Mechanisms

Our metabolomics approaches have been successfully used in a growing number of studies, including metabolic reprogramming during Myc-regulated tumorigenesis, cardiac metabolic shifts induced by rapamycin, metabolic characterization of mammalian skeletal muscles, metabolome regulation during naive-to-primed human embryonic stem cell transition, and etc.

a) H. Sperber, J. Mathieu, Y. Wang, A. Ferreccio, J. Hesson, Z. Xu, K. A. Fischer, A. Devi, D. Detraux, H. Gu, S. L. Battle, M. Showalter, C. Valensisi, J. H. Bielas, N. G. Ericson, L. Margaretha, A. M. Robitaille, D. Margineantu, O. Fiehn, D. Hockenbery, C. A. Blau, D. Raftery, A. A. Margolin, R. D. Hawkins, R. T. Moon, C. B. Ware, H. Ruohola-Baker*, “The Metabolome Regulates the Epigenetic Landscape During Naive-to-Primed Human Embryonic Stem Cell Transition”, Nat. Cell Bio., 17, 1523-1535, 2015. PMCID: PMC4662931

b) P. Carroll, D. Diolaiti, L. McFerrin, H. Gu, D. Djukovic, J. Du, P. Cheng, S. Anderson, M. Ulrich, J. Hurley, D. Raftery, D. Ayer, R. Eisenman*, “Deregulated Myc Requires MondoA/Mlx for Metabolic Reprogramming and Tumorigenesis”, Cancer Cell, 27, 271-285, 2015. PMCID: PMC4326605

c) C. Li, J. L. Dempsey, D. Wang, S. Lee, K. M. Weigel, Q. Fei, D. K. Bhatt, B. Prasad, D. Raftery, H. Gu*, J. Y. Cui*, “PBDEs Altered Gut Microbiome and Bile Acid Homeostasis in Male C57BL/6 Mice”, Drug Metab. Dispos., 2018. PMID: 29769268

d) R. J. Davis, M. Gönen, D. H. Margineantu, S. Handeli, J. Swanger, P. Hoellerbauer, P. J. Paddison, H. Gu, D. Raftery, J. E. Grim, D. M. Hockenbery, A. A. Margolin, B. E. Clurman, “Pan-cancer transcriptional signatures predictive of oncogenic mutations reveal that Fbw7 regulates cancer cell oxidative metabolism”, PNAS, 115, 5462-5467, 2018. PMID: 29735700