* Corresponding author,   # Equally contributed 

■ 2025

42.

Ikeda T*, Masujima Y, Watanabe K, Nishida A, Yamano M, Igarashi M, Sasaki N, Katoh H, Kimura I*.

"The free fatty acid receptor GPR164 maintains intestinal homeostasis and barrier function"

EMBO Rep. (2025) Oct 28 Online ahead of print  [Pubmed]

41.

Miyauchi E, Taida T, Uchiyama K, Nakanishi Y, Kato T, Koido S, Sasaki N, Ohkusa T, Sato N, Ohno H*.

"Smoking affects gut immune system of patients with inflammatory bowel diseases by modulating metabolomic profiles and mucosal microbiota"

GUT (2025) Aug 25 Online ahead of print  [Pubmed] プレスリリース

40.

Matsuzaki M, Imai A, Yanagisawa K, Oda T, Satsu H, Sasaki N*, Miyauchi E*.

"Mucin-dependent transcriptional dynamics of Akkermansia muciniphila in co-culture with human colonic organoids"

Biosci Biotechnol Biochem (2025) Oct 24: 89(11) 1649-1657 [Pubmed] プレスリリース

39.

Uchida S, Yokobori T*, Yanagisawa K, Erkhem-Ochir B, Dorjkhorloo G, Okami H, Katayama C, Shibasaki Y, Nakazawa N, Komine C, Shiraishi T, Okada T, Osone K, Kimura A, Sano A, Sakai M, Sasaki N, Shirabe K, Saeki H

"Intratumoral Lipopolysaccharide Positivity Related to Tumor-Associated Macrophage Infiltration and Poor Prognosis in Esophageal Squamous Cell Carcinoma"

Ann Surg Oncol (2025) Oct 32(10)8013-8023 [Pubmed]

38.

Sen A#, Imai A#, Miyauchi E, Yanagisawa K, Oda T, Sasaki F, Uchida S, Okada T, Yokobori T, Saeki H, Odamaki T, Sasaki N*.

"Comprehensive gene expression analysis of organoid-derived healthy human colonic epithelium and cancer cell line stimulated with live probiotic bacteria"

Sci Rep (2025) Jul 1 ; 15(1) 22325  [Pubmed] プレスリリース

37.

Takeuchi T, Miyauchi E, Nakanishi Y, Ito Y, Kato T, Yaguchi K, Kawasumi M, Tachibana N, Ito A, Shimamoto S, Matuyama A, Sasaki N, Kimura I, Ohno H*

"Acetylated cellulose suppressed body mass gain through gut commensals consuming host-accessible carbohydrates"

Cell Metab (2025) May 14; S1550-4131(15)00223-2  [Pubmed]

36.

Miyauchi E, Yamazaki K, Tsuboi Y, Nakajima T, Ono S, Mizuno K, Takahashi N, Imamura K, Morita H, Miura N, Okuda S, Kikuchi J, Sasaki N, Ohno H, Yamazaki K*

"Patients with periodontitis exhibit persistent dysbiosis of the gut microbiota and distinct serum metabolome"

J Oral Microbio (2025) May 8; 17(1)2499284  [Pubmed]  プレスリリース

35.

Gotoh N, Oda T, Kitamura Y, Shiraishi N, Aoyagi R, Omori A, Yanagisawa K, Iida M, Itai Y, Negishi H, Matsumura I, Kasamatsu T, Miyauchi E, Sasaki N, Takada S, Yokohama A, Handa H, Murakami H, Saitoh T*

"APEX1 Polymorphisms Affect Acute Myeloid Leukemia Risk, and Its Expression Is Involved in Cell Proliferation and Differentiation"

Int J Lab Hematol (2025) Apr. 47(2): 276-287 [Pubmed]

34.

Matsumura I, Oda T, Kasamatsu T, Murakami Y, Ishihara R, Ohmori A, Matsumoto A, Gotoh N, Kobayashi N, Miyazawa Y, Ogawa Y, Yokohama A, Sasaki N, Saitoh T, Handa H*

"Role of Rac1 in p53-Related Proliferation and Drug Sensitivity in Multiple Myeloma"

Cancers (2025) Jan 29; 17(3): 461  [Pubmed]

■ 2024

33.

