Publications
Publications resulting from research at BrUNMR
Publications resulting from research at BrUNMR
Landsman Research Facility (800 MHz):
Landsman Research Facility (800 MHz):
*Indicates off-campus researchers that used the facility.
2021:
2021:
“A dynamic understanding of cytochrome P450 structure and function through solution NMR” (T. C. Pochapsky) Curr. Opin. Biotech. 69, 35-42 (2021).
“A dynamic understanding of cytochrome P450 structure and function through solution NMR” (T. C. Pochapsky) Curr. Opin. Biotech. 69, 35-42 (2021).
“Synthesis of Mannosidase-Stable Man3 and Man4 Glycans Containing S-linked Man1a--2Man Termini” (M. Neralker, L. Tian, R. L. Redman, and I. J. Krauss) Org. Lett. 23, 3053-3057 (2021).
“Synthesis of Mannosidase-Stable Man3 and Man4 Glycans Containing S-linked Man1a--2Man Termini” (M. Neralker, L. Tian, R. L. Redman, and I. J. Krauss) Org. Lett. 23, 3053-3057 (2021).
2020:
2020:
“A Model for the Solution Structure of Human Fe(II)-Bound Acireductone Dioxygenase and Interactions with the Regulatory Domain of Marix Metalloproteinase I (MMP-I)” (X. Liu, A. Garber, J. Ryan, A. Deshpande, D. Ringe and T. C. Pochapsky) Biochemistry 59, 4238-4249 (2020).
“A Model for the Solution Structure of Human Fe(II)-Bound Acireductone Dioxygenase and Interactions with the Regulatory Domain of Marix Metalloproteinase I (MMP-I)” (X. Liu, A. Garber, J. Ryan, A. Deshpande, D. Ringe and T. C. Pochapsky) Biochemistry 59, 4238-4249 (2020).
“Enzyme-Substrate-Cofactor Dynamical Networks Revealed by High-Resolution Field Cycling Relaxometry” (M. M. Rosenberg, T. Yao, G. C. Patton, A. G. Redfield, M. F. Roberts and L. Hedstrom) Biochemistry 59, 2359-2370 (2020).
“Enzyme-Substrate-Cofactor Dynamical Networks Revealed by High-Resolution Field Cycling Relaxometry” (M. M. Rosenberg, T. Yao, G. C. Patton, A. G. Redfield, M. F. Roberts and L. Hedstrom) Biochemistry 59, 2359-2370 (2020).
“How directed evolution reshapes the energy landscape in an enzyme to boost catalysis” (R. Otten, R. A. P. Padua, H. A. Bunzel, V. Nguyen, W. Pitsawong, M. Patterson, S. Sui, S. L. Perry, A. E. Cohen, D. Hilvert and D. Kern) Science 370, 1442-1446 (2020).
“How directed evolution reshapes the energy landscape in an enzyme to boost catalysis” (R. Otten, R. A. P. Padua, H. A. Bunzel, V. Nguyen, W. Pitsawong, M. Patterson, S. Sui, S. L. Perry, A. E. Cohen, D. Hilvert and D. Kern) Science 370, 1442-1446 (2020).
2019:
2019:
“Probing the transition state in enzyme catalysis by high-pressure NMR dynamics” (J. B. Stiller, S. J. Kerns, M. Hoemberger, Y-J. Cho, R. Otten, M. F. Hagan and D. Kern) Nature Catalysis 2, 726-734 (2019).
“Probing the transition state in enzyme catalysis by high-pressure NMR dynamics” (J. B. Stiller, S. J. Kerns, M. Hoemberger, Y-J. Cho, R. Otten, M. F. Hagan and D. Kern) Nature Catalysis 2, 726-734 (2019).
“The endoplasmic reticulum (ER) chaperones BiP and Grp94 selectively associate when BiP is in the ADP conformation” (M. Sun, J. L. M. Kotler, S. Liu and T. O. Street) J. Biol. Chem. 294, 6387-6396 (2019).
“The endoplasmic reticulum (ER) chaperones BiP and Grp94 selectively associate when BiP is in the ADP conformation” (M. Sun, J. L. M. Kotler, S. Liu and T. O. Street) J. Biol. Chem. 294, 6387-6396 (2019).
“What your crystal structure will not tell you about enzyme function” (T. C. Pochapsky and S. S. Pochapsky) Acc. Chem. Res. 52, 1409-1418 (2019).
“What your crystal structure will not tell you about enzyme function” (T. C. Pochapsky and S. S. Pochapsky) Acc. Chem. Res. 52, 1409-1418 (2019).
2018:
2018:
“Mechanism of activating mutations and allosteric drug inhibition of the phosphatase SHP2” (R. A. P. Padua, Y. Sun, I. Marko, W. Pitsawong, J. B. Stiller, R. Otten and D. Kern) Nat. Commun. 9, article number 4507 (2018).
“Mechanism of activating mutations and allosteric drug inhibition of the phosphatase SHP2” (R. A. P. Padua, Y. Sun, I. Marko, W. Pitsawong, J. B. Stiller, R. Otten and D. Kern) Nat. Commun. 9, article number 4507 (2018).
“NMR 1H, 13C, 15N backbone and 13C side chain resonance assignment of the G12C mutant of human K-Ras bound to GDP” (A. K. Sharma, S.-J. Lee, A.C. Rigby and S. A. Townson) Biomol. NMR Assign. 12, 269-272 (2018).
“NMR 1H, 13C, 15N backbone and 13C side chain resonance assignment of the G12C mutant of human K-Ras bound to GDP” (A. K. Sharma, S.-J. Lee, A.C. Rigby and S. A. Townson) Biomol. NMR Assign. 12, 269-272 (2018).
“Some surprising implications of NMR-directed simulations of substrate recognition and binding by cytochrome P450cam (CYP101A1)” (E. K. Asciutto and T. C. Pochapsky) J. Mol. Biol., 430, 1295-1310 (2018).
“Some surprising implications of NMR-directed simulations of substrate recognition and binding by cytochrome P450cam (CYP101A1)” (E. K. Asciutto and T. C. Pochapsky) J. Mol. Biol., 430, 1295-1310 (2018).
2017:
2017:
“Substrate recognition by two different P450s: Evidence for conserved roles in a common fold” (D. R. Tietz, A. M. Colthart, S. S. Pochapsky and T. C. Pochapsky) Scientific Reports, 7, 13581 (2017).
“Substrate recognition by two different P450s: Evidence for conserved roles in a common fold” (D. R. Tietz, A. M. Colthart, S. S. Pochapsky and T. C. Pochapsky) Scientific Reports, 7, 13581 (2017).
“Solution conformations and dynamics of substrate-bound cytochrome P450 MycG” (D. R. Tietz, L. Podust, D. H. Sherman, and T. C. Pochapsky) Biochemistry, 56, 2701-2714 (2017).
“Solution conformations and dynamics of substrate-bound cytochrome P450 MycG” (D. R. Tietz, L. Podust, D. H. Sherman, and T. C. Pochapsky) Biochemistry, 56, 2701-2714 (2017).
“The metal drives the chemistry: Dual functions of acireductone dioxygenase" (A. Desphande, T. C. Pochapsky, and D. Ringe) Chem. Rev. 117, 10474-10501 (2017).
“The metal drives the chemistry: Dual functions of acireductone dioxygenase" (A. Desphande, T. C. Pochapsky, and D. Ringe) Chem. Rev. 117, 10474-10501 (2017).
“Dual chemistry catalyzed by human acireductone dioxygenase" (A. Desphande, T. C. Pochapsky, G. A. Petsko, and D. Ringe) Protein Eng. Des. Sel. 30, 197-204 (2017).
