Margarita Theodoropoulou

Current Position

• Post-doctoral Research Fellow at the Department of Computer Science and Biomedical Informatics, University of Thessaly.

Past Positions

• • Post-doctoral Research Fellow at the Section of Cell Biology and Biophysics, Department of Biology, School of Sciences, National and Kapodistrian University of Athens, Athens, Greece

Education

• • 2002-2008: B.Sc. in Biology, National and Kapodistrian University of Athens

  • 2008-2010: M.Sc. in Bioinformatics, National and Kapodistrian University of Athens

  • 2009-2014: Ph.D. in ‘Bioinformatics’, National and Kapodistrian University of Athens

Research interests

Cell Biology, Computational Biology, Bioinformatics

• • Biological Databases

  • Sequence Analysis

  • Transmembrane proteins

  • Pharmacogenomics

  • Protein-protein Interactions

  • Signal Transduction HMMs, ANNs

Publications

• Theodoropoulou M.C., Bagos P.G., Spyropoulos I.C. and Hamodrakas S.J., “gpDB: a database of GPCRs, G-proteins, effectors and their interactions.” Bioinformatics, 2008. 24(12): p. 1471-2. (Impact factor: 5,468, Citations: 27)

• Satagopam, V.P., Theodoropoulou, M.C., Stampolakis, C.K., Pavlopoulos, G.A., Papandreou, N.C., Bagos, P.G., Schneider, R., Hamodrakas, S.J. (2010) “GPCRs, G-proteins, Effectors and their interactions: Human-gpDB, a database employing advanced visualization tools and data integration techniques.” Database (Oxford),, Vol. 2010, Article ID baq019. (Impact factor: 3,179, Citations:13)

• Baltoumas, F.A., Theodoropoulou, M.C., Hamodrakas, S.J. “Interactions of the α-subunits of heterotrimeric G-proteins with GPCRs, effectors and RGS proteins: A critical review and analysis of interacting surfaces, conformational shifts, structural diversity and electrostatic potentials.” J. Struct. Biol. (2013), http://dx.doi.org/10.1016/j.jsb.2013.03.004 (Impact factor: 3.361, Citations: 25)

• Ioannidou, Z.S., Theodoropoulou, M.C., Papandreou, N.C., Willis, J.H., Hamodrakas, S.J. (2014) “CutProtFam-Pred: Detection and classification of putative structural cuticular proteins from sequence alone, based on profile Hidden Markov Models.” Insect. Biochem. Mol. Biol., Volume 52, September 2014, Pages 51-59. doi: 10.1016/j.ibmb.2014.06.004 (Impact Factor: 3.420, Citations: 13)

• Kostiou V.D.*, Theodoropoulou M.C.*, Hamodrakas S.J., "GprotPRED: Detection of the four distinct Gα families, the Gβ and the Gγ subunits using profile Hidden Markov Models (pHMMs)", 2016, BBA Proteins. Proteom., 1864 (5), pp. 435-440. doi: 10.1016/j.bbapap.2016.02.005 (*equally contributing authors) (Impact Factor: 2.747, Citations: -)

• Tsaousis G.N., Theodoropoulou M.C., Hamodrakas S.J., Bagos P.G. (2016) "Predicting alpha helical transmembrane proteins using HMMs", " Hidden Markov Models: Methods and Protocols", Methods in Molecular Biology (Accepted)

• Baltoumas F.A., Theodoropoulou M.C., Hamodrakas S.J., "Molecular Dynamics Simulations and Structure-Based Network Analysis Reveal Structural and Functional Aspects of G-protein Coupled Receptor Dimer Interactions", 2016, Journal of Computer-Aided Molecular Design (Accepted)

• Adamopoulos P.G., Kontos C.K., Theodoropoulou M.C., Hamodrakas S.J., Scorilas A., "Alternative Splicing Detection Tool (ASDT), a novel PERL algorithm for sensitive detection of splicing events from Next Generation Sequencing data: Application to the KLK1 gene", 2016 (Submitted)

• Theodoropoulou* M.C., Tsaousis* G.N., Litou Z.I., Bagos P.G., Hamodrakas S.J., "GPCRpipe: A pipeline for the detection of G-protein coupled receptors in proteomes", 2016 (In preparation) (*equally contributing authors)

• Theodoropoulou M.C., Logaridi A.S., Bagos P.G., Hamodrakas, S.J., "PLHG-DB: a database of peptide ligands of human G-protein coupled receptors", 2016 (In preparation)

• Kontou P.I., Pavlopoulou A., Dimou N.L., Theodoropoulou M.C., Tsaousis G.N., Hamodrakas S.J.,Bagos P.G., "The human GPCR signal transduction network ", 2016 (In preparation)