Publication

Overexpressed Nup88 stabilized through interaction with Nup62 promotes NFκB dependent pathways in cancer. Singh U, Bindra D, Samaiya A, Mishra RK. Frontiers in Oncology. 13:1095046. doi: 10.3389/fonc.2023.1095046. (2023) 

Human Behavior-Inspired Linchpin-Directed Catalysis for Traceless Precision Labeling of Lysine in Native Proteins. Thakur K, T K Sajeev, Singh SK, Rawale DG, Adusumalli SR, Kalra N, Shukla S, Mishra RK, Rai V. Bioconjugate Chem. 33(12):2370-2380. doi: 10.1021/acs.bioconjchem.2c00454 (2022) 

Traceless cysteine-linchpin enables precision engineering of lysine in native proteins. Reddy N C, Molla R, Joshi N P, Sajeev T K, Basu I, Kawadkar J, Kalra N, Mishra RK, Chakrabarty S, Shukla S, Rai V. Nat Commun. 13(1):6038. doi: 10.1038/s41467-022-33772-1 (2022). 

Residue-specific N-terminal glycine to aldehyde transformation renders analytically pure single-site labeled proteins. Sahu T, Kumar M, T K S, Joshi M, Mishra RK, Rai V. Chem Commun (Camb). 58(89):12451-12454. doi: 10.1039/d2cc04196k (2022).

In vitro and in cellulae methods for determining the target protein SUMOylation. Sajeev T K, Panda AK, Kawadkar J, Bindra D, Joshi PA, Joshi G, Singh HV, Mishra RK. Methods Enzymol. 675:397-424. doi: 10.1016/bs.mie.2022.07.017 (2022).

Implications of critical nodes-dependent unidirectional cross-talk between Plasmodium and Human SUMO pathway proteins in Plasmodium infection. Singh J S, Sajeev T K, Panigrahi R, Cherry P, Panchakshari NA, Shukla V K, Kumar A, Mishra RK. Biophysical J. 121(8):1367-1380. doi: 10.1016/j.bpj.2022.03.022. (2022)

SARS CoV-2 spike E156G/Δ157-158 mutations contribute to increased infectivity and immune escape. Mishra T, Dalavi R, Joshi G, Kumar A, Pandey P, Shukla S, Mishra RK, Chande A. Life Science Alliance. 5(7):e202201415. doi: 10.26508/lsa.202201415  (2022). 

In the pursuit of Distinctiveness: Transmembrane Nucleoporins and Their disease Associations. Bindra D and Mishra RK. Frontiers in Oncology. 11:784319.  doi: 103389/fonc.2021.784319 (2021)

Linchpins empower promiscuous electrophiles to enable site-selective modification of histidine and aspartic acid in proteins. Rawale DG, Thakur K, Sreekumar P, Sajeev TK, Ramesh A, Adusumalli SR , Mishra RK, Rai V. Chemical Science 12 (19), 6732-6736 (2021)

SUMO and SUMOylation Pathway at the Forefront of Host Immune Response. TK Sajeev, Joshi G, Arya P, Mahajan V, Chaturvedi A, Mishra RK. Front Cell Dev Biol. 9:681057. doi: 10.3389/fcell.2021.681057 (2021)

Molecular and Phenotypic Characterization following RNAi mediated knockdown in Drosophila. Mehta SJK, Joshi PA, Mishra RK. Bioprotocls 11(4) (2021), DOI: 10.21769/BioProtoc.3924 

Implantable HDAC-inhibiting chemotherapeutics derived from hydrophobic amino acids for localized anticancer therapy. Bhagat SD, Chanchal A, Gujrati M, Banerjee A, Mishra RK, Srivastava A.  Biomaterials Sci. 9, 261-271 (2021) 

A single amino acid Gly-tag enables metal-free protein purification.  Purushottam L, Unnikrishnan VB, Rawale DG , Gujrati M, Mishra SD, Sajeev TK, Neelesh CR, Adusumalli SR , Mishra RK, Rai V. Chemical Science 11, 13137-13142  (2020)  

Amphiphilic Small-Molecule Assemblies to Enhance the Solubility and Stability of Hydrophobic Drugs. Gangarde YM, Sajeev TK, Panigrahi NR, Mishra RK, Saraogi I. ACS Omega 5 (43): 28375-28381 (2020). 

