Normal and Pathological Red Cell Physiology

The proteome of neutrophils in sickle cell disease reveals an unexpected activation of interferon alpha signaling pathway. Hermand P, Azouzi S, Gautier EF, Guillonneau F, Bondet V, Duffy D, Dechavanne S, Tharaux PL, Mayeux P, Le Van Kim C, Koehl B. Haematologica. 2020 Dec 1;105(12):2851-2854. doi: 10.3324/haematol.2019.238295.

Metabolic rejuvenation upgrades circulatory functions of red blood cells stored under blood bank conditions. Marin M, Roussel C, Dussiot M, Ndour PA, Hermine O, Colin Y, Gray A, Landrigan M, Le Van Kim C, Buffet PA, Amireault P. Transfusion. 2020 Dec 31. doi: 10.1111/trf.16245. Online ahead of print.PMID: 33381865

Does endurance training improve red blood cell aging and hemorheology in moderate-trained healthy individuals? Bizjak DA, Tomschi F, Bales G, Nader E, Romana M, Connes P, Bloch W, Grau M. J Sport Health Sci. 2020 Dec;9(6):595-603. doi: 10.1016/j.jshs.2019.02.002. Epub 2019 Feb 10.PMID: 33308809  

Downregulation of Mitochondrial TSPO Inhibits Mitophagy and Reduces Enucleation during Human Terminal Erythropoiesis. Moras M, Hattab C, Gonzalez-Menendez P, Martino S, Larghero J, Le Van Kim C, Kinet S, Taylor N, Lefevre SD, Ostuni MA. Int J Mol Sci. 2020 Nov 28;21(23):9066. doi: 10.3390/ijms21239066.PMID: 33260618 

Association Between Nitric Oxide, Oxidative Stress, Eryptosis, Red Blood Cell Microparticles, and Vascular Function in Sickle Cell Anemia. Nader E, Romana M, Guillot N, Fort R, Stauffer E, Lemonne N, Garnier Y, Skinner SC, Etienne-Julan M, Robert M, Gauthier A, Cannas G, Antoine-Jonville S, Tressières B, Hardy-Dessources MD, Bertrand Y, Martin C, Renoux C, Joly P, Grau M, Connes P. Front Immunol. 2020 Nov 4;11:551441. doi: 10.3389/fimmu.2020.551441. eCollection 2020.PMID: 33250889 

Cell-derived microparticles and sickle cell disease chronic vasculopathy in sub-Saharan Africa: A multinational study. Dembélé AK, Lapoumeroulie C, Diaw M, Tessougue O, Offredo L, Diallo DA, Diop S, Elion J, Colin-Aronovicz Y, Tharaux PL, Jouven X, Romana M, Ranque B, Le Van Kim C. Br J Haematol. 2020 Nov 29. doi: 10.1111/bjh.17242. Online ahead of print.PMID: 33249569 

Mortality in children with sickle cell disease in mainland France from 2000 to 2015. Desselas E, Thuret I, Kaguelidou F, Benkerrou M, De Montalembert M, Odièvre MH, Lesprit E, Rumpler E, Fontanet A, Pondarre C, Brousse V. Haematologica. 2020 Jun 5;105(9):e440-443. doi: 10.3324/haematol.2019.237602.PMID: 33054059 

Effect of hydroxyurea exposure before puberty on sperm parameters in males with sickle cell disease. Joseph L, Jean C, Manceau S, Chalas C, Arnaud C, Kamdem A, Pondarre C, Habibi A, Bernaudin F, Allali S, De Montalembert M, Boutonnat-Faucher B, Arlet JB, Koehl B, Cavazzana M, Ribeil JA, Lionnet F, Berthaut I, Brousse V. Blood. 2020 Sep 24:blood.2020006270. doi: 10.1182/blood.2020006270. Online ahead of print.PMID: 32976551

Genetic Analysis of Patients With Sickle Cell Anemia and Stroke Before 4 Years of Age Suggest an Important Role for Apoliprotein E. JN, Smith AE, Cook R, Tewari S, Brent J, Wilkinson S, Brousse V, Inusa B, Menzel S, Rees DC. Circ Genom Precis Med. 2020 Oct;13(5):531-540. doi: 10.1161/CIRCGEN.120.003025. Epub 2020 Sep 14.PMID: 32924542 

