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studies in a larger number of high-risk patients will be conducted to verify these preliminary results. The authors thank the Vascular Surgery Department at the VA Medical Center, for their cooperation; Long Ngo, M.S., and Ida M. Tateo, M.S., for the statistical analysis; and Winifred molecular control mechanisms that regulate the activity of genes in response to fluctuating amounts of oxygen [1]. This Nobel Prize award is also a late honor for Prof. Manfred von Ardenne and his team at the Dresden Ardenne-Institute of the same name. As early as 1977, the scientists at the institute Auf dem Weißen Hirsch at the mountains around the city Dresden had questions about the energetic supply of the cell energy balance, especially about the role of oxygen concentration in the cells, worked [1]. Basically, the oxygen multi-step therapy helps with many energy-intensive life processes. Defined as a naturopathic treatment in Germany, there are a number of effects [1]. • Improvement of the oxygen status: What oxygen therapy brings can be measured and felt! • A special feature of the therapy: systemic long-term effects without side effects • Oxygen can help: 80% of all complaints are due to a lack of oxygen in cellular respiration! • Oxygen is a powerful material: a sudden increase in general mental and physical performance. • Radiance and beauty - the skin also benefits greatly from oxygen • Fit into old age: slowing down aging processes (anti-aging) • One more: energy, vitality, endurance, defenses and concentration • No hurdles: The application is very easy to implement The varicose veins of the legs lead to a backflow of the venous blood into the lower leg. Both the deep veins and the skin veins are under high pressure. This pressure is passed back to the capillaries unhindered. Both muscle spasm electrodes and venules have no venous valves, and control of the venous blood in the microcirculatory area is not possible. This means that the capillaries are under further tension, in addition to the reduction in the oxygen partial pressure, the venous pressure also causes the capillary walls to swell and cause a pathological deformation of these microcirculatory vessels [2,3]. On the one hand swelling of the capillary wall due to reduced oxygen partial pressure in the arteries, swelling and deformation of the capillary walls due to high venous back pressure. We are dealing here with an identical pathological effect on the capillary wall due to two completely different causes (Figure 1). Therapeutical view: oxygen multi-steptherapy for varicose veins-What can we do? It should be considered whether, in addition to the minimally invasive therapy of the varicose veins on the legs by means of micro-foam and catheter interventions (VenaSeal®, radio wave, laser), an accompanying treatment using oxygen multi-step therapy should be carried out [4]. Zierau UT, et al., J Angiol Vasc Surg 2021, 6: 075 DOI: 10.24966/AVS-7397/100075 HSOA Journal of Angiology & Vascular Surgery Case Study Ulf Thorsten Zierau* Founder and CEO of SAPHENION®-Vascular Surgeon, Germany Saphenion®: Oxygen MultiStep Therapy in Varicose Veins: Improvement of the Microcirculation- Our Prospective Study Results in 118 Cases Over 6 Months Abstract Oxygen multi-step therapy for Varicose Veins: Oxygen as an energy carrier, all mechanisms in the human organism during growth, its maintenance and its physical and mental activity require energy. This becomes particularly clear to the patient during cardiac work, breathing work in the lungs, skeletal muscles and intellectual work. The pathology of the microcirculation in the capillaries depends largely on the oxygen partial pressure and on the blood pressure in the supplying arteries and the high pressure in the draining veins. Keywords: Improvement of capillary function; Microcirculation of legs; Micro-foam; Micro-foam - reduction of OVT; Oxygen multistep therapy after sealing varicose veins; Varicose veins; VenaSeal®; VenaSeal® closure system - reduction of foreign body reaction Citation: Zierau UT (2021) Saphenion®: Oxygen Multi-Step Therapy in Varicose Veins: Improvement of the Microcirculation- Our Prospective Study Results in 118 Cases Over 6 Months. J Angiol Vasc Surg 6: 075. •
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