Study Outcomes
Primary Care Studies delivered in the CRN West Midlands
Find out more about the study outcomes of some of the primary care research studies delivered here in the CRN West Midlands.
The TIME Study
Thank you for helping make the TIME study a success
In 2015- 2017, 349 GP practices in the West Midlands helped the study team with recruitment for the Treatment in Morning vs Evening (TIME) study, enabling them to recruit over 21,000 participants. GP practices in West Midlands recruited 4037 participants, the highest number of all the 15 Clinical Research Network geographical areas .Without your assistance, this study would not have been possible, and we would like to thank you again for your support in achieving this.
The study aimed to investigate whether evening dosing of usual antihypertensive medication improved major cardiovascular outcomes compared with morning dosing in patients with hypertension. The last participant follow-up was made at the end of March 2021, and the study database was locked in July2022 before analysis.
This large, prospective, randomised study has demonstrated that evening dosing of usual antihypertensive medication was not different from morning dosing in terms of major cardiovascular outcomes. The participants you invited and who consented to participate helped us to develop this important knowledge about high blood pressure treatment. The TIME study results will benefit the many people who take medicines to lower their blood pressure now and in the future.
The TIME study results have now been published in The Lancet. You can access the paper, and a lay summary, from our study homepage.
PANORAMIC Trial
Over ten thousand participants from right across the UK have now taken part in the NIHR-funded and supported PANORAMIC trial - which is by far the world’s largest study into new antiviral treatments against COVID-19 in community, ambulatory care.
The Global Anticoagulant Registry in the FIELD (Garfield) is a prospective, multicentre, international registry of patients newly diagnosed with atrial fibrillation (AF)
Two-year outcomes of UK patients newly diagnosed with atrial fibrillation: findings from the prospective observational cohort study GARFIELD-AF, read the abstract here
Health-led Employment Trials Evaluation
This report draws on the main findings across the various impact analyses for the evaluation of the Health Led Trials which were run in the West Midlands Combined Authority and Sheffield City Region. Research report carried out by the Institute for Employment Studies on behalf of the Department for Work and Pensions. Access the report here.
ARTIC PC
The Antibiotics for lower respiratory tract infection in children presenting in primary care - ARTIC PC trial explored the clinical effectiveness and cost-effectiveness of amoxicillin for uncomplicated lower respiratory tract infections in children both overall and in clinical subgroup. 432 children were randomised to oral amoxicillin or placebo. Children who were not randomised could participate in a parallel observational study.
The trial concluded that amoxicillin for chest infections in children is unlikely to be effective. General practitioners should support parents to self-manage at home and give clear communication about when and how to seek medical help if they continue to be concerned.