Branham's core science courses are aligned with the New Generation Science Standards. All students begin with Biology their 9th grade year. Students will take Chemistry in 10th grade and Physics in 11th grade. All AP science courses are available to take after the completion of the prerequisites (biology and chemistry).

Biology is a lab science class that focuses on developing and mastering scientific and academic skills while exploring the interactions between life and Earth. Students will leave the class with the skills to be successful in all future science classes at Branham.