Photocatalytic Structures for Protein Modifications

Zhengyi Liu, Yasunori Okamoto, Shinichi Sato

ChemCatChem 2024

Switching Type I/Type II Reactions by Turning a Photoredox Catalyst into a Photo-Driven Artificial Metalloenzyme

Yasunori Okamoto*(*Corresponding author), Takuya Mabuchi, Keita Nakane, Akiko Ueno, Shinichi Sato*

ACS Catal.  2023, 13, 4134-4141. (Selected as cover feature)

Water-Soluble Tris(cyclometalated) Iridium(III) Complexes for Aqueous Electron and Energy Transfer Photochemistry

Mirjam R Schreier, Xingwei Guo, Björn Pfund, Yasunori Okamoto, Thomas R Ward, Christoph Kerzig, Oliver S Wenger

Acc. Chem. Res.  2022, 55, 1290-1300.

Intracellular Unnatural Catalysis Enabled by an Artificial Metallonezyme

Yasunori Okamoto*, Ryosuke Kojima (*Corresponding author)

Methods Mol. Biol. 2021, 2312, 287-300.

A visible‐light promoted amine oxidation catalyzed by a Cp*Ir complex

 Holly Jane Davis,  Daniel Häussinger,  Thomas R. Ward,* Yasunori Okamoto* (*Corresponding author)

ChemCatChem 2020, 12, 4512-4516.

Selected as a Highly Important Paper, Young Researcher Series, Cover feature, Author interview

Artificial Metalloenzymes: From Selective Chemical Transformations to Biochemical Applications

Tomoki Himiyama, Yasunori Okamoto* (*Corresponding author) 

Molecules 2020, 25, 2989

Reductive amination and enantioselective amine synthesis by photoredox catalysis

Xingwei Guo, Yasunori Okamoto, Mirjam R Schreier, Thomas R Ward, Oliver S Wenger

Eur. J. Org. Chem. 2020, 1288–1293

Cell‐Penetrating Dynamic‐Covalent Benzopolysulfane Networks

Yangyang Cheng, Lili Zong, Javier López‐Andarias, Eline Bartolami, Yasunori Okamoto, Thomas R Ward, Naomi Sakai, Stefan Matile

Angew. Chem. Int. Ed. 2019, 58, 9522 –9526

Diselenolane-Mediated Cellular Uptake:Efficient Cytosolic Delivery of Probes, Peptides, Proteins, Artificial Metalloenzymes and Protein-Coated Quantum Dots

Eline Bartolami, Dimitris Basagiannis, Lili Zong, Rémi Martinent, Yasunori Okamoto, Quentin Laurent, Thomas R. Ward, MarcosGonzalez-Gaitan, NaomiSakai, and Stefan Matile

Chem. Eur. J.  2019, 25, 4047 –4051

Structural basis for the heme transfer reaction in heme uptake machinery from Corynebacteria

Norifumi Muraki, Chihiro Kitatsuji, Yasunori Okamoto, Takeshi Uchida,  Koichiro Ishimori  and Shigetoshi Aono

Chem. Commun. 2019, 55, 13864-13867

A Cell-penetrating Artificial Metalloenzyme Regulates a Gene Switch in a Designer Mammalian Cell

Yasunori Okamoto, Ryosuke Kojima, Fabian Schwizer, Eline Bartolami, Tillmann Heinisch, Stefan Matile, Martin Fussenegger, Thomas R. Ward 

 Nat. Commun. 2018, article number 1943. (Highlighted in C&EN news and ChemistryWorld) Top 50 : Chemistry and Materials Science

Enantioselective synthesis of amines by combining photoredox and enzymatic catalysis in a cyclic reaction network

Xingwei Guo, Yasunori Okamoto, Mirjam R. Schreier, Thomas R. Ward, Oliver S. Wenger

Chem. Sci. 2018, 9, 5052-5056 (Highlighted in ChemistryWorld and Nature)

Artificial Metalloenzymes: Reaction Scope and Optimization Strategies

Fabian Schwizer, Yasunori Okamoto, Tillmann Heinisch, Yifan Gu, Michela M. Pellizzoni, Vincent Lebrun, Raphael Reuter, Valentin Köhler, Jared C. Lewis, and Thomas R. Ward 

Chem. Rev. 2018, 118, 142-213.

Transfer Hydrogenation Catalyzed by Organometallic Complexes using NADH as Reductant in a Biochemical Context

Yasunori Okamoto, Thomas R. Ward

Biochemistry 2017, 56, 5223-5224.

Cross-Regulation of an Artificial Metalloenzyme

Yasunori Okamoto, Thomas R. Ward 

Angew. Chem. Int. Ed. 2017, 56, 10156-10160.

Supramolecular Enzyme Mimics

Yasunori Okamoto, Thomas R. Ward,

in Comprehensive Supramolecular Chemistry II, 2017, vol. 4, 459–510. Atwood, J. L. Eds., Elsevier.

An NAD(P)H-Dependent Artificial Transfer Hydrogenase for Multienzymatic Cascades

Yasunori Okamoto, Valentin Köhler,Thomas R. Ward,

 J. Am. Chem. Soc. 2016,138, 5781-5784.  (highlighted in ACS select collection, and editorial)

Efficient In SituRegeneration of NADH Mimics by an Artificial Metalloenzyme 

Yasunori Okamoto, Valentin Köhler, Caroline E. Paul,Frank Hollmann,Thomas R. Ward

ACS. Catal. 2016, 6, 3553-3557.

From Photodriven Charge Accumulation to Fueling Enzyme Cascades in Molecular Factories

Yasunori Okamoto, Thomas R. Ward, Oliver S. Wenger

Chimia, 2016, 70, 395-397.

Heme-binding Properties of HupD functioning as a substrate-binding protein in a heme-uptake ABC-transporter system in Listeria monocytogenes”

Yasunori Okamoto, Hitomi Sawai, Mariko Ogura, Takeshi Uchida, Koichiro Ishimori, Takashi Hayashi, Shigetoshi Aono

Bull. Chem. Soc. Jpn. 2014, 87, 1140-1146.

H2O2-dependent substrate oxidation by an engineered diiron site in a bacterial hemerythrin

Yasunori Okamoto, Akira Onoda, Hiroshi Sugimoto, Yu Takano,  Shun Hirota, Donald M. Kurtz Jr., Yoshitsugu Shiro and Takashi Hayashi

Chem. Comm. 2014, 50, 3421-3423. (Front Cover)

Crystal Structure, Exogenous Ligand Binding, and Redox Properties of an Engineered Diiron Active Site in a Bacterial Hemerythrin

Yasunori Okamoto, Akira Onoda, Hiroshi Sugimoto, Yu Takano, Shun Hirota, Donald M. Kurtz, Jr., Yoshitsugu Shiro, and Takashi Hayashi

Inorg. Chem. 2013, 52, 13014-13020

Crystal Structure and Spectroscopic Studies of a Stable Mixed-Valent State of the Hemerythrin-like Domain of a Bacterial Chemotaxis Protein

Akira Onoda, Yasunori Okamoto, Hiroshi Sugimoto, Yoshitsugu Shiro, and Takashi Hayashi

Inorg. Chem. 2011, 50, 4892-4899.