Publications

Group's work on journal covers

Awarded Patents:

5) Inhibitors of Kinase Networks and Uses Thereof. Inventors: Herman O. Sintim, Neetu Dayal and Clement Opoku-Temeng. US 11,040,973. June 22, 2021

4) 4-Substituted Aminoisoquinoline Derivatives. Inventor: Herman O. Sintim. US 11,001,559. Awarded May 11, 2021

3) Docked Derived Compounds Against Laminin Receptor (37 LR) and Uses Thereof. Inventors: Marxa L. Figueiredo, Charles Samuel Umbaugh, Herman O. Sintim, Adriana Diaz-Quinones. US 10,438, 688 B2. 

2) Linked Diaryl Compounds with Anticancer Properties and Methods of Using the Same. Inventors: Herman O. Sintim, Jie Zhou, Changhao Wang, Rena Lapidus,​ US10,130,625B2. Awarded November 20, 2018

1) Phosphorylated and Branched Dihydroxy-Pentane-Dione (DPD) Analogs as Quorum Sensing Inhibitors in Bacteria. Inventors: Herman O. Sintim, William Bentley, Jacqueline A. I. Smith, Varnika Roy, Mariana T. Meyer, Reza Ghodssi  US 8952192 B2. Awarded February 10, 2015

Publications

171) 2’,4’-LNA-Functionalized 5′-S-phosphorothioester CDNs as STING agonist. Simpa K. Yeboah,  Abdulai Zigli,  Herman O. Sintim* ChemBioChem 2024 e202400321 https://doi.org/10.1002/cbic.202400321

170) Identification and characterization of a potent and selective HUNK inhibitor for treatment of HER2+ breast cancer.

Tinslee Dilday, Melissa Abt, Nicole Ramos-Solís, Neetu Dayal, Elizabeth Larocque, Adrian L Oblak, Herman O Sintim, Elizabeth S Yeh 

Cell Chem. Biol. 2024, 31, 1–11.

169) PDE-stable 2'3'-cGAMP analogues, containing 5’-S-phosphorothioester linkage, as STING Agonists. Simpa K. Yeboah and Herman O. Sintim* RSC Med. Chem. 2024, https://doi.org/10.1039/D3MD00593C

168) Discovery of imidazo [1, 2-b] pyridazine-containing TAK1 kinase inhibitors with excellent activities against multiple myeloma. Desmond Akwata, Allison L. Kempen, Jones Lamptey, Neetu Dayal, Nickolas R. Brauer, Herman O. Sintim*

RSC Med. Chem. 2024, doi: 10.1039/D3MD00415E

167) Identification of a selective FLT3 inhibitor with low activity against VEGFR, FGFR, PDGFR, c‐KIT, and RET anti‐targets.

Desmond Akwata, Allison L. Kempen, Neetu Dayal, Nickolas R. Brauer, Herman O. Sintim* ChemMedChem, 2024, 19, e202300442.

166) Global proteomics insights for a novel small compound targeting the non-integrin Laminin Receptor in a macrophage cell model. Abigail Haffner, Manoel Figueiredo Neto, Charles S. Umbaugh, Timothy B. Lescun, Herman O. Sintim, Marxa L. Figueiredo Front. Drug Discov. 2023, 3,  1326736. doi: 10.3389/fddsv.2023.1326736.

165) Engineered Vancomycin, with Increased Interactions with Peptidoglycan Stem Peptide, Conquers Non-tuberculosis Mycobacteria. Christopher Vennard, Temitope Oropo, Herman O. Sintim* J. Med. Chem. 2023, 66 (15), 10238-10240.

163) STING antagonists, synthesized via Povarov–Doebner type multicomponent reaction. Wilson WS Ong, Neetu Dayal, Riddhi Chaudhuri, Jones Lamptey, Herman O. Sintim* RSC Med. Chem., 2023,14, 1101-1113.

162) Proteomic and phosphoproteomic analyses of Jurkat T-cell treated with 2′ 3′ cGAMP reveals various signaling axes impacted by cyclic dinucleotides. Kenneth I. Onyedibe, Rodrigo Mohallem, Modi Wang, Uma K. Aryal, Herman O. Sintim* J. Proteomics 2023, 279, 104869.

161) Targeting RET Solvent-Front Mutants with Alkynyl Nicotinamide-Based Inhibitors. Ujjwol Khatri, Neetu Dayal, Xueqing Hu, Elizabeth Larocque, Nimishetti Naganna, Tao Shen, Xuan Liu, Frederick W Holtsberg, M Javad Aman, Herman O Sintim*, Jie Wu* Mol. Cancer Ther. 2023, 22 (6), 717–725.

160) Re-sensitization of Multidrug-Resistant and Colistin-Resistant Gram-Negative Bacteria to Colistin by Povarov/Doebner-Derived Compounds. Kenneth I. Onyedibe, Ansley M. Nemeth, Neetu Dayal, Richard D. Smith, Jones Lamptey, Robert K. Ernst, Roberta J. Melander, Christian Melander*, and Herman O. Sintim* ACS Infec. Dis. 2023, 9, 2, 283–295.

159) RET aberrant cancers and RET inhibitor therapies: Current state-of-the-art and future perspectives.

Alfredo Addeo, Ernesto Miranda, Petra den Hollander, Alex Friedlaender, Herman O. Sintim, Jie Wu, Sendurai A Mani, Vivek Subbiah Pharmacol. Ther. 2023 108344.

158) Targeting Serine Biosynthesis in Combination with the Modulation of Glutamine Metabolism Enhances Cellular Cytotoxicity in Acute Myeloid Leukemia. Kanwal Mahmood, Neetu Dayal, Dominique R Bollino, Herman O. Sintim, Ashkan Emadi Blood 2022, 140, 8801-8802.

157) An Expanding Role of 2′,3′-Cyclic Nucleotide Monophosphates in Bacteria. Christopher Vennard and Herman O. Sintim* ACS Cent. Sci. 2022, 8, 11, 1480–1483.

156) Mechanistic Studies and In Vivo Efficacy of an Oxadiazole-Containing Antibiotic

George A. Naclerio, Nader S. Abutaleb, Kenneth I. Onyedibe, Caroline Karanja, Hassan E. Eldesouky, Hsin-Wen Liang, Alexandra Dieterly, Uma K. Aryal, Tiffany Lyle, Mohamed N. Seleem, and Herman O. Sintim* J. Med. Chem. 2022, 2022, 65, 9, 6612–6630.

