Normal and Pathological Red Cell Physiology

ATPe Dynamics in Protozoan Parasites. Adapt or Perish. Lauri N, Bazzi Z, Alvarez CL, Leal Denis MF, Schachter J, Herlax V, Ostuni MA, Schwarzbaum PJ. Genes (Basel). 2018 Dec 27;10(1):16. doi: 10.3390/genes10010016.PMID: 30591699

The Genetic Landscape of Diamond-Blackfan Anemia. Ulirsch JC, Verboon JM, Kazerounian S, Guo MH, Yuan D, Ludwig LS, Handsaker RE, Abdulhay NJ, Fiorini C, Genovese G, Lim ET, Cheng A, Cummings BB, Chao KR, Beggs AH, Genetti CA, Sieff CA, Newburger PE, Niewiadomska E, Matysiak M, Vlachos A, Lipton JM, Atsidaftos E, Glader B, Narla A, Gleizes PE, O'Donohue MF, Montel-Lehry N, Amor DJ, McCarroll SA, O'Donnell-Luria AH, Gupta N, Gabriel SB, MacArthur DG, Lander ES, Lek M, Da Costa L, Nathan DG, Korostelev AA, Do R, Sankaran VG, Gazda HT. Am J Hum Genet. 2018 Dec 6;103(6):930-947. doi: 10.1016/j.ajhg.2018.10.027. Epub 2018 Nov 29.PMID: 30503522

ew insights into red cell rheology and adhesion in patients with sickle cell anaemia during vaso-occlusive crises. Lapoumeroulie C, Connes P, El Hoss S, Hierso R, Charlot K, Lemonne N, Elion J, Le Van Kim C, Romana M, Hardy-Dessources MD. Br J Haematol. 2019 Jun;185(5):991-994. doi: 10.1111/bjh.15686. Epub 2018 Nov 22.PMID: 30467840

International Society of Blood Transfusion Working Party on Red Cell Immunogenetics and Blood Group Terminology: Report of the Dubai, Copenhagen and Toronto meetings. Storry JR, Clausen FB, Castilho L, Chen Q, Daniels G, Denomme G, Flegel WA, Gassner C, de Haas M, Hyland C, Yanli J, Keller M, Lomas-Francis C, Nogues N, Olsson ML, Peyrard T, van der Schoot E, Tani Y, Thornton N, Wagner F, Weinstock C, Wendel S, Westhoff C, Yahalom V. Vox Sang. 2019 Jan;114(1):95-102. doi: 10.1111/vox.12717. Epub 2018 Nov 12.PMID: 3042142

Resolution of sickle cell disease-associated inflammation and tissue damage with 17R-resolvin D1. Matte A, Recchiuti A, Federti E, Koehl B, Mintz T, El Nemer W, Tharaux PL, Brousse V, Andolfo I, Lamolinara A, Weinberg O, Siciliano A, Norris PC, Riley IR, Iolascon A, Serhan CN, Brugnara C, De Franceschi L. Blood. 2019 Jan 17;133(3):252-265. doi: 10.1182/blood-2018-07-865378. Epub 2018 Nov 7.PMID: 30404812

Point-of-care screening for sickle cell disease in low-resource settings: A multi-center evaluation of HemoTypeSC, a novel rapid test. Steele C, Sinski A, Asibey J, Hardy-Dessources MD, Elana G, Brennan C, Odame I, Hoppe C, Geisberg M, Serrao E, Quinn CT. Am J Hematol. 2019 Jan;94(1):39-45. doi: 10.1002/ajh.25305. Epub 2018 Oct 31.PMID: 30290004

Absolute proteome quantification of highly purified populations of circulating reticulocytes and mature erythrocytes. Gautier EF, Leduc M, Cochet S, Bailly K, Lacombe C, Mohandas N, Guillonneau F, El Nemer W, Mayeux P. Blood Adv. 2018 Oct 23;2(20):2646-2657. doi: 10.1182/bloodadvances.2018023515.PMID: 30327373

