OOP Research

Richard Holleyman ST7 - Outcomes following hip surgery using registry data. PhD

Training Grade:

ST7

OOP (if research please state degree registered for):

Research - PhD

Location/Supervisors:

Newcastle University/Multiple

Summary of Project/OOPE:

My project studies outcomes following hip surgery using registry data from the National Hip Fracture Database (periprosthetic infection) and The UK Non-arthroplasty Hip Registry (outcomes of joint preservation surgery such as hip arthroscopy).

Specific Aims/Skills:

1. Deliver on the above

2. Build relationships with future collaborators

3. Increase understanding of statistical methodologies which underpin high quality observational studies.

Adam Farrier ST7 - Genetic process of chondrogenesis in vivo. PhD

Training Grade: ST7

OOP (if research please state degree registered for as shown below):

Research - PhD

Location/Supervisors:

Newcastle University Biosciences Institute, David Deehan, David Young

Summary of Project:

My project is focused around understanding the genetic process of Chondrogenesis in vivo. This involves in silico work to understand the epigenetic control of Chondrogenesis. The aim is to use this understanding to enhance the process of Chondrogenesis from a range of cell lines including mescenchymal stem cells using the latest CRISPR-cas9 based techniques for tissue engineering purposes. This understanding could be used to produce tissue engineered cartilage of similar quality to native joint hyaline cartilage as a potential future therapy for cartilage defects or osteoarthritis.

Specific aims

1. Develop proficiency in R data science coding

2. Prove Chondrogenesis can be enhanced in principle to lead on to future translational research

Helen Ingoe ST7 - Synthesis of contemporary evidence for the rib fracture fixation. MD and PGCert

OOPR (if research please state degree registered for):

MD and PG Cert (Research Methods)

Hull York Medical School

Location/Supervisors:

Professor Amar Rangan, Professor Catherine Hewitt; University of York and Dr Catriona McDaid; University of York

Summary of Project/OOPR:

I successfully completed my MD last year after taking a period of two years OOPR. I resided within the York Trials Unit which is the BOA’s Orthopaedic Research Centre (BOSRC) and was embedded within a lot of the day to day running of ongoing trials as well as the development of new projects. This was essentially an apprenticeship in trials and I was integrated within the day to day working of the trials unit. I completed modules which also secured me a PG Cert in research methods including, systematic review, randomised control trials health statistics as well as qualitative research.

My thesis centred on synthesising contemporary evidence for rib fracture fixation, to fill the gaps of knowledge that are required to inform a trial and provide recommendations for future study.

Specific Aims:

Systematic review of systematic reviews and a meta-analysis of primary research methods were used to examine effectiveness
Delphi consensus methods surveyed three international stakeholder groups to define a core outcome set and a consensus on indications and timing of rib fracture fixation
A United Kingdom (UK) survey assessed the provision of rib fracture care
An analysis of a UK trauma (TARN) database assessed factors that predict rib fixation and the outcomes of rib fracture patients

Ashley Scrimshire ST5 - Testing the effectiveness of quality improvement collaboratives for implementing change in the NHS. PhD

Training Grade:

ST5

OOP (if research please state degree registered for as shown below):

Research - PhD

Location/Supervisors:

Northumbria Healthcare NHS Foundation Trust – Prof Mike Reed

University of York – Dr Catriona McDaid & Prof David Torgerson

Summary of Project:

My project is a cluster randomised controlled trial testing the effectiveness of quality improvement collaboratives as a technique for implementing large scale change in the NHS. In particular I am looking at how collaboratives can be used to implement new preoperative pathways for anaemia screening and optimisation, and Staph. Aureus decolonisation, to improve postoperative outcomes following primary hip or knee replacement. This project has enabled me to develop my knowledge and experience in research, but also in leadership and large scale quality improvement. This work led to me working with other organisations such as NHS blood and Transplant and the GIRFT policy team in development of a national CQUIN target.