155) Comparative Studies to Uncover Mechanisms of Action of N-(1,3,4-Oxadiazol-2-yl)benzamide Containing Antibacterial Agents. George A. Naclerio, Kenneth I. Onyedibe, Caroline W. Karanja, Uma K. Aryal, and Herman O. Sintim* ACS Infect. Dis. 2022, 8, 4, 865–877.

154) Bacterial chemotaxis in static gradients quantified in a biopolymer membrane-integrated microfluidic platform.

Piao Hu, Khanh L Ly, Le PH Pham, Alex E Pottash, Kathleen Sheridan, Hsuan-Chen Wu, Chen-Yu Tsao, David Quan, William E Bentley, Gary W Rubloff, Herman O Sintim, Xiaolong Luo Lab Chip 2022, 22 (17), 3203-3216.

153) Membrane acting Povarov-Doebner derived compounds potently disperse preformed multidrug resistant Gram-positive bacterial biofilms. Neetu Dayal, Kenneth I. Onyedibe, Whitney M. Gribble, Herman O. Sintim* Eur. J. Med. Chem. 2022, 240, 114550.

152) Isoquinoline Antimicrobial Agent: Activity against Intracellular Bacteria and Effect on Global Bacterial Proteome.

Caroline W. Karanja, Nimishetti Naganna, Nader S. Abutaleb, Neetu Dayal, Kenneth I. Onyedibe, Uma Aryal, Mohamed N. Seleem, Herman O. Sintim* Molecules 2022, 27(16), 5085.

151) Global proteomics of fibroblast cells treated with bacterial cyclic dinucleotides, c-di-GMP and c-di-AMP. Kenneth I. Onyedibe, Samira Elmanfi, Uma K. Aryal, Eija Könönen, Ulvi Kahraman Gürsoy and Herman O. Sintim* J. Oral Microbiol. 2022, 14, 1. DOI: 10.1080/20002297.2021.2003617

150) c-di-GMP Induces COX-2 Expression in Macrophages in a STING-Independent Manner. Modi Wang, Riddhi Chaudhuri, Wilson W. S. Ong, Herman O. Sintim*. ACS Chem. Biol. 2021, 16, 1663-1670.

149) 3H-Pyrazolo[4,3-f]quinoline-based Kinase Inhibitors Inhibit the Proliferation of Acute Myeloid Leukemia Cells in Vivo.

Neetu Dayal, Eva Řezníčková, Delmis Hernandez, Miroslav Peřina, Sandra Torregrosa-Allen, Bennett D Elzey, Jana Škerlová, Haresh Ajani, Stefan Dukić, Martin Lepšík, Pavlína Řezáčová, Vladimír Kryštof, Radek Jorda, and Herman O. Sintim*

J. Med. Chem. 2021, 64, 10981-10996.

147) Starving Bacteria of Iron: A Potential Strategy to Disperse Bacterial Biofilms George A. Naclerio and Herman O. Sintim*, J. Med. Chem. 2021, 64, 7272-7274.

146) Bacterial Cyclic Dinucleotides and the cGAS–cGAMP–STING Pathway: A Role in Periodontitis? Samira Elmanfi, Mustafa Yilmaz, Wilson W.S. Ong, Kofi S. Yeboah, Herman O. Sintim, Mervi Gürsoy, Eija Könönen, Ulvi K. Gürsoy. Pathogens 2021, 10, 675. https://doi.org/10.3390/pathogens10060675

145) N-(1,3,4-Oxadiazol-2-yl)Benzamides as Antibacterial Agents against Neisseria gonorrhoeae George A. Naclerio, Nader S. Abutaleb, Marwa Alhashimi, Mohamed N. Seleem, Herman O. Sintim*, Int. J. Mol. Sci. 2021, 22, 2427. https://doi.org/10.3390/ijms22052427

144) Identification of a Mycobacterium tuberculosis Cyclic Dinucleotide Phosphodiesterase Inhibitor. Caroline W. Karanja, Kofi S. Yeboah, and Herman O. Sintim*, ACS Infectious Disease. 2021, 7, 309–317. 

143) A STING-based fluorescent polarization assay for monitoring activities of cyclic dinucleotide metabolizing enzymes. Caroline W. Karanja, Kofi S. Yeboah, Wilson W. S. Ong and Herman O. Sintim*, RSC Chem. Biol. 2021, 2, 206-214. doi: 10.1039/d0cb00187b

142) Zwitterionic liquid crystalline polythiophene as an antibiofouling biomaterial, Jinjia Xu, Jian Xu, Haesoo Moon, Herman O. Sintim, Hyowon Lee, J. Mater. Chem. B, 2021, 9, 349-356. doi: 10.1039/D0TB02264K

141) Activation of Gingival Fibroblasts by Bacterial Cyclic Dinucleotides and Lipopolysaccharide. Elmanfi, S.; Sintim, H.O.; Zhou, J.; Gürsoy, M.; Könönen, E.; Gürsoy, U.K. Pathogens 2020, 9(10), 792. DOI: 10.3390/pathogens9100792

140) Ultrapotent inhibitor of Clostridioides difficile growth, which suppresses recurrence in vivo. Naclerio GA, Abutaleb NS, Li D, Seleem MN, Sintim HO*. J. Med. Chem. 2020, 63, 11934–11944. doi: 10.1021/acs.jmedchem.0c01198

138) Homologous quorum sensing regulatory circuit (hQSRC): A dual-input genetic controller for modulating quorum sensing (QS)-mediated protein expression in E. coli. Pricila Hauk, Kristina Stephens, Chelsea Virgile, Eric VanArsdale, Alex Eli Pottash, John S Schardt, Steven M Jay, Herman O Sintim and , William E Bentley ACS Synth. Biol. 2020, 9, 2692-2702. https://doi.org/10.1021/acssynbio.0c00179

137) Use of High-Throughput Tools for Telescoped Continuous Flow Synthesis of an Alkynylnaphthyridine Anticancer Agent, HSN608. Shruti A. Biyani, Qingqing Qi, Jingze Wu, Yuta Moriuchi, Elizabeth A. Larocque, Herman O. Sintim and David H. Thompson, Org. Process Res. Dev. 2020, 24, 2240-2251. https://doi.org/10.1021/acs.oprd.0c00289

136) HSD1787, a Tetrahydro-3H-Pyrazolo[4,3-f]Quinoline Compound Synthesized via Povarov Reaction, Potently Inhibits Proliferation of Cancer Cell Lines at Nanomolar Concentrations. Neetu Dayal, Modi Wang, and Herman O. Sintim*, ACS Omega, 2020,  5, 23799-23807. DOI: 10.1021/acsomega.0c03001 

135) Global Proteomic Analyses of STING‐Positive and ‐Negative Macrophages Reveal STING and Non‐STING Differentially Regulated Cellular and Molecular Pathways. Aryal UK, Hedrick V, Onyedibe KI, Sobreira TJP, Sooreshjani MA, Wang M, Gürsoy UK, Sintim HO*. Proteomics Clin. Appl. 2020, 1900109. https://doi.org/10.1002/prca.201900109 

133) Zwitterionic Porous Conjugated Polymers as a Versatile Platform for Antibiofouling Implantable Bioelectronics. Xu, J.; Xu, J.; Moon, H.; Sintim, H. O.; Lee, H. ACS Appl. Polym. Mater. 2020, 2, 528-536. https://doi.org/10.1021/acsapm.9b00950.

