Fight or Flight: Stress Response & Recovery -Nicolette V.

Powtoon: Stressed Out!

Created by Karissa vanEgmond and Sara Kamstra, May 2017

Powerpoint: Fight or Flight

Created by Stephanie Knol, Ashley Lof, and Kylie Hordyk, January 2018

Fight or Flight

The fight or flight concept was first discovered by a physiologist named Walter Cannon in the 1920's . He first mentioned it about animals and how animals react to different variables of stress to gain energy to survive. This made people come to the realization that everyone has that wiring in their brain -- an automatic, innate response for dealing with stress. This determines whether we fight or flee from a stressor or any bodily harm. When our fight or flight response is activated, it sends out different hormones in our body (Goldstein, 2011). The fight or flight response is also called hyperarousal or the acute stress response.

What is stress?

We all get stressed at times and it depends on the person as to what degree of stress they can deal with. When our body is in a state of homeostasis, we are relaxed and we can say that everything is leveled out. But when something happens and we go through a trigger, trauma, or stimuli, our body moves from a state of homeostasis to a stressed state. When there is a threat, the sympathetic nerve fibres of the autonomic nervous system are activated and this leads to the release of certain hormones from the endocrine system (Britannia, 2016).


General Adaptation Syndrome

Hans Selye, a Canadian endocrinologist, described the body's response to stress with these stages:

1. Fight or flight response is the first alarm reaction. Your brain sends a message to your adrenal gland to release epinephrine (adrenaline) into your body and this starts preparing your body so it can react to danger. Your adrenaline gland also releases norepinephrine (noradrenaline) which causes a lot of the same reactions in your body.

2. Resistance stage is when the body tries to deal with the stress. The body releases the stress hormone, cortisol, which has many damaging effects. If the stress stops, the body normalizes; if the stress continues, the body adapts to it.

3. Exhaustion stage is when the body's resources are depleted; the body function is impaired and this can eventually cause death. The harmful long term effects of cortisol increase, and your immune system is suppressed. Your body not only feels drained mentally, but also physically (CalmClinic, 2017).The Fight-or-Flight Response

What causes stress?

  • Physical - for example, long distance running and your body becomes fatigued
  • Psychological or Emotional - for example, a hectic or high-pressure job or a traumatic experience
  • Resisting something you do not want to do
  • Getting scared
  • Long term stress caused by stimuli coming repeatedly

Fight or flight response is produced when the hypothalamus activates these two systems:

1. The sympathetic nervous system uses nerve pathways to initiate reactions in the body. This nervous system sends out impulses to glands and tells the adrenal medulla to release both epinephrine (adrenaline) and norepinephrine (noradrenaline) into the blood stream. These stress hormones cause many changes in the body, such as increase in heart rate and blood pressure (Layton, 2005).

2. The adrenal-cortical system uses the bloodstream. The adrenal-cortical-system is activated when the hypothalamus releases corticotrophin releasing factor (CRF) into the pituitary gland. The pituitary gland, which is a major endocrine gland, secretes the hormone adrenocorticotropic (ACTH) and it moves through the bloodstream and when it arrives at the adrenal cortex it activates the release of about 30 different hormones (Layton, 2005).

When stressed, the sudden flood of epinephrine, norepinephrine and other hormones cause many symptoms and changes in the body.

Main Stress Response Hormones

The 3 main hormones that respond to our stress are epinephrine (adrenaline), cortisol, and norepinephrine .

1. Epinephrine:

      • The hormone epinephrine is also called adrenaline and prepares the body for a fight or flight response. It increases the heart rate, breathing rate, opens the airways for better air flow, dilates blood vessels in the skeletal muscles, and mobilizes energy stores.
      • In a stressful situation your adrenal glands signal to produce adrenaline. For example, if you're changing car lanes and there is a car beside you. Your heart beat will rapidly increase, and you will breath faster. This is your adrenaline taking place.

2. Norepinephrine:

      • Norepinephrine is very similar to adrenaline and this hormone causes you to become more awake and acts like a backup from adrenaline.
      • This hormone has some of the same effects as epinephrine, but also increases blood pressure and affects the amygdala.
    • Both epinephrine and norepinephrine influence the conversion of glycogen and glucose and also the conversion of fats to fatty acids, which increases the energy supply and prepares the muscles to be able to respond if they are needed.

