https://learn.concord.org/resources/155/protein-partnering-and-function
In this activity, students explore what makes a "good fit" for a protein. They start with an exploration of the differences between small molecules and macromolecules such as proteins. They use cartoon representations to build "protein complexes" in a model and test the effects of shape and temperature on the strength of the fit. Students review polar and non-polar molecules and identify polar and non-polar regions of a given protein. Finally, students are challenged to find the best fit for a particular receptor based on shape and charges.
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Disciplinary Core Ideas
HS-PS2.B Types of Interactions
Attraction and repulsion between electric charges at the atomic scale explain the structure, properties, and transformations of matter, as well as the contact forces between material objects.