Research
From Biomolecular Engineering to Biochemical Systems Engineering
Artificial metalloenzymes (ArMs), which can be constructed by incorporating a synthetic metal complex into a protein matrix, are my main research interests. Thus, my research includes
(1) development of synthetic catalysts as an abiotic cofactor of artificial metalloenzyme,
(2) protein engineering to optimize reaction environment (e.g. hydrophobicity, chirality etc...)
(3) construction of artificial metalloenzymes with a developed abiotic cofactor and an engineered protein
(4) designing catalysis systems composed of natural/artificial enzymes for multistep chemical transformation in one pot or construction of out-of-equilibrium system.
1. Reaction Development
For more details, please refer following papers
J. Am. Chem. Soc. 2016,138, 5781-5784.
ChemCatChem 2020, 12, 4512-4516.
2. Protein Engineering
For more details, please refer following papers
Chem. Comm. 2014, 50, 3421-3423.
Inorg. Chem. 2013, 52, 13014-13020.
3. Arificial Metalloenzyme
For more details, please refer following papers
Chem. Rev. 2018, 118, 142-213.
ACS. Catal. 2023, 13, 4134-4141.
Comprehensive Supramolecular Chemistry II, 2017, vol. 4, 459–510. Atwood, J. L. Eds., Elsevier.
4. Arificial/Natural Enzymatic Reaction Network
For more details, please refer following papers
ACS. Catal. 2016, 6, 3553-3557.
J. Am. Chem. Soc. 2016,138, 5781-5784.
Angew. Chem. Int. Ed. 2017, 56, 10156-10160.
Nat. Commun. 2018, article number 1943.