Editing a γ-globin repressor binding site restores fetal hemoglobin synthesis and corrects the sickle cell disease phenotype. Weber L, Frati G, Felix T, Hardouin G, Casini A, Wollenschlaeger C, Meneghini V, Masson C, De Cian A, Chalumeau A, Mavilio F, Amendola M, Andre-Schmutz I, Cereseto A, El Nemer W, Concordet JP, Giovannangeli C, Cavazzana M, Miccio A. Sci Adv. 2020 Feb 12;6(7):eaay9392. doi: 10.1126/sciadv.aay9392. Print 2020 Feb.PMID: 32917636 

CORS (CROM20): A new high-prevalence antigen in the Cromer blood group system. Vrignaud C, Chiaroni J, Durieux-Roussel E, Le Van Kim C, Azouzi S, Peyrard T. Transfusion. 2020 Nov;60(11):E40-E42. doi: 10.1111/trf.16052. Epub 2020 Sep 8.PMID: 32897629 

Hemophagocytic lymphohystiocytosis after haemolytic transfusion reaction due to anti-Wra in a patient with myelodysplastic syndrome. Contejean A, Barreau S, Peyrard T, Bouscary D, Nataf J, Willems L. Transfus Med. 2020 Oct;30(5):410-412. doi: 10.1111/tme.12712. Epub 2020 Sep 7.PMID: 32893913 

Fetal hemoglobin rescues ineffective erythropoiesis in sickle cell disease. El Hoss S, Cochet S, Godard A, Yan H, Dussiot M, Frati G, Boutonnat-Faucher B, Laurance S, Renaud O, Joseph L, Miccio A, Brousse V, Mohandas N, El Nemer W. Haematologica. 2020 Aug 27:haematol.2020.265462. doi: 10.3324/haematol.2020.265462. Online ahead of print.PMID: 32855279

Oxidative stress activates red cell adhesion to laminin in sickle cell disease. Lizarralde-Iragorri MA, Lefevre SD, Cochet S, El Hoss S, Brousse V, Filipe A, Dussiot M, Azouzi S, Le Van Kim C, Rodrigues-Lima F, Français O, Le Pioufle B, Klei T, van Bruggen R, El Nemer W. Haematologica. 2020 Aug 27:haematol.2020.261586. doi: 10.3324/haematol.2020.261586. Online ahead of print.PMID: 32855277 

Appropriate thresholds for accurate screening for β-thalassemias in the newborn period: results from a French center for newborn screening. Allaf B, Pondarre C, Allali S, De Montalembert M, Arnaud C, Barrey C, Benkerrou M, Benhaim P, Bensaid P, Brousse V, Dollfus C, Eyssette-Guerreau S, Galacteros F, Gajdos V, Garrec N, Guillaumat C, Guitton C, Monfort-Gouraud M, Gouraud F, Holvoet L, Ithier G, Kamdem A, Koehl B, Malric A, Missud F, Monier B, Odièvre MH, Joly P, Renoux C, Patin F, Pissard S, Couque N. Clin Chem Lab Med. 2020 Aug 19:/j/cclm.ahead-of-print/cclm-2020-0803/cclm-2020-0803.xml. doi: 10.1515/cclm-2020-0803. Online ahead of print.PMID: 32813673 

Effects of sphingolipids overload on red blood cell properties in Gaucher disease. Dupuis L, Chipeaux C, Bourdelier E, Martino S, Reihani N, Belmatoug N, Billette de Villemeur T, Hivert B, Moussa F, Le Van Kim C, de Person M, Franco M. J Cell Mol Med. 2020 Sep;24(17):9726-9736. doi: 10.1111/jcmm.15534. Epub 2020 Aug 7.PMID: 32767726 

An Overview of Different Strategies to Recreate the Physiological Environment in Experimental Erythropoiesis. Deleschaux C, Moras M, Lefevre SD, Ostuni MA. Int J Mol Sci. 2020 Jul 24;21(15):5263. doi: 10.3390/ijms2115526 