Sensing of red blood cells with decreased membrane deformability by the human spleen. Safeukui I, Buffet PA, Deplaine G, Perrot S, Brousse V, Sauvanet A, Aussilhou B, Dokmak S, Couvelard A, Cazals-Hatem D, Mercereau-Puijalon O, Milon G, David PH, Mohandas N. Blood Adv. 2018 Oct 23;2(20):2581-2587. doi: 10.1182/bloodadvances.2018024562.PMID: 30305267

Hydroxyurea therapy modulates sickle cell anemia red blood cell physiology: Impact on RBC deformability, oxidative stress, nitrite levels and nitric oxide synthase signalling pathway. Nader E, Grau M, Fort R, Collins B, Cannas G, Gauthier A, Walpurgis K, Martin C, Bloch W, Poutrel S, Hot A, Renoux C, Thevis M, Joly P, Romana M, Guillot N, Connes P. Nitric Oxide. 2018 Dec 1;81:28-35. doi: 10.1016/j.niox.2018.10.003. Epub 2018 Oct 19.PMID: 30342855

Newborn screening for sickle cell disease in Europe: recommendations from a Pan-European Consensus Conference. Lobitz S, Telfer P, Cela E, Allaf B, Angastiniotis M, Backman Johansson C, Badens C, Bento C, Bouva MJ, Canatan D, Charlton M, Coppinger C, Daniel Y, de Montalembert M, Ducoroy P, Dulin E, Fingerhut R, Frömmel C, García-Morin M, Gulbis B, Holtkamp U, Inusa B, James J, Kleanthous M, Klein J, Kunz JB, Langabeer L, Lapouméroulie C, Marcao A, Marín Soria JL, McMahon C, Ohene-Frempong K, Périni JM, Piel FB, Russo G, Sainati L, Schmugge M, Streetly A, Tshilolo L, Turner C, Venturelli D, Vilarinho L, Yahyaoui R, Elion J, Colombatti R; with the endorsement of EuroBloodNet, the European Reference Network in Rare Haematological Diseases. Br J Haematol. 2018 Nov;183(4):648-660. doi: 10.1111/bjh.15600. Epub 2018 Oct 18.PMID: 30334577

Induction of ATP Release, PPIX Transport, and Cholesterol Uptake by Human Red Blood Cells Using a New Family of TSPO Ligands. Marginedas-Freixa I, Alvarez CL, Moras M, Hattab C, Bouyer G, Chene A, Lefevre SD, Le Van Kim C, Bihel F, Schwarzbaum PJ, Ostuni MA. Int J Mol Sci. 2018 Oct 10;19(10):3098. doi: 10.3390/ijms19103098.PMID: 30308949

CD34+ Hematopoietic Stem Cell Count Is Predictive of Vascular Event Occurrence in Children with Sickle Cell Disease. Kossorotoff M, De Montalembert M, Brousse V, Lasne D, Curis E, Smadja DM, Lacroix R, Bertil S, Masson E, Desguerre I, Bonnet D, Gaussem P. Stem Cell Rev Rep. 2018 Oct;14(5):694-701. doi: 10.1007/s12015-018-9835-8.PMID: 29931411

A microfluidic approach to study the effect of mechanical stress on erythrocytes in sickle cell disease. Lizarralde Iragorri MA, El Hoss S, Brousse V, Lefevre SD, Dussiot M, Xu T, Ferreira AR, Lamarre Y, Silva Pinto AC, Kashima S, Lapouméroulie C, Covas DT, Le Van Kim C, Colin Y, Elion J, Français O, Le Pioufle B, El Nemer W. Lab Chip. 2018 Sep 26;18(19):2975-2984. doi: 10.1039/c8lc00637g.PMID: 30168832

Subtotal and total splenectomy for hereditary pyropoikilocytosis: Benefits and outcomes. Pincez T, Guitton C, Landman-Parker J, Brousse V, Gauthier F, Da Costa L, Ghazal K, Dufillot D, Tchernia G, Picard V, Garçon L. Am J Hematol. 2018 Oct;93(10):E340-E342. doi: 10.1002/ajh.25223. Epub 2018 Sep 26.PMID: 30035308