Matsumoto R, Ogata K, Takahashi D, Kinashi Y, Yamada T, Morita R, Tanaka K, Hattori K, Endo M, Fujimura Y, Sasaki N, Ohno H, Ishihama Y, Kimura S*, Hase K*

"AP-1B regulates interactions of epithelial cells and intraepithelial lymphocytes in the intestine"

Cell Mol Life Sci (2024) Oct 5; 81(1):425 [Pubmed]

■ 2023

32.

Umeda S, Sujino T, Miyamoto K, Yoshimatsu Y, Harada Y, Nishiyama K, Aoto Y, Adachi K, Hayashi N, Amafuji K, Moritoki N, Shibata S, Sasaki N, Mita M, Tanemoto S, Ono K, Mikami Y, Sasabe J, Takabayashi K, Hosoe N, Suzuki T, Sato T, Atarashi K, Teratani T, Ogata H, Nakamoto N, Shiomi D, Ashida H, Kanai T*

"D-amino Acids Ameliorate Experimental Colitis and Cholangitis by Inhibiting Growth of Proteobacteria: Potential Therapeutic Role in Inflammatory Bowel Disease. "

Cell Mol Gastroenterol Hepatol  (2023) Aug 9; 16(6):1011-1-31 [Pubmed]

31.

Ishihara R, Oda T, Murakami Y, Matsumura I, Watanabe S, Asao Y, Masuda Y, Gotoh N, Kasamatsu T, Takei H, Kobayashi N, Sasaki N, Saitoh T, Murakami H, Handa H*.

"Myeloma Microenvironmental TIMP1 Induces the Invasive Phenotype in Fibroblasts to Modulate Disease Progression"

Int J Mol Sci (2023) Jan 22; 24(3):2216[Pubmed]

30.

Oda T*, Gotoh N, Kasamatsu T, Handa H, Saitoh T, Sasaki N*.

“DNA damage-induced cellular senescence is regulated by 53BP1 accumulation in the nuclear foci and phase separation”

Cell Prolif (2023) Jan 15;e13398  [Pubmed]

■ 2022 

29.

Yamazaki K, Miyauchi E, Kato T, Sato K, Suda W, Tsuzuno T, Yamada-Hara M, Sasaki N, Ohno H, Yamazaki K*.

“Dysbiotic human oral microbiota alters systemic metabolism via modulation of gut microbiota in germ-free mice”

J Oral Microbiol (2022) Aug 11;14(1):2110194. [Pubmed]

28.

Yoshimatsu Y, Sujino T*, Miyamoto K, Harada Y, Tanemoto S, Ono K, Umeda S, Yoshida K, Teratani T, Suzuki T, Mikami Y, Nakamoto N, Sasaki N, Takabayashi K, Hosoe N, Ogata H, Sawada K, Imamura T, Yoshimura A, Kanai T*. 

“Aryl hydrocarbon receptor signals in epithelial cells govern the recruitment and location of Helios+ Tregs in the gut”

Cell Rep (2022) May 10;39(6):110773.[Pubmed]

■ 2020 (独立以前の業績)

27.

Sasaki N*, Miyamoto K, Maslowski KM, Ohno H, Kanai T, Sato T*. 

“Development of a scalable co-culture system for gut anaerobes and human colon epithelium”

Gastroenterology (2020) 159(1): 388-390.[Pubmed]

■ 2019

26.

Nanki K, Fujii M, Shimokawa M, Matano M, Nishikori S, Date S, Takano A, Toshimitsu K, Ohta Y, Takahashi S, Sugimoto S, Ishimaru K, Kawasaki K, Nagai Y, Ishii R, Yoshida K, Sasaki N, Ishihara S, Kanai T, Sato T*. 

“Somatic inflammatory gene mutations accumulate in human ulcerative colitis epithelium”

Nature (2019) 577(7789): 254-259.[Pubmed]

25.