131) Lipoteichoic Acid Biosynthesis Inhibitors as Potent Inhibitors of S. aureus and E. faecalis Growth and Biofilm Formation. Naclerio GA, Onyedibe KI, Sintim HO*. Molecules, 2020, 25(10), E2277.  

130) Targeting Cyclic Dinucleotide Signaling with Small Molecules. Sintim HO*, Opoku-Temeng C. (2020)  In: Chou SH., Guiliani N., Lee V., Römling U. (eds) Microbial Cyclic Di-Nucleotide Signaling. Springer, Cham.  DOI: https://doi.org/10.1007/978-3-030-33308-9_33

129) Nicotinamide–Ponatinib Analogues as Potent Anti-CML and Anti-AML Compounds. Larocque, E.; Chu, E. F. Y.; Naganna, N.; Sintim, H. O.* ACS Omega 2020, 5, 6, 2690-2698. https://doi.org/10.1021/acsomega.9b03223.

128) Potent trifluoromethoxy, trifluoromethylsulfonyl, trifluoromethylthio and pentafluorosulfanyl containing (1,3,4-oxadiazol-2-yl)benzamides against drug-resistant Gram-positive bacteria. Naclerio GA, Abutaleb NS, Onyedibe, KI, Seleem MN,  Sintim HO.* RSC Med Chem, 2020, 11, 102-110. doi: 10.1039/C9MD00391F

127) Interrupting cyclic dinucleotide-cGAS-STING axis with small molecules. Mikek C, Wang M, Sooreshjani MA, Sintim HO.* MedChemComm, 2019, 10, 1999-2023. doi: 10.1039/C8MD00555A 

125) Squarate desymmetrisation–ozonolysis as an approach to β-substituted-α-ketosuccinates and squalestatin synthesis. Sintim HO, Valade A, Harling DC, Hodgson DM. Tetrahedron, 2019, 75, 130747. doi: 10.1016/j.tet.2019.130747

124) Amino alkynylisoquinoline and alkynylnaphthyridine compounds potently inhibit acute myeloid leukemia proliferation in mice. Naganna N, Opoku-Temeng C, Choi EY, Larocque E, Chang ET, Lapidus RG, Sintim HO. EBioMedicine, 2019, 40, 231-239 doi: 10.1016/j.ebiom.2019.01.012

123) Inhibitors of Intracellular Gram-Positive Bacterial Growth Synthesized via Povarov–Doebner Reactions. Dayal N, Opoku-Temeng C, Mohammad H, Abutaleb NS, Hernandez D, Onyedibe KI, Wang M, Zeller M, Seleem MN, Sintim HO. ACS Infect. Dis. 2019, 5, 1820-1830. doi: 10.1021/acsinfecdis.9b00022

122) Potently inhibiting cancer cell migration with novel 3H-pyrazolo[4,3-f]quinoline boronic acid ROCK inhibitors. Dayal N, Mikek CG, Hernandez D, Naclerio GA, Chu EF, Carter-Cooper BA, Lapidus RG, Sintim HO. Eur J Med Chem. 2019. 180, 449-456. doi: 10.1016/j.ejmech.2019.06.089

121) Antibacterial small molecules that potently inhibit Staphylococcus aureus lipoteichoic acid biosynthesis. Naclerio GA, Karanja CW, and Opoku-Temeng C, Sintim HO. ChemMedChem., 2019, 14, 1000-1004. doi:10.1002/cmdc.201900053 

119) Proteomic analysis of bacterial response to a 4-hydroxybenzylidene indolinone compound, which re-sensitizes bacteria to traditional antibiotics. Opoku-Temeng C, Onyedibe KI, Aryal UM, Sintim HO.  J Proteomics , 2019, 202, 103368. doi: 10.1016/j.jprot.2019.04.018

118) Ligand-Based Stability Changes in Duplex DNA Measured with a Microscale Electrochemical Platform. Robinson SM, Shen Z, Askim JR, Montgomery CB, Sintim HO, Semancik S. Biosensors, 2019, 9, 54, doi: 10.3390/bios9020054 

117) Alkylation of lithiated dimethyl tartrate acetonide with unactivated alkyl halides and application to an asymmetric synthesis of the 2,8-dioxabicyclo[3.2.1]octane core of squalestatins/zaragozic acids. Sintim HO, Al Mamari HH,  Almohseni HA, Fegheh-Hassanpour Y,  Hodgson DM. Beilstein J. Org. Chem. 2019, 15, 1194–1202. doi:10.3762/bjoc.15.116  

116) Regulation of gingival epithelial cytokine response by bacterial cyclic dinucleotides. Elmanfi S, Zhou J, Sintim HO, Könönen E, Gürsoy M & Gürsoy UK  J. Oral Microbiol., 2019, 11, 1. DOI: 10.1080/20002297.2018.1538927

115) Discriminating cyclic from linear nucleotides − CRISPR/Cas-related cyclic hexaadenosine monophosphate as a case study. Wang M and Sintim HO.  Analytical Biochemistry, 2019, 567, 21-26. DOI: 10.1016/j.ab.2018.11.022 

114) KRX-101, a novel FLT3 inhibitor, potently active against resistant FLT3-ITD/FLT3-TKD mutant AML in vitro and in vivo. Herman O Sintim, M. Javad Aman, Frederick Holtsberg, Ashkan Emadi and Rena G Lapidus. Blood, 2018, 132, 4049. doi: https://doi.org/10.1182/blood-2018-99-115260

113) Evidence of link between quorum sensing and sugar metabolism in Escherichia coli revealed via cocrystal structures of LsrK and HPr. Ha JH, Hauk P, Cho K, Eo Y, Ma X, Stephens K, Cha S, Jeong M, Suh JY, Sintim HO, Bentley WE, Ryu KS. Sci Adv. 2018, 1, 4(6), eaar7063.​ 

112) Proteomic analysis of RAW macrophages treated with cGAMP or c-di-GMP reveals differentially activated cellular pathways. Sooreshjani MA, Gursoy UK, Aryal UK and Sintim HO.  RSC Adv., 2018, 8, 36840-36851

111) N-(1,3,4-oxadiazol-2-yl)benzamide analogs, bacteriostatic agents against methicillin- and vancomycin-resistant bacteria. Opoku-Temeng C, Naclerio GA, Mohammad H, Dayal N, Abutaleb NS, Seleem MN, Sintim HO. Eur J Med Chem. 2018,155, 797-805.

