https://learn.concord.org/resources/779/mutations ( http://lab.concord.org/embeddable.html#interactives/sam/DNA-to-proteins/4-mutations.json )
Explore how changing the DNA sequence can change the amino acid sequence of a protein. Proteins are composed of long strings of amino acids. Proteins are coded for in the DNA. DNA is composed of four different types of nucleotides. Converting the information in DNA into protein is a two-step process, involving transcription and translation. In transcription each mRNA nucleotide pairs with the complementary DNA nucleotide. In translation, each tRNA nucleotide pairs with the complementary mRNA nucleotide. Thus, a change in the DNA sequence can change the amino acid sequence of the protein. There are three basic types of mutations: insertion, deletion and substitution. Some mutations are silent, meaning that there is no change in the protein, while others can cause major changes in the protein.
This activity runs entirely in a Web browser. Preferred browsers are: Google Chrome (versions 30 and above) Safari (versions 7 and above), Firefox (version 30 and above), Internet Explorer (version 10 or higher), and Microsoft Edge.
Performance Expectations
Heredity: Inheritance and Variation of Traits. Students who demonstrate understanding can: Develop and use a model to describe why structural changes to genes (mutations) located on chromosomes may affect proteins and may result in harmful, beneficial, or neutral effects to the structure and function of the organism.