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AFLOAT Trial (Antibiotics For LRTI in Older AdulTs) CPMS ID: 56324IRAS ID: 1010353
Recruitment closes - 01/05/2027
Aim: The AFLOAT Trial will test whether placebo is non-inferior to antibiotics by assessing the duration of symptoms in patients presenting to primary with a lower respiratory tract infection.
Intervention: Participants will be randomised to receive either a five day course of doxycycline or a matched placebo and will be recruited when they present to primary care with symptoms.
Requirements:
Practice staff will be required to recruit eligible patients when they present during a routine appointment. This will require completion of :
Eligibility assessment
Consent
Medical review (as per standard care)
Completion of baseline forms including symptom severity rating, Health related Quality of Life questionnaire
Randomisation and dispensing of IMP
Baseline activities can be done after the routine appointment by a delegated member of practice staff, however this will need to be done on the same day.
A 28 day follow up medical notes review will also be required (approx. 15 minutes)
Payments:
Research cost
If practice does NOT store the IMP on-site:
SIV: £352
eCRF completion/data transfer/query resolution £68.25
Medical Notes review £11.75
If practice DOES store the IMP onsite
Receive the above research costs pus an extra:
IMP temperature monitoring: 11.75 one-off fee
Dispensing of IMP: £7.83 per patient
Service Support Costs
Opportunistic recruitment, identifying patients who present to the practice: £121.50 (one off fee)
Informed consent: £51 per patient
Eligibility assessment: £17 per patient
Excess Treatment Costs
£8.50 per patient
Medal study - IRAS: 1007662
Only open to EMIS practices
Recruitment end date -TBC
Aim: The MEDAL trial is looking at patients with acute lower back pain with or without leg pain or sciatica . Prticpants to be randomised to one of 6 analgesic ladders if prescribede ana;gesia is indicated.
Requirements: ● Identify and sign-post potential participants to the centralised MEDAL team who will check eligibility and take consent , check trial medication safety, final confirmation of eligibility, randomise patients and prescribe the allocated medication ladder as per trial protocol and as requested by participant in advance (caveated with the requirement of a GP sign off)
Payments:
Service Support Costs
Installation of Pop up - 23.21
Receptionist use of pop and send GP details of patients 5.26 (Per 10 patients)
Research Costs
Site Initiation visit (SIV) & training - £248- one off payment includes GPS, nurses and reception staff.
Per patient Payment -£50 - Concomitant medication check (10 mins - TC)
- Recording patient participation (5mins - RC)
- Final check of eligibility and Randomisation (10mins - RC)
- Review/reporting of participant AEs/ SAEs (IF REQUIRED)
- Pregnancy testing (IF REQUIRED)
Archiving at site - £500
Excess Treatment Costs
Proposed per participant ETC £237.99
ASYMPTOMATIC - Assessing Symptom-driven versus Maintenance Preventer Therapy for the Outpatient Management of AsThma In Children IRAS: 297649
Only open to EMIS practices that are signed upto CPRD
Recruitment end date: 31/12/2025
Aim: Study is investigating whether children with mild asthma should take their inhaled corticosteroids regularly, or when they have symptoms.
Requirements: Database search run every few months, mailout (invite letter generated from EMIS system), consent and use an online platform. Once the patient is randomised then the practice won't have any more study related appointments with participants. A research nurse can act as PI as long as GCP trained
Payments:
Service Support Costs
15 mins check review participant list - £22.50
30 mins consent-£45 per patient
Research Costs
£300 for set up
£32.70 for any additional reporting
£14.10 per patient recruited
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