Prognostic factors of disease severity in infants with sickle cell anemia: A comprehensive longitudinal cohort study. Brousse V, El Hoss S, Bouazza N, Arnaud C, Bernaudin F, Pellegrino B, Guitton C, Odièvre-Montanié MH, Mames D, Brouzes C, Picard V, Nguyen-Khoa T, Pereira C, Lapouméroulie C, Pissard S, Gardner K, Menzel S, Le Van Kim C, Colin-Aronovicz Y, Buffet P, Mohandas N, Elie C, Maier-Redelsperger M, El Nemer W, de Montalembert M. Am J Hematol. 2018 Nov;93(11):1411-1419. doi: 10.1002/ajh.25260. Epub 2018 Sep 21.PMID: 30132969

Inherited or acquired modifiers of iron status may dramatically affect the phenotype in dehydrated hereditary stomatocytosis. Orvain C, Da Costa L, Van Wijk R, Pissard S, Picard V, Mansour-Hendili L, Cunat S, Giansily-Blaizot M, Cartron G, Schved JF, Aguilar-Martinez P. Eur J Haematol. 2018 Oct;101(4):566-569. doi: 10.1111/ejh.13135. Epub 2018 Aug 31.PMID: 29969830

An update on the pathogenesis and diagnosis of Diamond-Blackfan anemia. Da Costa L, Narla A, Mohandas N. F1000Res. 2018 Aug 29;7:F1000 Faculty Rev-1350. doi: 10.12688/f1000research.15542.1. eCollection 2018.PMID: 30228860

Paramacular temporal atrophy in sickle cell disease occurs early in childhood. Martin GC, Albuisson E, Brousse V, de Montalembert M, Bremond-Gignac D, Robert MP. Br J Ophthalmol. 2019 Jul;103(7):906-910. doi: 10.1136/bjophthalmol-2018-312305. Epub 2018 Aug 21.PMID: 30131379

Endothelial Cells Harbouring the JAK2V617F Mutation Display Pro-Adherent and Pro-Thrombotic Features. Guadall A, Lesteven E, Letort G, Awan Toor S, Delord M, Pognant D, Brusson M, Verger E, Maslah N, Giraudier S, Larghero J, Vanneaux V, Chomienne C, El Nemer W, Cassinat B, Kiladjian JJ. Thromb Haemost. 2018 Sep;118(9):1586-1599. doi: 10.1055/s-0038-1667015. Epub 2018 Aug 13.PMID: 30103245

An Optimized Lentiviral Vector Efficiently Corrects the Human Sickle Cell Disease Phenotype. Weber L, Poletti V, Magrin E, Antoniani C, Martin S, Bayard C, Sadek H, Felix T, Meneghini V, Antoniou MN, El-Nemer W, Mavilio F, Cavazzana M, Andre-Schmutz I, Miccio A. Mol Ther Methods Clin Dev. 2018 Aug 4;10:268-280. doi: 10.1016/j.omtm.2018.07.012. eCollection 2018 Sep 21.PMID: 30140714

Human erythrocytes release ATP by a novel pathway involving VDAC oligomerization independent of pannexin-1. Marginedas-Freixa I, Alvarez CL, Moras M, Leal Denis MF, Hattab C, Halle F, Bihel F, Mouro-Chanteloup I, Lefevre SD, Le Van Kim C, Schwarzbaum PJ, Ostuni MA. Sci Rep. 2018 Jul 30;8(1):11384. doi: 10.1038/s41598-018-29885-7.PMID: 30061676

How to mitigate the risk of inducing transfusion-associated adverse reactions. Garraud O, Cognasse F, Laradi S, Hamzeh-Cognasse H, Peyrard T, Tissot JD, Fontana S. Transfus Clin Biol. 2018 Nov;25(4):262-268. doi: 10.1016/j.tracli.2018.07.006. Epub 2018 Jul 27.PMID: 30139570

Fetal cerebral hemorrhage due to X-linked GATA1 gene mutation. Bouchghoul H, Quelin C, Loget P, Encha-Razavi F, Senat MV, Maheut L, Galimand J, Collardeau-Frachon S, Da Costa L, Martinovic J. Prenat Diagn. 2018 Sep;38(10):772-778. doi: 10.1002/pd.5320. Epub 2018 Jul 24.PMID: 29949202

