Project Overview:
We seek to create a fully adjustable mouse cradle that allows for optimal fMRI brain imaging and research by reducing vibration within the system in order to produce a clear picture. In addition to being modifiable, the cradle must also be made entirely of non-metallic and non-magnetic material, so as not to interfere with the magnetic field of the Bruker 7T Scanner. The resonance frequencies of 5 Hz and 1 kHz had to be especially avoided because the coil used for testing operates at 5 Hz and the scanner operates at 1 kHz.
Final Design:
For a more detailed background about Optogenetics, see Nature Method's video here:
The project's aim is to help in the study of optogenics, that is, the combination of genetic and optical methods to control specific events in targeted cells of living tissue, even within freely moving mammals and other animals, with the temporal precision needed to keep pace with functioning intact biological systems. The goal of optogenetics is to determine how specific activity patterns within specific brain cells ultimately give rise to thoughts, feeling and memories.
We chose isolation as our method to reduce vibration by creating a sys tem that held the cradle at the center of the bore, between two supporting air bladders. After testing the design, we found that, the two-ring system was not enough to balance the bore in the machine. There was an excess of material that reached out of the bore, that threw off the balance of the cradle, yet was necessary in order to safely remove the cradle from the machine. To counter this, we thought it prudent to add a third ring and air bladder to the end of the cradle, that would support the cradle in the bigger opening just outside the bore itself, and add a handle to the end of the cradle for ease of grasping. Unfortunately the time limits of the class prevented us from actually adding this piece to our design, but we provided the sponsor with Solid Works drawings and dimensions so that they could accomplish it in the near future.