110) Quorum sensing molecules regulate epithelial cytokine response and biofilm-related virulence of three Prevotella species. Fteita D, Könönen E, Gürsoy M, Ma X, Sintim HO, Gürsoy UK. Anaerobe, 2018, 3 (54), 128-135.   

109) Berenil binds tightly to parallel and mixed parallel/antiparallel G-quadruplex motifs with varied thermodynamic signatures. Clinton G. Mikek, Savannah J. West, J. Cole Gwin, Neetu Dayal, Herman O. Sintim* and Edwin A. Lewis* ACS Omega, 2018, 3 (9), pp 11582–11591  

108) Tetrahydro-3H-pyrazolo[4,3-a]phenanthridine-based CDK inhibitor. Clement Opoku-Temeng, Neetu Dayal, Delmis E. Hernandez, N. Naganna and Herman O. Sintim* Chem. Commun. 2018, 54, 4521-4524

107) Alkynylnicotinamide-based compounds as ABL1 inhibitors with potent activities against drug-resistant CML harboring ABL1(T315I) mutant kinase. Elizabeth A. Larocque, N Naganna, Clement Opoku-Temeng, Alyssa M. Lambrecht and Herman O. Sintim* ChemMedChem, 2018, 13, 1172-1180. https://doi.org/10.1002/cmdc.201700829

106) Alkene protection against acid using a bromide substituent: application in a total synthesis of(−)-6,7-dideoxysqualestatin H5. Hasanain A. A. Almohseni, Hamad H. Al Mamari,  Anne Valade,  Herman O. Sintim  and  David M. Hodgson  Chem. Commun. 2018, 54, 5354-5356. DOI:10.1039/C8CC02690D

105) On the ozonolysis of unsaturated tosylhydrazones as a direct approach to diazocarbonyl compounds. Younes Fegheh-Hassanpour,  Faisal Ebrahim, Tanzeel Arif,  Herman O. Sintim, Timothy D. W. Claridge,  Nader T. Amin and  David M. Hodgson Org. Biomol. Chem. 2018, 16, 2876-2884. DOI:10.1039/C8OB00435H

104) 3H-pyrazolo[4,3-f]quinoline haspin kinase inhibitors and anticancer properties. Clement Opoku-Temeng, Neetu Dayal, Moloud Aflaki Sooreshjani and Herman O. Sintim* Bioorg. Chem.2018, 78, 418-426. https://doi.org/10.1016/j.bioorg.2018.03.031

103) Suramin potently inhibits cGAMP synthase, cGAS, in THP1 cells to modulate IFN-β levels. Modi Wang, Moloud A Sooreshjani, Clinton Mikek, Clement Opoku-Temeng, Herman O Sintim*, Future Med. Chem. 2018 https://doi.org/10.4155/fmc-2017-0322

102) Dual FLT3/TOPK inhibitor with activity against FLT3-ITD secondary mutations potently inhibits acute myeloid leukemia cell lines. Neetu Dayal, Clement Opoku-Temeng, Delmis E Hernandez, Moloud Aflaki Sooreshjani, Brandon A Carter-Cooper, Rena G Lapidus & Herman O Sintim*, Future Med. Chem. 2018, 10(7):823-835 

101) Quorum sensing molecule dihydroxy-2,3-pentanedione and its analogs as regulators of epithelial integrity. Samira Elmanfi, Xiaochu Ma, Herman O. Sintim, Eija Kononen, Stina Syrjanen and Ulvi Kahraman Gursoy. J. Periodont. Res. 2018, DOI: 10.1111/jre.12528

100) Miniaturized whole-cell bacterial bioreporter assay for identification of quorum-sensing interfering compounds. Polina Ilina, Xiaochu Ma, Herman O. Sintim and Paivi Tammela J. Microbiol. Methods, 2018, https://doi.org/10.1016/j.mimet.2018.10.005

99) Inhibition of Innate Immune Cytosolic Surveillance by a M. tuberculosis Phosphodiesterase. Ruchi Jain Dey, Bappaditya Dey, Yue Zheng, Laurene S. Cheung, Jie Zhou, David Sayre, Pankaj Kumar, Haidan Guo, Herman O. Sintim*, William R. Bishai*  Nature Chem. Biol. 2017, 13, 210-217

98) Dipeptidyl peptidase IV and quorum sensing signaling in biofilm-related virulence of Prevotella aurantiaca. Dareen Fteita, Ahmed Ali Musrati, Eija Könönen, Xiaochu Ma, Mervi Gürsoy, Markus Peurla, Eva Söderling, Herman O. Sintim, Ulvi Kahraman Gürsoy. Anaerobe 2017, pii: S1075-9964(17)30168-3

97) Synthesis of (−)-6,7-Dideoxysqualestatin H5 by Carbonyl Ylide Cycloaddition–Rearrangement and Cross-electrophile Coupling. Younes Fegheh-Hassanpour, Tanzeel Arif, Herman O. Sintim, Hamad H. Al Mamari, and David M. Hodgson Org. Lett. 2017, 19 (13), 3540-3543.

96)  Cyclic Dinucleotides in Oral Bacteria and in Oral Biofilms. Gürsoy UK, Gürsoy M, Könönen E and Sintim HO Front. Cell. Infect. Microbiol. 2017, 7, 273. doi: 10.3389/fcimb.2017.00273

95)  Aminoisoquinoline benzamides, FLT3 and Src-family kinase inhibitors, potently inhibit proliferation of acute myeloid leukemia cell lines. Elizabeth Larocque, N Naganna, Xiaochu Ma, Clement Opoku-Temeng, Brandon Carter-Cooper, Gaurav Chopra, Rena G. Lapidus, Herman O. Sintim* Fut. Med. Chem. 2017, 9(11), 1213-1225.

94) Identification of new FLT3 inhibitors that potently inhibit AML cell lines, via an azo click-it/staple-it approach. Xiaochu Ma, Jie Zhou, Changhao Wang, Brandon Carter-Cooper, Elizabeth Larocque, Jonathan Fine, Genichiro Tsuji, Fan Yang, Gaurav Chopra, Rena G. Lapidus, and Herman O. Sintim* ACS Med. Chem. Lett. 2017, 8(5), 492-497.

92) Fluorescent analogs of cyclic and linear dinucleotides as phosphodiesterase and oligoribonuclease activity probes. Jie Zhou, Yue Zheng, Benjamin T. Roembke, Sarah M. Robinson, Clement Opoku-Temeng, David A. Sayre, Herman O. Sintim* RSC Adv., 2017,7, 5421-5426.

91) Targeting c-di-GMP signaling, biofilm formation and bacterial motility with small molecules. Clement Opoku-Temeng and Herman O. Sintim*, 2017 Methods Mol. Biol., pp 419-430.

90) Fluorescent 2-aminopurine c-di-GMP and GpG analogs as PDE probes. Jie Zhou, Clement Opoku-Temeng and Herman O. Sintim*, 2017 Methods Mol. Biol., pp 245-261.

89) Insightful directed evolution of Escherichia coli quorum sensing promoter region of the lsrACDBFG operon: a tool for synthetic biology systems and protein expression. Pricila Hauk, Kristina Stephens, Ryan Mckay, Chelsea Ryan Virgile, Hana Ueda, Marc Ostermeier, Kyoung-Seok Ryu, Herman O. Sintim, William E. Bentley Nucl. Acids Res. 2016, 44, 10515-10525. doi: 10.1093/nar/gkw981

88) Construction and characterization of a multilayered gingival keratinocyte culture model: the TURK-U model. Ulvi K. Gursoy, Mervi Gursoy, Eija Könönen, Herman O. Sintim, Veli-Jukka Uitto, Stina Syrjänen. Cytotechnology 2016, 68, 2345-2354. DOI: 10.1007/s10616-016-0029-4

87)  Computational understanding and experimental characterization of twice-as-smart quadruplex ligands as chemical sensors of bacterial nucleotide second messengers. Jie Zhou, Benjamin T. Roembke, Gabor Paragi, Aurelien Laguerre, Herman O. Sintim*, Celia Fonseca Guerra* and David Monchaud.  Sci. Rep. 2016, 6, 33888. doi: 10.1038/srep33888.

86) Autoinducer-2 analogs and electric fields- an antibiotic-free bacterial biofilm combination treatment. Sowmya Subramanian, Konstantinos Gerasopoulos, Min Guo, Herman O. Sintim, William E. Bentley and Reza Ghodssi, Biomed Microdevices 2016, 18, 95. dii.10.1007/s10544-016-0120-9

85) Inhibition of P. aeruginosa c-di-GMP phosphodiesterase RocR and swarming motility with a benzoisothiazolinone derivative. Yue Zheng, Genichiro Tsuji, Clement Opoku-Temeng & Herman O. Sintim* Chem. Sci. 2016, 7, 6238-6244.

84) Cyclic dinucleotide (c-di-GMP, c-di-AMP, cGAMP) signalings have come of age to be inhibited with small molecules. Clement Opoku-Temeng, Jie Zhou, Yue Zheng, & Herman O. Sintim* Chem. Commun. 2016, 52, 9327-9342.

83) Inhibition of cyclic diadenylate cyclase, DisA, by polyphenols. Clement Opoku-Temeng & Herman O. Sintim* Sci. Rep. 2016, 6, 25445.

82) Alkyne-substituted diminazene as G-quadruplex binders with anticancer activities. Changhao Wang, Brandon Carter-Cooper, Yixuan Du, Jie Zhou, Musabbir A. Saeed, Jinbing Liu, Min Guo, Benjamin Roembke, Clinton Mikek, Edwin A. Lewis, Rena G. Lapidus and Herman O. Sintim* Eur. J. Med. Chem. 2016, 118, 266–275.

81) Supramolecular polymer formation by cyclic dinucleotides and intercalators affects dinucleotide enzymatic processing. Shizuka Nakayama, Jie Zhou, Yue Zheng, Henryk Szmacinski and Herman O Sintim* Future Sci. OA 2016, doi:10.4155/fso.15.93  

80) Potent inhibition of cyclic diadenylate monophosphate cyclase by the antiparasitic drug, suramin. Clement Opoku-Temeng and Herman O. Sintim* Chem. Commun. 2016, 52, 3574-3577.

79) Cyclic dinucleotide detection with riboswitch-G-quadruplex hybrid. Genichiro Tsuji and Herman O. Sintim* Mol. BioSyst. 2016, 12, 773-777. 

78) Structure–activity relationship studies of c-di-AMP synthase inhibitor, bromophenol-thiohydantoin.Yue Zheng, Jie Zhou, Stefan M. Cooper Jr., Clement Opoku-Temeng, Amanda Moreira De Brito, Herman O. Sintim*, Tetrahedron, 2016, 72, 3554–3558.

77) Alkaloid Synthesis via Carbenoid Intermediates. Xiaochu Ma, Stefan M. Cooper, Fan Yang, Wenhao Hu and Herman O Sintim*. Curr. Org. Chem. 2016, 20, 82-101.

76) Fluorescence, Phosphorescence and Chemiluminescence. Noureen Siraj, Bilal El-Zahab, Suzana Hamdan, Tony E Karam, Louis H Haber, Min Li, Sayo O Fakayode, Susmita Das, Bertha Valle, Robert M Strongin, Gabor Patonay, Herman O Sintim, Gary A Baker, Aleeta Powe, Mark Lowry, Jan O Karolin, Chris D Geddes, Isiah M Warner. Anal. Chem. 2016, 88(1), 170-202.

75) Oligoribonuclease is the primary degradative enzyme for pGpG in Pseudomonas aeruginosa that is required for cyclic-di-GMP turnover. Mona W. Orr, Gregory P. Donaldson, Geoffrey B. Severin, Jingxin Wang, Herman O. Sintim, Christopher M. Walters and Vincent T. Lee.  Proc. Natl. Acad. Sci. USA, 2015, 112(36), E5048-E5057.

73) Membrane affinity of platensimycin and its dialkylamine analogs. Ian Rowe, Min Guo, Anthony Yasmann, Abigail Cember, Herman O. Sintim, Sergei Sukharev Int. J. Mol. Sci. 2015, 16(8), 17909-17932.

72) 3-Aminooxazolidinone AHL analogs as hydrolytically-stable quorum sensing agonists in Gram-negative bacteria. Min Guo, Yue zheng, Clement Opoku-Temeng, Rusty Starks, Xiaochu Ma and Herman O. Sintim* Med. Chem. Commun. 2015, 6, 1086-1092.

71) Bacterial secretions of nonpathogenic E. coli elicit inflammatory pathways: a closer investigation of interkingdom signaling. Amin Zargar, David N. Quan, Karen K. Carter, Min Guo, Herman O. Sintim, Gregory F. Payne and William Bentley mBio, 2015, 6(2), e00025-15.