Blocking Macrophage Migration Inhibitory Factor Protects Against Cisplatin-Induced Acute Kidney Injury in Mice. Li J, Tang Y, Tang PMK, Lv J, Huang XR, Carlsson-Skwirut C, Da Costa L, Aspesi A, Fröhlich S, Szczęśniak P, Lacher P, Klug J, Meinhardt A, Fingerle-Rowson G, Gong R, Zheng Z, Xu A, Lan HY. Mol Ther. 2018 Oct 3;26(10):2523-2532. doi: 10.1016/j.ymthe.2018.07.014. Epub 2018 Jul 17.PMID: 30077612

A novel non-invasive method to measure splenic filtration function in humans. El Hoss S, Dussiot M, Renaud O, Brousse V, El Nemer W. Haematologica. 2018 Oct;103(10):e436-e439. doi: 10.3324/haematol.2018.188920. Epub 2018 Jun 7.PMID: 29880604

Fluorescence Exclusion: A Simple Method to Assess Projected Surface, Volume and Morphology of Red Blood Cells Stored in Blood Bank. Roussel C, Monnier S, Dussiot M, Farcy E, Hermine O, Le Van Kim C, Colin Y, Piel M, Amireault P, Buffet PA. Front Med (Lausanne). 2018 May 30;5:164. doi: 10.3389/fmed.2018.00164. eCollection 2018.PMID: 29900172

Management of the blood supply for a Jk(a-b-) patient with an anti-Jk3 in preparation for an urgent heart transplant: An illustrative example of a successful international cooperation. Thonier V, Cohen-Bacrie S, Loussert I, Thornton N, Djoudi R, Woimant G, Boulat C, Pirenne F, Peyrard T. Transfus Clin Biol. 2019 Feb;26(1):48-55. doi: 10.1016/j.tracli.2018.04.002. Epub 2018 May 23.PMID: 29802018

A proposal for a rational transfusion strategy in patients of European and North African descent with weak D type 4.0 and 4.1 phenotypes. Flegel WA, Peyrard T, Chiaroni J, Tournamille C, Jamet D, Pirenne F. Blood Transfus. 2019 Mar;17(2):89-90. doi: 10.2450/2018.0059-18. Epub 2018 May 3.PMID: 31013249

Early Noninvasive Ventilation and Nonroutine Transfusion for Acute Chest Syndrome in Sickle Cell Disease in Children: A Descriptive Study. Heilbronner C, Merckx A, Brousse V, Allali S, Hubert P, de Montalembert M, Lesage F. Pediatr Crit Care Med. 2018 May;19(5):e235-e241. doi: 10.1097/PCC.0000000000001468.PMID: 29356722

High immunogenicity of red blood cell antigens restricted to the population of African descent in a cohort of sickle cell disease patients. Floch A, Gien D, Tournamille C, Chami B, Habibi A, Galactéros F, Bierling P, Djoudi R, Pondarré C, Peyrard T, Pirenne F. Transfusion. 2018 Jun;58(6):1527-1535. doi: 10.1111/trf.14633. Epub 2018 Apr 29.PMID: 29707783

Gene Therapy in Patients with Transfusion-Dependent β-Thalassemia. Thompson AA, Walters MC, Kwiatkowski J, Rasko JEJ, Ribeil JA, Hongeng S, Magrin E, Schiller GJ, Payen E, Semeraro M, Moshous D, Lefrere F, Puy H, Bourget P, Magnani A, Caccavelli L, Diana JS, Suarez F, Monpoux F, Brousse V, Poirot C, Brouzes C, Meritet JF, Pondarré C, Beuzard Y, Chrétien S, Lefebvre T, Teachey DT, Anurathapan U, Ho PJ, von Kalle C, Kletzel M, Vichinsky E, Soni S, Veres G, Negre O, Ross RW, Davidson D, Petrusich A, Sandler L, Asmal M, Hermine O, De Montalembert M, Hacein-Bey-Abina S, Blanche S, Leboulch P, Cavazzana M. N Engl J Med. 2018 Apr 19;378(16):1479-1493. doi: 10.1056/NEJMoa1705342.PMID: 29669226

