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deformation due to high venous pressure (left picture), swelling due to insufficient oxygen partial pressure (picture middle and right). Figure 2: Oxygen therapy for varicose veins: achievable increase in O2 - saturation with oxygen multi-step therapy. Figure 3: Oxygen Multistep therapy for varicose veins: Clinical picture of a patient with multiple ulcers - after VenaSeal® therapy and then after a series of 3 weeks regular combination of massage therapy and oxygen multi-step therapy healing of ulcers. Citation: Zierau UT (2021) Saphenion®: Oxygen Multi-Step Therapy in Varicose Veins: Improvement of the Microcirculation- Our Prospective Study Results in 118 Cases Over 6 Months. J Angiol Vasc Surg 6: 075. • Page 3 of 4 • J Angiol Vasc Surg ISSN: 2572-7397, Open Access Journal DOI: 10.24966/AVS-7397/100075 Volume 6 • Issue 2 • 100075 Saphenion®: Oxygen multistep therapy for varicose veins - Clinical experiences The remaining 118 patients reported fewer post-operative complaints - feeling of tension, swelling, tightness - and unrestricted athletic and professional resilience. In the clinical examinations first day, 14 days, 4 weeks and 3 months after therapy with the vein glue and micro-foam, we only saw reddening along the treated vein in 6 patients (5.1%) (foreign body reaction according to VenaSeal®) - this is nearly one third less of this side effect compared to the overall group of all 1647 patients (3215 truncal varicose veins) treated so far with the vein glue (here 7,48% foreign body reaction). We saw also 2 patients (1,7%) with micro-foam induced phlebitis (OVT)!Side effects minimal - in two cases patients reported about post therapeutic coughing and allergic similar reaction after Oxygen multistep therapy. Other side effects were not reported or seen! In particular, no deep vein thrombosis or OVT was seen after micro-foam therapy and related massagetherapy! According to these initial results from a comparatively small patient group of 118 patients, the advantages of the oxygen multi-step therapy coupled with massage therapy are already evident. It should be considered whether, in addition to minimally invasive therapy for varicose veins on the legs using micro-foam and catheter interventions (VenaSeal®, radio wave, laser), accompanying treatment using massage and oxygen Multi-Step Therapy (SMT) can generally be recommended to patients. We will definitely continue our research on this. The rehabilitation of the varicose veins initially leads to a significant reduction in venous pressure in the entire venous flow right through to the capillaries. This process is clearly supported by the post-operative massage. The accompanying oxygen therapy also generates a significant increase in the oxygen partial pressure with improved oxygen saturation of the cells and thus also leads to a swelling of the microcirculatory vessels, an improved immunological reaction to the foreign bodies, bio-glue and sclerotherapy foam, and faster wound healing [7,8]. Saphenion® - Oxygen multistep therapy for varicose veins - Our therapeutic consequences / discussion In addition to the special indications for vascular medicine-arteries, veins, microcirculation in all body regions - oxygen Multi-Step Therapy (SMT) also has very good effects in other diseases [9]. Although it is certainly not easy for a surgeon to use non-surgical therapy, we are now ready to use non-surgical therapies adjuvant to catheter interventions on the arterial and vein system in the sense of a holistic therapeutic approach [10]. The multi-step oxygen therapy is one of the effective adjuvant therapies that also provides the vascular specialist with non-surgical accompanying therapies to further improve the therapy results for our patients. In the past, oxygen multi-step therapy has certainly been somewhat underestimated and viewed as less effective. The importance of oxygen for tissues and cells has also been brought back into the light. Our own, still short experiences confirm the substantial additional effect of this therapy [7,8]. In addition to normalizing the venous pressure, the aim is to improve the oxygen partial pressure in order to improve the microcirculation in the legs in a sustainable and multi-functional way. In our first results, a reduction
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