70) Agents that inhibit bacterial biofilm formation. Nira Rabin, Yue Zheng, Clement Opoku-Temeng, Yixuan Du, Eric Bonsu and Herman O. Sintim* Future Med. Chem. 2015, 7, 647-671.

69) Biofilm formation mechanisms and targets for developing anti-biofilm agents. Nira Rabin, Yue Zheng, Clement Opoku-Temeng, Yixuan Du, Eric Bonsu and Herman O. Sintim* Future Med. Chem. 2015, 7, 493-512.

68) Unraveling curcumin degradation: Autoxidation proceeds through spiroepoxide and vinylether intermediates en route to the main bicyclopentadione. Odaine N. Gordon, Paula B. Luis, Herman O. Sintim and Claus Schneider J. Biol. Chem. 2015, 290, 4817-4828.

67) Geminal dihalogen isosteric replacement in hydrated AI-2 affords potent quorum sensing modulators. Min Guo, Yue Zheng, Jessica Terrell, Michal Ad, Clement Opoku-Temeng, William E. Bentley and Herman O. Sintim* Chem. Commun. 2015, 51, 2617-2620.

66) Rapid nucleic acid melting analyses using a microfabricated electrochemical platform. Zuliang Shen, Herman O. Sintim* and Steve Semancik* Anal. Chim. Acta, 2015, 853, 265-270.

65) Molecular Insights into How Ligands Activate or Inactivate LasR. Yue Zheng and Herman O. Sintim* Chem. Biol. 2014: 1261-1263.

64) AntibioticsThat Disrupt Cell Wall and Bacterial Membrane Formation and Integrity. Jingxin Wang and Herman O. Sintim*, Reference Module in Biomedical Sciences, 2014, doi:10.1016/B978-0-12-801238-3.00016-7

63) Identification of bromophenol thiohydantoin as an inhibitor of DisA, a c-di-AMP synthase, from a 1000 compound library, using the coralyne assay Yue Zheng, Jie Zhou, David Sayre and Herman O. Sintim* Chem. Commun. 2014, 50, 11234-11237.

62) Diminazene or berenil, a classic duplex minor groove binder, binds to G-quadruplexes with low nanomolar dissociation constants and the amidine groups are also critical for G-quadruplex binding. Jie Zhou, Vu Le, Dimpy Kalia, Shizuka Nakayama, Clinton Mikek, Edwin A. Lewis and Herman O. Sintim Mol. BioSyst. 2014, 10, 2724-2734.

61) STING ligand c-di-GMP improves cancer vaccination against metastatic breast cancer Dinesh Chandra, Wilber Quispe-Tintaya, Arthee Jahangir, Denise Asafu-Adjei, IIyssa Ramos, Herman O. Sintim, Jie Zhou, Yoshihiro Hayakawa, David K. R. Karaolis and Claudia Gravekamp Cancer Immunol. Res. 2014, doi: 10.1158/2326-6066.CIR-13-0123

60) Convenient detection of HPV virus in clinical sample using concurrent rolling circle and junction probe amplifications. Lei Yan, Kailong Liu and Herman O. Sintim* Chem. Commun. 2014, 50, 7147-7149.

59) Unexpected complex formation between coralyne and c–di-AMP provides a simple fluorescent turn-on assay to detect this bacterial second messenger. Jie Zhou , David A. Sayre, Yue Zheng, Henryk Szmacinski, and Herman O. Sintim*, Anal. Chem. 2014, 86, 2412-2420.

58) Synthesis of a Biotinylated Photocleavable Nucleotide Monophosphate for the Preparation of Natively Folded RNAs. Yiling Luo, Herman O. Sintim* and T. Kwaku Dayie* Meth. Enzymol. 2014, 549, 115-131.

57) A cyclic dinucleotide containing 2-aminopurine is a general fluorescent sensor for c-di-GMP and 3’3’-cGAMP. Benjamin Roembke, Jie Zhou, Yue Zheng, David Sayre, Laurentee S. Bernard, Allan Lizardo and Herman O. Sintim* Mol. BioSyst. 2014, 10, 1568-1575.

55) Isothermal amplified detection of DNA and RNA. Jie Zhou, Yue Zheng, Shizuka Nakayama, Benjamin Roembke, Adam Gamson and Herman O. Sintim*, Mol. BioSyst. 2014, 10, 970-1003.

54) Evolved Quorum Sensing Regulator, LsrR, for Altered Switching Functions. Bryn Adams, Karen Carter, Min Guo, Hsuan-Chen Wu, Chen-Yu Tsao, Herman O. Sintim, James Valdes, William Bentley, ACS Synth. Biol. 2014, 3, 210-219.

53) Crystal structures of the LsrR proteins complexed with phospho-AI-2 and two signal-interrupting analogs reveal distinct mechanisms for ligand recognition, Jung-Hye, Ha, Yumi Eo, Alexander Grishaev, Min Guo, Jacqueline Smith, Herman O. Sintim, Eun-Hee Kim, Hae-Kap Cheong, William Bentley, Kyoung-Seok Ryu, J. Am. Chem. Soc. 2013, 135, 15526-15535.

51) Small Molecule Inhibitors of AI-2 Signaling in Bacteria: State-of-the-Art and Future Perspectives for Anti-Quorum Sensing Agents. Min Guo, Sonja Gamby, Yue Zheng, Herman O. Sintim*  Int. J. Mol. Sci. 2013, 14, 17694-17728.

50) Nucleic acid detection using G-quadruplex amplification methodologies. Benjamin T. Roembke, Shizuka Nakayama, Herman O. Sintim* Methods, 2013, 64, 185-198.

49) N–O tethered carbenoid cyclopropanation facilitates the synthesis of a functionalized cyclopropyl-fused pyrrolidine

Dimpy Kalia, Gökce Merey, Min Guo, Herman O. Sintim* J. Org. Chem. 2013, 78, 6131-6142.

48) Selective binding of 2’-F-c-di-GMP to Ct-E88 and Cb-E43, new class I riboswitches from Clostridium tetani and Clostridium botulinum respectively. Yiling Luo, Jie Zhou, Jingxin Wang, T. Kwaku Dayie, Herman O. Sintim* Mol. BioSyst., 2013, 9, 1535-1539.

47) Probe design rules and effective enzymes for endonuclease-based detection of nucleic acids. Lei Yan, Shizuka Nakayama and Herman O. Sintim* Bioorg. Med. Chem. 2013, 21, 6181-6185. (Included in symposium-in-print for Oligonucleotides as Targets and Cellular Probe)

46) Octameric G8 c-di-GMP is an efficient peroxidase and this suggests that an open G-tetrad site can effectively enhance hemin peroxidation reactions.