Transfusion-associated hazards: A revisit of their presentation. Garraud O, Sut C, Haddad A, Tariket S, Aloui C, Laradi S, Hamzeh-Cognasse H, Bourlet T, Zeni F, Aubron C, Ozier Y, Laperche S, Peyrard T, Buffet P, Guyotat D, Tavernier E, Cognasse F, Pozzetto B, Andreu G. Transfus Clin Biol. 2018 May;25(2):118-135. doi: 10.1016/j.tracli.2018.03.002. Epub 2018 Apr 4.PMID: 29625790

Impact of hydroxycarbamide and interferon-α on red cell adhesion and membrane protein expression in polycythemia vera. Brusson M, De Grandis M, Cochet S, Bigot S, Marin M, Leduc M, Guillonneau F, Mayeux P, Peyrard T, Chomienne C, Le Van Kim C, Cassinat B, Kiladjian JJ, El Nemer W. Haematologica. 2018 Jun;103(6):972-981. doi: 10.3324/haematol.2017.182303. Epub 2018 Mar 29.PMID: 29599206 

Recurring mutations in RPL15 are linked to hydrops fetalis and treatment independence in Diamond-Blackfan anemia. Wlodarski MW, Da Costa L, O'Donohue MF, Gastou M, Karboul N, Montel-Lehry N, Hainmann I, Danda D, Szvetnik A, Pastor V, Paolini N, di Summa FM, Tamary H, Quider AA, Aspesi A, Houtkooper RH, Leblanc T, Niemeyer CM, Gleizes PE, MacInnes AW. Haematologica. 2018 Jun;103(6):949-958. doi: 10.3324/haematol.2017.177980. Epub 2018 Mar 29.PMID: 29599205 

Population Pharmacokinetics of Cefotaxime and Dosage Recommendations in Children with Sickle Cell Disease. Maksoud E, Koehl B, Facchin A, Ha P, Zhao W, Kaguelidou F, Benkerrou M, Mariani P, Faye A, Lorrot M, Jacqz-Aigrain E. Antimicrob Agents Chemother. 2018 Mar 27;62(4):e00637-17. doi: 10.1128/AAC.00637-17. Print 2018 Apr.PMID: 29378711

Induction of fetal hemoglobin synthesis by CRISPR/Cas9-mediated editing of the human β-globin locus. Antoniani C, Meneghini V, Lattanzi A, Felix T, Romano O, Magrin E, Weber L, Pavani G, El Hoss S, Kurita R, Nakamura Y, Cradick TJ, Lundberg AS, Porteus M, Amendola M, El Nemer W, Cavazzana M, Mavilio F, Miccio A. Blood. 2018 Apr 26;131(17):1960-1973. doi: 10.1182/blood-2017-10-811505. Epub 2018 Mar 8.PMID: 29519807

Lipid profiles in French West Indies sickle cell disease cohorts, and their general population. Lalanne-Mistrih ML, Connes P, Lamarre Y, Lemonne N, Hardy-Dessources MD, Tarer V, Etienne-Julan M, Mougenel D, Tressières B, Romana M. Lipids Health Dis. 2018 Mar 5;17(1):38. doi: 10.1186/s12944-018-0689-5.PMID: 29506549

The Gerbich blood group system: old knowledge, new importance. Jaskiewicz E, Peyrard T, Kaczmarek R, Zerka A, Jodlowska M, Czerwinski M. Transfus Med Rev. 2018 Apr;32(2):111-116. doi: 10.1016/j.tmrv.2018.02.004. Epub 2018 Mar 2.PMID: 29540278

Band 3 phosphorylation induces irreversible alterations of stored red blood cells. Azouzi S, Romana M, Arashiki N, Takakuwa Y, El Nemer W, Peyrard T, Colin Y, Amireault P, Le Van Kim C. Am J Hematol. 2018 May;93(5):E110-E112. doi: 10.1002/ajh.25044. Epub 2018 Feb 24.PMID: 29352741