“Dual chemistry catalyzed by human acireductone dioxygenase" (A. Desphande, T. C. Pochapsky, G. A. Petsko, and D. Ringe) Protein Eng. Des. Sel. 30, 197-204 (2017).
“Evolutionary drivers of thermoadaptation in enzyme catalysis” (V. Nguyen, C. Wilson, M. Hoemberger, J. B. Stiller, R. V. Agafonov, S. Kutter, J. English, D. L. Theobald and D. Kern) Science 355, 289-294 (2017).
“Evolutionary drivers of thermoadaptation in enzyme catalysis” (V. Nguyen, C. Wilson, M. Hoemberger, J. B. Stiller, R. V. Agafonov, S. Kutter, J. English, D. L. Theobald and D. Kern) Science 355, 289-294 (2017).
“NMR insight into myosin-binding subunit coiled-coil structure reveals binding interface with protein kinase G-Ia leucine zipper in vascular function” (A. K. Sharma, G. Birrane, C. Anklin, A.C. Rigby and S. L. Alper) J. Biol. Chem. 292, 7052-7065 (2017).
“NMR insight into myosin-binding subunit coiled-coil structure reveals binding interface with protein kinase G-Ia leucine zipper in vascular function” (A. K. Sharma, G. Birrane, C. Anklin, A.C. Rigby and S. L. Alper) J. Biol. Chem. 292, 7052-7065 (2017).
2016:
2016:
“Detection of substrate-dependent conformational changes in the P450 fold by nuclear magnetic resonance” (A. M. Colthart, D. R. Tietz, Y. Ni, J. L. Friedman, M. Dang and T. C. Pochapsky) Sci. Rep. 6, 22035 (2016).
“Detection of substrate-dependent conformational changes in the P450 fold by nuclear magnetic resonance” (A. M. Colthart, D. R. Tietz, Y. Ni, J. L. Friedman, M. Dang and T. C. Pochapsky) Sci. Rep. 6, 22035 (2016).
“Molecular Mechanism of Pin1-Tau Recognition and Catalysis” (T. Eichner, S. Kutter, W. Labeikovsky, V. Buosi and D. Kern) J. Mol. Biol. 428, 1760-1775 (2016).
“Molecular Mechanism of Pin1-Tau Recognition and Catalysis” (T. Eichner, S. Kutter, W. Labeikovsky, V. Buosi and D. Kern) J. Mol. Biol. 428, 1760-1775 (2016).
“5'-N-ethylcarboxamidoadenosine is not a paralog-specific Hsp90 inhibitor” (S. Liu and T. O. Street) Protein Sci. 25, 2209-2215 (2016).
“5'-N-ethylcarboxamidoadenosine is not a paralog-specific Hsp90 inhibitor” (S. Liu and T. O. Street) Protein Sci. 25, 2209-2215 (2016).
“Boc3Arg-Linked Ligands Induce Degradation by Localizing Target Proteins to the 20S Proteasome” (Y. She, M. J. C. Long, M. M. Rosenberg, S. Li, A. Kobjack, P. Lessans, R. T. Coffey and L. Hedstrom) ACS Chem. Biol. 11, 3328-3337 (2016).
“Boc3Arg-Linked Ligands Induce Degradation by Localizing Target Proteins to the 20S Proteasome” (Y. She, M. J. C. Long, M. M. Rosenberg, S. Li, A. Kobjack, P. Lessans, R. T. Coffey and L. Hedstrom) ACS Chem. Biol. 11, 3328-3337 (2016).
"Substrate and Cofactor Dynamics on Guanosine Monophosphate Reductase Probes by High Resolution Field Cycling 31P NMR Relaxometry" (M. M. Rosenberg, A. G. Redfield, M. F. Roberts and L. Hedstrom) J. Biol Chem. 291, 22988-22998 (2016).
"Substrate and Cofactor Dynamics on Guanosine Monophosphate Reductase Probes by High Resolution Field Cycling 31P NMR Relaxometry" (M. M. Rosenberg, A. G. Redfield, M. F. Roberts and L. Hedstrom) J. Biol Chem. 291, 22988-22998 (2016).
“Analysis of Loops that Mediate Protein-Protein Interactions and Translation into Submicromolar Inhibitors” (T. R. Siegert, M. J. Bird, K. M. Makwana and J. A. Kritzer) J. Am. Chem. Soc. 138, 12876-12884 (2016).
“Analysis of Loops that Mediate Protein-Protein Interactions and Translation into Submicromolar Inhibitors” (T. R. Siegert, M. J. Bird, K. M. Makwana and J. A. Kritzer) J. Am. Chem. Soc. 138, 12876-12884 (2016).
2015:
2015:
“The energy landscape of adenylate kinase during catalysis” (S. J. Kerns, R. V. Agafonov, Y-J. Cho, F. Pontiggia, R. Otten, D. V. Pachov, S. Kutter, L. A. Phung, P. N. Murphy, V. Thai, T. Alber, M. F. Hagan and D. Kern) Nat. Struct. Mol. Biol. 22, 124-131 (2015).
“The energy landscape of adenylate kinase during catalysis” (S. J. Kerns, R. V. Agafonov, Y-J. Cho, F. Pontiggia, R. Otten, D. V. Pachov, S. Kutter, L. A. Phung, P. N. Murphy, V. Thai, T. Alber, M. F. Hagan and D. Kern) Nat. Struct. Mol. Biol. 22, 124-131 (2015).
“Free energy landscape of activation in a signaling protein at atomic resolution” (F. Pontiggia, D. V. Pachov, M. W. Clarkson, J. Villali, M. F. Hagan, V. S. Pande and D. Kern) Nat. Common. 6, 7284 (2015).
“Free energy landscape of activation in a signaling protein at atomic resolution” (F. Pontiggia, D. V. Pachov, M. W. Clarkson, J. Villali, M. F. Hagan, V. S. Pande and D. Kern) Nat. Common. 6, 7284 (2015).
“Unfolding a molecular trefoil derived from a zwitterionic metallopeptide to form self-assembled nanostructures” (Y. Zhang, N. Zhou, J. Shi, S. S. Pochapsky, T. C. Pochapsky, B. Zhang, X. Zhang and B. Xu) Nat. Commun. 6, article number 6165 (2015).
“Unfolding a molecular trefoil derived from a zwitterionic metallopeptide to form self-assembled nanostructures” (Y. Zhang, N. Zhou, J. Shi, S. S. Pochapsky, T. C. Pochapsky, B. Zhang, X. Zhang and B. Xu) Nat. Commun. 6, article number 6165 (2015).
"In Vivo Biosynthesis of Terpene Nucleosides Provides Unique Chemical Markers of Mycobacterium tuberculosis Infection" (D. C. Young, E. Layre, S-J. Pan, A. Tapley, J. Adamson, C. Seshadri, Z. Wu, J. Buter, A. J. Minnaard, M. Coscolla, S. Gagneux, R. Copin, J. D. Ernst, W. R. Bishai, B. B. Snider and D. B. Moody) Chem. Biol. 22, 516-526 (2015).
"In Vivo Biosynthesis of Terpene Nucleosides Provides Unique Chemical Markers of Mycobacterium tuberculosis Infection" (D. C. Young, E. Layre, S-J. Pan, A. Tapley, J. Adamson, C. Seshadri, Z. Wu, J. Buter, A. J. Minnaard, M. Coscolla, S. Gagneux, R. Copin, J. D. Ernst, W. R. Bishai, B. B. Snider and D. B. Moody) Chem. Biol. 22, 516-526 (2015).
2014:
2014:
“Solution structure of a designed cyclic peptide ligand for nickel and copper ions” (M. R. Eshelman, A. R. Aldous, K. P. Neupane and J. A. Kritzer) Tetrahedron 70, 7651-7654 (2014).
