In 1949, the State of Massachusetts passed the "Regional Schools Act" to encourage small towns to form consolidated school districts with a single school committee and specified rights and obligations for member towns. The towns of Bolton, Lancaster and Stow agreed to regionalize for high school in 1951 and later for all grades. Nashoba Regional High School was constructed in 1961 to serve all those students in grades 9-12.
In 2000, NRHS was in need of expansion and renovation to serve the growing population. H.L. Turner Group was hired and according to their website, the project involved reconstructing facades, roofing, and envelope systems on the exterior while adding all new HVAC, electrical, and technology systems to the interior. Renovation of the existing buildings and additions for the performing arts spaces, gym, food court, and administration areas were linked by patterned circulation paths designed to reconnect new and old.
In 2018, the Nashoba Regional Space Task Force issue its final report that detailed the many space issues present at NRHS. That led the Nashoba Regional School district to apply for MSBA assistance to renovate or reconstruct. That application was denied due to limited availability of state funding.
In December of 2019, a second application was submitted and accepted. Nashoba Regional High School immediately entered Module One: The Eligibility Period of the MSBA Process.