Van Es JH, Wiebrands K, Lopez-Iglesias C, van de Wetering M, Zeinstra L, van den Born M, Korving J, Sasaki N, Peters P.J.,  van Oudenaarden A., Clevers H*. 

“Enteroendocrine and tuft cells support Lgr5 stem cells on Paneth cell depletion”

Proc Natl Acad Sci USA (2019) 116(52): 26599-26605.[Pubmed]

24.

Han S, Fink J, Jörg DJ, Lee E, Yum MK, Chatzeli L, Merker SR, Josserand M, Trendafilova T, Andersson-Rolf A, Dabrowska C, Kim H, Naumann R, Lee JH, Sasaki N, Mort RL, Basak O, Clevers H, Stange DE, Philpott A, Kim JK, Simons BD, Koo BK*.

“Defining the Identity and Dynamics of Adult Gastric Isthmus Stem Cells”

Cell Stem Cell (2019) 25(3): 342-356.[Pubmed]

23.

Bolhaqueiro A.C.F, Ponsioen B, Bakker B, Klaasen S, Kucukkose E, van Jaarsveld R.H, Vivie J, Verlaan-Klink I, Hami N, Spierings D.C.J, Sasaki N, Dutta D, Boj S.F, Vries R.G.J, Lansdorp P.M, van de Wetering M, van Oudenaarden A, Clevers H, Kranenburg O, Foijer F, Snippert H.J.G*, Kops G.J.P.*.

“Ongoing chromosomal instability and karyotype evolution in human colorectal cancer organoids”

Nature Genet. (2019) 51(5): 824-834.[Pubmed]

22.

Nakamoto N, Sasaki N., Aoki R, Miyamoto K, Teratani T, Suzuki T, Chu PS, Taniki N, Yamaguchi A, Kanamori M, Suda W, Kamada N, Hattori M, Yoshimura A, Honda K, Sato T*, Kanai T*.

“Gut pathobionts underlie intestinal barrier dysfunction and liver T helper 17 cell immune response in primary sclerosing cholangitis”

Nature Microbiology (2019) 4(3): 492-503.[Pubmed]

■ 2018

21.

Mito A, Nakano Y,Saitoh T, Gouraud SSS, Yamaguchi Y, Sato T, Sasaki N., Kojima-Aikawa K*.

“Lectin ZG16p inhibits proliferation of human colorectal cancer cells via its carbohydrate-binding sites”

Glycobiology (2018) 28(1): 21-31.[Pubmed]

20.

Sasaki N#, Roerink SF#, Lee-Six H, Young M, Alexandrov LB, Behjati S, Mitchell TJ, Lightfoot H, Egan DA, Pronk A, Smakman N, van Gorp J, Anderson E, Gamble S, Alder C, van de Wetering M, Campbell PJ, Stratton MR*, Clevers H*.

“Intra-tumour diversification in colorectal cancer at the single-cell level”

Nature (2018) 556(7702): 457-462. [Pubmed]

19.

Borten M, Bajikar S, Sasaki N., Clevers H, Janes K*. 

“Automated brightfield morphometry of 3D organoid populations by OrganoSeg”

Sci. Rep. (2018) 8(1): 5318. [Pubmed]

■ 2017

18.

Drost J, van Boxtel R, Blokzijl F, Mizutani T, Sasaki N, Sasselli V, de Ligt J, Behjati S, Grolleman JE, van Wezel T, Nik-Zainal S, Kuiper RP, Cuppen E, Clevers H*.

“Use of CRISPR-modified human stem cell organoids to study the origin of mutational signatures in cancer”

Science (2017) 358(6360): 234-238.[Pubmed]

■ 2016

17.

Blokzijl F, de Ligt J, Jager M, Sasselli V, Roerink S, Sasaki N, Huch M, Boymans S, Kuijk E, Prins P, Nijman IJ, Martincorena I, Mokry M, Wiegerinck CL, Middendorp S, Sato T, Schwank G, Nieuwenhuis EE, Verstegen MM, van der Laan LJ, de Jonge J, IJzermans JN, Vries RG, van de Wetering M, Stratton MR, Clevers H, Cuppen E*, van Boxtel R.

