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Thyroid inflammation in Hashimoto thyroiditis (TRIUMPH) - IRAS 333533
PIC Study for Newcastle only
Recruitment end date: 30.11.2026
Aim: A randomised, double-blind trial recruiting 48 women with Hashimoto’s thyroiditis with persistent fatigue. Participants will be treated with mycophenolate mofetil (MMF) or placebo to determine proof-of-concept that improving chronic inflammation can help improve persistent symptoms. The primary outcome will be determined by changes in number of inflammatory thyroid lymphocytes, assayed by flow cytometry.
Requirements:
Search for eligible participants using pre built search
Screen the list and remove any patients who are unsuitable for the study
Text or mail out via Docmail
Coordinate with RRDN Agile team staff so participants can come into the practice for a blood test. This will be carried out by RRDN agile staff.
Payments:
SSC's
Preparation for Database search - £23.21
Database search - £23.21
Check Lists for Exclusions - £36 per 40 patients
RC's
local coordination and set up - £113.21
Text message batch - £6.65
mail out - £10.96 per 25 patients
The Parent and Baby Project - Preventing food allergy in infants with early tastes of common food allergens: feasibility and cluster randomised controlled trial - IRAS 351201
PIC Study for South Tees and Newcastle
Aim: The aim of the study is to test a new approach to allergy prevention in infants aged 0-3 months. Those randomised to intervention will introduce small traces of egg and peanut from 17-weeks. Those in the control arm will follow standard food introduction guidelines.
Requirements: Monthly for 6 months, practices will be required to run a prebuilt search in SystmOne or EMIS, screen, and send an approved text message to parents/guardians of potentially eligible infants. Practices can also opportunistically invite potentially eligible participants in vaccine clinics. Practices will also be required to carry out a medical notes review of recruited participants.
Payments:
Monthly database searches for 6 months: £141.00
Eligibility check for monthly mail-outs (15 mins per month for 6 months): £153.00
Site set-up training: £46.25
Text out (one per month for 6 months): £78.00
Medical notes reviews (2 hours of GP time): £194.00
Integrated Bipolar Parenting Intervention - IRAS: 309190
Recruitment end date: 31.01.2027
Aim: The study aims to support an underserved population by assessing whether providing parents who experience bipolar disorder with online parenting support leads to their children having fewer behavioural problems. This project will also investigate if this intervention helps parents feel less stressed and more confident about their parenting, and to experience fewer mood or anxiety problems.
Requirements: PICs will be expected to support recruitment by identifying potential participants, through database searches. PICs would then be expected to make contact with these potential participants by letter, email, or phone to inform them of the study. In so doing, it is expected that PICs would provide the potential participants with a description of the study, an overview of what participation involves, and a link to the trial’s online registration of interest form. PICs will not be expected to provide participant information sheets or to consent participants.
Payments:
Service Support Costs : Preparation for database search 1hr -practice manager = £23.21
Database search 1hr - practice manager = £23.21
Check lists for Exclusions - GP (10pts ) =£9.00
Smell Test Direct - IRAS 285735 CPMS 46245
PIC Study inviting patient on behalf of the research site Newcastle - Clinical Ageing Research Unit (Sites need to be within a 1.5 hour drive of CAV)
Recruitment end date: March 2026
Aim: The Smell Test Direct study aims to better understand the link between loss of smell and risk of brain disease. This study, run by The Michael J. Fox Foundation for Parkinson’s Research, is exploring this link by providing study participants with a simple scratch-and-sniff test that they can do from home.
Requirements: Run the prebuilt search and approve list of patients to be contacted
Payments: Practice will receive £7 per patient consented to the study from their practice.
UK-EDI IRAS 258093
UK-EDI IRAS 258093
PIC Study for QE Hospital Gateshead
Recruitment end date: 31.12.2025
Aim:This is an observational cohort study aimed at determining the feasibility of detecting pancreatic cancer in individuals over fifty years of age who are newly diagnosed with Diabetes Mellitus (DM).
Requirements: GP Practices will act as PICs to refer potential participants to Secondary Care. Practices will be asked to sign PIC agreement, import & run health record searches, install pop up, database search and eligibility screening and mailout via Docmail.
Payment:Service Support Costs
Initial database search - £13.48
Initial patient eligibility check - £40.00
Maximum of 6* follow up database searches - £36.74
Maximum of 6* follow up eligibility checks - £15.00
Total SSCs available £135.22
*6 additional searches/checks expected for practices participating over the whole 28 month recruitment period
Research Costs
GP training - £90.00
Nurse training - £26.96
Upload to Docmail - £13.48
Subsequent uploads to Docmail** - £15.00
Total research costs available £135.44
**6 additional Docmail uploads expected for practices participating over the whole 28 month recruitment period
ASCEnD - IRAS: 1007468
PIC study referring to The CAPE Clinic, Newcastle
Recruitment end date: 31/08/2025
Aim: ASCEnD is a pragmatic open label RCT in bipolar depression of quetiapine vs aripiprazole/sertraline combination
Requirements: Practice to act as a PIC site for CNTW - recruitment will take place at the CAPE clinic in Newcastle Centre
Run a pre built search
Screen the list of patients to exclude anyone who is not eligible
Text out to eligible patients
Payments:
Service Support:
● Database search - £21
● Screen lists for exclusions - £90 (per 50 patients)
● Opportunistic invite per participant approached:
GP - £4.50
Pharmacist - £2.75
Practice Nurse - £1.16
Research costs:
PIC local Coordination and set up - £113.21
Mail out using Docmail (per mail out) £13.29 or Sending of Text Message to inform patients of study (per text out) £6.65
Sterling PMR - IRAS: 1005826
PIC study referring to The James Cook University Hospital and Newcastle Hospitals
Recruitment end date: 31/01/2026
Aim: A non commercial study trying to find out whether adding a disease-modifying anti-rheumatic drug (DMARD) to steroid treatment helps people with polymyalgia rheumatica.
Requirements: Practice to act as a PIC site for the study site, The James Cook University Hospital and Newcastle Hospitals.
Run a pre built search
Screen the list of patients to exclude anyone who is not eligible
Mail out via Docmail to eligible patients
Payments:
Service Support:
Database search £21
Eligibility check (exclusions) £44
Add pop-up to GP system to identify patients opportunistically during appointments £4
Research costs:
Study specific training (reading through guidelines for conducting search and mail out) £121 one off payment
**ON HOLD** An investigation of the efficacy of a novel sensory discrimination training device for the management of phantom limb pain: A randomised, single-blind placebo-controlled trial. [PHANTOM RELIEF Trial] CPMS ID: 57918, IRAS ID: 250336 PIC
Recruitment end date: April 2025
Aim: This study will investigate the efficacy of a novel, fully automated non-invasive medical device which delivers sensory discrimination training. Participants will receive the device to use in their own homes, remotely supported by qualified physiotherapist throughout participation.
Requirements: GP Practices will act as PICs to identify and invite potential participants. Practices will be asked to sign PIC agreement, import & run a search, eligibility screening and mailout via packs that the study team will provide. You may also be asked to send out a reminder mailout to those that havnt responded.
Payment:
Service Support Costs
Preparation and Database search £46.42
Checklists for Exclusions £9 per 5 participants
Reminder mail out checklist for exclusions £9 per 5 participants
Research Costs
Local coordination and set up £113.21
Send invite letters (include IDs to match responses) £3.32 per 5 participants
Send reminder invite letters to non-responders £2.19 per 5 participants
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