- Berguerand N
Cell Reports. 2013 Mar 5. Link
C9ORF72 expansion in a family with bipolar disorder and frontotemporal dementia.
Meisler MH, Grant AE, Jones JM, Lenk GM, He F, Todd PK, Kamali M, Albin RL, Lieberman AP, Langenecker SA, McInnis MG.
Bipolar Disorders 2013 May;15(3):326-32. Link
Impaired activity-dependent FMRP translation and enhanced mGluR-dependent LTD in Fragile X premutation mice.
Iliff AJ, Renoux AJ, Krans A, Usdin K, Sutton MA, Todd PK.
Human Molecular Genetics 2012; Link
Kill the messenger where it lives.
Nature. 2012 Aug 2; 488 (7409):36-8. Link
Neurodegeneration the RNA way.
Progress in Neurobiology. 97 (2): 173–189. 2012 Link
Epigenetics in Nucleotide repeat disorders.
Seminars in Neurology. 2011 Nov;31 (5):470-83. 2011 Link
Histone Deacetylases Suppress CGG Repeat-Induced Neurodegeneration Via Transcriptional Silencing in Models of Fragile X Tremor Ataxia Syndrome.
Todd PK, Oh S-Y, Krans A, Pandey UB, DiProspero NA, Min K-T, Taylor JP, Paulson HL.
PLoS Genetics, 6(12): e1001240, 2010. Link
*Highlighted in Nature Chemical Biology, 7(1), 2011
RNA-mediated neurodegeneration in repeat expansion disorders.
Annals of Neurology 2010; 67: 291-300. Link
Autophagy and the ubiquitin-proteasome system: collaborators in neuroprotection.
Nedelsky NB, Todd PK, Taylor JP.
Biochemica Biophysica Acta 2008; 1782: 691-699 Link
The fragile X mental retardation protein is required for type-1 metabotropic glutamate receptor-dependent translation of PSD-95.
Todd PK, Mack KJ, Malter JS.
Proceedings of the National Academy of Science. 2003; 100: 14374-8 Link
*Highlighted in Nature reviews Neuroscience 5,4 2004
Whisker stimulation-dependent translation of FMRP in the barrel cortex requires activation of type 1 metabotropic glutamate receptors.
Todd PK, Malter JS, Mack KJ.
Brain Research Molecular Brain Research 2003; 110: 267-278 Link
Fragile X mental retardation protein in plasticity and disease.
Journal of Neuroscience Research 2002; 70: 623-30 Link
Phosphorylation, CREB, and Mental Retardation.
Pediatric Research 2001; 50: 672 Link
Sensory stimulation increases cortical expression of the fragile X mental retardation protein in vivo.
Brain Research Molecular Brain Research 2000; 80: 17-25 Link
Behavioral sensitization and Extra-cellular dopamine responses to amphetamine after various treatments.
Kuczenski R, Segal DS, Todd PK.
Psychopharmacology 1997;134(3):221-229.
Other Published Materials:
Hereditary Cerebellar Ataxia
Todd PK, Shakkottai V, Gilman S.
In Textbook of Clinical Neurology, 2011
The Differential Diagnosis and treatment of Cerebellar Ataxia in Adults.