“Tissue-specific mutation accumulation in human adult stem cells during life”

Nature (2016) 538(7624): 260-264.[Pubmed]

16.

Sasaki N, Sachs N, Wiebrands K, Ellenbroek SI, Fumagalli A, Lyubimova A, Begthel H, van den Born M, van Es JH, Karthaus WR, Li VS, López-Iglesias C, Peters PJ, van Rheenen J, van Oudenaarden A, Clevers H*.

“Reg4+ deep crypt secretory cells function as epithelial niche for Lgr5+ stem cells in colon”

Proc Natl Acad Sci USA (2016) 113(37): E5399-407.[Pubmed]

■ 2015

15.

Grün D, Lyubimova A, Kester L, Weibrands K, Basak O, Sasaki N, Clevers H, van Oudenaarden A*.

“Single-cell mRNA sequencing reveals rare intestinal cell types”

Nature (2015) 525(7568): 251-5.[Pubmed]

14.

Huch M, Gehart H, van Boxtel R, Hamer K, Blokzijl F, Verstegen MM, Ellis E, van Wenum M, Fuchs SA, de Ligt J, van de Wetering M, Sasaki  N, Boers SJ, Kemperman H, de Jonge J, Ijzermans JN, Nieuwenhuis EE, Hoekstra R, Strom S, Vries RR, van der Laan LJ, Cuppen E, Clevers H*.

“Long-term culture of genome-stable bipotent stem cells from adult human liver”

Cell (2015) 160(1-2): 299-312.[Pubmed]

■ 2013

13.

Schwank G, Koo BK, Sasselli V, Dekkers JF, Heo I, Demircan T, Sasaki N, Boymans S, Cuppen E, van der Ent CK, Nieuwenhuis EE, Beekman JM, Clevers H*.

“Functional repair of CFTR by CRISPR/Cas9 in intestinal stem cell organoid of cystic fibrosis patients”

Cell Stem Cell (2013) 13(6): 653-658.[Pubmed]

12.

Schwank G, Andersson-Rolf A, Koo BK, Sasaki N, Clevers H*.

“Generation of BAC transgenic epithelial organoids”

Plos One (2013) 8(10): e76871.[Pubmed]

11.

Huch M, Dorrell C, Boj SF, van ES JH, Li VS, van de Wetering M, Sato T, Hamer K, Sasaki N, Finegold MJ, Haft A, Vries RG, Grompe M, Clevers H*.

“In vitro expansion of single Lgr5+ liver stem cells induced by Wnt-driven regeneration”

Nature (2013) 494(7436): 247-250.[Pubmed]

10.

Aoyama N, Yamakawa T, Sasamura T, Yoshida Y, Ohori M, Okubo H, Iida E, Sasaki N, Ueda R, Matsuno K*.

“Loss- and gain-of-function analyses of vacuolar protein sorting 2 in Notch signaling of Drosophila melanogaster”

Genes Genet Syst. (2013) 88(1): 45-57.[Pubmed]

■ 2012

9.

van Es JH, Sato T, van de Wetering M, Lyubimova A, Nee AN, Gregorieff A, Sasaki N, Zeinstra L, van den Born M, Korving J, Martens AC, Barker N, van Oudenaarden A, Clevers H*.

“Dll1+ secretory progenitor cells revert to stem cells upon crypt damage”

Nat Cell Biol. (2012) 14(10): 1099-1104.[Pubmed]

■ 2011年以前の業績 (消化管業界へ入門前)

8.

Oyama T, Harigaya K, Sasaki N, Okamura Y, Kokubo H, Saga Y, Hozumi K, Suganami A, Tamura Y, Nagase T, Koga H, Nishimura M, Sakamoto R, Sato M, Yoshida N, Kitagawa M*.

