Normal and Pathological Red Cell Physiology

The permeability of human red blood cell membranes to hydrogen peroxide is independent of aquaporins. Orrico F, Lopez AC, Saliwonczyk D, Acosta C, Rodriguez-Grecco I, Mouro-Chanteloup I, Ostuni MA, Denicola A, Thomson L and Möller MN. J Biol Chem. 2021 Dec 17:101503. doi: 10.1016/j.jbc.2021. 101503. 

Strenuous exercise in warm environment is associated with improved microvascular function in sickle cell trait. Reminy K, Ngo Sock ET, Romana M, Connes P, Ravion S, Henri S, Hue O, Hardy-Dessources MD, Antoine-Jonville S. Eur J Appl Physiol. 2021 Oct 11. doi: 10.1007/s00421-021-04821-2. 

Extracellular Vesicles in Sickle Cell Disease: Plasma Concentration, Blood Cell Types Origin Distribution and Biological Properties. Nader E, Garnier Y, Connes P, Romana M. Front Med (Lausanne). 2021 Aug 20;8:728693. doi: 10.3389/fmed.2021.728693. eCollection 2021.

Plasmodium vivax binds host CD98hc (SLC3A2) to enter immature red blood cells. Malleret B, El Sahili A, Tay MZ, Carissimo G, Ong ASM, Novera W, Lin J, Suwanarusk R, Kosaisavee V, Chu TTT, Sinha A, Howland SW, Fan Y, Gruszczyk J, Tham WH, Colin Y, Maurer-Stroh S, Snounou G, Ng LFP, Chan JKY, Chacko AM, Lescar J, Chandramohanadas R, Nosten F, Russell B, Rénia L. Nat Microbiol. 2021 Aug;6(8):991-999. doi: 10.1038/s41564-021-00939-3. Epub 2021 Jul 22

Renal allograft DARCness in subclinical acute and chronic active ABMR. Kläger J, Eskandary F, Böhmig GA, Kozakowski N, Kainz A, Colin Aronovicz Y, Cartron JP, Segerer S, Regele H.. Transpl Int. 2021 Aug;34(8):1494-1505. doi: 10.1111/tri.13904. Epub 2021 Jun 25 

Extracellular ATP hydrolysis in Caco-2 human intestinal cell line. Schachter J, Alvarez CL, Bazzi Z, Faillace MP, Corradi G, Hattab C, Rinaldi DE, Gonzalez-Lebrero R, Molineris MP, Sévigny J, Ostuni MA, Schwarzbaum PJ. Biochim Biophys Acta Biomembr. 2021 Jun 30:183679. doi: 10.1016/j.bbamem.2021.183679.Online ahead of print.

Low incidence of COVID-19 severe complications in a large cohort of children with sickle cell disease: a protective role for basal interferon-1 activation? Brousse V, Holvoet L, Pescarmona R, Viel S, Perret M, Visseaux B, Ferre VM, Ithier G, Le Van Kim C, Benkerrou M, Missud F, Koehl B. Haematologica. 2021 May 13. doi: 10.3324/haematol.2021.278573. Online ahead of print.

Brain injury pathophysiology study by a multimodal approach in children with sickle cell anemia with no intra or extra cranial arteriopathy. Brousse V, Pondarre C, Kossorotoff M, Arnaud C, Kamdem A, de Montalembert M, Boutonnat-Faucher B, Allali S, Bourdeau H, Charlot K, Bertil S, Da Costa L, Connes P, Grévent D, Verlhac S. Haematologica. 2021 Apr 22. doi: 10.3324/haematol.2020.278226.

 Metabolic rejuvenation upgrades circulatory functions of red blood cells stored under blood bank conditions. Marin M, Roussel C, Dussiot M, Ndour PA, Hermine O, Colin Y, Gray A, Landrigan M, Le Van Kim C, Buffet PA, Amireault P. Transfusion. 2021 Mar;61(3):903-918. doi: 10.1111/trf.16245. Epub 2020 Dec 31.

Ineffective erythropoiesis in sickle cell disease: new insights and future implications. El Nemer W, Godard A, El Hoss S. Curr Opin Hematol. 2021 May 1;28(3):171-176. doi: 10.1097/MOH.

