The CAM lab is equipped for 3D computerized visualization and advanced quantitative analysis of anatomy and morphology. Available equipment in the CAM lab includes graphics-optimized CPUs, a 3D microscribe, and a surface scanner. CT and MRI scanners are available in imaging suites near campus. MicroCT and PET scanners are available through the UNTHSC Pre-Clinical Imaging Core.
The Muscloskeletal Biology Lab is equipped for dissection- and histological-based analyses of hard and soft tissues, with an embedding & sectioning histological suite, a Meiji MT500 biological trifocal microscope, and a Meiji EMZ stereo trifocal microscope. Confocal microscopy is available through the UNTHSC Microscopy Core Facility.
This core facility is equipped with the necessary equipment for in-vivo, high resolution imaging of small animals. This core features a 7T MRI system, a CT 80 system with a PET Clip-On ring from MR Solutions, and PowerScan and VivoQuant work stations for image analysis. The CT 80 is capable of stand-alone CT operations and can be used with the PET ring for sequential multimodality imaging.
Our research in ontogeny & functional morphology and human craniofacial health uses rodent models to investigate the relationship between feeding behaviors and musculoskeletal biology, and how these relationships change as individuals age.
Our research in human musculoskeletal health uses imaging data from the New Mexico Decedent Image Database and human skeletal remains obtained through museum collections.
parameters: size, shape, and functional modularity of the mandible and cranium
methods: microCT scanning, geometric morphometric (GMM) analyses, finite element modeling (FEM)
parameters: microstructure of bone and regional differences in bone growth rates
methods: in-vivo calcein labeling of bone and subsequent fluorescent histological analyses.
parameters: osteoclast and osteoblast activity, the contribution of the organic and mineral components of bone to skeletal strength and function, bone mineralization
methods: longitudinal analyses (ELISA) of serum-based markers of bone activity; microCT- and DEXA-based analysis of BMD
parameters: size/volume, mechanical advantage, and physiological cross-sectional areas (PCSAs) of masticatory muscle
methods: gross dissection and contrast-enhanced micro-CT scanning (such as diceCT and PTA-CT)
parameters: fiber type composition of of masticatory muscles
methods: histology (immunohistochemical staining)