“Solution structure of a designed cyclic peptide ligand for nickel and copper ions” (M. R. Eshelman, A. R. Aldous, K. P. Neupane and J. A. Kritzer) Tetrahedron 70, 7651-7654 (2014).
“A bicyclic peptide scaffold promotes phosphotyrosine mimicry and cellular uptake” (J. S. Quartararo, M. R. Eshelman, L. Peraro, H. Yu, J. D. Baleja, Y-S. Lin and J. A. Kritzer) Bioorg. Med. Chem. 22, 6387-6391 (2014).
“A bicyclic peptide scaffold promotes phosphotyrosine mimicry and cellular uptake” (J. S. Quartararo, M. R. Eshelman, L. Peraro, H. Yu, J. D. Baleja, Y-S. Lin and J. A. Kritzer) Bioorg. Med. Chem. 22, 6387-6391 (2014).
"Molecular profiling of Mycobacterium tuberculosis identifies tuberculosinyl nucleoside products of the virulence-associated enzyme Rv3378c" (E. Layne, H. J. Lee, D. C. Young, A. J. Martinet, J. Buter, A. J. Minnaard, J. W. Annand, S. M. Fortune, B. B. Snider, I. Matsunaga, E. J. Rubin, T. Alber and D. B. Moody) Proc. Natl. Acad. Sci. USA 111, 2978-2983 (2014).
"Molecular profiling of Mycobacterium tuberculosis identifies tuberculosinyl nucleoside products of the virulence-associated enzyme Rv3378c" (E. Layne, H. J. Lee, D. C. Young, A. J. Martinet, J. Buter, A. J. Minnaard, J. W. Annand, S. M. Fortune, B. B. Snider, I. Matsunaga, E. J. Rubin, T. Alber and D. B. Moody) Proc. Natl. Acad. Sci. USA 111, 2978-2983 (2014).
2013:
2013:
“The Dynamic Structure of alpha-Synuclein Multimers” (T. Gurry, O. Ullman, C. K. Fisher, I. Perovic and T. C. Pochapsky) J. Am. Chem. Soc. 135, 3865-3872 (2013).
“The Dynamic Structure of alpha-Synuclein Multimers” (T. Gurry, O. Ullman, C. K. Fisher, I. Perovic and T. C. Pochapsky) J. Am. Chem. Soc. 135, 3865-3872 (2013).
"Backbone and sidechain 1H, 15N and 13C assignments of Tyrosine Phosphatase related to Biofilm formation A (TpbA) of Pseudomonas aeruginosa" (D. Koveal, T. B. Jayasundera, T. K. Wood, W. Peti and R. Page) Biomol. NMR Assign. 7, 57-59 (2013).
"Backbone and sidechain 1H, 15N and 13C assignments of Tyrosine Phosphatase related to Biofilm formation A (TpbA) of Pseudomonas aeruginosa" (D. Koveal, T. B. Jayasundera, T. K. Wood, W. Peti and R. Page) Biomol. NMR Assign. 7, 57-59 (2013).
2012:
2012:
“Substrate Recognition by the Multifunctional Cytochrome P450 MycG in Mycinamicin Hydroxylation and Epoxidation Reactions” (S. Li, D. R. Tietz, F. U. Rutaganira, T. C. Pochapsky, D. H. Sherman and L. M. Podust) J. Biol. Chem. 287, 37880-37890 (2012).
“Substrate Recognition by the Multifunctional Cytochrome P450 MycG in Mycinamicin Hydroxylation and Epoxidation Reactions” (S. Li, D. R. Tietz, F. U. Rutaganira, T. C. Pochapsky, D. H. Sherman and L. M. Podust) J. Biol. Chem. 287, 37880-37890 (2012).
"Docking Interactions of Hematopoietic Tyrosine Phosphatase with MAP Kinases ERK2 and p38 alpha" (A. Piserchio, D. M. Francis, D. Koveal, K. N. Dalby, R. Page, W. Peti and R. Ghose) Biochemistry 51, 8047-8049 (2012).
"Docking Interactions of Hematopoietic Tyrosine Phosphatase with MAP Kinases ERK2 and p38 alpha" (A. Piserchio, D. M. Francis, D. Koveal, K. N. Dalby, R. Page, W. Peti and R. Ghose) Biochemistry 51, 8047-8049 (2012).
"A Competitive Stapled Peptide Screen Identifies a Selective Small Molecule that Overcomes MCL-1-Dependent Leukemia Cell Survival" (N. A. Cohen, M. L. Stewart, E. Gavathiotis, J. L. Tepper, S. R. Bruekner, B. Koss, J. T. Opferman and L. D. Walensky) Chem. Biol. 19, 1175-1186 (2012).
"A Competitive Stapled Peptide Screen Identifies a Selective Small Molecule that Overcomes MCL-1-Dependent Leukemia Cell Survival" (N. A. Cohen, M. L. Stewart, E. Gavathiotis, J. L. Tepper, S. R. Bruekner, B. Koss, J. T. Opferman and L. D. Walensky) Chem. Biol. 19, 1175-1186 (2012).
"Solution Structural Ensembles of Substrate-Free Cytochrome P450(cam)" (E. K. Asciutoo, M. J. Young, J. Madura, S. S. Pochapsky and T. C. Pochapsky) Biochemistry 51, 3383-3393 (2012).
"Solution Structural Ensembles of Substrate-Free Cytochrome P450(cam)" (E. K. Asciutoo, M. J. Young, J. Madura, S. S. Pochapsky and T. C. Pochapsky) Biochemistry 51, 3383-3393 (2012).
"Antiparallel EmrE exports drugs by exchanging between asymmetric structures" (E. A. Morrison, G. T. DeKoster, S. Dutta, R. Vafabakhsh, M. W. Clarkson, A. Bahl, D. Kern, T. Ha and K. A. Henzler-Wildman) Nature 481, 45-50 (2012).
"Antiparallel EmrE exports drugs by exchanging between asymmetric structures" (E. A. Morrison, G. T. DeKoster, S. Dutta, R. Vafabakhsh, M. W. Clarkson, A. Bahl, D. Kern, T. Ha and K. A. Henzler-Wildman) Nature 481, 45-50 (2012).
"Solution structure and backbone dynamics of human liver Fatty Acid binding protein: Fatty Acid binding revisited" (J. Cai, C. Lucke, Z. J. Chem, Y. Qiao, E. Klimtchuk and J. A. Hamilton) Biophys. J. 102, 2585-2594 (2012).
"Solution structure and backbone dynamics of human liver Fatty Acid binding protein: Fatty Acid binding revisited" (J. Cai, C. Lucke, Z. J. Chem, Y. Qiao, E. Klimtchuk and J. A. Hamilton) Biophys. J. 102, 2585-2594 (2012).
"Direct and selective small-molecule activation of proapoptotic BAX" (E. Gavathiotis, D. E. Reyna, J. A. Bellairs, E. S. Leshchiner and L. D. Walensky) Nat. Chem. Biol. 8, 639-645 (2012).
"Direct and selective small-molecule activation of proapoptotic BAX" (E. Gavathiotis, D. E. Reyna, J. A. Bellairs, E. S. Leshchiner and L. D. Walensky) Nat. Chem. Biol. 8, 639-645 (2012).
"Direct NMR Observation and pKa Determination of the Asp102 side Chain in a Serine Protease" (P. Everill, J. L. Sudmeier and W. W. Bachovchin) J. Am. Chem. Soc. 134, 2348-2354 (2012).
"Direct NMR Observation and pKa Determination of the Asp102 side Chain in a Serine Protease" (P. Everill, J. L. Sudmeier and W. W. Bachovchin) J. Am. Chem. Soc. 134, 2348-2354 (2012).
2011:
2011:
“A Short Asymmetric Route to the Bromophycolide A and D Skeleton” (H. Lin, S. S. Pochapsky and I. J. Krauss) Org. Lett. 13, 1222-1225 (2011).
