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Romina Zappacosta after obtaining a Degree in Chemistry and Pharmaceutical Technologies at the University of Chieti, Italy, earned her Ph.D. Degree in Pharmaceutical Sciences at the same University. She is currently a post-doc research fellow in Organic Chemistry at the Department of Pharmacy of the University “G. d’Annunzio” of Chieti, Italy.
Her main field of interest is supramolecular aggregation of natural and synthetic surfactants, with special focus on liposome stability, targeting and capacity to entrap different guests. Recently she studied the role of electromagnetic radiation in the processes of induction and/or prevention of formation of methane hydrates.
► Contatti
email: r.zappacosta@unich.it
n. telefono: +39 0871 3554789
Pubblicazioni
24. K. Cortese, S. Marconi, C. Aiello, M. C. Gagliani, S. Pilato, R. Zappacosta, A. Fontana,* P. Castagnola,* Liposomes loaded with the proteasome inhibitor z-Leucinyl-Leucinyl-Norleucinal are effective in inducing apoptosis in colorectal cancer cell lines. Membranes, 10, 91:1-11 (2020).
23. N. Bernabò,* J. Machado-Simoes, L. Valbonetti, M. Ramal-Sanchez, G. Capacchietti, A. Fontana, R. Zappacosta, P. Palestini, L. Botto , M. Marchisio, P. Lanuti, M. Ciulla, A. Di Stefano, E. Fioroni, M. Spina, B. Barboni, Graphene Oxide increases mammalian spermatozoa fertilizing ability by extracting cholesterol from their membranes and promoting capacitation. Sci. Rep., 9, 8155:1-13 (2019).
22. B. Sinjari, J. Pizzicannella, M. D'Aurora, R. Zappacosta, V. Gatta, A. Fontana, O. Trubiani,* F. Diomede, Curcumin/Liposome nanotechnology as delivery platform for antinflammatory activities via NFkB/ERK/pERK pathway in human dental pulp treated with 2-HydroxyEthyl MethAcrylate (HEMA). Front. Physiol., 10, 633 (2019) doi:10.3389/fphys.2019.00633
21. R. Zappacosta, M. Aschi, A. Ammazzalorso, P. Di Profio, A. Fontana, G. Siani,* Embedding calix[4]resorcinarenes in liposomes: experimental and computational investigation of the effect of resorcinarene inclusion on liposome properties and stability. Biochim. Biophys. Acta-Biomembr., 1861(6), 1252-1259 (2019).
20. R. Zappacosta, B. Cornelio, S. Pilato, G. Siani, F. Estour,* M. Aschi, A. Fontana,* Effect of the Incorporation of Functionalized Cyclodextrins in the Liposomal Bilayer. Molecules, 24(7), 1387:1-15 (2019). This article belongs to the Special Issue Cyclodextrin Chemistry 2018. DOI: 10.3390/molecules24071387
19. S. Mannana, A. Gugliandolo, E. Cavalli, F. Diomede, R. Iori, R. Zappacosta, P. Bramanti, P. Conti, A. Fontana, O. Trubiani, E. Mazzon,* Human Gingival Mesenchymal Stem Cells (GMSCs) pre-treated with vesicular Moringin nanostructures as a new therapeutic approach in a mouse model of Spinal Cord Injury. J. Tissue Eng. Regen. Med., 13(7), 1109-1121 (2019) doi:10.1002/term.2857
18. A. Di Crescenzo, M. Tiecco, R. Zappacosta, S. Boncompagni, P. Di Profio, V. Ettorre, A. Fontana, R. Germani, G. Siani,* Novel zwitterionic natural deep eutectic solvents as environmentally friendly media for spontaneous self-assembly of gold nanoparticles. J. Mol. Liq., 268, 371-375 (2018).
17. M. Di Giulio,* R. Zappacosta, S. Di Lodovico, E. Di Campli, G. Siani, A. Fontana, L. Cellini, Antimicrobial and antibiofilm efficacy of graphene oxide against chronic wound microorganisms. Antimicrob. Agents Chemother., 62, e00547-18, 1-9 (2018). DOI: 10.1128/AAC.00547-18
16. D. Pieragostino, I. Cicalini, P. Lanuti, E. Ercolino, M. di Ioia, M. Zucchelli, R. Zappacosta, S. Miscia, M. Marchisio, P. Sacchetta, M. Onofrj, P. Del Boccio,* Enhanced release of acid sphingomyelinase-enriched exosomes generates a lipidomics signature in CSF of Multiple Sclerosis patients. Sci. Rep., 8,3071 (2018).
15. P. Di Profio,* V. Canale, F. Marvulli, R. Zappacosta, A. Fontana, G. Siani, R. Germani, Chemoinformatic design of amphiphilic molecules for methane hydrate inhibition. J. Chemometr., 32, e3008: 1-13 (2018).