Association between Oxidative Stress, Genetic Factors, and Clinical Severity in Children with Sickle Cell Anemia. Renoux C, Joly P, Faes C, Mury P, Eglenen B, Turkay M, Yavas G, Yalcin O, Bertrand Y, Garnier N, Cuzzubbo D, Gauthier A, Romana M, Möckesch B, Cannas G, Antoine-Jonville S, Pialoux V, Connes P. J Pediatr. 2018 Apr;195:228-235. doi: 10.1016/j.jpeds.2017.12.021. Epub 2018 Feb 13.PMID: 29449005

Coexistent sickle-cell anemia and autoimmune disease in eight children: pitfalls and challenges. Li-Thiao-Te V, Uettwiller F, Quartier P, Lacaille F, Bader-Meunier B, Brousse V, de Montalembert M. Pediatr Rheumatol Online J. 2018 Jan 17;16(1):5. doi: 10.1186/s12969-017-0221-x.PMID: 29343274 

Involvement of hepcidin in iron metabolism dysregulation in Gaucher disease. Lefebvre T, Reihani N, Daher R, de Villemeur TB, Belmatoug N, Rose C, Colin-Aronovicz Y, Puy H, Le Van Kim C, Franco M, Karim Z. Haematologica. 2018 Apr;103(4):587-596. doi: 10.3324/haematol.2017.177816. Epub 2018 Jan 5.PMID: 29305416 

Glycophorin-C sialylation regulates Lu/BCAM adhesive capacity during erythrocyte aging. Klei TRL, de Back DZ, Asif PJ, Verkuijlen PJJH, Veldthuis M, Ligthart PC, Berghuis J, Clifford E, Beuger BM, van den Berg TK, van Zwieten R, El Nemer W, van Bruggen R. Blood Adv. 2018 Jan 3;2(1):14-24. doi: 10.1182/bloodadvances.2017013094. eCollection 2018 Jan 9.PMID: 29344581 

Microparticles in sickle cell disease. Romana M, Connes P, Key NS. Clin Hemorheol Microcirc. 2018;68(2-3):319-329. doi: 10.3233/CH-189014.PMID: 29614639 

Blood rheological abnormalities in sickle cell anemia. Connes P, Renoux C, Romana M, Abkarian M, Joly P, Martin C, Hardy-Dessources MD, Ballas SK. Clin Hemorheol Microcirc. 2018;68(2-3):165-172. doi: 10.3233/CH-189005.PMID: 29614630 

Implications of a paediatrician-psychologist tandem for sickle cell disease care and impact on cognitive functioning. Lerner A, Picard H, May A, Gajdos V, Malou-Dhaussy L, Maroja-Cox F, Salomon L, Odièvre MH. Eur J Pediatr. 2018 Feb;177(2):193-203. doi: 10.1007/s00431-017-3050-5. Epub 2017 Nov 29.PMID: 29185057 

The ammonia transporter RhCG modulates urinary acidification by interacting with the vacuolar proton-ATPases in renal intercalated cells. Bourgeois S, Bounoure L, Mouro-Chanteloup I, Colin Y, Brown D, Wagner CA. Kidney Int. 2018 Feb;93(2):390-402. doi: 10.1016/j.kint.2017.07.027. Epub 2017 Oct 18.PMID: 29054531 

Decrease of externalized phosphatidylserine density on red blood cell-derived microparticles in SCA patients treated with hydroxycarbamide. Garnier Y, Ferdinand S, Connes P, Garnier M, Etienne-Julan M, Lemonne N, Romana M. Br J Haematol. 2018 Aug;182(3):448-451. doi: 10.1111/bjh.14810. Epub 2017 Jun 27.PMID: 28653368 

Prevalence of sickle cell disease among Grenadian newborns. Antoine M, Lee K, Donald T, Belfon Y, Drigo A, Polson S, Martin F, Mitchell G, Etienne-Julan M, Hardy-Dessources MD. J Med Screen. 2018 Mar;25(1):49-50. doi: 10.1177/0969141317695356. Epub 2017 Mar 24.PMID: 29183229