Abstract: Pittsburgh has changed considerably since deindustrialization, with a shift in industry from steel to medicine and reliance shifting from public to private infrastructure. Segregation patterns form in response to the economic status of a region. Exclusionary zoning codes have shaped the defined segregation patterns in Pittsburgh. As these zones become increasingly obsolete with the fall of the steel industry and the subsequent rise in a white-collar based economy, the potential for these zones to change becomes great. This study utilizes the Dissimilarity Index to measure changes in segregation levels in Pittsburgh’s twenty most segregated neighborhoods as measured in 1970, from then to 2020. This study found that segregation levels have lowered in all neighborhoods evaluated except one. This reveals that overall, Pittsburgh is desegregating. The results of this study also reflect the effects that private infrastructure, a decreasing population, and areas of concentrated poverty can have on the demographic populations of a city.