14. N. Bernabò,* A. Fontana, M. R. Sanchez, L. Valbonetti, G. Capacchietti, R. Zappacosta, L. Greco, M. Marchisio, P. Lanuti, E. Ercolino, B. Barboni, Graphene oxide affects in vitro fertilization outcome by interacting with sperm membrane in an animal model. Carbon, 129, 428-437 (2018).
13. R. Zappacosta, A. Di Crescenzo, V. Ettorre, A. Fontana, M. Pierini, G. Siani,* Ionic liquids as “masking” solvents on the relative strength of bases in proton transfer reactions. ChemPlusChem, 83, 35-41 (2018).
12. A. Di Crescenzo, P. Di Profio, G. Siani, R. Zappacosta, A. Fontana,* Optimizing the interactions of surfactants with graphitic surfaces and clathrate hydrates. Langmuir, 32, 6559–6570 (2016).
11. A. Fontana,* S. Guernelli, N. Zaccheroni, R. Zappacosta, D. Genovese, L. De Crescentini, S. Riela, Micellization properties of cardanol as a renewable co-surfactant. Org. Biomol. Chem., 13, 9214-9222 (2015).
10. R. Zappacosta, M. Di Giulio, V. Ettorre, D. Bosco, C. Hadad, G. Siani, S. Di Bartolomeo, A. Cataldi, L. Cellini,* A. Fontana,* Liposome induced exfoliation of graphite to few-layer graphene dispersion with antibacterial activity. J. Mater. Chem. B, 3, 6520-6527 (2015).
9. R. Zappacosta, A. Fontana,* A. Credi, A. Arduini, A. Secchi,* Incorporation of Calix[6]Arene Macrocycles and (Pseudo)Rotaxanes in Bilayer Membranes: Towards Controllable Liposomal Artificial Channels. Asian J. Org. Chem., 4, 262-270 (2015)
8. R. Zappacosta, A. Di Crescenzo, P. Di Profio, A. Fontana, G. Siani,* Thermodynamic Analysis of Anion and Cation Effects on the Keto-Enol Equilibrium in Ionic Liquids . A Comparative Study with Conventional Solvents. J. Org. Chem. 80, 2333-2338 (2015).
7. R. Zappacosta, G. Siani, S. Silvi, A. Credi, A. Fontana,* Light-driven directed proton transport across liposomal membrane. Langmuir, 30, 13667 - 13672 (2014).
6. S. Guernelli, R. Zappacosta, G. Siani, D. Spinelli, A. Fontana,* Elucidating chemical reactivity and transition state of mononuclear rearrangement of heterocycles through the use of compartimentalized micellar media. J. Mol. Catal. A-Chem., 383-384, 114 - 120 (2014), published online 1 December 2013.
5. R. Bussolati, P. Carrieri, A. Secchi, A. Arduini,* A. Credi, M. Semeraro, M. Venturi, S. Silvi,* D. Velluto, R. Zappacosta, A. Fontana,* Hierarchical Self-assembly of Amphiphilic Calix[6]arene Wheels and Viologen Axles in Water. Org. Biomol. Chem., 11, 5944 – 5953 (2013).
4. P. Marracino, A. Amadei, F. Apollonio, G. d’Inzeo, M. Liberti, A. Di Crescenzo, A. Fontana, R. Zappacosta, M. Aschi,* Modeling of chemical reactions in micelle: water-mediated keto-enol interconversion as a case study. J. Phys. Chem. B, 115, 8102-8111 (2011).
3. M. Aschi, R. Zappacosta, P. De Maria, G. Siani, A. Fontana, A. Amadei, Entropy-Energy Balance in Base Catalyzed Keto-Enol Interconversion: A Joint Theoretical and Experimental Investigation. Int. J. Quantum Chem., 111, 1293-1305 (2011), published online 12 May 2010.
2. R. Zappacosta, M. Semeraro, M. Baroncini, S. Silvi, M. Aschi, A. Credi,* A. Fontana,* Liposome destabilization by a 2,7-diazapyrenium derivative through formation of transient pores in the lipid bilayer. Small, 6, 952-959 (2010).
1. A. Fontana, S. Guernelli, P. Lo Meo, E. Mezzina, S. Morganti, R. Noto,* E. Rizzato, D. Spinelli, R. Zappacosta, On the behaviour of the (Z)-phenylhydrazones of some 5-alkyl-3-benzoyl-1,2,4-oxadiazoles in solution and in gas-phase: kinetic and spectrometric evidence in favour of self-assembly. Tetrahedron, 64, 733-740 (2008), published online 6 November 2007.
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