Collect information
Check, try and decide
https://mikrotikconfig.com/firewall/
https://sudonull.com/post/96175-We-clean-the-Internet-from-annoying-ads-AD-Blocker-for-MikroTik
https://www.reddit.com/r/pihole/comments/f1yf4k/mikrotik_nat_rules_pihole_block_ads_from/
https://paul.is-a-geek.org/2018/02/dns-based-adblock-using-mikrotik-routeros/
https://rickfreyconsulting.com/dns-filtering-using-mikrotik-pi-hole-and-opendns/