Research Themes

Osteogenesis Imperfecta 

The Menegaz Lab invtestigates the cellular and structural mechanisms underlying the development of craniofacial phenotypes in a mouse model of osteogenesis imperfecta (OI), also known as brittle bone disease. 

OI is a genetic disorder of Type I collagen and is characterized by skeletal fragility and increased fracture susceptibility. Pediatric patients with OI suffer from the underdevelopment of the midface and jaws, severe dental malocclusions (underbite), impacted teeth, and in some cases compromised tooth mechanical properties. 

Our research uses a mouse model of OI to ask how these skeletal and dental issues develop in the craniofacial complex. We are also investigating behavioral and pharmaceutical interventions to prevent and/or alleviate these issues in OI patients. 

Early Life Stress: Effects on Bone, Muscle, and Brain

Stressors during early life, including early weaning, can affect the growth and function of craniofacial tissues during later life. These tissues include bone, muscle, and brain. The goal of this research is to better understand whether environmental stress and biobehavioral factors may contribute to musculoskeletal dysmorphologies and/or differences in brain development. 

Collaborators on this project include the Harlan Jones, PhD, and Mark Cunningham, PhD, at UNT Health.