Perhaps this isn't an issue anymore?
I downloaded the tarball from CPAN and used the standard Perl Makefile, make, sudo make install commands and
(this was on Intel)
So before you despair, try that first.
Many people report having trouble getting DBD::mysql to install on OS X 10.4. We have had real trouble with this on a couple of machines. Here's what I did last time that eventually worked.
And that worked. Now, I also did a lot of other unsuccessful things in the meantime, so if some of those affected the outcome, I'm not sure. I've looked over:
and other sites, seems there is no really clear answer floating around anywhere.
Smart people, help us here and give some better advice on what to do to get DBD::mysql installed.