Specific aims:

1) Develop my research knowledge and experience of running a large scale trial

2) Complete my PhD

Will Fishley ST4 - Improving outcomes in arthroplasty. PhD

Training Grade: ST4

OOP(if research please state degree registered for as shown below):

Research - PhD

Location/Supervisors: Northumbria Healthcare NHS Foundation Trust (Mike Reed), University of York (Joy Adamson, Puvan Tharmanathan)

Summary of Project:

My research is focused on improving outcomes of arthroplasty surgery. I am developing a cohort study of patients undergoing total hip replacements and total knee replacements, and plan to run a randomised controlled trial within this. My academic work towards a PhD will be through the University of York. I will also be running a collaborative quality improvement project across multiple trusts.

Specific Aims/Skills:

1. Gain experience of designing and running a large cohort study

2. Gain experience of running a randomised controlled trial

3. Develop research and critical appraisal skills, and complete PhD

4. Run collaborative quality improvement project in arthroplasty surgery

Tony Sorial ST3 - Genetics and epigenetics of disabling MSK disease. PhD

Training Grade:

ST3

OOP (if research please state degree registered for):

Research - PhD

Location/Supervisors:

Newcastle University (David Deehan, John Loughlin), Washington University in St Louis, MO, USA (Farsh Guilak), Universität Wien, Vienna, Austria (Gerhard Wiche), University of Manchester (Judith Hoyland)

Summary of Project:

My project focusses on understanding the genetics and epigenetics of disabling musculoskeletal (MSK) diseases (mainly osteoarthritis). I aim to use this information to develop CRISPR-based, tissue engineered therapies from Mesenchymal Stem Cells (MSCs) and Human induced Pluripotent Stem Cells (HiPSCs). I will be spending 9 months in Newcastle then heading over to the USA for 18 months as a Fulbright scholar to work with a lab in St Louis then back to Newcastle with 4 weeks stops in Vienna and Manchester in Year 3.

My specific aims are:

1) Build translational link across multiple centres to bridge the gap between osteoarthritis genetics, tissue engineering and regenerative medicine

2) Apply acquired knowledge to develop novel therapies derived from MSCs and HiPSCs.

In future, this work aims to develop pathways for the production and

Sami Anjum ST2 - Can statins (via TLR4) attenuate the inflammatory response to orthopaedic wear

Training Grade: ST2

OOP (if research please state degree registered for as shown below):

Research - MD/PhD

Location/Supervisors:

Translational and Clinical Research Institue, Newcastle University

Professor Alison Tyson-Capper, Professor John Kirby, Professor David Deehan

Summary of Project:

Survival of total hip replacements is around 85% at 20 years with the most common reason for revision being aseptic loosening of the implant secondary to osteolysis, which is caused by immune-mediated reactions to implant debris. These debris can also cause pseudotumour formation. I have previously demonstrated that toll-like receptor 4 (TLR4), an innate immune receptor, can mediate these observed immune responses. Statin use in epidemiological studies has been associated with reduced overall risk of revision surgery after hip replacement. In-vitro studies have demonstrated the potential for statins to reduce orthopaedic debris-induced immune responses, in addition to potentially enhancing bone growth. As literature from cardiological investigations demonstrate that statins can reduce the expression of TLR4, this could be an exciting mechanism to exploit to reduce the host immune response to orthopaedic wear debris.

Specific Aims/Skills:

The aim of the project is to establish whether statins, via TLR4, can attenuate the inflammatory response to orthopaedic wear debris found within orthopaedic biomaterials and improve bone growth.

To investigate the ability of statins to attenuate the immune cytokine response in-vitro in response to a range of relevant orthopaedic biomaterials
To investigate the ability of statins to attenuate secreted factors responsible for pseudotumour formation and pro-inflammatory adhesion molecule expression in-vitro in response to biomaterials
To assess the ability of statins to enhance bone growth using in-vitro models
To determine if TLR4 is implicated in any observed change in immune response profile
To use this opportunity to identify novel mechanisms for translation for patient benefit, forge collaborations both within Newcastle University and other institutes which excel in immunotribological research, to generate data for an MD/PhD higher degree.

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