“A Short Asymmetric Route to the Bromophycolide A and D Skeleton” (H. Lin, S. S. Pochapsky and I. J. Krauss) Org. Lett. 13, 1222-1225 (2011).
"Experimentally Restrained Molecular Dynamics Simulations for Characterizing the Open States of Cytochrome P450cam" (E. K. Asciutto, M. Dang, S. S. Pochapsky, J. Madura and T. C. Pochapsky) Biochemistry 50, 1664-1671 (2011).
"Experimentally Restrained Molecular Dynamics Simulations for Characterizing the Open States of Cytochrome P450cam" (E. K. Asciutto, M. Dang, S. S. Pochapsky, J. Madura and T. C. Pochapsky) Biochemistry 50, 1664-1671 (2011).
"Spring-loading the active site of cytochrome P450cam" (M. Dang, S. S. Pochapsky and T. C. Pochapsky) Metallomics 3, 339-343 (2011).
"Spring-loading the active site of cytochrome P450cam" (M. Dang, S. S. Pochapsky and T. C. Pochapsky) Metallomics 3, 339-343 (2011).
"A soluble alpha-synuclein construct forms a dynamic tetramer" (W. Wang, I. Perovic, J. Chittuluru, A. Kagnanovich, L. T. T. Nguyen, J. Liao, J. R. Auclair, D. Johnson, A. Landeru, A. K. Simorellis, S. Ju, M. R. Cookson, R. J. Asturias, J. N. Agar, B. N. Webb, C. H. Kang, D. Ringe, G. A. Petsko, T. C. Pochapsky and Q. Q. Hoang) Proc. Natl. Acad. Sci. USA 108, 17797-17802 (2011).
"A soluble alpha-synuclein construct forms a dynamic tetramer" (W. Wang, I. Perovic, J. Chittuluru, A. Kagnanovich, L. T. T. Nguyen, J. Liao, J. R. Auclair, D. Johnson, A. Landeru, A. K. Simorellis, S. Ju, M. R. Cookson, R. J. Asturias, J. N. Agar, B. N. Webb, C. H. Kang, D. Ringe, G. A. Petsko, T. C. Pochapsky and Q. Q. Hoang) Proc. Natl. Acad. Sci. USA 108, 17797-17802 (2011).
"Molecular Investigations of the Structure and Function of the Protein Phosphatase 1-Spinophilin-Inhibitor 2 Heterotrimeric Complex" (B. Dancheck, M. J. Rgausa, M. Allaire, A. C. Nairn, R. Page and W. Peti) Biochemistry 50, 1238-1246 (2011).
"Molecular Investigations of the Structure and Function of the Protein Phosphatase 1-Spinophilin-Inhibitor 2 Heterotrimeric Complex" (B. Dancheck, M. J. Rgausa, M. Allaire, A. C. Nairn, R. Page and W. Peti) Biochemistry 50, 1238-1246 (2011).
"Backbone and side chain 1H, 15N and 13C assignments of the KSR1 CA1 domain" (D. Koveal, A. S. Pinheiro, W. Peti and R. Page)Biomol. NMR Assign. 5, 39-41 (2011).
"Backbone and side chain 1H, 15N and 13C assignments of the KSR1 CA1 domain" (D. Koveal, A. S. Pinheiro, W. Peti and R. Page)Biomol. NMR Assign. 5, 39-41 (2011).
"The Structural Signature of the MYPT1-PP1 Interaction" (A. S. Pinheiro, J. A . Marsh, J. D. Forman-Kay and W. Peti) J. Am. Chem. Soc. 133, 73-80 (2011).
"The Structural Signature of the MYPT1-PP1 Interaction" (A. S. Pinheiro, J. A . Marsh, J. D. Forman-Kay and W. Peti) J. Am. Chem. Soc. 133, 73-80 (2011).
"Structural basis of p38 alpha regulation by hematopoietic tyrosine phophatase" (D. Francis, D. Koveal, B. Rozycki, G. Hummer, R. Page and W. Peti) Nat. Chem. Biol. 7, 916-924 (2011).
"Structural basis of p38 alpha regulation by hematopoietic tyrosine phophatase" (D. Francis, D. Koveal, B. Rozycki, G. Hummer, R. Page and W. Peti) Nat. Chem. Biol. 7, 916-924 (2011).
"The NLRP12 Pyrin Domain: Structure, Dynamics and Functional Insights" (A. S. Pinheiro, C. Eibl, Z. Ekman-Vural, R. Schwarzenbacher and W. Peti) J. Mol. Biol. 413, 790-803 (2011).
"The NLRP12 Pyrin Domain: Structure, Dynamics and Functional Insights" (A. S. Pinheiro, C. Eibl, Z. Ekman-Vural, R. Schwarzenbacher and W. Peti) J. Mol. Biol. 413, 790-803 (2011).
2010:
2010:
“Synthesis of (+/-)-Bistellettadine A” (M. Yu, S. S. Pochapsky and B. B. Snider) Org. Lett. 12, 828-831 (2010).
“Synthesis of (+/-)-Bistellettadine A” (M. Yu, S. S. Pochapsky and B. B. Snider) Org. Lett. 12, 828-831 (2010).
“Communication between the Zinc and Nickel Sites in Dimeric HypA: Metal Recognition and pH Sensing" (R. W. Herbst, I. Perovic, V. Martin-Diaconescu, K. O'Brien, P. T. Chivers, S. S. Pochapsky, T. C. Pochapsky and M. J. Maroney) J. Am. Chem. Soc. 132, 10338-10351 (2010).
“Communication between the Zinc and Nickel Sites in Dimeric HypA: Metal Recognition and pH Sensing" (R. W. Herbst, I. Perovic, V. Martin-Diaconescu, K. O'Brien, P. T. Chivers, S. S. Pochapsky, T. C. Pochapsky and M. J. Maroney) J. Am. Chem. Soc. 132, 10338-10351 (2010).
"Structural Diversity in Free and Bound States of Intrinsically Disordered Protein Phosphatase 1 Regulators" (J. A Marsh, B. Dancheck, M. J. Ragusa, M. Allaire, J. D. Forman-Kay and W. Peti) Structure 18, 1094-1103 (2010).
"Structural Diversity in Free and Bound States of Intrinsically Disordered Protein Phosphatase 1 Regulators" (J. A Marsh, B. Dancheck, M. J. Ragusa, M. Allaire, J. D. Forman-Kay and W. Peti) Structure 18, 1094-1103 (2010).
"BH3-Triggered Structural Reorganization Drives the Activation of Proapoptotic BAX" (E. Gavathiotis, D. E. Reyna, M. L. Davis, G. H. Bird and L. D. Walensky) Mol. Cell 40, 481-492 (2010).
"BH3-Triggered Structural Reorganization Drives the Activation of Proapoptotic BAX" (E. Gavathiotis, D. E. Reyna, M. L. Davis, G. H. Bird and L. D. Walensky) Mol. Cell 40, 481-492 (2010).
"Three-dimensional Structure of he NLRP7 Pyrin Domain: Insight into Pyrin-Pyrin-Mediated Effector Domain Signaling in Innate Immunity" (A. S. Pinheiro, M. Proell, C. Eibl, R. Page, R. Schwarzenbacher and W. Peti) J. Biol. Chem. 285, 27402-27410 (2010).
"Three-dimensional Structure of he NLRP7 Pyrin Domain: Insight into Pyrin-Pyrin-Mediated Effector Domain Signaling in Innate Immunity" (A. S. Pinheiro, M. Proell, C. Eibl, R. Page, R. Schwarzenbacher and W. Peti) J. Biol. Chem. 285, 27402-27410 (2010).