Versatile Dimerisation Process of Translocator Protein (TSPO) Revealed by an Extensive Sampling Based on a Coarse-Grained Dynamics Study. Rao R, Diharce J, Dugué B, Ostuni MA, Cadet F, Etchebest C. J Chem Inf Model. 2020 Aug 24;60(8):3944-3957. doi: 10.1021/acs.jcim.0c00246. Epub 2020 Aug 5.PMID: 32697916 

Chronic Granulomatous Disease with the McLeod Phenotype: a French National Retrospective Case Series. Lhomme F, Peyrard T, Babinet J, Abou-Chahla W, Durieu I, Moshous D, Neven B, Rohrlich PS, Albinni S, Amiranoff D, Dumont MD, Lortholary O, Héritier S, Marguet C, Suarez F, Fischer A, Blanche S, Hermine O, Mahlaoui N. J Clin Immunol. 2020 Jul;40(5):752-762. doi: 10.1007/s10875-020-00791-w. Epub 2020 Jun 19.PMID: 32562208 

Characterization of red blood cell microcirculatory parameters using a bioimpedance microfluidic device. Xu T, Lizarralde-Iragorri MA, Roman J, Ghasemi R, Lefèvre JP, Martincic E, Brousse V, Français O, El Nemer W, Le Pioufle B. Sci Rep. 2020 Jun 17;10(1):9869. doi: 10.1038/s41598-020-66693-4.PMID: 32555353

CX3CL1 homo-oligomerization drives cell-to-cell adherence. Ostuni MA, Hermand P, Saindoy E, Guillou N, Guellec J, Coens A, Hattab C, Desuzinges-Mandon E, Jawhari A, Iatmanen-Harbi S, Lequin O, Fuchs P, Lacapere JJ, Combadière C, Pincet F, Deterre P. Sci Rep. 2020 Jun 3;10(1):9069. doi: 10.1038/s41598-020-65988-w.PMID: 32494000 

The Human Spleen in Malaria: Filter or Shelter? Henry B, Roussel C, Carucci M, Brousse V, Ndour PA, Buffet P. Trends Parasitol. 2020 May;36(5):435-446. doi: 10.1016/j.pt.2020.03.001. Epub 2020 Mar 30.PMID: 32298631 

Plasma microparticles of sickle patients during crisis or taking hydroxyurea modify endothelium inflammatory properties. Garnier Y, Ferdinand S, Garnier M, Cita KC, Hierso R, Claes A, Connes P, Hardy-Dessources MD, Lapouméroulie C, Lemonne N, Etienne-Julan M, El Nemer W, Romana M. Blood. 2020 Jul 9;136(2):247-256. doi: 10.1182/blood.2020004853.PMID: 32285120 

The Red Blood Cell-Inflammation Vicious Circle in Sickle Cell Disease. Nader E, Romana M, Connes P. Front Immunol. 2020 Mar 13;11:454. doi: 10.3389/fimmu.2020.00454. eCollection 2020.PMID: 32231672 

A Tutsi family harbouring two new RHCE variant alleles and a new haplotype in the Rh blood group system. Deleers M, Thonier V, Claes V, Daelemans C, Peyrard T, El Kenz H. Vox Sang. 2020 Jul;115(5):451-455. doi: 10.1111/vox.12905. Epub 2020 Mar 20.PMID: 32196693 

Platelet Counting: Ugly Traps and Good Advice. Proposals from the French-Speaking Cellular Hematology Group (GFHC). Baccini V, Geneviève F, Jacqmin H, Chatelain B, Girard S, Wuilleme S, Vedrenne A, Guiheneuf E, Toussaint-Hacquard M, Everaere F, Soulard M, Lesesve JF, Bardet V. J  Clin Med. 2020 Mar 16;9(3):808. doi: 10.3390/jcm9030808.PMID: 32188124 

Red Blood Cell AE1/Band 3 Transports in Dominant Distal Renal Tubular Acidosis Patients. Bertocchio JP, Genetet S, Da Costa L, Walsh SB, Knebelmann B, Galimand J, Bessenay L, Guitton C, De Lafaille R, Vargas-Poussou R, Eladari D, Mouro-Chanteloup I. Kidney Int Rep. 2020 Jan 13;5(3):348-357. doi: 10.1016/j.ekir.2019.12.020. eCollection 2020 Mar.PMID: 3215445 