Inherited glycosylphosphatidylinositol defects cause the rare Emm-negative blood phenotype and developmental disorders. Duval R, Nicolas G, Willemetz A, Murakami Y, Mikdar M, Vrignaud C, Megahed H, Cartron JP, Masson C, Wehbi S, Koehl B, Hully M, Siquier K, Chemaly N, Rotig A, Lyonnet S, Colin Y, Barcia G, Cantagrel V, Le Van Kim C, Hermine O, Kinoshita T, Peyrard T, Azouzi S. Blood. 2021 Mar 24:blood.2020009810. doi: 10.1182/blood.2020009810. Online ahead of print. PMID: 3376370

Deficient mitophagy pathways in sickle cell disease. Martino S, Arlet JB, Odièvre MH, Jullien V, Moras M, Hattab C, Lefebvre T, Gouya L, Ostuni MA, Lefevre SD, Le Van Kim C. Br J Haematol. 2021 Mar 22. doi: 10.1111/bjh.17416.

Sickle Cell Trait Modulates the Proteome and Phosphoproteome of Plasmodium falciparum-Infected Erythrocytes. Chauvet M, Chhuon C, Lipecka J, Dechavanne S, Dechavanne C, Lohezic M, Ortalli M, Pineau D, Ribeil JA, Manceau S, Le Van Kim C, Luty AJF, Migot-Nabias F, Azouzi S, Guerrera IC, Merckx A. Front Cell Infect Microbiol. 2021 Mar 24;11:637604. doi: 10.3389/fcimb.2021.637604. eCollection 2021. PMID: 33842387 

ABCG2 Is Overexpressed on Red Blood Cells in Ph-Negative Myeloproliferative Neoplasms and Potentiates Ruxolitinib-Induced Apoptosis. Buks R, Brusson M, Cochet S, Galochkina T, Cassinat B, Nemazanyy I, Peyrard T, Kiladjian JJ, de Brevern AG, Azouzi S, El Nemer W. Int J Mol Sci. 2021 Mar 29;22(7):3530. doi: 10.3390/ijms22073530.

The equilibrative nucleoside transporter 1 (ENT1) is critical for nucleotide homeostasis and optimal erythropoiesis. Mikdar M, Gonzalez-Menendez P, Cai X, Zhang Y, Serra M, Dembélé AK, Boschat AC, Sanquer S, Chhuon C, Guerrera IC, Sitbon M, Hermine O, Colin Y, Le Van Kim C, Kinet S, Narla M, Xia Y, Peyrard T, Taylor N, Azouzi S. Blood. 2021 Mar 10:blood.2020007281. doi: 10.1182/blood.2020007281. Online ahead of print.

Human erythroid differentiation requires VDAC1-mediated mitochondrial clearance. Moras M, Hattab C, Gonzalez-Menendez P, Fader CM, Dussiot M, Larghero J, Le Van Kim C, Kinet S, Taylor N, Lefevre SD, Ostuni MA. Haematologica. 2021 Jan 7. doi: 10.3324/haematol.2020.257121.   

Rapid clearance of storage-induced micro-erythrocytes alters transfusion recovery. Roussel C, Morel A, Dussiot M, Marin M, Colard M, Fricot-Monsinjon A, Martinez A, Chambrion C, Henry B, Casimir M, Volle G, Dépond M, Dokmak S, Paye F, Sauvanet A, Le Van Kim C, Colin Y, Georgeault S, Roingeard P, Spitalnik SL, Ndour PA, Hermine O, Hod EA, Buffet PA, Amireault P. Blood. 2021 Mar 3:blood.2020008563. doi: 10.1182/blood.2020008563. 