Benjamin Roembke, Jingxin Wang, Shizuka Nakayama, Jie Zhou, Herman O. Sintim* RSC Advances, 2013, 3, 6305-6310.

45) Nucleotide, c-di-GMP, c-di-AMP, cGMP, cAMP, ppGpp, signaling in bacteria and implications in pathogenesis. Dimpy Kalia, Shizuka Nakayama, Min Guo, Jie Zhou, Yue Zheng, Yiling Luo, Benjamin Roembke, Gokce Merey, Herman O. Sintim* Chem. Soc. Rev. 2013, 42, 305-341.

44) AI-2 analogs and antibiotics: A synergistic approach to reduce bacterial biofilms. Varnika Roy, Mariana Meyer, Jacqueline Smith, Sonja Gamby, Herman O. Sintim, Reza Ghodssi, William Bentley, Appl. Microbiol. Biotechnol. 2013, 97, 2627-2638.

 

43) Potent suppression of c-di-GMP synthesis via I-site allosteric inhibition of diguanylate cyclases with 2'-F-c-di-GMP. Jie Zhou, Sarah Watt, Jingxin Wang, Shizuka Nakayama, David A. Sayre, Yiu-fai Lam, Vincent T. Lee and Herman O. Sintim* Bioorg. Med. Chem. 2013, 21, 4396–4404.

42) Detection of single-stranded nucleic acids via colorimetric means, G-quadruplex probes. Shizuka Nakayama and Herman O. Sintim*, Methods Mol. Biol., 2013, 1039, 153-159.

41) Endo-S-c-di-GMP Analogues-Polymorphism and Binding Studies with Class I Riboswitch. Jie Zhou, David A. Sayre, Jingxin Wang, Nirmal Pahadi and Herman O. Sintim*,  Molecules 2012, 17, 13376-13389

                                    Conformer bias in substrate could affect binding to c-di-GMP receptors (conformational steering).

40) Nanomolar fluorescent detection of c-di-GMP using a modular aptamer strategy. Shizuka Nakayama, Yiling Luo, Jie Zhou, T. Kwaku Dayie and Herman O. Sintim* Chem. Commun. 2012, 48, 9059-9061.                                                                                  

39) Investigating the interactions between cations, peroxidation substrates and G-quadruplex topology in DNAzyme peroxidation reactions using statistical testing. Shizuka Nakayama and Herman O. Sintim* Anal. Chim. Acta 2012, 747, 1-6. (Featured Article for October 2012)

38) Altering the communication networks of multispecies microbial systems using a diverse toolbox of AI-2 analogs. Sonja Gamby, Varnika Roy, Min Guo, Jacqueline A. I. Smith, Jingxin Wang, Xiao wang, Jessica E Stewart, William E Bentley, and Herman O. Sintim* ACS Chem. Biol. 2012, 7, 1023-1030. (Selected as Cover for June 2012)

37) Signal-on electrochemical Y or junction probe detection of nucleic acid. Zuliang Shen, Shizuka Nakayama, Steve Semancik, Herman O. Sintim* Chem. Commun. 2012, 48, 7580-7582.

36) Inhibitors of fatty acid synthesis in prokaryotes and eukaryotes as anti-infective, anticancer and antiobesity drugs. Jingxin Wang, Ryan Hudson, Herman O. Sintim* Future Med. Chem. 2012, 4, 1113-1151.

 

35) A pro-Drug Approach for Selective Modulation of AI-2-Mediated Bacterial Cell-to-Cell Communication. Min Guo, Sonja Gamby, Shizuka Nakayama, Jacqueline Smith, Herman O. Sintim* Sensors, 2012, 12, 3762-3772

34) C-di-GMP-proflavine-hemin supramolecular complex, has peroxidase activity- implication for a simple colorimetric detection.  Shizuka Nakayama, Kevin G. Roelofs, Vincent T. Lee and Herman O.Sinim*, Mol.BioSyst. 2012, 8, 726-729.

33) A rapid assay for affinity and kinetics of molecular interactions with nucleic acids. Gregory P. Donaldson, Kevin G. Roelofs, Yiling Luo, Herman O. Sintim and Vincent T. Lee, Nucleic Acids Res. 201240, e48.

 

32) Diamidinium and iminium aromatics as new aggregators of the bacterial signaling molecule, c-di-GMP. Ilana Kelsey, Shizuka Nakayama, Herman O. Sintim, Bioorg. Med. Chem. Lett. 2012, 22, 881-885.

 

31) Molecular Fluorescence, Phosphorescence, and Chemiluminescence Spectrometry. Susmita Das,Aleeta Powe, Gary Baker, Bertha Valle, Bilal El-Zahab, Herman Sintim, Mark Lowry, Sayo Fakayode, Matthew McCarroll, Gabor Patonay, Min Li, Robert Strongin, Maxwell Geng, IsiahWarner. Anal. Chem. 2012, 84, 597-625.

 

 

30) Differential binding of 2’-biotinylated analogs of c-di-GMP with c-di-GMP riboswitches and binding proteins. Yiling Luo, Jie Zhou, Sarah K. Watt, Vincent T. Lee, T. Kwaku Dayie and Herman O. Sintim* Mol.BioSyst. 2012, 8, 772-778.

29) Evidence of magnetic isotope effects during thermochemical sulfate reduction. Harry Oduro, Brian Harms, Herman O. Sintim, Alan J. Kaufman, George Cody, James Farquhar, Proc. Natl. Acad. Sci. USA, 2011, 108, 17635-17638.

 

28) Differential radial capillary action of ligand assay for high-throughput detection of protein-metabolite interactions. Kevin Roelofs, Jingxin Wang, Herman O. Sintim, Vincent T. Lee, Proc. Natl. Acad. Sci. USA, 2011, 108, 15528-15533.

 

27) Effects on membrane lateral pressure suggest permeation mechanisms for bacterial quorum signaling molecules. Kishore Kamaraju, Jacqueline A. I. Smith, Jingxin Wang, Varnika Roy, Herman O. Sintim, William E. Bentley and Sergei Sukharev, Biochemistry, 2011, 50, 6983-6993.

26) Conservative Change to the Phosphate Moiety of c-di-GMP Remarkably Affects Its Polymorphism and Binding Abilities to DGC, PDE and PilZ Proteins. Jingxin Wang, Jie Zhou, Gregory Donaldson, Shizuka Nakayama, Lei Yan, Yiu-Fai Lam, Vincent Lee, Herman Sintim* J. Am. Chem. Soc. 2011, 133, 9320-9330.