Deficiency of αII-spectrin affects endothelial cell-matrix contact and migration leading to impairment of angiogenesis in vitro. Machnicka B, Ponceau A, Picot J, Colin Y, Lecomte MC. Cell Mol Biol Lett. 2020 Feb 3;25:3. doi: 10.1186/s11658-020-0200-y. eCollection 2020.PMID: 32042281 

Usefulness of azacitidine therapy in a sickle cell disease patient with myelodysplastic syndrome. De Luna G, Darnige L, Roueff S, Peyrard T, Pouchot J, Arlet JB.  Ann Hematol. 2020 Mar;99(3):661-662. doi: 10.1007/s00277-020-03940-8. Epub 2020 Jan 31.PMID: 32006149 

Semaphorin 7A: A novel marker of disease activity in Gaucher disease. Franco M, Reihani N, Dupuis L, Collec E, Billette de Villemeur T, de Person M, Moussa F, Berger MG, Belmatoug N, Le Van Kim C. Am J Hematol. 2020 May;95(5):483-491. doi: 10.1002/ajh.25744. Epub 2020 Feb 7.PMID: 31990411 

TSPO2 translocates 5-aminolevulinic acid into human erythroleukemia cells. Manceau H, Lefevre SD, Mirmiran A, Hattab C, Sugier HR, Schmitt C, Peoc'h K, Puy H, Ostuni MA, Gouya L, Lacapere JJ. Biol Cell. 2020 Apr;112(4):113-126. doi: 10.1111/boc.201900098. Epub 2020 Feb 5.PMID: 31989647 

Lack of the multidrug transporter MRP4/ABCC4 defines the PEL-negative blood group and impairs platelet aggregation. Azouzi S, Mikdar M, Hermand P, Gautier EF, Salnot V, Willemetz A, Nicolas G, Vrignaud C, Raneri A, Mayeux P, Bole-Feysot C, Nitschké P, Cartron JP, Colin Y, Hermine O, Jedlitschky G, Cloutier M, Constanzo-Yanez J, Ethier C, Robitaille N, St-Louis M, Le Van Kim C, Peyrard T. Blood. 2020 Feb 6;135(6):441-448. doi: 10.1182/blood.2019002320.PMID: 31826245 

Red blood cell autoantibodies: The importance of being earnestly autoadsorbed. Beguet-Yachine M, Lafarge X, Besiers C, Augis V, Ramelet S, Peyrard T, Thonier V. Transfus Med. 2020 Feb;30(1):73-74. doi: 10.1111/tme.12648. Epub 2019 Nov 26.PMID: 31769550 

Detergent-free isolation of native red blood cell membrane complexes. Desrames A, Genetet S, Delcourt MP, Goossens D, Mouro-Chanteloup I. Biochim Biophys Acta Biomembr. 2020 Feb 1;1862(2):183126. doi: 10.1016/j.bbamem.2019.183126. Epub 2019 Nov 16.PMID: 31738902

Dengue in hospitalized children with sickle cell disease: A retrospective cohort study in the French departments of America. Elenga N, Celicourt D, Muanza B, Elana G, Hocquelet S, Tarer V, Maillard F, Sibille G, Divialle Doumdo L, Petras M, Tressières B, Etienne-Julan M.  Infect Public Health. 2020 Feb;13(2):186-192. doi: 10.1016/j.jiph.2019.07.015. Epub 2019 Sep 20.PMID: 31548164

Salivary extracellular vesicles can modulate purinergic signalling in oral tissues by combined ectonucleoside triphosphate diphosphohydrolases and ecto-5'-nucleotidase activities. González DA, Barbieri van Haaster MM, Quinteros Villarruel E, Hattab C, Ostuni MA, Orman B. Mol Cell Biochem. 2020 Jan;463(1-2):1-11. doi: 10.1007/s11010-019-03624-6. Epub 2019 Sep 17.PMID: 31531757