2009:
2009:
“Structural and Dynamic Implications of an Effector-induced Backbone Amide cis-trans Isomerization in Cytochrome P450(cam)” (E. K. Ascuitto, J. D. Madura, S. S. Pochapsky, B. OuYang and T. C. Pochapsky) J. Mol. Biol. 388, 801-814 (2009).
“Structural and Dynamic Implications of an Effector-induced Backbone Amide cis-trans Isomerization in Cytochrome P450(cam)” (E. K. Ascuitto, J. D. Madura, S. S. Pochapsky, B. OuYang and T. C. Pochapsky) J. Mol. Biol. 388, 801-814 (2009).
“Redox-Dependent Dynamics in Cytochrome P450(cam)” (S. S. Pochapsky, M. Dang, B. OuYang, A. K. Simorellis and T. C. Pochapsky)Biochemistry 48, 4254-4261 (2009).
“Redox-Dependent Dynamics in Cytochrome P450(cam)” (S. S. Pochapsky, M. Dang, B. OuYang, A. K. Simorellis and T. C. Pochapsky)Biochemistry 48, 4254-4261 (2009).
“Transient Non-native Hydrogen Bonds Promote Activation of a Signaling Protein” (A. K. Gardino, J. Villali, A. Kivenson, M. Lei, C. F. Liu, P. Steindel, E. Z. Eissenmesser, W. Labeikovsky, M. Wolf-Watz, M. W. Clarkson and D. Kern) Cell 139, 1109-1118 (2009).
“Transient Non-native Hydrogen Bonds Promote Activation of a Signaling Protein” (A. K. Gardino, J. Villali, A. Kivenson, M. Lei, C. F. Liu, P. Steindel, E. Z. Eissenmesser, W. Labeikovsky, M. Wolf-Watz, M. W. Clarkson and D. Kern) Cell 139, 1109-1118 (2009).
“Hidden alternative structures of proline isomerase essential for catalysis” (J. S. Fraser, M. W. Clarkson, S. C. Degnan, R. Erion, D. Kern and T. Alber) Nature 462, 669-673 (2009).
“Hidden alternative structures of proline isomerase essential for catalysis” (J. S. Fraser, M. W. Clarkson, S. C. Degnan, R. Erion, D. Kern and T. Alber) Nature 462, 669-673 (2009).
"Mesodynamics in the SARS nucleocapsid measured by NMR field cycling " (M. W. Clarkson, M. Lei, E. Z. Eissenmesser, W. Labeikovsky, A. Redfield and D. Kern) J. Biomol. NMR 45, 217-225 (2009).
"Mesodynamics in the SARS nucleocapsid measured by NMR field cycling " (M. W. Clarkson, M. Lei, E. Z. Eissenmesser, W. Labeikovsky, A. Redfield and D. Kern) J. Biomol. NMR 45, 217-225 (2009).
"Disorder and Structure in the Rab11 Binding Domain of Rab11 Family Interacting Protein 2" (J. Wei, Y. Liu, K. Bose, G. D. Henry and J. D. Baleja) Biochemistry 48, 549-557 (2009).
"Disorder and Structure in the Rab11 Binding Domain of Rab11 Family Interacting Protein 2" (J. Wei, Y. Liu, K. Bose, G. D. Henry and J. D. Baleja) Biochemistry 48, 549-557 (2009).
2008:
2008:
“Structural Basis of Substrate Recognition by Hematopoietic Tyrosine Phosphatase” (D. A. Critton, A. Tortajada, G. Stetson, W. Peti and R. Page) Biochemistry 47, 13336-13345 (2008).
“Structural Basis of Substrate Recognition by Hematopoietic Tyrosine Phosphatase” (D. A. Critton, A. Tortajada, G. Stetson, W. Peti and R. Page) Biochemistry 47, 13336-13345 (2008).
“Detailed Structural Characterization of Unbound Protein Phosphatase 1 Inhibitors” (B. Dancheck, A. C. Naim and W. Peti) Biochemistry47, 12346-12356 (2008).
“Detailed Structural Characterization of Unbound Protein Phosphatase 1 Inhibitors” (B. Dancheck, A. C. Naim and W. Peti) Biochemistry47, 12346-12356 (2008).
"A functional proline switch in cytochrome P450cam" (B. OuYang, S. S. Pochapsky, M. Dang and T. C. Pochapsky) Structure 16, 916-923 (2008).
"A functional proline switch in cytochrome P450cam" (B. OuYang, S. S. Pochapsky, M. Dang and T. C. Pochapsky) Structure 16, 916-923 (2008).
“Completing the circuit: Direct-observe 13C,15N double-quantum spectroscopy permits sequential resonance assignments near a paramagnetic center in acireductone dioxygenase” (S. S. Pochapsky, J. C. Sunshine and T. C. Pochapsky) J. Am. Chem. Soc. 130, 2156-2157 (2008).
“Completing the circuit: Direct-observe 13C,15N double-quantum spectroscopy permits sequential resonance assignments near a paramagnetic center in acireductone dioxygenase” (S. S. Pochapsky, J. C. Sunshine and T. C. Pochapsky) J. Am. Chem. Soc. 130, 2156-2157 (2008).
"Characterization of metal binding in the active sites of acireductone dioxygenase isoforms from Klebsiella ATCC 8724" (S. Chai, T. Ju, M. Dang, R. Goldsmith, M. J. Maroney and T. C. Pochapsky) Biochemistry 47, 2428 -2438 (2008).
"Characterization of metal binding in the active sites of acireductone dioxygenase isoforms from Klebsiella ATCC 8724" (S. Chai, T. Ju, M. Dang, R. Goldsmith, M. J. Maroney and T. C. Pochapsky) Biochemistry 47, 2428 -2438 (2008).
"Rotation of Lipids in Membranes: Molecular Dynamics Simulation, 31P Spin-Lattice Relaxation, and Rigid-Body Dynamics" (J. B. Klauda, M. F. Roberts,A. G. Redfield, B. R. Brooks & R. W. Pastor) Biophys. J. 94(8):3074-83 (2008).
"Rotation of Lipids in Membranes: Molecular Dynamics Simulation, 31P Spin-Lattice Relaxation, and Rigid-Body Dynamics" (J. B. Klauda, M. F. Roberts,A. G. Redfield, B. R. Brooks & R. W. Pastor) Biophys. J. 94(8):3074-83 (2008).
“Synthesis of 7-Epineoptilocaulin, Mirabilin B, and Isoptilocaulin. A Unified Biosynthetic Proposal for the Ptilocaulin and Batzelladine Alkaloids. Synthesis and Structure Revision of Netamines E and G” (M. Yu, S. S. Pochapsky and B. B. Snider) J. Org. Chem. 73, 9065-9074 (2008).
“Synthesis of 7-Epineoptilocaulin, Mirabilin B, and Isoptilocaulin. A Unified Biosynthetic Proposal for the Ptilocaulin and Batzelladine Alkaloids. Synthesis and Structure Revision of Netamines E and G” (M. Yu, S. S. Pochapsky and B. B. Snider) J. Org. Chem. 73, 9065-9074 (2008).
"Engineering and Characterization of a single chain surrogate light chain variable domain" (L. Morstadt, A. Bohm, D. Yuksel, K. Kumar, B. D. Stollar and J. D. Baleja) Protein Sci. 17, 458-465 (2008).
"Engineering and Characterization of a single chain surrogate light chain variable domain" (L. Morstadt, A. Bohm, D. Yuksel, K. Kumar, B. D. Stollar and J. D. Baleja) Protein Sci. 17, 458-465 (2008).
2007:
2007:
“Formal synthesis of (+/-)-platensimycin” (Y. F. Zou, C. H. Chem, C. D. Taylor, B. M. Foxman and B. B. Snider) Org. Lett. 9, 1825-1828 (2007).
