QT prolonging drugs - for full listing of drugs to be avoided, please see https://crediblemeds.org/index.php/new-drug-list

List of drugs which may prolong QT interval and increase the risk of torsades de pointes tachycardia

Drugs to be avoided in patients with congenital long QT syndrome

Main target organ central nervous system

Antipsychotic drugs

  • chlorpromazine

  • haloperidol

  • thioridazine

  • mesoridazine

  • pimozide

  • other phentiazine derivates

  • other butyrophenone derivates

  • other piperidine derivates

Antidepressants

  • amitriptyline

  • doxepine

  • litium

  • prenylamine

  • methadone

Group includes some antiemetic & travel sickness drugs and drugs against vertigo.

Antiarrhythmic drugs

  • disopyramide

  • dofetilide

  • ibutilide

  • procainamide

  • quinidine

  • sotalol

  • amiodarone

  • flecainide

Antihistamines

  • difenhydramine

  • terfenadine

  • astemizole

  • combination drugs which contain pseudoephedrine

  • terfenadine

Antimicrobics

  • erythromycin

  • chlarithromycin

  • other macrolide antimicrobics at least when used simultaneously with antihistamines or amiodarone

  • halofantrine

  • sulfonamides

  • pentamidine

  • sparfloxacin

  • other fluorocinolones

  • sakinavir

Others

  • cholorocine

  • cisapride

  • sildenafile

  • tamoxifen

  • methadone

  • domperidone

  • droperidol

  • clobutinol

Drugs which may cause hypokalemia

  • several diuretics

  • corticosteroids

  • beta-2 adrenergic agonists

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