Drosophila ELYS regulates Dorsal dynamics during development. Mehta SJK, Kumar V, Mishra RK. J Biol Chem.  295(8):2421-2437 (2020). 

Single-site glycine-specific labeling of proteins. Purushottam L, Adusumalli SR , Singh U, Unnikrishnan VB , Rawale DG , Gujrati M, Mishra RK, Rai V. Nature communications 10 (1), 1-9 (2019).

SUMOylation of periplakin is critical for efficient reorganization of keratin filament network. Gujrati M, Mittal R, Ekal L, Mishra RK. Molecular Biology of Cell 30 (3), 357-369 (2019).

Single-site labeling of native proteins enabled by a chemoselective and site-selective chemical technology. Adusumalli SR, Rawale DG, Singh U, Tripathi P, Paul R, Kalra N, Mishra RK, Shukla S, Rai V. Journal of the American Chemical Society 140 (44), 15114-15123 (2018).

An Endogenous Reactive Oxygen Species (ROS)- Activated Histone Deacetylase Inhibitor Prodrug for cancer Chemotherapy. Bhagat SD, Singh U,  Mishra RK, Srivastava A.  ChemMedChem 13 (19), 2073-2079 (2018).

Backbone and side-chain resonance assignments of Plasmodium falciparum SUMO.  Singh JS, Shukla VK, Gujrati M, Mishra RK, Kumar A.  Biomol NMR Assign. 11(1): 17-20 (2017).

Cell Permeating Nano-Complexes of Amphiphilic Polyelectrolyte Enhances Solubility, Stability, and Anti-Cancer Efficacy of Curcumin. Fatima MT, Chanchal A, Yavvari PS, Bhagat SD, Gujrati M, Mishra RK, Srivastava A. Biomacromolecules. 17(7): 2573-83 (2016).

The Nup107-160 complex and g-TuRC regulate microtubule polymerization at kinetochore. Ram Kumar Mishra, Papia Chakraborty, Alexei Arnaoutov, Beatriz M.A. Fontoura, Mary Dasso. Nat. Cell Biol. 12(2):164-9 (2010).

Vesicular stomatitis virus inhibits mitotic progression and triggers cell death. Chakraborty P, Seemann J, Mishra RK, Wei JH, Weil L, Nussenzveig DR, Heiber J, Barber GN, Dasso M, Fontoura BM. EMBO Rep.10(10):1154-60 (2009).

Residue-level NMR view of the urea-driven equilibrium folding transition of SUMO-1 (1-97): native preferences do not increase monotonously. Kumar A, Srivastava S, Kumar, Mishra R, Mittal R, Hosur RV. J Mol Biol. 361(1):180-94 (2006).

Local structural preferences and dynamics restrictions in the urea-denatured state of SUMO-1: NMR characterization. Kumar A, Srivastava S, Mishra RK, Mittal R, Hosur RV. Biophys J. 90(7):2498-509 (2006).

Structural characterization of the large soluble oligomers of the GTPase effector domain of dynamin. Chugh J, Chatterjee A, Kumar A, Mishra RK, Mittal R, Hosur RV. FEBS J. 273 (2), 388-397 (2006) 

Folding regulates autoprocessing of HIV-1 protease precursor. Chatterjee A, Mridula P, Mishra RK, Mittal R, Hosur RV. J Biol Chem. 280(12):11369-78 (2005).

Dynamin interacts with members of the sumoylation machinery. Mishra RK, Jatiani SS, Kumar A, Simhadri VR, Hosur RV, Mittal R. J Biol Chem. 279(30):31445-54 (2004).