“Formal synthesis of (+/-)-platensimycin” (Y. F. Zou, C. H. Chem, C. D. Taylor, B. M. Foxman and B. B. Snider) Org. Lett. 9, 1825-1828 (2007).
"The isolated sixth gelsolin repeat and headpiece domain of villin bundle F-actin in the presence of calcium and are linked by a 40-residue unstructured sequence" (S. L. Smirnov, N. G. Isern, Z. G. Jiang, D. W. Hoyt and C. J. McKnight) Biochemistry 46, 7488-7496 (2007).
"The isolated sixth gelsolin repeat and headpiece domain of villin bundle F-actin in the presence of calcium and are linked by a 40-residue unstructured sequence" (S. L. Smirnov, N. G. Isern, Z. G. Jiang, D. W. Hoyt and C. J. McKnight) Biochemistry 46, 7488-7496 (2007).
BrUNMR (400-600 MHz):
BrUNMR (400-600 MHz):
2023:
2023:
"De Novo Synthetic Approach to 2,4-Diamino-2, 4, 6-trideoxyhexoses (DATDH): Bacterial and Rare Deoxy-Amino Sugars" (O. Vasquez, A. Alibrandi and C. S. Bennett) Org. Lett. Article ASAP (2023).
"De Novo Synthetic Approach to 2,4-Diamino-2, 4, 6-trideoxyhexoses (DATDH): Bacterial and Rare Deoxy-Amino Sugars" (O. Vasquez, A. Alibrandi and C. S. Bennett) Org. Lett. Article ASAP (2023).
2022:
2022:
"An Optimized Synthesis of Fmoc-L-Homopropargylglycine-OH" (D. Polyak and I. J. Krauss) J. Org. Chem. 87, 3841-3844 (2022).
"An Optimized Synthesis of Fmoc-L-Homopropargylglycine-OH" (D. Polyak and I. J. Krauss) J. Org. Chem. 87, 3841-3844 (2022).
2021:
2021:
"Sunlight-activated phase change materials for controlled heat storage and triggered release" (Y. Shi, M. A. Gerkman, Q. Qui, S. Zhang and G. G. D. Han) J. Mater. Chem. A 9, 9798-9808 (2021).
"Sunlight-activated phase change materials for controlled heat storage and triggered release" (Y. Shi, M. A. Gerkman, Q. Qui, S. Zhang and G. G. D. Han) J. Mater. Chem. A 9, 9798-9808 (2021).
2020:
2020:
"Mechanism Underlying Anti-Markovnikov Addition in the reaction of Pentalenene Synthase" (J. O. Matos, R. P. Kumar, A. C. Ma, M. Patterson, I. J. Krauss and D. D. Oprian) Biochemistry 59, 3271-3283 (2020).
"Mechanism Underlying Anti-Markovnikov Addition in the reaction of Pentalenene Synthase" (J. O. Matos, R. P. Kumar, A. C. Ma, M. Patterson, I. J. Krauss and D. D. Oprian) Biochemistry 59, 3271-3283 (2020).
2019:
2019:
"Direct Evidence of an Enzyme-Generated LPP Intermediate in (+)-Limonene Synthase Using a Fluorinated GPP Substrate Analog" (B. R. Morehouse, R. P. Kumar, J. O. Matos, Q. Yu, K. Malik, J. Sebastian Temme, I. J. Krauss and D. D. Oprian) ACS Chem. Biol. 14, 2035-2043 (2019).
"Direct Evidence of an Enzyme-Generated LPP Intermediate in (+)-Limonene Synthase Using a Fluorinated GPP Substrate Analog" (B. R. Morehouse, R. P. Kumar, J. O. Matos, Q. Yu, K. Malik, J. Sebastian Temme, I. J. Krauss and D. D. Oprian) ACS Chem. Biol. 14, 2035-2043 (2019).
2018:
2018:
“Dynamics of human protein kinase Aurora A linked to drug selectivity” (W. Pitsawong, V. Buosi, R. Otten, R. V. Agafonov, A. Zorba, N. Kern, S. Kutter, G. Kern, R. A. P. Padua, X. Meniche and D. Kern) ELIFE 7, article number e36656 (2018).
“Dynamics of human protein kinase Aurora A linked to drug selectivity” (W. Pitsawong, V. Buosi, R. Otten, R. V. Agafonov, A. Zorba, N. Kern, S. Kutter, G. Kern, R. A. P. Padua, X. Meniche and D. Kern) ELIFE 7, article number e36656 (2018).
“Rescue of conformational dynamics in enzyme catalysis by directed evolution” (R. Otten, L. Liu, L. R. Kenner, M. W. Clarkson, D. Mavor, D. S. Tawfik, D. Kern and J. S. Fraser) Nat. Commun. 9, article number 1314 (2018).
“Rescue of conformational dynamics in enzyme catalysis by directed evolution” (R. Otten, L. Liu, L. R. Kenner, M. W. Clarkson, D. Mavor, D. S. Tawfik, D. Kern and J. S. Fraser) Nat. Commun. 9, article number 1314 (2018).
2017:
2017:
"Structural Characterization of Early Michaelis Complexes in the Reaction Catalyzed by (+)-Limonene Synthase from Citrus sinensis Using Fluorinated Substrate Analogues" (R. P. Kumar, B. R. Morehouse, J. O. Matos, K. Malik, H. Lin, I. J. Krauss and D. D. Oprian) Biochemistry 56, 1716-1725 (2017).
"Structural Characterization of Early Michaelis Complexes in the Reaction Catalyzed by (+)-Limonene Synthase from Citrus sinensis Using Fluorinated Substrate Analogues" (R. P. Kumar, B. R. Morehouse, J. O. Matos, K. Malik, H. Lin, I. J. Krauss and D. D. Oprian) Biochemistry 56, 1716-1725 (2017).
2016:
2016:
"Conformational Selection in a Protein-Protein Interaction Revealed by Dynamic Pathway Analysis" (K. S. Chakrabarti, R. V. Agafonov, F. Pontiggia, R. Otten, M. K. Higgins, G. F. X. Schertler, D. D. Oprian and D. Kern) Cell Reports 14, 32-42 (2016).
"Conformational Selection in a Protein-Protein Interaction Revealed by Dynamic Pathway Analysis" (K. S. Chakrabarti, R. V. Agafonov, F. Pontiggia, R. Otten, M. K. Higgins, G. F. X. Schertler, D. D. Oprian and D. Kern) Cell Reports 14, 32-42 (2016).
"Regulation of Microtubule Assembly by Tau and not by Pin1" (S. Kutter, T. Eichner, A. M. Deaconescu and D. Kern) J. Mol. Biol. 428, 1742-1759 (2016).
"Regulation of Microtubule Assembly by Tau and not by Pin1" (S. Kutter, T. Eichner, A. M. Deaconescu and D. Kern) J. Mol. Biol. 428, 1742-1759 (2016).
"Substrate and Cofactor Dynamics on Guanosine Monophosphate Reductase Probes by High Resolution Field Cycling 31P NMR Relaxometry" (M. M. Rosenberg, A. G. Redfield, M. F. Roberts and L. Hedstrom) J. Biol Chem. 291, 22988-22998 (2016).
"Substrate and Cofactor Dynamics on Guanosine Monophosphate Reductase Probes by High Resolution Field Cycling 31P NMR Relaxometry" (M. M. Rosenberg, A. G. Redfield, M. F. Roberts and L. Hedstrom) J. Biol Chem. 291, 22988-22998 (2016).
2015:
2015:
"Phospholipid-binding Sites of Phosphatase and Tensin Homolog (PTEN) EXPLORING THE MECHANISM OF PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE ACTIVATION" (Y. Wei, B. Stec, A. G. Redfield, E. Weerapana and M. F. Roberts) J. Biol. Chem. 290, 1592-1606 (2015).