Oxidative stress, inflammation, blood rheology and microcirculation in adults with sickle cell disease: effects of hydroxyurea treatment and impact of sickle cell syndrome. Connes P, Möckesch B, Tudor Ngo Sock E, Hardy-Dessources MD, Reminy K, Skinner S, Billaud M, Nader E, Tressieres B, Etienne-Julan M, Guillot N, Lemonne N, Hue O, Romana M, Antoine-Jonville S. Eur J Haematol. 2021 Feb 24. doi: 10.1111/ejh.13607

Loss of alpha globin genes is associated with improved microvascular function in patients with sickle cell anemia. Romana M, Reminy K, Moeckesch B, Charlot K, Hardy-Dessources MD, Doumdo L, Tressieres B, Etienne-Julan M, Lemonne N, Denton C, Coates T, Petras M, Antoine-Jonville S, Connes P. Am J Hematol. 2021 Feb 13. doi: 10.1002/ajh.26126

Sickle Cell Maculopathy: Microstructural Analysis Using OCTA and Identification of Genetic, Systemic, and Biological Risk Factors. Fares S, Hajjar S, Romana M, Connes P, Acomat M, Zorobabel C, Zuber K, Boulanger-Scemama E, Etienne-Julan M, David T, Beral L. Am J Ophthalmol. 2021 Jan 4;224:7-17. doi: 10.1016/j.ajo.2020.11.019.

Toward a conversational agent to support the self-management of adults and young adults with Sickle Cell Disease: Usability and Usefulness Study. Issom DZ, Hardy-Dessources MD, Romana M, Hartvigsen G, Lovis C. Front Digit Health. 2021 Jan 29;3:600333. doi: 10.3389/fdgth.2021.600333. PMID: 34713087; PMCID: PMC8521934.

Performance of African-ancestry-specific polygenic hazard score varies according to local ancestry in 8q24. Karunamuni RA, Huynh-Le MP, Fan CC, Thompson W, Lui A, Martinez ME, Rose BS, Mahal B, Eeles RA, Kote-Jarai Z, Muir K, Lophatananon A; UKGPCS Collaborators, Tangen CM, Goodman PJ, Thompson IM Jr, Blot WJ, Zheng W, Kibel AS, Drake BF, Cussenot O, Cancel-Tassin G, Menegaux F, Truong T, Park JY, Lin HY, Taylor JA, Bensen JT, Mohler JL, Fontham ETH, Multigner L, Blanchet P, Brureau L, Romana M, Leach RJ, John EM, Fowke JH, Bush WS, Aldrich MC, Crawford DC, Cullen J, Petrovics G, Parent MÉ, Hu JJ, Sanderson M; PRACTICAL Consortium, Mills IG, Andreassen OA, Dale AM, Seibert TM. Prostate Cancer Prostatic Dis. 2021 Jun 14. doi: 10.1038/s41391-021-00403-7. Epub ahead of print. PMID: 34127801.

Vasculopathy in Sickle Cell Disease: From Red Blood Cell Sickling to Vascular Dysfunction. Nader E, Conran N, Romana M, Connes P. Compr Physiol. 2021 Apr 1;11(2):1785-1803. doi: 10.1002/cphy.c200024. PMID: 33792905.

Cell-derived microparticles and sickle cell disease chronic vasculopathy in sub-Saharan Africa: A multinational study. Dembélé AK, Lapoumeroulie C, Diaw M, Tessougue O, Offredo L, Diallo DA, Diop S, Elion J, Colin-Aronovicz Y, Tharaux PL, Jouven X, Romana M, Ranque B, Le Van Kim C. Br J Haematol. 2021 Feb;192(3):634-642. doi: 10.1111/bjh.17242. Epub 2020 Nov 29. PMID: 33249569.

African-specific improvement of a polygenic hazard score for age at diagnosis of prostate cancer. Karunamuni RA, Huynh-Le MP, Fan CC, Thompson W, Eeles RA, Kote-Jarai Z, Muir K; UKGPCS Collaborators, Lophatananon A, Tangen CM, Goodman PJ, Thompson IM Jr, Blot WJ, Zheng W, Kibel AS, Drake BF, Cussenot O, Cancel-Tassin G, Menegaux F, Truong T, Park JY, Lin HY, Bensen JT, Fontham ETH, Mohler JL, Taylor JA, Multigner L, Blanchet P, Brureau L, Romana M, Leach RJ, John EM, Fowke J, Bush WS, Aldrich M, Crawford DC, Srivastava S, Cullen JC, Petrovics G, Parent MÉ, Hu JJ, Sanderson M, Mills IG, Andreassen OA, Dale AM, Seibert TM; PRACTICAL Consortium. Int J Cancer. 2021 Jan 1;148(1):99-105. doi: 10.1002/ijc.33282. Epub 2020 Sep 24. PMID: 32930425.