“Mastermind-like 1 (MamL1) and mastermind-like 3 (MamL3) are essential for Notch signaling in vivo”

Development (2011) 138(23): 5235-5246.[Pubmed]

7.

Sasaki N, Kiso M, Kitagawa M, Saga Y*.

“The repression of Notch signaling occurs via the destabilization of mastermind-like 1 by Mesp2 and is essential for somitogenesis”

Development (2011) 138(1): 55-64.[Pubmed]

6.

Cornier AS, Staehling-Hampton K, Delventhal KM, Saga Y, Caubet JF, Sasaki N, Ellard S, Young E, Ramirez N, Carlo SE, Torres J, Emans JB, Turnpenny PD, Pourquié O*.

“Mutations in the MESP2 gene cause spondylothoracic dysostosis/Jarcho-Levin syndrome”

Am J Hum Genet. (2008) 82(6):1334-1341.[Pubmed]

5.

Sasaki N#, Morimoto M#, Oginuma M, Kiso M, Igarashi K, Aizaki K, Kanno J, Saga Y*.

“The negative regulation of Mesp2 by mouse Ripply2 is required to establish the rostro-caudal patterning within a somite”

Development (2007) 134(7):1561-1569.[Pubmed]

4.

Sasamura T, Ishikawa HO, Sasaki N, Higashi S, Kanai M, Nakao S, Ayukawa T, Aigaki T, Noda K, Miyoshi E, Taniguchi N, Matsuno K*.

“The O-fucosyltransferase O-fut1 is an extracellular component that is essential for the constitutive endocytic trafficking of Notch in Drosophila”

Development (2007) 134(7): 1347-1356.[Pubmed]

3.

Sasaki N, Sasamura T, Ishikawa HO, Kanai M, Ueda R, Saigo K, Matsuno K*.

“Polarized exocytosis and transcytosis of Notch during its apical localization in Drosophila epithelial cells”

Genes Cells (2007) 12(1): 89-103.[Pubmed]

2.  

Morimoto M, Kiso M, Sasaki N, Saga Y*.

“Cooperative Mesp activity is required for normal somitogenesis along the anterior-posterior axis”

Dev. Biol. (2006) 300(2): 687-98.[Pubmed]

1.

Sasamura T, Sasaki N, Miyashita F, Nakao S, Ishikawa HO, Ito M, Kitagawa M, Harigaya K, Spana E, Bilder D, Perrimon N, Matsuno K*.

“neurotic, a novel maternal neurogenic gene, encodes an O-fucosyltransferase that is essential for Notch-Delta interactions”

Development (2003) 130(20):4785-4795.[Pubmed]

12. 佐々木 伸雄*

｢オルガノイドを用いた粘膜エコシステムデザイン学｣

 腸内細菌学会誌  2024年10月  

11. 今井 淳稀，佐々木 伸雄*，佐藤 俊朗

｢ヒト大腸オルガノイドを用いた腸内細菌との共培養研究｣

 腸内細菌学会誌  2024年8月  

10. 今井 淳稀，佐々木 伸雄*

｢腸内細菌研究における腸管オルガノイド｣

  臨床免疫・アレルギー科  2024年1月  

9. 内田 真太郎，宮内 栄治*

｢腸管粘膜付着細菌叢の解析法｣

  臨床免疫・アレルギー科  2024年1月  

8. 宮内 栄治*，佐々木　伸雄*

｢腸内代謝物質を介した免疫系の修飾｣

日本生化学会誌 腸内デザインに向けた代謝物質の機能理解 (佐々木 伸雄，福田 真嗣 / 編)  2023年9月  

7. 佐々木　伸雄*

｢腸内環境を自在にデザインする未来の創生を目指し｣

The Kitakanto Journal  2023年2月  

6. 佐々木　伸雄*, 小田 司，佐藤 俊朗*

｢腸オルガノイド｣

臨床免疫・アレルギー科  2021年11月

5. 佐々木　伸雄*

｢腸内細菌-宿主細胞の相互作用メカニズムを紐解く新規共培養系の開発｣

臨床免疫・アレルギー科  2021年1月

4. 佐々木　伸雄*, クレバース ハンス.