25) RNAs synthesized using photocleavablebiotinylatednucleotides have dramatically improved catalytic efficiency. Yiling Luo, Nadukkudy Eldho, Herman O. Sintim*, T.Kwaku Dayie* Nucleic Acids Res. 2011, 39,8559-8571.

 

24) Thiazole Orange-Induced c-di-GMP Quadruplex Formation Facilitates a Simple Fluorescent Detection of This Ubiquitous Biofilm Regulating Molecule. Shizuka Nakayama, Ilana Kelsey, Jingxin Wang, Kevin Roelofs, Bogdan Stefane, Yiling Luo, Vincent Lee and Herman O. Sintim* J. Am. Chem. Soc. 2011, 133, 4856-4864.

23) C-di-GMP can form remarkably stable G-quadruplexes at physiological conditions in the presence of some planar intercalators. Shizuka Nakayama, Ilana Kelsey, Jingxin Wang and Herman O. Sintim* Chem.Commun. 2011, 47, 4766-4768.

22)DNA-based peroxidation catalyst-what is the exact role of topology on catalysis and is there a special binding site for catalysis? Shizuka Nakayama, Jingxin Wang and Herman O. Sintim* Chem. Eur. J. 2011, 17, 5691-5698.

20) Isothermal detection of RNA with restriction endonucleases. Lei Yan, Shizuka Nakayama, Saron Yitbarek, Isabel Greenfield, Herman O. Sintim* Chem. Commun, 2011, 200-2002. (This article is included in the 2011 Emerging Investigators Special Issue). This paper was selected as a HOT article by the editors.

19) Synthetic analogs tailor native AI-2 signaling across bacterial species. Varnika Roy, Jacqueline A. I. Smith, Jingxin Wang, Jessica Stewart, William Bentley and Herman O. Sintim* J. Am. Chem. Soc. 2010, 132 (32), 11141-11150. [PDF]

18) Remote C-H functionalization: using the N-O moiety as an atom-economical tether to obtain 1,5- and the rare 1,7-C-H insertions. Jingxin Wang, Bogdan Stefane, Deana Jaber, Jacqueline A. I. Smith, Christopher Vickery, Mouhamed Diop and Herman O. Sintim* Angew. Chem. Int. Ed. 2010, 49, 3964-3968.

17) Paradigm shift in discovering next-generation anti-infective agents: targeting quorum sensing, c-di-GMP signaling and biofilm formation in bacteria with small molecules. Herman O. Sintim*, Jacqueline A. I. Smith, Jingxin Wang, Shizuka Nakayama and Lei Yan Future Med. Chem.2010, 2, 1005-1035.

 

16) Biomolecule detection with peroxidase-mimicking DNAzymes; expanding detection modality with fluorogeniccompounds. Shizuka Nakayama and Herman O. Sintim* Mol. BioSyst. 2010, 6, 89 - 91.

15) Biological screening of a diverse set of AI-2 analogues in Vibrioharveyisuggests that receptors which are involved in synergistic agonism of AI-2 and analogues are promiscuous.Jacqueline A. I. Smith, JingxinWang, Sao-Mai Nguyen-Mau, Vincent Lee and Herman O. Sintim* Chem. Commun, 2009, 7033 - 7035.

13) Efforts towards the identification of simpler platensimycinanalogs- the total synthesis of oxazinidinylplatensimycin Jingxin Wang, Vincent Lee and Herman O. Sintim* Chem. Eur. J.,2009, 15, 2747-2750.

12) Junction Probes- Sequence Specific Detection of Nucleic Acids via Template Enhanced Hybridization Processes Shizuka Nakayama, Lei Yan and Herman O. Sintim*, J. Am. Chem. Soc., 2008, 130 (38), 12560-12561.

11) A simple solid-phase synthesis of the ubiquitous bacterial signaling molecule, c-di-GMP and analogues Irene Kiburu, Andrew Shurer, Lei Yan and Herman O. Sintim*, Mol. BioSyst. (Emerging investigators special issue), 2008, 4, 518 - 520.

10) Herman O. Sintim* and Jingxin Wang, Update on AH3 reactions Encyclopedia of Reagents for Organic Synthesis (EROS) 2008 John Wiley & Sons, Ltd. DOI:10.1002/047084289X.ra082.pub2

 

9) Herman O. Sintim* and Jingxin Wang, Update on BocN3 reactions, Encyclopedia of Reagents for Organic Synthesis (EROS) 2008 John Wiley & Sons, Ltd. DOI: 10.1002/047084289X.rb364.pub2

Publications from Oxford and Stanford

8) Nonpolar Nucleoside Mimics as Active Substrates for Human Thymidine Kinases. Sarah K. Jarchow-Choy, Elena Sjuvarsson, Herman O. Sintim, StaffanEriksson and Eric T. Kool J. Am. Chem. Soc. 2009 131, 5488–5494.

 

 

7) The DifluorotolueneThe DifluorotolueneDebate - a Decade later, Eric T. Kool and Herman O. Sintim, Chem. Commun., 2006, 3665-3675.

6) Remarkable sensitivity to DNA base shape in the DNA polymerase active site, Herman O. Sintim and Eric T. Kool, Angew. Chem. Int. Ed., 2006, 45, 1974-1979.

5) Enhanced base pairing and replication efficiency of thiothymidines, expanded size variants of thymidine, Herman O. Sintim and Eric T. Kool, J. Am. Chem. Soc., 2006, 128, 396-397.

4) A non-carbohydrate based approach to polyhydroxylated pyrrolizidines; total synthesis of natural products hyacinthacine A1 and 1-epiaustraline, Timothy J. Donohoe, Herman O. Sintim, and J. Hollinshead, J. Org. Chem., 2005, 70, 7297-7304.

3) Utility of the ammonia-free Birch reduction of electron-deficient pyrroles: total synthesis of the 20S proteasome inhibitor, clasto-lactacystinbeta-lactone, Timothy J. Donohoe, Herman O. Sintim, Leena Sisangia, Karl W. Ace, Paul M. Guyo, Andrew Cowley, and John D. Harling, Chem. Eur. J., 2005, 11, 4227-4238.

2) A Concise Total Synthesis of (±)-1-Epiaustraline, Timothy J. Donohoe and Herman O. Sintim, Org.Lett., 2004, 6, 2003-2006.

1) An efficient synthesis of lactacysinAn efficient synthesis of lactacysinbeta-lactone, Timothy J. Donohoe, Herman O. Sintim, Leena Sisangia, and John D. Harling, Angew. Chem. Int. Ed., 2004, 43, 2293-2296.