Mechanisms

Our metabolomics methods have been successfully applied in various studies, including:

• Cancer Research: Understanding how metabolism changes in tumors controlled by the Myc gene.

• Heart Health: Studying how metabolism in the heart changes when treated with rapamycin.

• Muscle Science: Analyzing the metabolism of skeletal muscles in mammals.

• Stem Cell Research: Examining how the metabolism of human embryonic stem cells changes as they transition from a naive to a more specialized state.

a) H. Sperber, J. Mathieu, Y. Wang, A. Ferreccio, J. Hesson, Z. Xu, K. A. Fischer, A. Devi, D. Detraux, H. Gu, S. L. Battle, M. Showalter, C. Valensisi, J. H. Bielas, N. G. Ericson, L. Margaretha, A. M. Robitaille, D. Margineantu, O. Fiehn, D. Hockenbery, C. A. Blau, D. Raftery, A. A. Margolin, R. D. Hawkins, R. T. Moon, C. B. Ware, H. Ruohola-Baker*, “The Metabolome Regulates the Epigenetic Landscape During Naive-to-Primed Human Embryonic Stem Cell Transition”, Nat. Cell Bio., 17, 1523-1535, 2015. PMCID: PMC4662931

b) P. Carroll, D. Diolaiti, L. McFerrin, H. Gu, D. Djukovic, J. Du, P. Cheng, S. Anderson, M. Ulrich, J. Hurley, D. Raftery, D. Ayer, R. Eisenman*, “Deregulated Myc Requires MondoA/Mlx for Metabolic Reprogramming and Tumorigenesis”, Cancer Cell, 27, 271-285, 2015. PMCID: PMC4326605

c) C. Li, J. L. Dempsey, D. Wang, S. Lee, K. M. Weigel, Q. Fei, D. K. Bhatt, B. Prasad, D. Raftery, H. Gu*, J. Y. Cui*, “PBDEs Altered Gut Microbiome and Bile Acid Homeostasis in Male C57BL/6 Mice”, Drug Metab. Dispos., 2018. PMID: 29769268

d) R. J. Davis, M. Gönen, D. H. Margineantu, S. Handeli, J. Swanger, P. Hoellerbauer, P. J. Paddison, H. Gu, D. Raftery, J. E. Grim, D. M. Hockenbery, A. A. Margolin, B. E. Clurman, “Pan-cancer transcriptional signatures predictive of oncogenic mutations reveal that Fbw7 regulates cancer cell oxidative metabolism”, PNAS, 115, 5462-5467, 2018. PMID: 29735700