2014:
2014:
“Evidence Against the "Y-T Coupling" Mechanism of Activation in the Response Regulator NtrC” (J. Villali, F. Pontiggia, M. W. Clarkson, M. F. Hagan and D. Kern) J. Mol. Biol. 426, 1554-1567 (2014).
“Evidence Against the "Y-T Coupling" Mechanism of Activation in the Response Regulator NtrC” (J. Villali, F. Pontiggia, M. W. Clarkson, M. F. Hagan and D. Kern) J. Mol. Biol. 426, 1554-1567 (2014).
“Energetic dissection of Gleevec's selectivity toward human tyrosine kinases” (R. V. Agafonov, C. Wilson, R. Otten, V. Buosi and D. Kern) Nat. Struct. Mol. Biol. 21, 848-853 (2014).
“Energetic dissection of Gleevec's selectivity toward human tyrosine kinases” (R. V. Agafonov, C. Wilson, R. Otten, V. Buosi and D. Kern) Nat. Struct. Mol. Biol. 21, 848-853 (2014).
"Cytotoxic Amphiphiles and Phosphoinositides Bind to Two Discrete Sites on the Akt1 PH Domain" (C. S. Gradziel, Y. L. Wang, B. Stec, A. G. Redfield and M. F. Roberts) Biochemistry 53, 462-472 (2014).
2013:
2013:
“AProlyl-Isomerase Mediates Dopamine-Dependent Plasticity and Cocaine Motor Sensitization” (J. M. Park, J-H. Hu, A. Milshteyn, P-W. Zhang, C. G. Moore, S. Park, M. C. Datko, R. D. Domino, C. M. Reyes, X. J. Wang, F. A. Etzkorn, B. Xiao, K. K. Szumlinski, D. Kern, D. J. Linden and P. F. Worley) Cell 154, 637-650 (2013).
“AProlyl-Isomerase Mediates Dopamine-Dependent Plasticity and Cocaine Motor Sensitization” (J. M. Park, J-H. Hu, A. Milshteyn, P-W. Zhang, C. G. Moore, S. Park, M. C. Datko, R. D. Domino, C. M. Reyes, X. J. Wang, F. A. Etzkorn, B. Xiao, K. K. Szumlinski, D. Kern, D. J. Linden and P. F. Worley) Cell 154, 637-650 (2013).
“Metabolites of PPI-2458, a Selective, Irreversible Inhibitor of Methionine Aminopeptidase-2: Structure Determination and In Vivo Activity” (C. C. Arico-Muendel, B. Belanger, D. Benjamin, H. S. Blanchette, T. M. Caiazzo, P. A. Centrella, J. DeLorey, E. G. Doyle, U. Gradhand, S. T. Griffin, S. Hill, M. T. Labenski, B. A. Morgan, G. O'Donovan, K. Prasad, S. Skinner, N. Taghizadeh, C. D. Thompson, J. Wakefield, W. Westlin and K. F. White) Drug Metab. Dispos. 41, 814-826 (2013).
“Metabolites of PPI-2458, a Selective, Irreversible Inhibitor of Methionine Aminopeptidase-2: Structure Determination and In Vivo Activity” (C. C. Arico-Muendel, B. Belanger, D. Benjamin, H. S. Blanchette, T. M. Caiazzo, P. A. Centrella, J. DeLorey, E. G. Doyle, U. Gradhand, S. T. Griffin, S. Hill, M. T. Labenski, B. A. Morgan, G. O'Donovan, K. Prasad, S. Skinner, N. Taghizadeh, C. D. Thompson, J. Wakefield, W. Westlin and K. F. White) Drug Metab. Dispos. 41, 814-826 (2013).
2012:
2012:
"High-Resolution NMR field-cycling device for full-range relaxation and structural studies of biopolymers on a shared commercial instrument" (A. G. Redfield) J. Biomol. NMR 52, 159-177 (2012).
2011:
2011:
"Catalytic asymmetric [4+2] additions with aliphatic nitroalkenes" (K. J. Bartelson, R. P. Singh, B. M. Foxman and L. Deng) Chem. Sci. 2, 1940-1944 (2011).
2010:
2010:
“Dissecting the Microscopic Steps of the Cyclophilin A Enzymatic Cycle on the Biological HIV-1 Capsid Substrate by NMR” (D. A. Bosco, E. Z. Eisenmesser, M. W. Clarkson, M. Wolf-Watz, W. Labeikovsky, O. Millet and D. Kern) J. Mol. Biol. 403, 723-738 (2010).
“Dissecting the Microscopic Steps of the Cyclophilin A Enzymatic Cycle on the Biological HIV-1 Capsid Substrate by NMR” (D. A. Bosco, E. Z. Eisenmesser, M. W. Clarkson, M. Wolf-Watz, W. Labeikovsky, O. Millet and D. Kern) J. Mol. Biol. 403, 723-738 (2010).
“Probing Microsecond Tie Scale Dynamics In Proteins by Methyl 1H Carr-Purcell-Meiboom-Gill Relaxation Dispersion NMR Measurements. Application to Activation of the Signaling Protein NtrC” (R. Otten, J. Villali, D. Kern and F. A. A. Mulder) J. Am. Chem. Soc. 132, 17004-17014 (2010).
“Probing Microsecond Tie Scale Dynamics In Proteins by Methyl 1H Carr-Purcell-Meiboom-Gill Relaxation Dispersion NMR Measurements. Application to Activation of the Signaling Protein NtrC” (R. Otten, J. Villali, D. Kern and F. A. A. Mulder) J. Am. Chem. Soc. 132, 17004-17014 (2010).
"Defining Specific Lipid Binding Sites for a Peripheral Membrane Protein in Situ Using Subtesla Field-cycling NMR" (M. M. Pu, A. Orr, A. G. Redfield and M. F. Roberts)J. Biol. Chem. 285, 26916-26922 (2010).
2008:
2008:
“Structural, Biochemical, and in Vivo Characterization of the First Virally Encoded Cyclophilin from the Mimivirus” (V. Thai, P. Renesto, C. A. Fowler, D. J. Brown T. Davis, W. Gu, D. D. Pollock, D. Kern, D. Raoult and E. Z. Eisenmesser) J. Mol. Biol. 378, 71-86 (2008).
“Structural, Biochemical, and in Vivo Characterization of the First Virally Encoded Cyclophilin from the Mimivirus” (V. Thai, P. Renesto, C. A. Fowler, D. J. Brown T. Davis, W. Gu, D. D. Pollock, D. Kern, D. Raoult and E. Z. Eisenmesser) J. Mol. Biol. 378, 71-86 (2008).
2007:
2007:
“Structure and Dynamics of Pin1 During Catalysis by NMR” (W. Labeikovsky, E. Z. Eisenmesser, D. A. Bosco and D. Kern) J. Mol. Biol. 367, 1370-1381 (2007).
“Structure and Dynamics of Pin1 During Catalysis by NMR” (W. Labeikovsky, E. Z. Eisenmesser, D. A. Bosco and D. Kern) J. Mol. Biol. 367, 1370-1381 (2007).
“A hierarchy of timescales in protein dynamics is linked to enzyme catalysis” (K. A. Henzler-Wildman, M. Lei, V. Thai, S. J. Kerns, M. Karplus and D. Kern) Nature 450, 913-916 (2007).
“A hierarchy of timescales in protein dynamics is linked to enzyme catalysis” (K. A. Henzler-Wildman, M. Lei, V. Thai, S. J. Kerns, M. Karplus and D. Kern) Nature 450, 913-916 (2007).
2006:
2006:
"Specific effects of potassium ion binding on wild-type and L358P cytochrome P450cam" (B. OuYang, S. S. Pochapsky, G. M. Pagani and T. C. Pochapsky) Biochemistry 45, 14379-14388 (2006).