3. Cortisol:

    • This hormone promotes and pushes amino acids to convert into glucose and it influences fats to convert into fatty acids. The glucose increases our blood flow and the fatty acids increase our heart rate and speed up our breathing.
    • Cortisol is a steroid hormone also produced by the adrenal gland, but instead of reacting immediately it takes a couple minutes. First your amygdala in your brain signals that there is a threat and brings this message to your hypothalamus which signals to produce an CRH hormone and this hormone signals to produce the ACTH hormone. After all these steps, the ACTH hormone signals to your adrenal gland to make cortisol.
    • This stress hormone is also captured in the hair shaft and there is a link between the cortisol levels in hair and the risk of having a stress-related heart attack (Klein, 2013).

Some other stress hormones are:

  • Glucagon: glucose is converted to glycogen to increase blood sugar
  • Insulin: will decrease in production which will increase blood sugar level
  • Antidiuretic hormone (ADH): retains water to increase blood pressure

Adrenaline and noradrenline are two separate but related hormones and neurotransmitters.They are produced in the medulla of the adrenal glands and in some neurons of the central nervous system. They are released into the bloodstream and serve as chemical mediators, and also convey the nerve impulses to various organs. Adrenaline has many different actions depending on the type of cells it is acting upon. However, the overall effect of adrenaline is to prepare the body for the ‘fight or flight’ response in times of stress, i.e. for vigorous and/or sudden action. Key actions of adrenaline include increasing the heart rate, increasing blood pressure, expanding the air passages of the lungs, enlarging the pupil in the eye (see photo), redistributing blood to the muscles and altering the body’s metabolism, so as to maximise blood glucose levels (primarily for the brain). A closely related hormone, noradrenaline, is released mainly from the nerve endings of the sympathetic nervous system (as well as in relatively small amounts from the adrenal medulla). There is a continuous low level of activity of the sympathetic nervous system resulting in release of noradrenaline into the circulation, but adrenaline release is only increased at times of acute stress

A quick overview of the Fight or Flight Stress Response.

https://www.youtube.com/watch?v=JtSP7gJuRFE

What are the symptoms of stress?

  • blood pressure, respiration rate, and heart rate increase
  • muscle tension
  • pupils dilate
  • frequent urination
  • irritability
  • tiredness
  • trouble sleeping
  • increase blood flow to the brain and skeletal muscles
  • upset stomach
  • headache
  • shaking hands
  • perspiring more than normal

This video by Bozeman Science clearly explains the fight or flight concept and how our body reacts to stress.

https://www.youtube.com/watch?v=m2GywoS77qc

What are the long term effects of stress?

There are many long term effects of stress. If the hormone cortisol continues to run through your body, then it is hard to stop the harmful effects of cortisol. You may experience high blood pressure, and with that is an increased rate for heart attacks. Your immune system will be in a weakened state, which could lead to a risk for illnesses. Your organs can start to experience structural damage because they have a harder time fighting against the stress hormones. Rashes and hives, stomach and intestinal problems, sleep disorders and depression are other examples of the long term effects of stress.

This video goes into depth about how stress can have a lasting effect on your body. It goes into great detail how stress causes you to have physical ailments.

https://www.youtube.com/watch?v=1B0PGFnYnv4

How should we deal with stress?

  • organize your time
  • get more sleep
  • avoid drinking coffee, caffeinated drinks, any alcohol. These drinks may make you feel better at the time but can cause you to crash.
  • if it doesn't go away, go to the doctor
  • communicate to others about your stress
  • live a healthy lifestyle
  • get proper nutrition
  • relaxation
  • get physical exercise
  • practice breathing exercises
  • set realistic goals and plan to achieve them
  • remove the stressors (Harvard Health Publ. 2016)

A concluding video summarizing a lot of the material mentioned.

https://www.youtube.com/watch?v=sQj6GMrt8EE

Pictures:

1. Berczi, I. Walter Cannons Flight or Fight Response. (n.d.).Retrieved from ttps://home.cc.umanitoba.ca/~berczii/hans-selye/walter-cannon-fight-or-flight-response.html

2. Wikipedia. (n.d.). Retrieved from https://en.wikipedia.org/wiki/Fight-or-flight_response

3. Cherry, K. (2016. July 20). Fight-or-Flight Response - Why is it Important? Retrieved from https://www.verywell.com/what-is-the-fight-or-flight-response-2795194

4. Layton, J. (2005. September). How Fear Works. Retrieved from http://science.howstuffworks.com/life/inside-the-mind/emotions/fear2.htm

5. Understanding the Amazing Flight or Fight Response. (n.d.). Retrieved from http://www.thinklikeahorse.org/flight_or_fight.html

6. Ranabir, S. (2011. March 15). Stress. Retrieved from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3079864

7. Stress Cartoons. (n.d.). Retrieved from http://cartoonistforhire.co.uk/CartoonStudio/StressCartoons.html


References: