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Levitation Technology can be used to enrich viable organoids in culture prior to continued propagation due to its gentlest, large and low pressure technology. Organoids are too large and fragile to put through conventional sorting or enrichment methods.Â
Levitation Technology is the only technology that can enable biopharma/pharma late development work using organoids to study ex vivo multicellular models for drug response.
Levitation Technology can be used to enrich for the healthiest tissue dissociated cells used to create organoids in culture. Using LeviPrep Mouse Tissue Dissociation protocols, highly viable cells can be accessed upstream to organoid generation.
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Create consistent, viable, high-fitness samples for organoid generation
Clean up debris, and dead cells before organoid propagation
Enrich consistent viable and quality samples before cryopreservation
Create consistent, viable, high-fitness samples prior to cell-based assay
Reduce cell number to create test organoid cultures
Shorten timelines by accelerating growth
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Background Information
Organoids can be a powerful tool for a broad swath of research applications as they recapitulate organ functionality and recreate disease physiology in a simplified model system. In developing drugs or treatment plans, organoids can also be used in high-throughput screening assays to see an array of effects induced on varying tissue types.
The maintenance of the organoids is a critical step that still has its challenges. Passaging organoid lines for their continued survival relies on the enrichment of highly viable cells, and specific cell types from dissociated organoids for re-culture. If organoid lines are not properly passaged, and become non-viable, research efforts can be set back by months as new lines need to be derived or thawed.
Organoids can be frozen as a whole and dissociated in single cells. When researchers thaw a frozen organoid line, it takes time to get it to grow in a robust way. Factors like cell viability, the amount of cells frozen down and years of storage can impact the recovery of the line.
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