"Specific effects of potassium ion binding on wild-type and L358P cytochrome P450cam" (B. OuYang, S. S. Pochapsky, G. M. Pagani and T. C. Pochapsky) Biochemistry 45, 14379-14388 (2006).
“One protein, two enzymes revisited: A structural entropy switch interconverts the two isoforms of acireductone dioxygenase” (T. Ju, R. B. Goldsmith, S. C. Chai, M. J. Maroney, S. S. Pochapsky and T. C. Pochapsky) J. Mol. Biol. 393, 823-834 (2006).
“One protein, two enzymes revisited: A structural entropy switch interconverts the two isoforms of acireductone dioxygenase” (T. Ju, R. B. Goldsmith, S. C. Chai, M. J. Maroney, S. S. Pochapsky and T. C. Pochapsky) J. Mol. Biol. 393, 823-834 (2006).
“Comparison of the complexes formed by cytochrome P450cam with cytochrome b5 and putidaredoxin, two effectors of camphor hydroxylase activity” (L. Rui, S. S. Pochapsky & T. C. Pochapsky) Biochemistry 45 3887-3897 (2006).
“Comparison of the complexes formed by cytochrome P450cam with cytochrome b5 and putidaredoxin, two effectors of camphor hydroxylase activity” (L. Rui, S. S. Pochapsky & T. C. Pochapsky) Biochemistry 45 3887-3897 (2006).
"A refined model for the structure of acireductone dioxygenase from Klebsiella ATCC 8724 incorporating residual dipolar couplings” (T. C. Pochapsky, S. S. Pochapsky , T. Ju, C. Hoefler and J. Liang) J. Biomol. NMR 34, 117-127 (2006).
"A refined model for the structure of acireductone dioxygenase from Klebsiella ATCC 8724 incorporating residual dipolar couplings” (T. C. Pochapsky, S. S. Pochapsky , T. Ju, C. Hoefler and J. Liang) J. Biomol. NMR 34, 117-127 (2006).
"High resolution P-31 NMR field cycling probes phospholipid dynamics and interactions with
"High resolution P-31 NMR field cycling probes phospholipid dynamics and interactions with
phosphatidylinositol-specifle phospholipase C" (Roberts, M. F. & Redfield, A. G.) FASEB J. 20(4), A61-A61 Part 1 (2006).
phosphatidylinositol-specifle phospholipase C" (Roberts, M. F. & Redfield, A. G.) FASEB J. 20(4), A61-A61 Part 1 (2006).
2005:
2005:
"Detection of a high-barrier conformational change in the active site of cytochrome P450(cam) upon binding of putidaredoxin" (J. Y. Wei, T. C. Pochapsky and S. S. Pochapsky ) J. Am. Chem. Soc. 127, 6974-6976 (2005).
"Detection of a high-barrier conformational change in the active site of cytochrome P450(cam) upon binding of putidaredoxin" (J. Y. Wei, T. C. Pochapsky and S. S. Pochapsky ) J. Am. Chem. Soc. 127, 6974-6976 (2005).
"Enzyme dynamics during catalysis measured by NMR spectroscopy" (D. Kern, E. Z. Eisenmesser and M. Wolf-Watz) Meth. Enzymol. 394, 507-524 (2005).
"Enzyme dynamics during catalysis measured by NMR spectroscopy" (D. Kern, E. Z. Eisenmesser and M. Wolf-Watz) Meth. Enzymol. 394, 507-524 (2005).
2004:
2004:
"Letter to the Editor: H-1, C-13 and N-15 chemical shift assignments of an enolase-phosphatase, E1 from Klebsiella oxytoca" ( M. Kostic and T. C. Pochapsky) J. Biomol. NMR 30, 359-360 (2004).
"Letter to the Editor: H-1, C-13 and N-15 chemical shift assignments of an enolase-phosphatase, E1 from Klebsiella oxytoca" ( M. Kostic and T. C. Pochapsky) J. Biomol. NMR 30, 359-360 (2004).
"Phospholipid bilayer surface configuration probed quantitatively by P-31 field cycling NMR" (M. F. Roberts and A. G. Redfield) Proc. Natl. Acad. Sci. USA 101, 17066-17071 (2004).
"Phospholipid bilayer surface configuration probed quantitatively by P-31 field cycling NMR" (M. F. Roberts and A. G. Redfield) Proc. Natl. Acad. Sci. USA 101, 17066-17071 (2004).
"High-resolution P-31 field cycling NMR as a probe of phospholipid dynamics" (M. F. Roberts and A. G. Redfield) J. Am. Chem. Soc.126, 13765-13777 (2004).
"High-resolution P-31 field cycling NMR as a probe of phospholipid dynamics" (M. F. Roberts and A. G. Redfield) J. Am. Chem. Soc.126, 13765-13777 (2004).
"High-resolution field-cycling NMR studies of a DNA octamer as a probe of phosphodiester dynamics and comparison with computer simulation" (M. F. Roberts, Q. Z. Cui, C. J. Turner, D. A. Case and A. G. Redfield) Biochemistry 43, 3637-3650 (2004).
"High-resolution field-cycling NMR studies of a DNA octamer as a probe of phosphodiester dynamics and comparison with computer simulation" (M. F. Roberts, Q. Z. Cui, C. J. Turner, D. A. Case and A. G. Redfield) Biochemistry 43, 3637-3650 (2004).
"Field-cycling method with central transition readout for pure quadrupole resonance detection in dilute systems" (D. Ivanov and A. G. Redfield) J. Magn. Reson. 166, 19-27 (2004).
"Field-cycling method with central transition readout for pure quadrupole resonance detection in dilute systems" (D. Ivanov and A. G. Redfield) J. Magn. Reson. 166, 19-27 (2004).
"Catalysis and binding of cyclophilin a with different HIV-1 capsid constructs" (D. A. Bosco and D. Kern) Biochemistry 43, 6110-6119 (2004).
"Catalysis and binding of cyclophilin a with different HIV-1 capsid constructs" (D. A. Bosco and D. Kern) Biochemistry 43, 6110-6119 (2004).
2003:
2003:
"Structure and dynamics of paramagnetic proteins by NMR" ( M. Kostic and T. C. Pochapsky) ACS Symposium Series 858, 214- (2003).
"Structure and dynamics of paramagnetic proteins by NMR" ( M. Kostic and T. C. Pochapsky) ACS Symposium Series 858, 214- (2003).
"A conserved histidine in vertebrate-type ferredoxins is critical for redox-dependent dynamics" ( M. Kostic, R. Bernhardt and T. C. Pochapsky) Biochemistry 42, 8171-8182 (2003).
"A conserved histidine in vertebrate-type ferredoxins is critical for redox-dependent dynamics" ( M. Kostic, R. Bernhardt and T. C. Pochapsky) Biochemistry 42, 8171-8182 (2003).
"A model for effector activity in a highly specific biological electron transfer complex: The cytochrome P450(cam)-putidaredoxin couple" ( S. S. Pochapsky, J. Wei and T. C. Pochapsky) Biochemistry 42, 5649-5656 (2003).
"A model for effector activity in a highly specific biological electron transfer complex: The cytochrome P450(cam)-putidaredoxin couple" ( S. S. Pochapsky, J. Wei and T. C. Pochapsky) Biochemistry 42, 5649-5656 (2003).
"Shuttling device for high-resolution measurements of relaxation and related phenomena in solution at low field, using a shared commercial 500 MHz NMR instrument" ( A. G. Redfield) Magn. Reson. Chem. 41, 753-768 (2003).
"Shuttling device for high-resolution measurements of relaxation and related phenomena in solution at low field, using a shared commercial 500 MHz NMR instrument" ( A. G. Redfield) Magn. Reson. Chem. 41, 753-768 (2003).