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Why are they important?
Why are they important?
These factors are important for cell growth and help control the timing of cell division. Information from both inside and outside of the cell are used to help regulate the cell cycle. (Khan Academy, The cell cycle is highly regulated, 2008)
Internal Factors
Internal Factors
Cyclins and CDKs
p53 Gene
Oncogenes
(Khan Academy, The cell cycle is highly regulated, 2008)
External Factor
External Factor
Growth Factors:
Contact Inhibition
(Khan Academy, The cell cycle is highly regulated, 2008)
External Factors Explained:
External Factors Explained:
Growth Factors:
Growth Factors:
Protein that are released from other cells are used to stimulate cell division. (Mrs.Matarrese's notes)
Contact Inhibition:
Contact Inhibition:
To prevent overgrowth, cells stop diving when they touch their neighboring cell. (Mrs.Matarrese's notes)
Internal Factors Explained
Internal Factors Explained
Cyclins and CDKs
Cyclins and CDKs
Cyclin is a protein that regulates the to process of the cell cycle.
CDKs (Cyclin-Dependent Kinases), This targets proteins to move the cell through the cell cycle.
(Khan Academy, The cell cycle is highly regulated, 2008)
p53 Genes
p53 Genes
p53 Gene: The genes are known as the "gaurdian of the genome", The gene stops the cell cycle whenever it sense DNA damage and activates DNA repair (p53 can trigger apoptosis).
(Khan Academy, The cell cycle is highly regulated, 2008)
Oncogenes
Oncogenes
Oncogenes: These are mutated genes that may lead to a unorganized cell division. (May lead to cancer).
(Khan Academy, The cell cycle is highly regulated, 2008)
Bibliography:
Image Hyperlinks:
Pritzter School- Cancer cell
Pinterest- Internal and External Factor
ScienceDirect- Growth factors
Nature- Contact Inhibition
PraxilLabs- Cyclins and CDKs
Wikipedia- p53 Genes
Youtube - Oncogene
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