Campbell Coordinated Advanced Placement Biology Unit 3 Genetics

Post date: May 26, 2015 5:32:38 PM

Life is not found in atoms or molecules or genes, but in their organization; not in symbiosis but in synthesis. ~ Edwin Grant Conklin

https://docs.google.com/presentation/d/1s2gsrf54IWZIhM07pLzXeg9GUJwo4sHjy3ztSe1iYf8/edit?usp=sharing

Chapter 13 & 14

“It is in our genes to try and understand the universe, and to be enchanted by the learning the way.” ~Lewis Thomas

Test Bank 13

https://drive.google.com/file/d/0BxdZuQ_xr2UMaVp4ZXNPVVg4Nk0/view?usp=sharing

Presentation 13

https://docs.google.com/presentation/d/1deJazNcwUso9UQwtx7wrXt_xLo1fIxfMpPC_DNW5s_E/edit?usp=sharing

Test Bank 14

https://docs.google.com/document/d/1_WIBqbwIQ_VF4ax2CuWoKBT6Z1v57L1QhKCE-wUTwSM/edit?usp=sharing

Presentation 14

https://docs.google.com/presentation/d/110NGzK-9HI88L3AhWZOnPyGcFZNvW46UID5J7RuqKio/edit?usp=sharing

Dihybrid Cross Practice Questions

1. A ♂housefly is heterozygous for Eye color and Wing pattern mates with a ♀ who is recessive for both. Solve.

E=Red e=White

W=two wings w=additional vestigial four wings

2. In pigeons the iridescence is caused by a dominant allele. A plain pattern is recessive. Grey feather color is also caused by a dominant allele and white color by a recessive allele.

A ♂pigeon is heterozygous for iridescence and Homozygous dominant for color pattern mates with a ♀ who is Homozygous dominant for both. Solve.

I=iridescence i=plain

G=Gray g=white

3. In horses, black is dependent upon a dominant gene, B, and chestnut (brown) upon its recessive allele, b. Being a soild color is dominant S and having spots is recessive s.

A ♂horse is Homozygous dominant for color and Homozygous recessive for spotting mates with a ♀ who is recessive for both. Solve.

Open Response Questions 13 & 14

1. Describe in detail the process of meiosis as it occurs in an organism with a

diploid chromosome number of 4 (2n = 4). Include labeled diagrams in your

discussion. Indicate when and how each of the following occurs in meiosis.

a. Crossing over

b. Nondisjunction

2. Meiosis reduces chromosome number and rearranges genetic information.

(a) Explain how the reduction and rearrangement are accomplished in

meiosis.

(b) Several human disorders occur as a result of defects in the meiotic

process. Identify ONE such chromosomal abnormality; what effects

does it have on the phenotype of people with the disorder? Describe

how this abnormality could result from a defect in meiosis.

(c) Production of offspring by parthenogenesis or cloning bypasses the

typical meiotic process. Describe either parthenogenesis or cloning

and compare the genomes of the offspring with those of the parents.

3. In dragonflies iridescence is caused by a dominant allele. A matte phenotype is recessive. Green color is also caused by a dominant allele and a Blue color by a recessive allele.

A ♂ Dragonfly is heterozygous for iridescence and Homozygous dominant for color pattern mates with a ♀ who is Homozygous dominant for both. Solve.

I = iridescence i = plain G = Green g = Blue

Chapters 15 & 16

"Ruin is a gift. Ruin is the road to transformation." — Elizabeth Gilbert

Test Bank 15

https://drive.google.com/file/d/0BxdZuQ_xr2UMWm9MUjd3WndJOEU/view?usp=sharing

Presentation 15

https://docs.google.com/presentation/d/1VEAznsH9WHfC5uYzDUiW_kFm48RqkaLsRxbJEBREwfQ/edit?usp=sharing

Test Bank 16

https://docs.google.com/document/d/1XPecdF747EorDpCSmI5mXhmZqny0-TH5F9R8qwJqfu8/edit?usp=sharing

Presentation 16

https://docs.google.com/presentation/d/11d2-T9vqpcYihsgS8CMKlP0n1szePvNH5Y1it-IzN1o/edit?usp=sharing

Assignment 1 Chromosomal Disorder PPT

https://www.youtube.com/watch?v=4MqeoSxSy3w

I. You & your partner choose from the following list…

Down Syndrome

Duchenne muscular dystrophy

Hemophilia

Tay Sachs disease

Cystic Fibrosis

Sickle-cell Anemia

Huntington's disease

Klinefelter syndrome

Turner-syndrome

Prader–Willi syndrome

Phenylketonuria

Neurofibromatosis

II. Create a Power Point with the following qualifiers. Please paraphrase and quote rather than cut & paste.

Title [5p]

Short story poem about the life of an afflicted individual [10p]

Introduction/symptoms [10p]

Statistics (number or percent of population affected) [10p]

Cause(s)... [25p]

Type of mutation

Gene(s) affected, including the chromosome and other traits associated with the genes of that chromosome

Epistasis or Pleiotropy

Sex Linked, Autosomal, Aneuploidy, Monosomic,, Trisomic, Polyploidy

Treatments [10p]

One picture of affected individuals, organs, or cells [10p]

One video (interview with affected person or introduction about disorder) [10p]

Workcited (Greater than or equal to 5 resources in APA format) [10 points]

A Day in the Life. Students compose a short story, PowerPoint presentation, video, poem, song, or significant piece of art to describe a day in the life of a teenager afflicted with a single gene disorder or chromosomal abnormality. Students should include the science behind the disorder (i.e., causes and effects) and identify a social, medical, or ethical issue(s) associated with human genetic disorders.

Assignment 2 Lick your Rat mini-lab

1. Number your laboratory report 1-6 leaving a couple spaces in between each item.
2. cLick here to go to the website
3. Read the two opening paragraphs
4. Before clicking on the “what type of rat mother are you” hypothesize about the outcome of mother rats licking their pups 1, note the claim in the text “It turns out that the difference between a calm and an anxious rat is not genetic.”
5. After clicking on the “what type of rat mother are you” explain what a GR gene is 2.
6. You may need to do a few trials of lick your rat. What was the outcome to the GR gene when the rat pups are licked often (fast clicking with your mouse) versus not (slow clicking) 3?
7. Click on the “investigate high and low nurtured rats pups” box. Click on the GR gene box and explain 4 the connection between in methyl molecules, GR gene, and nurturing.
8. Scroll down to the next sub heading “Anxious Behavior Can Be an Advantage.” What evidence supports that claim 5?
9. Scroll down to the next sub heading “A Different Kind of Inheritance.” The UUHS is claiming “Mom's behavior actually programs the pups' DNA in a way that will make them more likely to succeed.” How is that subjective to the environment 6?

J. Gather the materials to make your own Histone Model

Assignment 3 Virtual Electrophoresis

1. Go to the website http://learn.genetics.utah.edu/content/labs/gel/
2. List the materials for the experiment (on going in experiment)
3. Record the procedure
4. Answer the following questions...
   1. How are the different lengths of DNA significant?
   2. What is the function of a restriction enzyme?
   3. What is the relationship between DNA and polarization of the chamber?
   4. Use the "Can DNA Demand a Verdict?" link to explain why this technique used in a criminal investigation?

Open Response Questions 15 & 16

1. Describe the effect of histone acetylation and DNA methylation on gene expression using the following terms...

a. Differential gene expression, histone acetylation, DNA methylation,

epigenetic inheritance, promoter

b. Use “Lick your rat” as an example.

2. State the conclusions reached by Mendel in his work on the inheritance of characteristics. Explain how each of the following deviates from these conclusions:

1. Autosomal linkage
2. Sex-linked (X-linked) inheritance
1. Polygenic (multiple-gene) inheritance

3. Explain the experiment Griffith experiment using the terms...

Chapters 17 & 18

"Ruin is a gift. Ruin is the road to transformation." — Elizabeth Gilbert

Test Bank 17

https://docs.google.com/document/d/10r_ifooNSPNaRN0bAdoMvveFBqzhvuMwdheSc5BQWJ0/edit?usp=sharing

Presentation 17

https://docs.google.com/presentation/d/1My5xhftWnLi4yMB2UWdLw3iJGG7w8GOMYG1o8QFBQQU/edit?usp=sharing

Test Bank 18

https://docs.google.com/document/d/1p3s0EYrZN0cb0AQ7E2CRNJI6i1jRF3olPyqOS4wSa7o/edit?usp=sharing

Presentation 18

https://docs.google.com/presentation/d/1PSA5I8SAVGKFDPCTXzhcrVRasfLWgpu-itKX64hDhSg/edit#slide=id.p7

1. A portion of specific DNA molecule consists of the following sequence of nucleotide triplets.

TAC - GAA - CTT - GGG - TCC

This DNA sequence codes for the following short polypeptide...

methionine - leucine - glutamic acid - proline - arginine

a. Describe the steps in the synthesis of this polypeptide.

b. What would be the effect of a deletion or an addition in one of the DNA nucleotides?

c. What would be the effects of a substitution in one of the nucleotides?

2. The p53 protein can activate genes involved in apoptosis, or programmed cell death.

a. Discuss how mutations in genes coding for proteins that function in apoptosis could contribute to cancer using the following terms and attached picture...

oncogene, proto-oncogene, Ras gene, p53, Cell cycle

b. Describe one hereditary factor and one non-hereditary factor contributing to cancer.

3. Describe 2 of the following 4 chromosomal alterations. In light of evolution, are individual alterations such as these beneficial or detrimental? Include a hypothetical or literal example in your answer...

Deletion

Duplication

Inversion

Translocation

4. Describe the effect of histone acetylation and DNA methylation on gene expression using the following terms...

a. Differential gene expression, histone acetylation, DNA methylation,

epigenetic inheritance, promoter

b. Use “Lick your rat” as an example.

5. State the conclusions reached by Mendel in his work on the inheritance of characteristics. Explain how each of the following deviates from these conclusions:

Autosomal linkage

Sex-linked (X-linked) inheritance

Polygenic (multiple-gene) inheritance

6. Explain the Griffith experiment using the below terms...

R-strain

S-strain

Recombinant

Semiconservative model

Transformation

Chapters 19 - 21

"Ruin is a gift. Ruin is the road to transformation." — Elizabeth Gilbert

Test Bank 19

https://docs.google.com/document/d/1OC_Py3DEnmXDZSf4y4rQgpV6Y3Ow05q9gm6Ip6PSx9k/edit?usp=sharing

Presentation 19

https://docs.google.com/presentation/d/1rQfA_tPHOaz_x6PRXOlIwUOOINszBQIpvqByMFDPaVs/edit?usp=sharing

Test Bank 20

https://docs.google.com/document/d/1WnOrYG8yVe4vpsP9McewzRNz9XRr9lnjqrQVNkLWhHc/edit?usp=sharing

Presentation 20

https://docs.google.com/presentation/d/1dUM-216Lbo6aKHhEbwbuCkeU5Gs1xP8Lp4-IgNJ70ys/edit?usp=sharing

Test Bank 21

https://docs.google.com/document/d/1Ibq-9vvX9guCkd6VMMfIOgT4QPzltfauKzU_3lRe0mw/edit?usp=sharing

Presentation 21

https://docs.google.com/presentation/d/1DvIXQyd8BmWUipROcatNNr2ADvfwIx7YuFHeu3LTav0/edit?usp=sharing

I. When bacteria infect an animal, the number of bacteria in the body increases in an exponential fashion. After infection by a virulent animal virus with a lytic replicative cycle, there is no evidence of infection for a while. Then the number of viruses rises suddenly and subsequently increases in a series of steps. Explain the difference in the curves using the following terms...

• Lytic cycle
• Infection
• Virus
• Host
• Bacteria
• Exponential
• Mitosis

II. Describe how (use word bank below) bacteria can being enlisted to produce human insulin as medicine

• Plasmid
• Vector
• Restriction enzyme
• Sticky ends
• Donor
• Recipient
• Central dogma

III. Provide evidence (word bank below) that suggest the homeobox DNA sequence evolved very early in the history of life...

• Diagrams
• Hox genes
• FOXP2 gene
• Evo-devo
• Embryo
• Diversity

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