Noninvasive glucose monitoring
Self-monitoring of blood glucose is a prerequisite for achieving tight metabolic control in patients with diabetes mellitus on intensified insulin therapy. Currently the control of the body glucose is performed in blood samples obtained by pricking the finger. This procedure, considered unpleasant and painful by many diabetic patients, has to be performed several times a day. Thus a reliable method for non-invasive glucose monitoring (NIGM) could present a great relief to millions of patients with diabetes around the world. With a non-invasive monitoring device it is possible to improve the compliance of diabetes patients and better control their blood glucose level, which helps the patients to reduce the number of hypoglycemic events by warning the patient in advance of the risk of a forthcoming hypoglycemic event (blood glucose level too low).
Previous approaches to NIGM have faced challenges due to complex perturbations that affect the measurement, such as natural physiological variations of the body conditions. This has pointed towards the need not only to monitor glucose or the effects of glucose variations itself but also other parameters that can be impacted by changes in the biophysical characteristics of skin (such as temperature, blood perfusion or sweat and skin hydration). Correction of these parameters that can be considered as perturbing could improve the quality of NIGM. The multisensor platform under development at Solianis Monitoring AG is directed to address these challenges.
References:
"Cutaneous blood perfusion as a perturbing factor for non invasive glucose monitoring", A. Caduff, M.S. Talary and P. Zakharov, Diabetes Technol Ther. 2010, 12(1) 1-9. [DOI]