｢1細胞レベルで明らかにされた大腸がんの腫瘍内不均一性｣

臨床免疫・アレルギー科  2019年1月，71(1):86-91.

3. Sasaki N, Clevers H*.

“Studying cellular heterogeneity and drug sensitivity in colorectal cancer using organoid technology”

Curr. Opin. Genet. Dev. (2018) 52: 117-122. [Pubmed]

2. 佐々木　伸雄*, クレバース ハンス.

｢大腸がんにおいて1細胞のレベルで明らかにされた単一の腫瘍における不均一性｣

ライフサイエンス新着レビュー  2018年 [On line]

1. 佐々木　伸雄*, クレバース ハンス.

｢大腸幹細胞特異的ニッシェによる粘膜上皮の恒常性維持機構｣

臨床免疫・アレルギー科  2016年10月，66(4):407-412.

9. 佐々木　伸雄*

｢腸内細菌叢は肥満や糖尿病と密接な関係がある｣

カラー図解 人体の細胞生物学【改訂第2版】（坂井建雄・石崎泰樹 / 監修）2025年1月 258-259. 日本医事新報社

8. 柳澤 宏太，今井 淳稀，佐々木　伸雄*

｢腸管オルガノイドを用いた宿主-腸内細菌の相互作用検証システムの開発｣

オルガノイド研究（谷口 英樹 / 監修）2024年8月 209-217. エヌ・ティー・エス

7. 佐々木　伸雄*

｢オルガノイドが切り拓く腸内細菌学の新時代｣

実験医学増刊  オルガノイドがもたらすライフサイエンス革命（武部 貴則 / 編）2024年3月 208-213. 羊土社

6. 宣　旭，佐々木　伸雄*

｢第8章-3　オルガノイドを用いた解析｣

実験医学別冊  改訂版もっとよくわかる！腸内細菌叢（福田　真嗣 / 編）2022年11月 113-117. 羊土社

5. 佐々木　伸雄*，金井 隆典，佐藤 俊朗*．

｢オルガノイド培養法を用いた宿主-細菌の相互作用に関する研究｣

実験医学別冊  決定版オルガノイド実験スタンダード（佐藤 俊朗・武部 隆典・永楽 元次/編）2019年 334-340. 羊土社

4. Sasaki N, Sato T, Hans Clevers*.

“Intestinal Epithelial Lgr5+ Stem Cell Niche and organoid”

Biology and Engineering of Stem Cell Niche (Edited by Ajaykumar Vishwakarma, Jeffrey M. Karp) (2017) 111-125.

3. 佐々木　伸雄，佐藤 俊朗*．

｢腸管上皮オルガノイド：幹細胞制御機構の理解と腸管オルガノイド培養法｣

実験医学増刊  再生医療と疾患解明の鍵となる組織幹細胞（戸田口 淳也・長澤 丘司/編）2016年 34(17): 90-96. 羊土社

2. 佐々木　伸雄*．

｢筋｣

モデル動物利用マニュアル〜生物機能モデルと新しいリソース・リサーチツール (小幡裕一・城石俊彦・芹川忠夫・田中啓二・米川博道/編). 

2011年2月 108-110. エル・アイ・シー

1. 笹村　剛司，佐々木　伸雄，石川　裕之，松野　健治*．

｢Notch情報伝達系における糖鎖修飾の機能｣

糖鎖科学の新展開〜機能解明・次世代材料・医薬品開発に向けて〜 　(谷口直之・伊藤幸成/監修) エヌ・ティー・エス 2005年8月 265-272.

佐藤 俊朗，佐々木 伸雄

｢上皮細胞培養用培養容器及びその使用｣．日本特許庁．特開2024-28791(P2024-28791A)

中本 伸宏，佐々木 伸雄，青木 亮，宮本 健太郎，佐藤 俊朗，金井 隆典．

｢肝臓で炎症を誘導する、Klebsiella pneumoniae菌株｣．日本特許庁．特開2019-187416(P2019-187416A)